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11. 发明授权

US5803927A Electrotherapy method and apparatus for external defibrillation 失效
标题翻译：用于外部除颤的电疗方法和装置
公开(公告)号：US5803927A
公开(公告)日：1998-09-08
申请号：US824713
申请日：1997-02-19
申请人： David Cameron , Thomas D. Lyster , Daniel J. Powers , Bradford E. Gliner , Clinton S. Cole , Carlton B. Morgan
发明人： David Cameron , Thomas D. Lyster , Daniel J. Powers , Bradford E. Gliner , Clinton S. Cole , Carlton B. Morgan
IPC分类号： A61N1/39
CPC分类号： A61N1/3937 , A61N1/3906 , A61N1/3912
摘要： An electrotherapy method and apparatus for delivering a multiphasic waveform from an energy source to a patient. The preferred embodiment of the method comprises the steps of charging the energy source to an initial level; discharging the energy source across the electrodes to deliver electrical energy to the patient in a multiphasic waveform; monitoring a patient-dependent electrical parameter during the discharging step; shaping the waveform of the delivered electrical energy based on a value of the monitored electrical parameter, wherein the relative duration of the phases of the multiphasic waveform is dependent on the value of the monitored electrical parameter. The preferred apparatus comprises an energy source; two electrodes adapted to make electrical contact with a patient; a connecting mechanism forming an electrical circuit with the energy source and the electrodes when the electrodes are attached to a patient; and a controller operating the connecting mechanism to deliver electrical energy from the energy source to the electrodes in a multiphasic waveform the relative phase durations of which are based on an electrical parameter monitored during delivery of the electrical energy. The preferred defibrillator apparatus weighs less than 4 pounds and has a volume less than 150 cubic inches, and most preferably, weighs approximately three pounds or less and has a volume of approximately 141 cu.in.
摘要翻译：一种用于将多相波形从能量源递送到患者的电疗方法和装置。该方法的优选实施例包括以下步骤：将能源充电至初始水平; 通过电极排出能量源，以多相波形向患者输送电能; 在放电步骤期间监测与患者相关的电参数; 基于所监测的电参数的值对输送的电能的波形进行整形，其中多相波形的相位的相对持续时间取决于被监测的电参数的值。优选的装置包括能源; 两个电极，适于与患者进行电接触; 当电极附接到患者时，形成与能量源和电极的电路的连接机构; 以及控制器，其操作所述连接机构，以多相波形将能量从所述能量源传递到所述电极，所述多相波形的相对相位持续时间基于在所述电能传递期间监测的电参数。优选的除颤器装置重量小于4磅，体积小于150立方英寸，最优选重约3磅或更小，体积约为141立方英寸。

12. 发明授权

US5776166A Method for applying a multiphasic waveform 失效
标题翻译：应用多相波形的方法
公开(公告)号：US5776166A
公开(公告)日：1998-07-07
申请号：US803095
申请日：1997-02-20
申请人： Bradford E. Gliner , Thomas D. Lyster , Clinton S. Cole , Daniel J. Powers , Carlton B. Morgan
发明人： Bradford E. Gliner , Thomas D. Lyster , Clinton S. Cole , Daniel J. Powers , Carlton B. Morgan
IPC分类号： A61N1/39
CPC分类号： A61N1/3937 , A61N1/3906 , A61N1/3912
摘要： This invention provides an external defibrillator and defibrillation method that automatically compensates for patient-to-patient impedance differences in the delivery of electrotherapeutic pulses for defibrillation and cardioversion. In a preferred embodiment, the defibrillator has an energy source that may be discharged through electrodes on the patient to provide a biphasic voltage or current pulse. In one aspect of the invention, the first and second phase duration and initial first phase amplitude are predetermined values. In a second aspect of the invention, the duration of the first phase of the pulse may be extended if the amplitude of the first phase of the pulse fails to fall to a threshold value by the end of the predetermined first phase duration, as might occur with a high impedance patient. In a third aspect of the invention, the first phase ends when the first phase amplitude drops below a threshold value or when the first phase duration reaches a threshold time value, whichever comes first, as might occur with a low to average impedance patient. This method and apparatus of altering the delivered biphasic pulse thereby compensates for patient impedance differences by changing the nature of the delivered electrotherapeutic pulse, resulting in a smaller, more efficient and less expensive defibrillator.
摘要翻译：本发明提供一种外部除颤器和除颤方法，其自动补偿用于除颤和心脏复律的电疗脉冲递送中的患者对患者的阻抗差异。在优选实施例中，除颤器具有能够通过患者身上的电极排出的能量源，以提供双相电压或电流脉冲。在本发明的一个方面，第一和第二相位持续时间和初始第一相位振幅是预定值。在本发明的第二方面中，如果脉冲的第一相位的幅度在预定的第一相位持续时间结束时不能下降到阈值，则脉冲的第一相位的持续时间可能会延长与高阻抗患者。在本发明的第三方面中，当第一相位幅度下降到低于阈值时或当第一相位持续时间达到阈值时间值（以先到者为准）时，第一相位结束，如同低平均阻抗患者可能发生的那样。改变输送的双相脉冲的这种方法和装置由此通过改变递送的电疗脉冲的性质来补偿患者的阻抗差异，导致更小，更有效和更便宜的除颤器。

