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11. 发明申请

US20090298910A1 REGULATION OF EPIGENETIC CONTROL OF GENE EXPRESSION 有权
标题翻译：基因表达调控
公开(公告)号：US20090298910A1
公开(公告)日：2009-12-03
申请号：US11721326
申请日：2005-12-12
申请人： Richard H. Griffey , Timothy Vickers , Ranjan Perera
发明人： Richard H. Griffey , Timothy Vickers , Ranjan Perera
IPC分类号： A61K31/7088 , G01N33/00 , G01N33/566 , C12Q1/68 , C07H21/04 , C12N5/06
CPC分类号： C12N15/113 , C12N15/11 , C12N15/111 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2320/11 , C12N2320/12 , C12N2330/10 , Y10T436/143333 , C12N2310/3525
摘要： Methods are provided for the identification of compounds that selectively modulate epigenetic changes in gene expression. Compounds, compositions, kits or assays devices, and methods are provided for modulating the expression, endogenous levels or the function of small non-coding RNAs cognate to or transcribed by heterochromatic regions subject to epigenetic regulation (i.e., promoters, enhancers, centromeres, telomeres, origins of DNA replication, imprinted loci, or loci marked by dosage-compensation), and for modulating the formation or function of heterochromatin in cells, tissues or animals.
摘要翻译：提供了用于鉴定选择性调节基因表达的表观遗传变化的化合物的方法。提供化合物，组合物，试剂盒或测定装置和方法用于调节受表观遗传调节的异染色体区域（即启动子，增强子，着丝粒，端粒）相关或转录的小非编码RNA的表达，内源水平或功能，DNA复制起点，印迹位点或由剂量补偿标记的基因座），并调节细胞，组织或动物中异染色质的形成或功能。

12. 发明授权

US08093061B2 Methods of determining potency of chemically-synthesized oligonucleotides 有权
公开(公告)号：US08093061B2
公开(公告)日：2012-01-10
申请号：US12445854
申请日：2007-10-18
申请人： Walter F Lima , Timothy Vickers , Stanley T Crooke
发明人： Walter F Lima , Timothy Vickers , Stanley T Crooke
IPC分类号： G01N33/53 , G01N33/00
CPC分类号： C12Q1/6876 , C12N15/111 , C12N2310/11 , C12N2310/14 , C12N2320/10 , Y10T436/143333
摘要： Provided herein are methods for determining potency of RNAi agents. Such methods include, but are not limited to, cell-based and cell-free assays that measure binding of an RNAi agent with Ago2 or that measure Ago2 activity in the presence of such RNAi agents. Also provided are assays that determine potency of RNAi agents by assessing their ability to compete with other RNAi agents, including control RNAi agents, for binding and/or activation of Ago2.

13. 发明授权

US07879992B2 Modification of MyD88 splicing using modified oligonucleotides 有权
标题翻译：使用修饰的寡核苷酸修饰MyD88剪接
公开(公告)号：US07879992B2
公开(公告)日：2011-02-01
申请号：US11339785
申请日：2006-01-24
申请人： Timothy Vickers , Nicholas M. Dean
发明人： Timothy Vickers , Nicholas M. Dean
IPC分类号： C07H21/04
CPC分类号： C12N15/113 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3231 , C12N2310/341 , C12N2310/345 , C12N2310/3521
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of MyD88. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding MyD88. Methods of using these compounds for modulation of MyD88 expression and for treatment of diseases associated with expression of MyD88 are provided.
摘要翻译：提供反义化合物，组合物和方法用于调节MyD88的表达。组合物包含靶向编码MyD88的核酸的反义化合物，特别是反义寡核苷酸。提供了使用这些化合物调节MyD88表达和治疗MyD88表达相关疾病的方法。

