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11. 发明申请

US20090011985A1 GH SECRETAGOGUES AND USES THEREOF 有权
标题翻译： GH秘密及其用途
公开(公告)号：US20090011985A1
公开(公告)日：2009-01-08
申请号：US11877395
申请日：2007-10-23
申请人： Thierry Abribat , Andre De Villers , Soraya Allas , Denis Gravel , Alcide Chapdelaine
发明人： Thierry Abribat , Andre De Villers , Soraya Allas , Denis Gravel , Alcide Chapdelaine
IPC分类号： A61K38/25 , A61P3/00
CPC分类号： A61K38/25 , C07K14/60
摘要： The invention relates to use of a GH secretagogue (e.g. GRF or an analog thereof) for (1) altering a lipid parameter in a subject; (2) altering a body composition parameter in a subject, (3) treating a condition characterized by deficient or decreased bone formation in a subject (4) improving daytime vigilance and/or cognitive function in a subject, (5) improving a metabolic condition in a subject, (6) improving anabolism in a catabolic condition in a subject, and/or (7) improving and/or reconstituting immune function in a subject.
摘要翻译：本发明涉及GH促分泌素（例如GRF或其类似物）用于（1）改变受试者的脂质参数的用途; （2）改变受试者的身体组成参数，（3）治疗受试者（4）中骨形成不足或减少的病症，改善受试者的白天警惕性和/或认知功能，（5）改善代谢状况在主题中，（6）改善受试者中分解代谢状态的合成代谢，和/或（7）改善和/或重建受试者的免疫功能。

12. 发明申请

US20050197288A1 GH secretagogues and uses thereof 有权
标题翻译： GH促分泌素及其用途
公开(公告)号：US20050197288A1
公开(公告)日：2005-09-08
申请号：US10969463
申请日：2004-10-20
申请人： Thierry Abribat , Andre Villers , Soraya Allas , Denis Gravel , Alcide Chapdelaine
发明人： Thierry Abribat , Andre Villers , Soraya Allas , Denis Gravel , Alcide Chapdelaine
IPC分类号： A61K38/25 , A61P3/00 , A61P21/06 , A61P25/28 , A61P37/04
CPC分类号： A61K38/25 , C07K14/60
摘要： The invention relates to use of a GH secretagogue (e.g. GRF or an analog thereof) for (1) altering a lipid parameter in a subject; (2) altering a body composition parameter in a subject, (3) treating a condition characterized by deficient or decreased bone formation in a subject (4) improving daytime vigilance and/or cognitive function in a subject, (5) improving a metabolic condition in a subject, (6) improving anabolism in a catabolic condition in a subject, and/or (7) improving and/or reconstituting immune function in a subject.
摘要翻译：本发明涉及GH促分泌素（例如GRF或其类似物）用于（1）改变受试者的脂质参数的用途; （2）改变受试者的身体组成参数，（3）治疗受试者（4）中骨形成不足或减少的病症，改善受试者的白天警惕性和/或认知功能，（5）改善代谢状况在主题中，（6）改善受试者中分解代谢状态的合成代谢，和/或（7）改善和/或重建受试者的免疫功能。

13. 发明授权

US6148822A Proprioceptive sole or pedal device containing crystals for treatment of statural disorders 失效
标题翻译：本体感的鞋底或踏板装置含有晶体，用于治疗自然障碍
公开(公告)号：US6148822A
公开(公告)日：2000-11-21
申请号：US204300
申请日：1998-12-03
申请人： Christophe Cron , Thierry Pautrot , Thierry Abribat
发明人： Christophe Cron , Thierry Pautrot , Thierry Abribat
IPC分类号： A43B7/00 , A43B17/00 , A61H39/00 , A61N5/06 , A61B19/00
CPC分类号： A43B7/146 , A43B1/0027 , A43B17/00 , A43B17/003 , A43B7/00 , A43B7/1455 , A61H39/00 , A61N5/0619 , A61H2039/005 , A61H2205/12 , A61N2005/0631 , A61N2005/0645
摘要： The present invention relates to an article such as a sole or a shoe adapted to contact the sole of a foot, which incorporates at least one unoriented mineral which is capable of developing a color in the wavelength range between about 400 nm and 900 nm and stimulates the reflex zones located at the sole of the foot. The method of utilizing such article is also disclosed.
摘要翻译：本发明涉及一种适于接触足底的鞋底或鞋的制品，其包含至少一种未取向的矿物，其能够显现在约400nm和900nm之间的波长范围内的颜色并刺激反射区位于脚底。还公开了利用这种制品的方法。