13. 发明授权

US5601612A Method for applying a multiphasic waveform 失效
标题翻译：应用多相波形的方法
公开(公告)号：US5601612A
公开(公告)日：1997-02-11
申请号：US601234
申请日：1996-02-14
申请人： Bradford E. Gliner , Thomas D. Lyster , Clinton S. Cole , Daniel J. Powers , Carlton B. Morgan
发明人： Bradford E. Gliner , Thomas D. Lyster , Clinton S. Cole , Daniel J. Powers , Carlton B. Morgan
IPC分类号： A61N1/39
CPC分类号： A61N1/3937 , A61N1/3906 , A61N1/3912
摘要： This invention provides an external defibrillator and defibrillation method that automatically compensates for patient-to-patient impedance differences in the delivery of electrotherapeutic pulses for defibrillation and cardioversion. In a preferred embodiment, the defibrillator has an energy source that may be discharged through electrodes on the patient to provide a biphasic voltage or current pulse. In one aspect of the invention, the first and second phase duration and initial first phase amplitude are predetermined values. In a second aspect of the invention, the duration of the first phase of the pulse may be extended if the amplitude of the first phase of the pulse fails to fall to a threshold value by the end of the predetermined first phase duration, as might occur with a high impedance patient. In a third aspect of the invention, the first phase ends when the first phase amplitude drops below a threshold value or when the first phase duration reaches a threshold time value, whichever comes first, as might occur with a low to average impedance patient. This method and apparatus of altering the delivered biphasic pulse thereby compensates for patient impedance differences by changing the nature of the delivered electrotherapeutic pulse, resulting in a smaller, more efficient and less expensive defibrillator.
摘要翻译：本发明提供一种外部除颤器和除颤方法，其自动补偿用于除颤和心脏复律的电疗脉冲递送中的患者对患者的阻抗差异。在优选实施例中，除颤器具有能够通过患者身上的电极排出的能量源，以提供双相电压或电流脉冲。在本发明的一个方面，第一和第二相位持续时间和初始第一相位振幅是预定值。在本发明的第二方面中，如果在预定的第一相位持续时间结束时脉冲的第一相位的幅度不能下降到阈值，则脉冲的第一相位的持续时间可能会延长与高阻抗患者。在本发明的第三方面中，当第一相位幅度下降到低于阈值时或当第一相位持续时间达到阈值时间值（以先到者为准）时，第一相位结束，如同低平均阻抗患者可能发生的那样。改变输送的双相脉冲的这种方法和装置由此通过改变递送的电疗脉冲的性质来补偿患者的阻抗差异，导致更小，更有效和更便宜的除颤器。