14. 发明申请

US20100267149A1 METHODS OF DETERMINING POTENCY OF CHEMICALLY-SYNTHESIZED OLIGONUCLEOTIDES 有权
标题翻译：确定化学合成寡核苷酸的方法
公开(公告)号：US20100267149A1
公开(公告)日：2010-10-21
申请号：US12445854
申请日：2007-10-18
申请人： Walter F. Lima , Timothy Vickers , Stanley T. Crooke
发明人： Walter F. Lima , Timothy Vickers , Stanley T. Crooke
IPC分类号： G01N33/53
CPC分类号： C12Q1/6876 , C12N15/111 , C12N2310/11 , C12N2310/14 , C12N2320/10 , Y10T436/143333
摘要： Provided herein are methods for determining potency of RNAi agents. Such methods include, but are not limited to, cell-based and cell-free assays that measure binding of an RNAi agent with Ago2 or that measure Ago2 activity in the presence of such RNAi agents. Also provided are assays that determine potency of RNAi agents by assessing their ability to compete with other RNAi agents, including control RNAi agents, for binding and/or activation of Ago2.
摘要翻译：本文提供了确定RNAi剂效力的方法。这样的方法包括但不限于测量RNAi剂与Ago2的结合或在这种RNAi剂存在下测量Ago2活性的基于细胞和无细胞的测定。还提供了通过评估其与其他RNAi试剂（包括对照RNAi试剂）竞争与Ago2结合和/或激活的能力来测定RNAi试剂的效力的测定法。

15. 发明申请

US20100041047A1 EFFICIENT REDUCTION OF TARGET RNA'S BY SINGLE- AND DOUBLE-STRANDED OLIGOMERIC COMPOUNDS 审中-公开
标题翻译：单链和双链寡聚化合物有效减少目标RNA
公开(公告)号：US20100041047A1
公开(公告)日：2010-02-18
申请号：US12511437
申请日：2009-07-29
申请人： Timothy Vickers , Seongjoon Koo , C. Frank Bennett , Stanley T. Crooke , Nicholas M. Dean , Brenda F. Baker
发明人： Timothy Vickers , Seongjoon Koo , C. Frank Bennett , Stanley T. Crooke , Nicholas M. Dean , Brenda F. Baker
IPC分类号： C12Q1/68 , C07H21/02
CPC分类号： C12N15/1138 , C12N15/113 , C12N15/1137 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/341 , C12N2310/346 , C12N2310/53 , C12N2310/3525
摘要： The present invention provides, inter alia, methods of selecting a single-stranded oligomeric compounds for inhibiting RNA expression, methods of generating double-stranded oligomeric compounds, methods of identifying optimized double-stranded oligomeric compounds, methods of selecting optimized single-stranded oligomeric compounds, methods of selecting optimized double-stranded oligomeric compounds, methods of identifying multifunctional oligomeric compounds, methods for optimizing target region selection for modulation of RNA expression, methods of optimizing expression modulation of RNA, and the like. The present invention further provides oligomeric compounds, 8-80 nucleobases in length targeted to a target RNA, wherein said oligomeric compound hybridizes to said target RNA and inhibits RNA levels by at least 50% in both single-stranded and double-stranded forms, and multifunctional oligomeric compounds.
摘要翻译：本发明尤其提供了选择用于抑制RNA表达的单链寡聚化合物的方法，产生双链寡聚化合物的方法，鉴定优化的双链寡聚化合物的方法，选择优化的单链寡聚化合物的方法选择优化的双链寡聚化合物的方法，鉴定多功能寡聚化合物的方法，用于优化用于调节RNA表达的靶区选择的方法，优化RNA表达调节的方法等。本发明进一步提供低聚化合物，长度靶向靶RNA的8-80个核碱基，其中所述寡聚化合物与所述靶RNA杂交并且以单链和双链形式抑制至少50％的RNA水平，以及多官能寡聚化合物。

