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11. 发明申请

US20090076205A1 Preparation method of small particle sized polybutadiene latex used for the production of ABS 有权
标题翻译：用于生产ABS的小粒径聚丁二烯胶乳的制备方法
公开(公告)号：US20090076205A1
公开(公告)日：2009-03-19
申请号：US11665134
申请日：2005-10-09
申请人： Liben Huang , Zhiqiang Wan , Yizhang Li , Jian Zhou , Xingcai Jiang , Shufeng Wang , Chengbao Li , Yuliang Lou , Yan Liu
发明人： Liben Huang , Zhiqiang Wan , Yizhang Li , Jian Zhou , Xingcai Jiang , Shufeng Wang , Chengbao Li , Yuliang Lou , Yan Liu
IPC分类号： C08K5/098
CPC分类号： C08F36/06 , C08F2/38 , C08F2/24
摘要： A preparation method of small particle-sized polybutadiene latex used for the production of ABS is disclosed, which includes putting components comprising 34.00-45.00% by weight of the butadiene, 0-6.0% by weight of the second monomer, 52.11-63.13% by weight of the desalinized water, 0.12-0.22% by weight of the mercaptan(TDM), 0.80-2.60% by weight of the emulsifiers composed of potassium abietate and potassium oleate, into the same polymerization reactor, then heating the mixture of the components and stirring the same at a temperature range of 60-75° C. The reaction lasts for 9-12 hours and the conversion is higher than 97%. The method has the advantages such as higher conversion, shorter reaction period and lower latex viscosity. During the first stage of the reaction, more heat is released by increasing the reaction rate. When the conversion reaches 40-80%, the heat release rate of intermediate stage is depressed by decreasing the reaction temperature. When the conversion is higher than 80%, the reaction temperature reaches the highest. Thus, severe heat release is avoided. Moreover, the butadiene polymerization can be controlled steadily and the reaction period is shortened.
摘要翻译：公开了一种用于生产ABS的小粒径聚丁二烯胶乳的制备方法，其包括将包含34.00-45.00重量％的丁二烯，0-6.0重量％的第二单体，52.11-63.13％的组分脱盐水的重量，硫醇（TDM）的0.12-0.22重量％，由松油酸钾和油酸钾组成的乳化剂的0.80-2.60重量％，加入到相同的聚合反应器中，然后加热组分的混合物，在60-75℃的温度范围内搅拌该反应。反应持续9-12小时，转化率高于97％。该方法具有转化率高，反应时间短，胶乳粘度低等优点。在反应的第一阶段，通过提高反应速率释放更多的热量。当转化率达到40-80％时，通过降低反应温度来抑制中间阶段的放热速率。当转化率高于80％时，反应温度达到最高。因此，避免了严重的放热。此外，可以稳定地控制丁二烯聚合，缩短反应时间。

12. 发明授权

US07416732B2 Papilloma virus-like particles, fusion proteins as well as processes for their production 失效
标题翻译：乳头瘤病毒样颗粒，融合蛋白以及其生产过程
公开(公告)号：US07416732B2
公开(公告)日：2008-08-26
申请号：US11358474
申请日：2006-02-21
申请人： Lutz Gissmann , Jian Zhou , Martin Muller , Jeanette Painstil
发明人： Lutz Gissmann , Jian Zhou , Martin Muller , Jeanette Painstil
IPC分类号： A61K39/12
CPC分类号： C07K14/005 , A61K38/00 , A61K39/12 , A61K2039/5256 , A61K2039/5258 , C07K2319/00 , C12N7/00 , C12N2710/20022 , C12N2710/20023 , C12N2710/20034
摘要： The invention relates to the recombinant production of proteins as well as VLPs which are suitable as a vaccine for therapeutic and prophylactic vaccination. The invention also relates to processes for the production and purification of recombinant papilloma virus proteins and fusion proteins.
摘要翻译：本发明涉及适合作为治疗和预防性接种疫苗的蛋白质以及VLP的重组生产。本发明还涉及生产和纯化重组乳头状瘤病毒蛋白和融合蛋白的方法。