14. 发明授权

US06047212A External defibrillator capable of delivering patient impedance compensated biphasic waveforms 失效
标题翻译：外部除颤器能够提供患者阻抗补偿双相波形
公开(公告)号：US06047212A
公开(公告)日：2000-04-04
申请号：US946843
申请日：1997-10-08
申请人： Bradford E. Gliner , Thomas D. Lyster , Clinton S. Cole , Daniel J. Powers , Carlton B. Morgan
发明人： Bradford E. Gliner , Thomas D. Lyster , Clinton S. Cole , Daniel J. Powers , Carlton B. Morgan
IPC分类号： A61N1/39
CPC分类号： A61N1/3937 , A61N1/3906 , A61N1/3912
摘要： This invention provides an external defibrillator and defibrillation method that automatically compensates for patient-to-patient impedance differences in the delivery of electrotherapeutic pulses for defibrillation and cardioversion. In a preferred embodiment, the defibrillator has an energy source that may be discharged through electrodes on the patient to provide a biphasic voltage or current pulse. In one aspect of the invention, the first and second phase duration and initial first phase amplitude are predetermined values. In a second aspect of the invention, the duration of the first phase of the pulse may be extended if the amplitude of the first phase of the pulse fails to fall to a threshold value by the end of the predetermined first phase duration, as might occur with a high impedance patient. In a third aspect of the invention, the first phase ends when the first phase amplitude drops below a threshold value or when the first phase duration reaches a threshold time value, whichever comes first, as might occur with a low to average impedance patient. This method and apparatus of altering the delivered biphasic pulse thereby compensates for patient impedance differences by changing the nature of the delivered electrotherapeutic pulse, resulting in a smaller, more efficient and less expensive defibrillator.
摘要翻译：本发明提供一种外部除颤器和除颤方法，其自动补偿用于除颤和心脏复律的电疗脉冲递送中的患者对患者的阻抗差异。在优选实施例中，除颤器具有能够通过患者身上的电极排出的能量源，以提供双相电压或电流脉冲。在本发明的一个方面，第一和第二相位持续时间和初始第一相位振幅是预定值。在本发明的第二方面中，如果脉冲的第一相位的幅度在预定的第一相位持续时间结束时不能下降到阈值，则脉冲的第一相位的持续时间可能会延长与高阻抗患者。在本发明的第三方面中，当第一相位幅度下降到低于阈值时或当第一相位持续时间达到阈值时间值（以先到者为准）时，第一相位结束，如同低平均阻抗患者可能发生的那样。改变输送的双相脉冲的这种方法和装置由此通过改变递送的电疗脉冲的性质来补偿患者的阻抗差异，导致更小，更有效和更便宜的除颤器。

15. 发明授权

US5836978A Electrotherapy method for producing a multiphasic discharge based upon a patient-dependent electrical parameter and time 失效
标题翻译：基于患者依赖的电参数和时间产生多相放电的电疗方法
公开(公告)号：US5836978A
公开(公告)日：1998-11-17
申请号：US909656
申请日：1997-08-12
申请人： Bradford E. Gliner , Thomas D. Lyster , Clinton S. Cole , Daniel J. Powers , Carlton B. Morgan
发明人： Bradford E. Gliner , Thomas D. Lyster , Clinton S. Cole , Daniel J. Powers , Carlton B. Morgan
IPC分类号： A61N1/39
CPC分类号： A61N1/3937 , A61N1/3906 , A61N1/3912
摘要： This invention provides an external defibrillator and defibrillation method that automatically compensates for patient-to-patient impedance differences in the delivery of electrotherapeutic pulses for defibrillation and cardioversion. In a preferred embodiment, the defibrillator has an energy source that may be discharged through electrodes on the patient to provide a biphasic voltage or current pulse. In one aspect of the invention, the first and second phase duration and initial first phase amplitude are predetermined values. In a second aspect of the invention, the duration of the first phase of the pulse may be extended if the amplitude of the first phase of the pulse fails to fall to a threshold value by the end of the predetermined first phase duration, as might occur with a high impedance patient. In a third aspect of the invention, the first phase ends when the first phase amplitude drops below a threshold value or when the first phase duration reaches a threshold time value, whichever comes first, as might occur with a low to average impedance patient. This method and apparatus of altering the delivered biphasic pulse thereby compensates for patient impedance differences by changing the nature of the delivered electrotherapeutic pulse, resulting in a smaller, more efficient and less expensive defibrillator.
摘要翻译：本发明提供一种外部除颤器和除颤方法，其自动补偿用于除颤和心脏复律的电疗脉冲递送中的患者对患者的阻抗差异。在优选实施例中，除颤器具有能够通过患者身上的电极排出的能量源，以提供双相电压或电流脉冲。在本发明的一个方面，第一和第二相位持续时间和初始第一相位振幅是预定值。在本发明的第二方面中，如果脉冲的第一相位的幅度在预定的第一相位持续时间结束时不能下降到阈值，则脉冲的第一相位的持续时间可能会延长与高阻抗患者。在本发明的第三方面中，当第一相位幅度下降到低于阈值时或当第一相位持续时间达到阈值时间值（以先到者为准）时，第一相位结束，如同低平均阻抗患者可能发生的那样。改变输送的双相脉冲的这种方法和装置由此通过改变递送的电疗脉冲的性质来补偿患者的阻抗差异，导致更小，更有效和更便宜的除颤器。

