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11. 发明授权

US06482836B1 CRF antagonistic quino- and quinazolines 失效
标题翻译： CRF拮抗喹诺酮和喹唑啉
公开(公告)号：US06482836B1
公开(公告)日：2002-11-19
申请号：US09403393
申请日：1999-10-19
申请人： Charles Huang , Keith M. Wilcoxen , Chen Chen , Mustapha Haddach , James R. McCarthy
发明人： Charles Huang , Keith M. Wilcoxen , Chen Chen , Mustapha Haddach , James R. McCarthy
IPC分类号： A61K314706
CPC分类号： C07D215/233 , C07D215/12 , C07D215/36 , C07D215/42 , C07D239/94 , C07D401/04
摘要： This invention concerns compounds of formula including the stereoisomers and the pharmaceutically acceptable acid addition salt forms thereof, wherein R1 is C1-6alkyl, NR6R7, OR6 or SR7; R2 is hydrogen, C1-6alkyl, C1-6alkyloxy or C1-6alkylthio; R3 is Ar1 or Het1; R4 and R5 are each independently selected from hydrogen, halo, C1-6alkyl, C1-6alkyloxy, trifluoromethyl, cyano, nitro, amino, and mono- or di(C1-6alkyl)amino; R6 is hydrogen, C1-6alkyl, C1-6alkylsulfonyl, C1-6alkylsulfoxy or C1-6alkylthio; R7 is hydrogen, C1-8alkyl, mono- or di(C3-6cycloalkyl)methyl, C3-6cycloalkyl, C3-6alkenyl, hydroxyC1-6alkyl, C1-6alkylcarbonyloxy-C1-6alkyl or C1-6alkyloxyC1-6alkyl; R6 is C1-8alkyl, mono- or di(C3-6cycloalkyl)-methyl, Ar2CH2, C1-6alkyloxyC1-6alkyl, hydroxyC1-6alkyl, C3-6alkenyl, thienylmethyl, furanylmethyl, C1-6alkylthioC1-6alkyl, mono- or di(C1-6alkyl)aminoC1-6alkyl, di(C1-6alkyl)amino, C1-6alkylcarbonylC1-6alkyl; or R6 and R7 taken together with the nitrogen atom to which they are attached may form a pyrrolidinyl, piperidinyl, homopiperidinyl or morpholinyl group, optionally substituted with C1-6alkyl or C1-6alkyloxyC1-6alkyl; and Ar1 and Ar2 are each optionally substituted phenyl; and Het1 is optionally substituted pyridinyl; having CRF receptor antagonistic properties; pharmaceutical compositions containing such compounds as active ingredients; methods of treating disorders related to hypersecretion of CRF such as depression, anxiety, substance abuse, by administering an effective amount of a compound of formula (I).
摘要翻译：本发明涉及包括立体异构体及其药学上可接受的酸加成盐形式的化合物，其中R 1是C 1-6烷基，NR 6 R 7，OR 6或SR 7; R2是氢，C1-6烷基，C1-6烷氧基或C1-6烷硫基; R3是Ar1或Het1; R 4和R 5各自独立地选自氢，卤素，C 1-6烷基，C 1-6烷氧基，三氟甲基，氰基，硝基，氨基和单或二（C 1-6烷基）氨基; R6是氢，C1-6烷基，C1-6烷基磺酰基，C1-6烷基亚磺酰基或C1-6烷硫基; R 7是氢，C 1-8烷基，一或二（C 3-6环烷基）甲基，C 3-6环烷基，C 3-6烯基，羟基C 1-6烷基，C 1-6烷基羰氧基-C 1-6烷基或C 1-6烷氧基C 1-6烷基; R 6是C 1-8烷基，单或二（C 3-6环烷基） - 甲基，Ar 2 CH 2，C 1-6烷氧基C 1-6烷基，羟基C 1-6烷基，C 3-6烯基，噻吩基甲基，呋喃基甲基，C 1-6烷硫基C 1-6烷基，单或二 1-6烷基）氨基C 1-6烷基，二（C 1-6烷基）氨基，C 1-6烷基羰基C 1-6烷基; 或R6和R7与它们所连接的氮原子一起可以形成任选被C 1-6烷基或C 1-6烷氧基C 1-6烷基取代的吡咯烷基，哌啶基，高哌啶基或吗啉基; Ar 1和Ar 2各自为任意取代的苯基; Het1是任选取代的吡啶基; 具有CRF受体拮抗特性; 含有这些化合物作为活性成分的药物组合物; 通过施用有效的治疗来治疗与CRF过度分泌有关的疾病的方法，例如抑郁，焦虑，药物滥用

