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11. 发明授权

US08361747B2 Antibodies against human angiopoietin 2 有权
公开(公告)号：US08361747B2
公开(公告)日：2013-01-29
申请号：US13358813
申请日：2012-01-26
申请人： Ulrich Brinkmann , Remko Albert Griep , Klaus Kaluza , Anita Kavlie , Christian Klein , Joerg Thomas Regula , Werner Scheuer
发明人： Ulrich Brinkmann , Remko Albert Griep , Klaus Kaluza , Anita Kavlie , Christian Klein , Joerg Thomas Regula , Werner Scheuer
IPC分类号： C12P21/06 , C12N15/87 , C12N1/20 , C12N15/74 , C07H21/04
CPC分类号： C07K16/22 , A61K39/00 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C12N15/85
摘要： The present invention relates to antibodies against human Angiopoietin 2 (anti-ANG-2 antibodies), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.

12. 发明授权

US08133979B2 Antibodies against human angiopoietin 2 有权
标题翻译：抗人血管生成素抗体2
公开(公告)号：US08133979B2
公开(公告)日：2012-03-13
申请号：US12635825
申请日：2009-12-11
申请人： Ulrich Brinkmann , Remko Albert Griep , Klaus Kaluza , Anita Kavlie , Christian Klein , Joerg Thomas Regula , Werner Scheuer
发明人： Ulrich Brinkmann , Remko Albert Griep , Klaus Kaluza , Anita Kavlie , Christian Klein , Joerg Thomas Regula , Werner Scheuer
IPC分类号： C07K16/46 , C07K16/28
CPC分类号： C07K16/22 , A61K39/00 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C12N15/85
摘要： The present invention relates to antibodies against human Angiopoietin 2 (anti-ANG-2 antibodies), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
摘要翻译：本发明涉及抗人血管生成素2（抗ANG-2抗体）的抗体，其生产方法，含有所述抗体的药物组合物及其应用。

13. 发明申请

US20140065151A1 ANTIBODIES AGAINST HUMAN ANGIOPOIETIN 2 审中-公开
标题翻译：抗体人类抗体2
公开(公告)号：US20140065151A1
公开(公告)日：2014-03-06
申请号：US13548244
申请日：2012-07-13
申请人： Ulrich Brinkmann , Remko Albert Griep , Klaus Kaluza , Anita Kavlie , Christian Klein , Joerg Thomas Regula , Werner Scheuer
发明人： Ulrich Brinkmann , Remko Albert Griep , Klaus Kaluza , Anita Kavlie , Christian Klein , Joerg Thomas Regula , Werner Scheuer
IPC分类号： C07K16/22
CPC分类号： C07K16/22 , A61K39/00 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C12N15/85
摘要： The present invention relates to a method of treating a disease or disorder in a patient comprising administering, to a patient in need of such treatment, an antibody which binds specifically to human angiopoietin-2 (ANG-2). The present invention also relates to a method for preventing metastasis in a patient suffering from primary cancer comprising administering, to a patient in need of such preventative treatment, an antibody which binds specifically to human angiopoietin-2 (ANG-2).
摘要翻译：本发明涉及治疗患者疾病或病症的方法，包括向需要这种治疗的患者施用特异性结合人血管生成素-2（ANG-2）的抗体。本发明还涉及一种用于预防患有原发性癌症的患者转移的方法，包括向需要这种预防性治疗的患者施用特异性结合人血管生成素-2（ANG-2）的抗体。

14. 发明授权

US08399626B2 Antibodies against human angiopoietin 2 有权
公开(公告)号：US08399626B2
公开(公告)日：2013-03-19
申请号：US13358831
申请日：2012-01-26
申请人： Ulrich Brinkmann , Remko Albert Griep , Klaus Kaluza , Anita Kavlie , Christian Klein , Joerg Thomas Regula , Werner Scheuer
发明人： Ulrich Brinkmann , Remko Albert Griep , Klaus Kaluza , Anita Kavlie , Christian Klein , Joerg Thomas Regula , Werner Scheuer
IPC分类号： C07K16/46 , C07K16/28
CPC分类号： C07K16/22 , A61K39/00 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C12N15/85
摘要： The present invention relates to antibodies against human Angiopoietin 2 (anti-ANG-2 antibodies), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.