16. 发明授权

US5735879A Electrotherapy method for external defibrillators 失效
标题翻译：外用除颤器电疗法
公开(公告)号：US5735879A
公开(公告)日：1998-04-07
申请号：US803094
申请日：1997-02-20
申请人： Bradford E. Gliner , Thomas D. Lyster , Clinton S. Cole , Daniel J. Powers , Carlton B. Morgan
发明人： Bradford E. Gliner , Thomas D. Lyster , Clinton S. Cole , Daniel J. Powers , Carlton B. Morgan
IPC分类号： A61N1/39
CPC分类号： A61N1/3937 , A61N1/3906 , A61N1/3912
摘要： This invention provides an external defibrillator and defibrillation method that automatically compensates for patient-to-patient impedance differences in the delivery of electrotherapeutic pulses for defibrillation and cardioversion. In a preferred embodiment, the defibrillator has an energy source that may be discharged through electrodes on the patient to provide a biphasic voltage or current pulse. In one aspect of the invention, the first and second phase duration and initial first phase amplitude are predetermined values. In a second aspect of the invention, the duration of the first phase of the pulse may be extended if the amplitude of the first phase of the pulse fails to fall to a threshold value by the end of the predetermined first phase duration, as might occur with a high impedance patient. In a third aspect of the invention, the first phase ends when the first phase amplitude drops below a threshold value or when the first phase duration reaches a threshold time value, whichever comes first, as might occur with a low to average impedance patient. This method and apparatus of altering the delivered biphasic pulse thereby compensates for patient impedance differences by changing the nature of the delivered electrotherapeutic pulse, resulting in a smaller, more efficient and less expensive defibrillator.
摘要翻译：本发明提供一种外部除颤器和除颤方法，其自动补偿用于除颤和心脏复律的电疗脉冲递送中的患者对患者的阻抗差异。在优选实施例中，除颤器具有能够通过患者身上的电极排出的能量源，以提供双相电压或电流脉冲。在本发明的一个方面，第一和第二相位持续时间和初始第一相位振幅是预定值。在本发明的第二方面中，如果脉冲的第一相位的幅度在预定的第一相位持续时间结束时不能下降到阈值，则脉冲的第一相位的持续时间可能会延长与高阻抗患者。在本发明的第三方面中，当第一相位幅度下降到低于阈值时或当第一相位持续时间达到阈值时间值（以先到者为准）时，第一相位结束，如同低平均阻抗患者可能发生的那样。改变输送的双相脉冲的这种方法和装置由此通过改变递送的电疗脉冲的性质来补偿患者的阻抗差异，导致更小，更有效和更便宜的除颤器。