12. 发明授权

US08533310B2 Method and apparatus for acceleration by prefetching associated objects 有权
标题翻译：通过预取相关对象来加速的方法和装置
公开(公告)号：US08533310B2
公开(公告)日：2013-09-10
申请号：US12044861
申请日：2008-03-07
申请人： Charles Huang , Nitin Gupta , Vivasvat Keswani , Bart Robinson
发明人： Charles Huang , Nitin Gupta , Vivasvat Keswani , Bart Robinson
IPC分类号： G06F15/173 , G06F15/16 , G06F9/34
CPC分类号： H04L67/28
摘要： Association information is used to build association trees to associate base pages and embedded objects at a proxy. An association tree has a root node containing a URL for a base page, and zero or more leaf nodes each containing a URL for an embedded object. In most cases, an association tree will maintain the invariant that all leaves contain distinct URLs. However, it is also possible to have an association tree in which the same URL appears in multiple nodes. An association tree may optionally contain one or more internal nodes, each of which contains a URL that is an embedded object for some other base page, but which may also be fetched as a base page itself. Given a number of association trees and a base-page URL, a prefetch system finds the root or interior node corresponding to that URL (if any) and traverses the tree from that node, prefetching URLs until the URL of the last leaf node is prefetched. The prefetching starts the process of bringing over the various embedded objects before the user or program would ordinarily fetch them.
摘要翻译：关联信息用于构建关联树以将代理服务器的基本页面和嵌入的对象关联。关联树具有包含基页的URL的根节点，以及包含嵌入对象的URL的零个或多个叶节点。在大多数情况下，关联树将保留不变量，所有叶都包含不同的URL。然而，也可能有一个关联树，其中相同的URL出现在多个节点中。关联树可以可选地包含一个或多个内部节点，每个内部节点包含作为一些其他基本页面的嵌入对象的URL，但是也可以将其作为基本页面本身获取。给定一些关联树和基页URL，预取系统找到对应于该URL（如果有的话）的根节点或内部节点，并从该节点遍历树，预取URL直到预取最后一个叶节点的URL 。预取开始在用户或程序通常抓取它们之前引导各种嵌入对象的过程。

13. 发明授权

US08500802B2 Two-piece prosthetic valves with snap-in connection and methods for use 有权
公开(公告)号：US08500802B2
公开(公告)日：2013-08-06
申请号：US13043211
申请日：2011-03-08
申请人： Ernest Lane , Shouyan Lee , Charles Huang
发明人： Ernest Lane , Shouyan Lee , Charles Huang
IPC分类号： A61F2/24
CPC分类号： A61F2/2412 , A61F2/2409
摘要： A prosthetic heart valve assembly includes a gasket member and a valve member including a plurality of fasteners and a plurality of engagement members corresponding to the fasteners. The fasteners and/or engagement members may be configured to guide the engagement members into engagement with the fasteners. For example, the fasteners may include U-shaped spring-biased clips, e.g., attached to a core or other portion of a sewing cuff of the gasket member, and the engagement members may include latches or barbed protrusions that engage one or more holes in the fasteners. During use, the gasket member is introduced into a tissue annulus, and secured to the annulus, e.g., using a plurality of clips directed through the sewing cuff. The valve member is then introduced into the annulus and the engagement members are snapped or otherwise guided into engagement with the fasteners to secure the valve member relative to the gasket member.