16. 发明申请

US20070094926A1 BIOREACTOR FOR GROWING BIOLOGICAL MATERIALS SUPPORTED ON A LIQUID SURFACE 审中-公开
标题翻译：生物反应器，用于生长液体表面上支持的生物材料
公开(公告)号：US20070094926A1
公开(公告)日：2007-05-03
申请号：US11469675
申请日：2006-09-01
申请人： R. Branson , Keith Everett , Bob Hester , Timothy Vickers
发明人： R. Branson , Keith Everett , Bob Hester , Timothy Vickers
IPC分类号： A01G31/06
CPC分类号： C12M21/02 , C12M23/14 , C12M23/24 , C12M23/44 , C12M23/48 , Y10S47/06
摘要： A bioreactor assembly of the present invention for holding a media and supporting growth of a plurality of plants. The assembly includes a light source and a container having a light transmissive wall structure and defining a reservoir. A major axis of the reservoir is substantially horizontal allowing the reservoir to be filled with media to a partial level and to define a relatively large surface area for support of the plants. The assembly may also include clamps to secure and seal separate wall structure portions of the container together, and end caps to the wall portions, to define an aseptic environment. As another option, the clamps may define openings therethrough that allow passage of various devices for measuring and controlling bioreactor function such as a gas supply nozzle, a gas exit nozzle, an air temperature probe, a pH probe, a sampling drain, a gas composition probe and a media temperature probe.
摘要翻译：本发明的用于保持培养基并支持多种植物生长的生物反应器组件。组件包括光源和具有透光壁结构并限定储存器的容器。储存器的长轴基本上是水平的，允许储存器被填充到局部水平的介质并且限定用于支撑植物的相对大的表面积。组件还可以包括用于将容器的分离的壁结构部分固定并密封在一起的夹具以及将端盖封闭到壁部分，以限定无菌环境。作为另一选择，夹具可以限定穿过其中的开口，其允许用于测量和控制生物反应器功能的各种装置的通过，例如气体供应喷嘴，气体出口喷嘴，空气温度探针，pH探针，取样排水口，气体组成探头和介质温度探头。

17. 发明申请

US20060172962A1 Modification of MYD88 splicing using modified oligonucleotides 有权
标题翻译：使用修饰的寡核苷酸修饰MYD88剪接
公开(公告)号：US20060172962A1
公开(公告)日：2006-08-03
申请号：US11339785
申请日：2006-01-24
申请人： Timothy Vickers , Nicholas Dean
发明人： Timothy Vickers , Nicholas Dean
IPC分类号： A61K48/00
CPC分类号： C12N15/113 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3231 , C12N2310/341 , C12N2310/345 , C12N2310/3521
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of MyD88. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding MyD88. Methods of using these compounds for modulation of MyD88 expression and for treatment of diseases associated with expression of MyD88 are provided.
摘要翻译：提供反义化合物，组合物和方法用于调节MyD88的表达。组合物包含靶向编码MyD88的核酸的反义化合物，特别是反义寡核苷酸。提供了使用这些化合物调节MyD88表达和治疗MyD88表达相关疾病的方法。

18. 发明授权

US06368863B1 Reagents and methods for modulating gene expression through RNA mimicry 失效
标题翻译：通过RNA模拟调节基因表达的试剂和方法
公开(公告)号：US06368863B1
公开(公告)日：2002-04-09
申请号：US09255899
申请日：1999-02-23
申请人： David J. Ecker , Thomas W. Bruice , Timothy Vickers
发明人： David J. Ecker , Thomas W. Bruice , Timothy Vickers
IPC分类号： C12N1511
CPC分类号： A61K31/70 , A61K31/7105 , A61K38/00 , C07H21/00 , C07K14/005 , C12N15/1132 , C12N15/67 , C12N15/85 , C12N2310/13 , C12N2310/315 , C12N2310/321 , C12N2740/16322 , C12Q1/68 , C12Q1/6897 , C12Q1/703 , C12N2310/3521
摘要： Methods for modulating expression of a gene are provided. The methods comprise the steps of selecting a portion of an RNA coded by the gene, wherein the RNA is capable of interacting with a protein, preparing an oligonucleotide or oligonucleotide analog to mimic the portion of the RNA, and contacting cells containing the gene with the oligonucleotide or oligonucleotide analog. Methods of treating a disease are also provided. The methods comprise selecting a portion of an RNA coded by a gene whose expression is believed to be responsible for the disease, preparing an oligonucleotide or oligonucleotide analog to mimic the portion, and contacting an organism suspected of having the disease with the oligonucleotide or oligonucleotide analog.
摘要翻译：提供调节基因表达的方法。所述方法包括选择由该基因编码的RNA的一部分的步骤，其中所述RNA能够与蛋白质相互作用，制备寡核苷酸或寡核苷酸类似物以模拟RNA部分，并将含有该基因的细胞与寡核苷酸或寡核苷酸类似物。还提供了治疗疾病的方法。所述方法包括选择由被认为是对该疾病负责的基因编码的RNA的一部分，制备寡核苷酸或寡核苷酸类似物以模拟该部分，并将疑似患有疾病的生物与寡核苷酸或寡核苷酸类似物。