17. 发明授权

US5607454A Electrotherapy method and apparatus 失效
标题翻译：电疗方法和装置
公开(公告)号：US5607454A
公开(公告)日：1997-03-04
申请号：US227553
申请日：1994-04-14
申请人： David Cameron , Thomas D. Lyster , Daniel J. Powers , Bradford E. Gliner , Clinton S. Cole , Carlton B. Morgan
发明人： David Cameron , Thomas D. Lyster , Daniel J. Powers , Bradford E. Gliner , Clinton S. Cole , Carlton B. Morgan
IPC分类号： A61N1/39
CPC分类号： A61N1/3937 , A61N1/3906 , A61N1/3912
摘要： An electrotherapy method and apparatus for delivering a multiphasic waveform from an energy source to a patient. The preferred embodiment of the method comprises the steps of charging the energy source to an initial level; discharging the energy source across the electrodes to deliver electrical energy to the patient in a multiphasic waveform; monitoring a patient-dependent electrical parameter during the discharging step; shaping the waveform of the delivered electrical energy based on a value of the monitored electrical parameter, wherein the relative duration of the phases of the multiphasic waveform is dependent on the value of the monitored electrical parameter. The preferred apparatus comprises an energy source; two electrodes adapted to make electrical contact with a patient; a connecting mechanism forming an electrical circuit with the energy source and the electrodes when the electrodes are attached to a patient; and a controller operating the connecting mechanism to deliver electrical energy from the energy source to the electrodes in a multiphasic waveform the relative phase durations of which are based on an electrical parameter monitored during delivery of the electrical energy. The preferred defibrillator apparatus weighs less than 4 pounds and has a volume less than 150 cubic inches, and most preferably, weighs approximately three pounds or less and has a volume of approximately 141 cu. in.
摘要翻译：一种用于将多相波形从能量源递送到患者的电疗方法和装置。该方法的优选实施例包括以下步骤：将能源充电至初始水平; 通过电极排出能量源，以多相波形向患者输送电能; 在放电步骤期间监测与患者相关的电参数; 基于所监测的电参数的值对输送的电能的波形进行整形，其中多相波形的相位的相对持续时间取决于被监测的电参数的值。优选的装置包括能源; 两个电极，适于与患者进行电接触; 当电极附接到患者时，形成与能量源和电极的电路的连接机构; 以及控制器，其操作所述连接机构，以多相波形将能量从所述能量源传递到所述电极，所述多相波形的相对相位持续时间基于在所述电能传递期间监测的电参数。优选的除颤器装置重量小于4磅，体积小于150立方英寸，最优选重约3磅或更小，体积约为141立方厘米。在。

18. 发明授权

US06347248B1 Electrotherapy method 有权
标题翻译：电疗法
公开(公告)号：US06347248B1
公开(公告)日：2002-02-12
申请号：US09687839
申请日：2000-10-13
申请人： Bradford E. Gliner
发明人： Bradford E. Gliner
IPC分类号： A61N136
CPC分类号： A61N1/3937
摘要： An electrotherapy apparatus, such as a defibrillator, includes a connecting mechanism coupled between an energy source and electrodes. The connecting mechanism allows selective coupling of the energy source to the electrodes. The energy source includes a capacitor and a high voltage power supply for charging the capacitor. The electrotherapy apparatus further includes a waveform measuring device for measuring a patient ECG waveform. The electrotherapy apparatus also includes a controller coupled to the connecting mechanism, the energy source, and the waveform measuring device. The controller actuates the connecting mechanism to deliver a bi-phasic waveform to the patient. In addition, the controller analyzes the ECG waveform to detect when the patient is experiencing either course arrhythmia or fine arrhythmia. The detection of course arrhythmia or fine arrhythmia can be done by comparing the amplitude of the ECG waveform to a predetermined amplitude value, by comparing the power spectrum of the ECG waveform to a predetermined frequency value, by measuring the duration of the arrhythmia, or by measuring some combination of these ECG waveform characteristics. Based upon whether the patient is experiencing course arrhythmia or fine arrhythmia, the controller adjusts the amplitude and/or duration of the bi-phasic waveform applied to the patient to optimize the likelihood of defibrillation.
摘要翻译：诸如除颤器的电疗设备包括连接在能量源和电极之间的连接机构。连接机构允许能量源与电极的选择性耦合。能量源包括用于对电容器充电的电容器和高压电源。电疗装置还包括用于测量患者ECG波形的波形测量装置。电疗装置还包括耦合到连接机构，能量源和波形测量装置的控制器。控制器致动连接机构以向患者传递双相波形。此外，控制器分析ECG波形以检测患者何时经历过程心律失常或精神心律失常。通过将ECG波形的功率谱与预定的频率值进行比较，可以通过将ECG波形的振幅与预定的振幅值进行比较，通过测量心律失常的持续时间，或者通过测量这些ECG波形特征的一些组合。基于患者是否正在经历心律失常或精神心律失常，控制器调整施加到患者的两相波形的幅度和/或持续时间，以优化除颤的可能性。