14. 发明申请

US20110190877A1 Two-Piece Prosthetic Valves with Snap-In Connection and Methods for Use 有权
标题翻译：具有快速连接的两片假肢瓣和使用方法
公开(公告)号：US20110190877A1
公开(公告)日：2011-08-04
申请号：US13043211
申请日：2011-03-08
申请人： Ernest Lane , Shouyan Lee , Charles Huang
发明人： Ernest Lane , Shouyan Lee , Charles Huang
IPC分类号： A61F2/24
CPC分类号： A61F2/2412 , A61F2/2409
摘要： A prosthetic heart valve assembly includes a gasket member and a valve member including a plurality of fasteners and a plurality of engagement members corresponding to the fasteners. The fasteners and/or engagement members may be configured to guide the engagement members into engagement with the fasteners. For example, the fasteners may include U-shaped spring-biased clips, e.g., attached to a core or other portion of a sewing cuff of the gasket member, and the engagement members may include latches or barbed protrusions that engage one or more holes in the fasteners. During use, the gasket member is introduced into a tissue annulus, and secured to the annulus, e.g., using a plurality of clips directed through the sewing cuff. The valve member is then introduced into the annulus and the engagement members are snapped or otherwise guided into engagement with the fasteners to secure the valve member relative to the gasket member.
摘要翻译：假体心脏瓣膜组件包括垫圈构件和包括多个紧固件和对应于紧固件的多个接合构件的阀构件。紧固件和/或接合构件可构造成引导接合构件与紧固件接合。例如，紧固件可以包括U形弹簧偏置的夹子，例如，附接到垫圈构件的缝合箍的芯部或其他部分，并且接合构件可包括接合一个或多个孔的闩锁或有倒钩的突起紧固件。在使用期间，垫圈构件被引入到组织环中，并且例如通过使用穿过缝合袖带的多个夹子固定到环形空间。然后将阀构件引入到环形空间中，并且接合构件被卡扣或以其它方式被引导成与紧固件接合以将阀构件相对于垫圈构件固定。

15. 发明申请

US20090119504A1 INTERCEPTING AND SPLIT-TERMINATING AUTHENTICATED COMMUNICATION CONNECTIONS 审中-公开
标题翻译：互连和分离终止认证通信连接
公开(公告)号：US20090119504A1
公开(公告)日：2009-05-07
申请号：US12352959
申请日：2009-01-13
申请人： Thomas van Os , Puneet Mehra , Nitin Gupta , Kartik Subbana , Charles Huang
发明人： Thomas van Os , Puneet Mehra , Nitin Gupta , Kartik Subbana , Charles Huang
IPC分类号： H04L9/00
CPC分类号： H04L9/083 , H04L9/3213 , H04L9/3271 , H04L63/02 , H04L63/0428 , H04L63/0823 , H04L2209/56 , H04L2209/76
摘要： Systems and methods are provided for enabling optimization of communications within a networked computing environment requiring secure, authenticated client-server communication connections. Optimization is performed by a pair of intermediary network devices installed in a path of communications between the client and the server. A secure, authenticated communication connection between the client and server is split-terminated at a pair of intermediary network devices by intercepting a request from the client for a client-server connection, authenticating the client at the intermediaries, establishing a first secure, authenticated connection to the client, authenticating the client or an intermediary to the server, and establishing a second secure, authenticate connection to the server. Depending on the operative authentication protocol (e.g., NTLM, Kerberos), an intermediary may interface with a domain controller, key distribution center or other entity.
摘要翻译：提供了系统和方法，用于实现需要安全的，认证的客户机 - 服务器通信连接的联网计算环境内的通信优化。优化由安装在客户端和服务器之间的通信路径中的一对中间网络设备执行。客户端与服务器之间的一个安全的，经过身份验证的通信连接通过截取来自客户端的客户机 - 服务器连接的请求，在中介机构认证客户机，建立第一个安全的，认证的连接向客户端认证客户端或服务器的中介，以及建立到服务器的第二安全认证连接。根据操作认证协议（例如，NTLM，Kerberos），中介可以与域控制器，密钥分配中心或其他实体进行接口。