15. 发明申请

US20120226119A1 VIVO TUMOR VASCULATURE IMAGING 审中-公开
标题翻译：血管肿瘤血管成像
公开(公告)号：US20120226119A1
公开(公告)日：2012-09-06
申请号：US13383197
申请日：2010-07-09
申请人： Michael Dobosz , Christian Kein , Johannes Sam , Werner Scheuer
发明人： Michael Dobosz , Christian Kein , Johannes Sam , Werner Scheuer
IPC分类号： A61B5/02 , A61B6/00
CPC分类号： A61K49/0058
摘要： The present invention relates to non-invasive methods of and uses for in vivo imaging tumor vasculature in a subject comprising detecting a fluorescence labelled anti-CD31 antibody. In a further aspect the present invention relates to non-invasive methods of and uses for in vivo monitoring the therapeutic efficacy of an anti-angiogenic agent in a subject comprising detecting a fluorescence labelled anti-CD31 antibody. In addition, a kit for use in the methods of the present invention is provided which comprises a fluorescence labelled anti-CD31 antibody and means for near-infrared fluorescence imaging to detect the antibody in a subject.
摘要翻译：本发明涉及用于体内成像肿瘤脉管系统的非侵入性方法和用途，其包括检测荧光标记的抗CD31抗体。在另一方面，本发明涉及用于体内监测受试者中抗血管生成剂的治疗功效的非侵入性方法和用途，所述方法包括检测荧光标记的抗CD31抗体。此外，提供了用于本发明方法的试剂盒，其包含荧光标记的抗CD31抗体和用于近红外荧光成像的装置，以检测受试者中的抗体。

16. 发明申请

US20110236388A1 BISPECIFIC, BIVALENT ANTI-VEGF/ANTI-ANG-2 ANTIBODIES 有权
标题翻译： BISPECIFIC，BIVALENT ANTI-VEGF / ANTI-ANG-2 ANTIBODIES
公开(公告)号：US20110236388A1
公开(公告)日：2011-09-29
申请号：US13071127
申请日：2011-03-24
申请人： Monika Baehner , Sabine Imhof-Jung , Anita Kavlie , Hubert Kettenberger , Christian Klein , Joerg Thomas Regula , Wolfgang Schaefer , Juergen Michael Schanzer , Werner Scheuer , Kay-Gunnar Stubenrauch , Markus Thomas
发明人： Monika Baehner , Sabine Imhof-Jung , Anita Kavlie , Hubert Kettenberger , Christian Klein , Joerg Thomas Regula , Wolfgang Schaefer , Juergen Michael Schanzer , Werner Scheuer , Kay-Gunnar Stubenrauch , Markus Thomas
IPC分类号： A61K39/395 , C07K16/22 , C07H21/00 , A61P9/00 , A61P35/00 , C12N15/63 , C12P21/02 , C12N5/10 , C12N1/00
CPC分类号： C07K16/22 , A61K2039/505 , C07K16/3015 , C07K16/3046 , C07K16/468 , C07K2317/31 , C07K2317/35 , C07K2317/52 , C07K2317/522 , C07K2317/56 , C07K2317/66 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： The present invention relates to bispecific, bivalent antibodies against human vascular endothelial growth factor (VEGF/VEGF-A) and against human angiopoietin-2 (ANG-2), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
摘要翻译：本发明涉及针对人血管内皮生长因子（VEGF / VEGF-A）和针对人血管生成素-2（ANG-2）的双特异性二价抗体，其生产方法，含有所述抗体的药物组合物及其用途。

17. 发明申请

US20110223159A1 TUMOR THERAPY WITH AN ANTI-VEGF ANTIBODY 审中-公开
标题翻译：肿瘤治疗与抗VEGF抗体
公开(公告)号：US20110223159A1
公开(公告)日：2011-09-15
申请号：US13111784
申请日：2011-05-19
申请人： Thomas Friess , Max Hasmann , Werner Scheuer
发明人： Thomas Friess , Max Hasmann , Werner Scheuer
IPC分类号： A61K39/395 , A61P35/00 , A61P35/04
CPC分类号： C07K16/22 , A61K39/3955 , A61K2039/505 , A61K2039/545 , C07K2317/76 , C07K2317/92
摘要： The present invention provides a method of treating a patient suffering from relapsed HER2 positive cancer with an anti-VEGF antibody during or after treatment with an anti-HER2 antibody. The invention also provides a kit comprising an anti-VEGF antibody.
摘要翻译：本发明提供了在用抗HER2抗体治疗期间或之后用抗VEGF抗体治疗患有复发性HER2阳性癌症的患者的方法。本发明还提供了包含抗VEGF抗体的试剂盒。