19. 发明授权

US06405081B1 Damped biphasic energy delivery circuit for a defibrillator 有权
标题翻译：用于除颤器的阻尼双相能量输送电路
公开(公告)号：US06405081B1
公开(公告)日：2002-06-11
申请号：US09299456
申请日：1999-04-22
申请人： Thomas D. Lyster , Bradford E. Gliner , Daniel J. Powers
发明人： Thomas D. Lyster , Bradford E. Gliner , Daniel J. Powers
IPC分类号： A61N139
CPC分类号： A61N1/3937 , A61N1/39 , A61N1/3912
摘要： A defibrillator capable of delivering a damped biphasic truncated (DBT) defibrillation pulse is provided. An energy storage circuit is coupled across a high voltage switch such as an H-bridge for delivering a defibrillation pulse to the patient through a pair of electrodes. A controller operates to control the entire defibrillation process and detects shockable rhythms from the patient via an ECG front end. The energy storage circuit consists of an energy storage capacitor, a series inductor, a shunt diode, and optionally a resistor in series with the inductor. The controller measures as the patient dependent parameter the time interval between the initial delivery of the defibrillation pulse and the occurrence of the peak current or voltage to determine the first and second phases of the defibrillation pulse to provide for compensation for patient impedance. Other types of patient dependent parameters, measured either before or during delivery of the DBT defibrillation pulse, could be alternatively employed to achieve the impedance compensation.
摘要翻译：提供能够递送阻尼双相截断（DBT）除颤脉冲的除颤器。能量存储电路跨越诸如H桥的高电压开关耦合，用于通过一对电极向病人传递除颤脉冲。控制器操作以控制整个除颤过程，并通过ECG前端检测患者的可震荡节律。能量存储电路由能量存储电容器，串联电感器，并联二极管和可选地与电感器串联的电阻器组成。控制器测量作为依赖于患者的参数，初始递送除颤脉冲之间的时间间隔和峰值电流或电压的出现以确定除颤脉冲的第一和第二相以提供患者阻抗的补偿。可以替代地使用在DBT除颤脉冲的传送之前或期间测量的其他类型的患者依赖参数来实现阻抗补偿。

20. 发明授权

US08926676B2 Systems and methods for applying signals, including contralesional signals, to neural populations 有权
标题翻译：将信号（包括对数信号）应用于神经群体的系统和方法
公开(公告)号：US08926676B2
公开(公告)日：2015-01-06
申请号：US11697696
申请日：2007-04-06
申请人： Alvaro Pascual-Leone , Bradford E. Gliner , David Himes , Leif R. Sloan
发明人： Alvaro Pascual-Leone , Bradford E. Gliner , David Himes , Leif R. Sloan
IPC分类号： A61N1/36
CPC分类号： A61N1/36171 , A61N1/36082 , A61N1/36103 , A61N1/3615
摘要： Systems and methods for applying signals, including contralesional electromagnetic signals, to neural populations, are disclosed. A particular method can be directed to treating a patient having a subject neural population in a first (e.g., ipsilesional) hemisphere of the brain, with the subject neural population having, or previously having, a functionality capable of being improved. The method can include directing an application of electromagnetic signals at least proximate to a target neural population at a second (e.g., contralesional) hemisphere of the brain to at least constrain a functionality of the target neural population, which has transcallosal communication with the first hemisphere.
摘要翻译：公开了将信号（包括对数电磁信号）应用于神经群体的系统和方法。具体方法可以涉及在脑的第一（例如ipsilesional）半球中治疗具有受试者神经群体的患者，其中受试者神经群体具有或预先具有能够改善的功能。该方法可以包括将电磁信号的应用引导至少接近于大脑的第二（例如，对照）半球处的目标神经群体，以至少约束目标神经群体的功能，该目标神经群体与第一半球具有蜕皮通讯。

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