16. 发明授权

US07125390B2 Wrap around body massager 失效
标题翻译：包裹身体按摩器
公开(公告)号：US07125390B2
公开(公告)日：2006-10-24
申请号：US10654560
申请日：2003-09-03
申请人： Roman S. Ferber , Charles Huang , John E. Nemazi , Michael D. Turner
发明人： Roman S. Ferber , Charles Huang , John E. Nemazi , Michael D. Turner
IPC分类号： A61H23/02
CPC分类号： A61H23/0263 , A61H7/001
摘要： The present invention discloses a hand-held body massager having a transverse housing with a massage region. A massage unit is oriented within the housing for parting a massage effect from the massage region. A pair of elongate arms are each pivotally connected to opposed ends of the housing with the massage region oriented therebetween. Each arm includes a handle to be grasped by a user so that the user may urge the massage region against a target surface of the user's body.
摘要翻译：本发明公开了一种具有按摩区域的横向壳体的手持式身体按摩器。按摩单元定位在外壳内，用于分离按摩区域的按摩效果。一对细长的臂各自枢转地连接到壳体的相对的端部，按摩区域定向在其间。每个臂包括由使用者抓握的手柄，使得使用者可以将按摩区域推向使用者身体的目标表面。

17. 发明申请

US20050010141A1 Percussive massager with variable node spacing 失效
标题翻译：具有可变节点间距的冲击式按摩器
公开(公告)号：US20050010141A1
公开(公告)日：2005-01-13
申请号：US10495738
申请日：2003-03-17
申请人： Lev Mordechai , Roman Ferber , Charles Huang
发明人： Lev Mordechai , Roman Ferber , Charles Huang
IPC分类号： A61H20060101 , A61H1/00 , A61H7/00 , A61H23/00 , A61H23/02
CPC分类号： A61H23/0254 , A61H7/001 , A61H23/0263 , A61H2201/0153 , A61H2201/0157 , A61H2201/164 , A61H2201/1669 , A61H2205/12
摘要： A percussive massager is provided having a housing supporting a motor having an output shaft rotatably driven thereby. At least one positioning member is movably connected to a percussion arm which is attached to the housing and operably connected to the motor output shaft. At least two massage nodes are operably connected to the percussion arm, one of which being attached to the positioning member, to form a massage surface and move toward and away from the housing to provide a percussive massage effect. A rotary mechanism is rotatable with respect to the percussion arm and drives the positioning member toward and away from a central region of the housing. An ancillary transmission has an output and an input for operably imparting rotation to the rotary mechanism such that the spacing of the massage nodes progressively increases and decreases.
摘要翻译：提供一种冲击式按摩器，其具有支撑马达的壳体，该马达具有由其旋转地驱动的输出轴。至少一个定位构件可移动地连接到连接到壳体并可操作地连接到电动机输出轴的冲击臂。至少两个按摩节点可操作地连接到冲击臂，其中一个被附接到定位构件，以形成按摩表面并朝向和远离壳体移动以提供冲击式按摩效果。旋转机构可相对于冲击臂旋转并且驱动定位构件朝向和远离壳体的中心区域。辅助变速器具有用于可操作地向旋转机构施加旋转的输出和输入，使得按摩节点的间隔逐渐增加和减小。

18. 发明授权

US4583724A Multiple-purpose vice for wood working 失效
标题翻译：多用途木材加工
公开(公告)号：US4583724A
公开(公告)日：1986-04-22
申请号：US748674
申请日：1985-06-25
申请人： Charles Huang
发明人： Charles Huang
IPC分类号： B25B1/20 , B25B1/24 , B25B5/00 , B23Q1/04
CPC分类号： B25B5/006 , B25B1/20 , B25B1/2405 , B25B1/2426
摘要： A multiple-purpose vice for wood working includes a lead screw and two guide bars slidingly defined by two bench clamps on a bench, two center-rest clamping jaws mounted on two jaw bases slidingly inserted with the lead screw and the two guide bars for clamping flat-surface work piece, two universal clamping jaws rotatably mounted on the jaw bases for clamping irregular-shaped work piece and an outside-span clamping base clamped on the bench beyond the span between the two bench clamps for clamping larger work piece not allowed to be clamped within the span of two bench clamps.
摘要翻译：用于木材加工的多用途工具包括一个导螺杆和两个导杆，两个导板由两个台架夹在台架上滑动，两个安装在两个卡爪基座上的中心支撑夹爪滑动地插入导螺杆，两个导杆夹紧平面工件，两个通用夹爪，可旋转地安装在颚座上，用于夹紧不规则形状的工件，夹紧在工作台上的外跨夹紧基座超出两个工作台夹具之间的跨距，用于夹紧不允许的较大工件夹紧在两个工作台夹具的跨度内。