14. 发明授权

US5939386A Chimeric fatty body-pro-GRF (1-29) analogs with increased biological potency 失效
标题翻译：具有增加的生物效力的嵌合脂肪体亲GRF（1-29）类似物
公开(公告)号：US5939386A
公开(公告)日：1999-08-17
申请号：US702113
申请日：1996-08-23
申请人： Michel Ibea , Thierry Abribat , Paul Brazeau
发明人： Michel Ibea , Thierry Abribat , Paul Brazeau
IPC分类号： A61K38/00 , A61K38/22 , A61P3/02 , A61P5/02 , A61P43/00 , C07K14/60 , C07K19/00 , G01N33/68 , A61K38/25
CPC分类号： C07K14/60 , A61K38/00 , Y10S930/12
摘要： The present invention relates to chimeric fatty body-pro-GRF analogs with increased biological potency, their application as anabolic agents and in the diagnosis and treatment of growth hormone deficiencies. The chimeric fatty body-pro-GRF analogs include an hydrophobic moiety (tail), and can be prepared, either by anchoring one or several hydrophobic tails to the GRF, or by substituting one or several amino-acids by a pseudomicellar residue in the chemical synthesis of GRF. The GRF analogs of the present invention are biodegradable, non-immunogenic and exhibit an improved anabolic potency with a reduced dosage and prolonged activity.
摘要翻译：本发明涉及具有增加的生物学效力的嵌合脂肪体前GRF类似物，其作为合成代谢剂的应用以及生长激素缺陷的诊断和治疗。嵌合脂肪体前GRF类似物包括疏水部分（尾部），并且可以通过将一个或几个疏水尾部锚定到GRF，或者通过用化学物质中的假胶体残基取代一个或几个氨基酸来制备 GRF的合成。本发明的GRF类似物是可生物降解的，非免疫原性的，并且具有降低的剂量和延长的活性的改善的合成代谢功效。

15. 发明授权

US5861379A Chimeric fatty body-pro-GRF analogs with increased biological potency 失效
标题翻译：具有增加的生物效力的嵌合脂肪体亲GRF类似物
公开(公告)号：US5861379A
公开(公告)日：1999-01-19
申请号：US702114
申请日：1996-08-23
申请人： Michel Ibea , Thierry Abribat , Paul Brazeau
发明人： Michel Ibea , Thierry Abribat , Paul Brazeau
IPC分类号： A61K38/00 , A61K38/22 , A61P3/02 , A61P5/02 , A61P43/00 , C07K14/60 , C07K19/00 , G01N33/68 , A61K38/25
CPC分类号： C07K14/60 , A61K38/00 , Y10S930/12
摘要： The present invention relates to chimeric fatty body-pro-GRF analogs with increased biological potency, their application as anabolic agents and in the diagnosis and treatment of growth hormone deficiencies. The chimeric fatty body-pro-GRF analogs include an hydrophobic moiety (tail), and can be prepared, either by anchoring one or several hydrophobic tails to the GRF, or by substituting one or several amino-acids by a pseudomicellar residue in the chemical synthesis of GRF. The GRF analogs of the present invention are biodegradable, non-immunogenic and exhibit an improved anabolic potency with a reduced dosage and prolonged activity.
摘要翻译：本发明涉及具有增加的生物学效力的嵌合脂肪体前GRF类似物，其作为合成代谢剂的应用以及生长激素缺陷的诊断和治疗。嵌合脂肪体前GRF类似物包括疏水部分（尾部），并且可以通过将一个或几个疏水尾部锚定到GRF，或者通过用化学物质中的假胶体残基取代一个或几个氨基酸来制备 GRF的合成。本发明的GRF类似物是可生物降解的，非免疫原性的，并且具有降低的剂量和延长的活性的改善的合成代谢功效。