18. 发明申请

US20110064736A1 TUMOR THERAPY WITH AN ANTIBODY FOR VASCULAR ENDOTHELIAL GROWTH FACTOR AND AN ANTIBODY FOR HUMAN EPITHELIAL GROWTH FACTOR RECEPTOR TYPE 2 审中-公开
标题翻译：肿瘤治疗与血管内皮生长因子和人类上皮生长因子受体2型抗体的抗体
公开(公告)号：US20110064736A1
公开(公告)日：2011-03-17
申请号：US12947264
申请日：2010-11-16
申请人： Thomas Friess , Max Hasmann , Werner Scheuer
发明人： Thomas Friess , Max Hasmann , Werner Scheuer
IPC分类号： A61K39/395 , A61P35/00
CPC分类号： A61K39/39558 , A61K39/3955 , A61K2039/507 , C07K16/22 , C07K16/3015 , C07K16/32 , C07K2317/24
摘要： The present invention provides a method of treating a breast cancer disease in a patient who has failed prior treatment with an anti-VEGF antibody, comprising administering to the patient a therapeutically effective amount of an anti-HER2 antibody while continuing said anti-VEGF antibody therapy. The invention also provides corresponding pharmaceutical kits and pharmaceutical compositions.
摘要翻译：本发明提供了一种治疗患有先前用抗VEGF抗体治疗失败的患者的乳腺癌疾病的方法，其包括向患者施用治疗有效量的抗HER2抗体，同时继续进行所述抗VEGF抗体治疗。本发明还提供相应的药物试剂盒和药物组合物。

19. 发明授权

US09339560B2 Method for determining the anti-tumor efficacy of monoclonal antibodies 有权
标题翻译：确定单克隆抗体的抗肿瘤功效的方法
公开(公告)号：US09339560B2
公开(公告)日：2016-05-17
申请号：US13061770
申请日：2009-09-21
申请人： Birgit Bossenmaier , Valeria Lifke , Werner Scheuer
发明人： Birgit Bossenmaier , Valeria Lifke , Werner Scheuer
IPC分类号： A61K39/395 , A61K49/16 , A61K49/00 , C07K16/32 , A61K39/00
CPC分类号： A61K49/0008 , A61K2039/505 , A61K2039/5152 , A61K2039/5156 , A61K2039/545 , C07K16/32
摘要： The present invention relates to a method for determining the anti-tumor efficacy of monoclonal antibodies in pre-clinical rodent testings and the use of said method for the reduction of side testings.
摘要翻译：本发明涉及用于确定单克隆抗体在临床前啮齿动物试验中的抗肿瘤功效的方法，以及所述用于减少侧面试验的方法。

20. 发明申请

US20120230918A1 NON-INVASIVE IN VIVO OPTICAL IMAGING METHOD 审中-公开
标题翻译：非侵入式光学成像方法
公开(公告)号：US20120230918A1
公开(公告)日：2012-09-13
申请号：US13387515
申请日：2010-07-28
申请人： Michael Dobosz , Werner Scheuer , Steffen Strobel
发明人： Michael Dobosz , Werner Scheuer , Steffen Strobel
IPC分类号： A61B5/06
CPC分类号： G01N33/582 , A61B3/1241 , A61B5/0059 , A61B5/14555 , A61B5/415 , A61B5/418 , A61K49/0021 , A61K49/0032 , A61K49/0034 , G01N21/6408 , G01N21/6428
摘要： The present invention relates to a non-invasive method of determining the presence, quantifying the blood level, and/or monitoring or determining the blood clearance of a fluorescent analyte which comprises a fluorescent entity and a second entity, in the blood of a subject, comprising or consisting of the steps: (a) directing excitation light of at least one predetermined wavelength onto a delineated region comprising at least a portion of the pupil of said subject, to excite the fluorescent entity, (b) receiving light emitted from said fluorescent analyte with a wavelength distinguishable from the predetermined wavelength of (a), through the eye of said subject, thereby determining the presence, quantifying the blood level, and/or monitoring or determining the blood clearance of said fluorescent analyte in the blood of said subject. The present invention further relates to a fluorescent analyte or fluorescent label as defined in any one of the preceding claims for use in any one of the preceding methods. The present invention furthermore relates to the use of a fluorescent analyte or fluorescent label as defined in any one of the preceding claims for the preparation of a diagnostic composition which is to be employed in any one of the preceding methods. The present invention furthermore relates to a device for use in any of the methods defined herein.
摘要翻译：本发明涉及一种在受试者的血液中确定包含荧光实体和第二实体的荧光分析物的存在，量化血液水平和/或监测或确定荧光分析物的血液清除率的非侵入性方法，包括或由以下步骤组成：（a）将至少一个预定波长的激发光引导到包括所述受试者的瞳孔的至少一部分的描绘区域上，以激发荧光实体，（b）接收从所述荧光通过所述受试者的眼睛，具有与（a）的预定波长可区分的波长的分析物，从而确定所述受试者的血液中所述荧光分析物的存在，定量血液水平和/或监测或确定所述荧光分析物的血液清除率。本发明还涉及如前述权利要求中任一项所述的荧光分析物或荧光标记，其用于前述任何一种方法。本发明还涉及如前述权利要求中任一项所述的荧光分析物或荧光标记物在制备用于上述任何一种方法中的诊断组合物的用途。本发明还涉及用于本文定义的任何方法的装置。

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