19. 发明授权

US08806246B1 Enforcing and complying with a computing device power policy 有权
标题翻译：执行并遵守计算设备电源策略
公开(公告)号：US08806246B1
公开(公告)日：2014-08-12
申请号：US13101936
申请日：2011-05-05
申请人： Jojo Wu , Fay Li , Marco Wu , Charles Huang
发明人： Jojo Wu , Fay Li , Marco Wu , Charles Huang
IPC分类号： G06F1/26 , G06F15/173
CPC分类号： G06F9/4893 , G06F1/3228 , G06F1/329 , Y02D10/24
摘要： A computing device configured for enforcing a computing device power policy is described. The computing device includes a processor and executable instructions stored in memory that is in electronic communication with the processor. The computing device generates a power policy. The computing device also sends the power policy. The computing device further receives a suspicious process alert. Additionally, the computing device determines whether to terminate a suspicious process. The computing device also sends a process termination command if it is determined to terminate the suspicious process.
摘要翻译：描述了配置用于实施计算设备电源策略的计算设备。计算设备包括处理器和存储在与处理器电子通信的存储器中的可执行指令。计算设备生成电源策略。计算设备还发送电源策略。计算设备还接收可疑过程警报。此外，计算设备确定是否终止可疑过程。如果确定终止可疑过程，则计算设备还发送过程终止命令。

20. 发明申请

US20090192599A1 TWO-PIECE PROSTHETIC VALVES WITH SNAP-IN CONNECTION AND METHODS FOR USE 有权
标题翻译：具有中断连接的两级前置阀和使用方法
公开(公告)号：US20090192599A1
公开(公告)日：2009-07-30
申请号：US12419059
申请日：2009-04-06
申请人： Ernest Lane , Shouyan Lee , Charles Huang
发明人： Ernest Lane , Shouyan Lee , Charles Huang
IPC分类号： A61F2/24
CPC分类号： A61F2/2412 , A61F2/2409
摘要： A prosthetic heart valve assembly includes a gasket member and a valve member including a plurality of fasteners and a plurality of engagement members corresponding to the fasteners. The fasteners and/or engagement members may be configured to guide the engagement members into engagement with the fasteners. For example, the fasteners may include U-shaped spring-biased clips, e.g., attached to a core or other portion of a sewing cuff of the gasket member, and the engagement members may include latches or barbed protrusions that engage one or more holes in the fasteners. During use, the gasket member is introduced into a tissue annulus, and secured to the annulus, e.g., using a plurality of clips directed through the sewing cuff. The valve member is then introduced into the annulus and the engagement members are snapped or otherwise guided into engagement with the fasteners to secure the valve member relative to the gasket member.
摘要翻译：假体心脏瓣膜组件包括垫圈构件和包括多个紧固件和对应于紧固件的多个接合构件的阀构件。紧固件和/或接合构件可构造成引导接合构件与紧固件接合。例如，紧固件可以包括U形弹簧偏置的夹子，例如，附接到垫圈构件的缝合箍的芯部或其他部分，并且接合构件可包括接合一个或多个孔的闩锁或有倒钩的突起紧固件。在使用期间，垫圈构件被引入到组织环中，并且例如通过使用穿过缝合袖带的多个夹子固定到环形空间。然后将阀构件引入到环形空间中，并且接合构件被卡扣或以其它方式被引导成与紧固件接合以将阀构件相对于垫圈构件固定。

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