16. 发明授权

US5834418A Process for the preparation of platelet growth factors extract 失效
标题翻译：制备血小板生长因子提取物的方法
公开(公告)号：US5834418A
公开(公告)日：1998-11-10
申请号：US618560
申请日：1996-03-20
申请人： Paul Brazeau , Thierry Abribat , Michel Ibea , Michele Boushira
发明人： Paul Brazeau , Thierry Abribat , Michel Ibea , Michele Boushira
IPC分类号： A61K35/14 , A61K35/19 , A61K38/17 , C07K14/435
CPC分类号： A61K38/39 , A61K35/19 , A61K38/18 , A61K38/38
摘要： The present invention relates to a process for the preparation of porcine platelet-extract containing matured growth factors, which comprises the steps of: a) centrifuging whole porcine blood at about 1000 g to about 5000 g to isolate the platelets from the platelet-rich-plasma; b) resuspending the isolated platelets of step a) in Plasma-Lyte A and centrifuging to concentrate the platelets; c) washing the concentrated platelets of step b); d) lyophilizing the washed platelets of step c); whereby causing lysis of the platelets and producing the platelet extract in optimal amount.
摘要翻译：本发明涉及一种制备含有成熟生长因子的猪血小板提取物的方法，其包括以下步骤：a）将大约1000g至大约5000g的整个猪血液离心，从血小板富集的血清中分离出血小板，等离子体; b）将步骤a）的分离的血小板重悬于血浆 - 细胞A中并离心以浓缩血小板; c）洗涤步骤b）的浓缩血小板; d）冻干洗涤的步骤c）的血小板; 从而引起血小板裂解并产生最佳量的血小板提取物。

17. 发明申请

US20120100121A1 Pegylated L-Asparaginase 审中-公开
标题翻译：聚乙二醇化的L-天冬酰胺酶
公开(公告)号：US20120100121A1
公开(公告)日：2012-04-26
申请号：US13382276
申请日：2010-07-06
申请人： Thierry Abribat
发明人： Thierry Abribat
IPC分类号： A61K38/50 , A61P35/02 , C12N9/96 , A61P35/00
CPC分类号： C12N9/82 , A61K38/50 , A61K47/60 , C12N9/96 , C12Y305/01001 , Y02A50/473
摘要： Disclosed is a conjugate of a protein having substantial L-asparagine aminohydrolase activity and polyethylene glycol. In particular, the polyethylene glycol has a molecular weight less than or equal to about 5000 Da and the protein is an L-asparaginase from Erwinia. The conjugate of the invention has shown superior properties such as maintenance of a high level of in vitro activity and an unexpected increase in half-life in vivo. Also disclosed are methods of producing the conjugate and use of the conjugate in therapy. In particular, a method is disclosed for use of the conjugate in the treatment of cancer, particularly Acute Lymphoblastic Leukemia (ALL). More specifically, a method is disclosed for use of the conjugate as a second line therapy for patients who have developed hypersensitivity or have had a disease relapse after treatment with other L-asparaginase preparations.
摘要翻译：公开了具有大量L-天冬酰胺氨基水解酶活性的蛋白质和聚乙二醇的缀合物。特别地，聚乙二醇具有小于或等于约5000Da的分子量，蛋白质是来自欧文氏菌的L-天冬酰胺酶。本发明的缀合物显示出优异的性质，例如保持高水平的体外活性和体内半衰期的意想不到的增加。还公开了在治疗中产生缀合物和缀合物的用途的方法。特别地，公开了用于结合物治疗癌症，特别是急性淋巴细胞性白血病（ALL）的方法。更具体地说，公开了一种使用缀合物作为二次线治疗患者的方法，该方法已经发展为超敏反应，或者在用其它L-天冬酰胺酶制剂处理后已经发生疾病复发。