19. 发明授权

US5874564A Reagents and methods for modulating gene expression through RNA mimicry 失效
标题翻译：通过RNA模拟调节基因表达的试剂和方法
公开(公告)号：US5874564A
公开(公告)日：1999-02-23
申请号：US461418
申请日：1995-06-05
申请人： David J. Ecker , Thomas W. Bruice , Timothy Vickers
发明人： David J. Ecker , Thomas W. Bruice , Timothy Vickers
IPC分类号： C12Q1/68 , C12Q1/70 , C07H21/02 , C07H21/04
CPC分类号： C12Q1/6897 , C12Q1/703
摘要： Expression of genes may be modulated by employment of compositions which are capable of RNA mimicry. A portion of RNA coded by the gene whose expression is to be modulated is selected which is capable of interacting with one or more proteins. An oligonucleotide or oligonucleotide analog is then prepared in such a way as to mimic the portion of the RNA. Cells containing the gene are then contacted with the oligonucleotide or oligonucleotide analog to effect the modulation. Therapeutic compositions and methods, especially for the treatment of human immunodeficiency, are disclosed.
摘要翻译：可以通过使用能够进行RNA模拟的组合物来调节基因的表达。选择由其表达被调节的基因编码的RNA的一部分，其能够与一种或多种蛋白质相互作用。然后制备寡核苷酸或寡核苷酸类似物，以模拟RNA的部分。然后将含有该基因的细胞与寡核苷酸或寡核苷酸类似物接触以进行调节。公开了治疗组合物和方法，特别是用于治疗人类免疫缺陷。

20. 发明授权

US09550990B2 Regulation of epigenetic control of gene expression 有权
标题翻译：调控基因表达的表观遗传控制
公开(公告)号：US09550990B2
公开(公告)日：2017-01-24
申请号：US11721326
申请日：2005-12-12
申请人： Richard H. Griffey , Timothy Vickers , Ranjan Perera
发明人： Richard H. Griffey , Timothy Vickers , Ranjan Perera
IPC分类号： C12N15/11 , C12N15/113
CPC分类号： C12N15/113 , C12N15/11 , C12N15/111 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2320/11 , C12N2320/12 , C12N2330/10 , Y10T436/143333 , C12N2310/3525
摘要： Methods are provided for the identification of compounds that selectively modulate epigenetic changes in gene expression. Compounds, compositions, kits or assays devices, and methods are provided for modulating the expression, endogenous levels or the function of small non-coding RNAs cognate to or transcribed by heterochromatic regions subject to epigenetic regulation (i.e., promoters, enhancers, centromeres, telomeres, origins of DNA replication, imprinted loci, or loci marked by dosage-compensation), and for modulating the formation or function of heterochromatin in cells, tissues or animals.
摘要翻译：提供了用于鉴定选择性调节基因表达的表观遗传变化的化合物的方法。提供化合物，组合物，试剂盒或测定装置和方法用于调节受表观遗传调节的异染色体区域（即启动子，增强子，着丝粒，端粒）相关或转录的小非编码RNA的表达，内源水平或功能，DNA复制起点，印迹位点或由剂量补偿标记的基因座），并调节细胞，组织或动物中异染色质的形成或功能。

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