18. 发明授权

US07067488B2 Modified GLP-1 peptides with increased biological potency 失效
标题翻译：具有增加的生物效能的修饰的GLP-1肽
公开(公告)号：US07067488B2
公开(公告)日：2006-06-27
申请号：US10671340
申请日：2003-09-25
申请人： Denis Gravel , Krishna Peri , Thierry Abribat , Abdelkrim Habi
发明人： Denis Gravel , Krishna Peri , Thierry Abribat , Abdelkrim Habi
IPC分类号： A61K38/22 , C07K14/575
CPC分类号： C07K14/605 , A61K38/26
摘要： The present invention relates to a GLP-1 peptide having the following formula, or a pharmaceutically acceptable salt thereof: X-His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-lle-Ala-Trp-Leu-val-Lys-Gly-Arg-Y (SEQ ID NO. 1) wherein X is a rigidifying hydrophobic moiety and wherein Y is selected from the group consisting of OH, NH2 and Gly-OH. Moreover, the present invention relates to pharmaceutical compositions comprising a therapeutically effective amount of a peptide of the present invention, or a pharmaceutically acceptable salt thereof, in association with at least one constituent selected from a pharmaceutically acceptable carrier, diluent, and excipient.
摘要翻译：本发明涉及具有下式的GLP-1肽或其药学上可接受的盐：<？in-line-formula description =“In-line formula”end =“lead”？> X-His-Ala- Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ala-Ala-Trp-Leu-val- Lys-Gly-Arg-Y（SEQ ID NO.1）<？in-line-formula description =“In-line Formulas”end =“tail”？>其中X是刚性疏水部分，其中Y选自由OH，NH 2和Gly-OH组成的组。此外，本发明涉及包含治疗有效量的本发明的肽或其药学上可接受的盐与至少一种选自药学上可接受的载体，稀释剂和赋形剂的成分的药物组合物。

19. 发明授权

US6024093A Proprioceptive sole or pedal device containing crystals for treatment of statural disorders 失效
标题翻译：本体感的鞋底或踏板装置含有晶体，用于治疗自然障碍
公开(公告)号：US6024093A
公开(公告)日：2000-02-15
申请号：US180213
申请日：1999-02-08
申请人： Christophe Cron , Thierry Pautrot , Thierry Abribat
发明人： Christophe Cron , Thierry Pautrot , Thierry Abribat
IPC分类号： A43B7/00 , A43B17/00 , A61H39/00 , A61N5/06 , A61B19/00
CPC分类号： A43B7/146 , A43B1/0027 , A43B17/00 , A43B17/003 , A43B7/00 , A43B7/1455 , A61H39/00 , A61N5/0619 , A61H2039/005 , A61H2205/12 , A61N2005/0631 , A61N2005/0645
摘要： An article such as a sole or a shoe adapted to contact the sole of a foot, which incorporates at least one crystalline substance which is capable of developing a color in the wavelength range between about 400 nm and 900 nm and stimulates the reflex zones located at the sole of the foot. The method of utilizing such article is also disclosed.
摘要翻译： PCT No.PCT / CA97 / 00303 Sec。 371日期1999年2月8日 102（e）日期1999年2月8日PCT提交1997年5月1日PCT公布。公开号WO97 / 41819 日期1997年11月13日一种诸如适合接触足底的鞋底或鞋的制品，其包含至少一种结晶物质，其能够显现出在约400nm至900nm之间的波长范围内的颜色并刺激反射区位于脚底。还公开了利用这种制品的方法。

20. 发明授权

US5817627A Long-acting galenical formulation for GRF peptides 失效
标题翻译： GRF肽的长效盖仑制剂
公开(公告)号：US5817627A
公开(公告)日：1998-10-06
申请号：US661329
申请日：1996-06-14
申请人： Paul Brazeau , Thierry Abribat , Michel Ibea
发明人： Paul Brazeau , Thierry Abribat , Michel Ibea
IPC分类号： A61K9/00 , A61K9/22 , A61K38/25 , A01N37/18 , A01J21/00 , A61K38/00 , C07K5/00
CPC分类号： A61K9/0024 , A61K38/25 , Y10S514/955 , Y10S514/96
摘要： The present invention relates to a long-acting galenical formulation of GRF peptides, pro-GRF and/or analogs thereof which comprises about 1 to about 100 mg of a GRF peptide, fragment or analog thereof pressed from about 1 to about 100 kg/mm.sup.2 in a tablet for parenteral administration, whereby these GRF peptides are released as the tablet is eroded.
摘要翻译：本发明涉及GRF肽，前GRF和/或其类似物的长效格列布利配方，其包含约1至约100mg被压制约1至约100kg / mm 2的GRF肽，其片段或类似物在用于肠胃外给药的片剂中，由于当片剂被侵蚀时，这些GRF肽被释放。

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