13. 发明授权

US07290615B2 Fluid having recyclable viscosity 有权
标题翻译：流体具有可回收粘度
公开(公告)号：US07290615B2
公开(公告)日：2007-11-06
申请号：US10943577
申请日：2004-09-17
申请人： Yenny Christanti , Diankui Fu , Jian Zhou
发明人： Yenny Christanti , Diankui Fu , Jian Zhou
IPC分类号： E21B37/00
CPC分类号： C09K8/52 , C09K2208/30
摘要： Compositions are given that have high viscosities at one pH range and low viscosities at another pH range. Methods are given for using such compositions in oilfield treatments. In particular CT wellbore cleanout compositions and methods are given in which a viscous fluid is injected into a wellbore; the fluid entrains particles and carries them to the surface; the viscosity of the fluid is reduced by reducing or increasing the pH; the particles settle from the fluid; the viscosity of the fluid is increased by increasing or reducing the pH; and the fluid is re-injected into the wellbore. Suitable surfactants are anionic surfactants, or mixtures of surfactants containing anionic surfactants, that aggregate into three-dimensional structures that substantially increase the viscosity at high pH but not at low pH. Other suitable surfactants are cationic surfactants with co-surfactants that aggregate below a certain pH but not above.
摘要翻译：给出了在一个pH范围内具有高粘度并在另一pH范围内具有低粘度的组合物。给出了在油田处理中使用这些组合物的方法。特别是给出了将其中的粘性流体注入到井眼中的CT井眼清洁组合物和方法; 流体夹带颗粒并将其携带到表面; 通过降低或增加pH降低流体的粘度; 颗粒从液体中沉淀出来; 通过增加或降低pH来增加流体的粘度; 并将流体再次注入井眼。合适的表面活性剂是阴离子表面活性剂或含有阴离子表面活性剂的表面活性剂的混合物，其聚集成三维结构，其在高pH但不在低pH下显着增加粘度。其它合适的表面活性剂是具有共表面活性剂的阳离子表面活性剂，其聚集低于一定pH但不高于。

14. 发明申请

US20070213232A1 Viscoelastic Surfactant Gels With Reduced Salt Concentration 审中-公开
标题翻译：具有降低盐浓度的粘弹性表面活性剂凝胶
公开(公告)号：US20070213232A1
公开(公告)日：2007-09-13
申请号：US10574592
申请日：2004-10-11
申请人： Robert Hartshorne , Trevor Lloyd Hughes , Gary Tustin , Jian Zhou , Timothy Jones
发明人： Robert Hartshorne , Trevor Lloyd Hughes , Gary Tustin , Jian Zhou , Timothy Jones
IPC分类号： E21B43/26
CPC分类号： C09K8/68 , C09K2208/30
摘要： A well bore treatment fluid of viscoelastic surfactants and methods for increasing the viscosity of the fluid at high temperature without increasing its salt concentration by adding a organic hydrophilic-lipophilic compound and reducing the salt concentration below 6 percent.
摘要翻译：粘弹性表面活性剂的孔眼处理液和通过添加有机亲水亲油性化合物并将盐浓度降低至6％以下，在不增加其盐浓度的情况下在高温下增加流体的粘度的方法。

15. 发明申请

US20070154902A1 Papilloma virus vaccine 审中-公开
标题翻译：乳头状瘤病毒疫苗
公开(公告)号：US20070154902A1
公开(公告)日：2007-07-05
申请号：US11455236
申请日：2006-06-19
申请人： Ian Frazer , Jian Zhou
发明人： Ian Frazer , Jian Zhou
IPC分类号： C12Q1/70 , C12Q1/68
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/5258 , C12N7/00 , C12N2710/20022 , C12N2710/20023 , C12N2710/20034 , C12N2710/20043 , C12Q1/701 , Y10S977/802
摘要： A method of providing papilloma virus like particles which may be used for diagnostic purposes or for incorporation in a vaccine for use in relation to infections caused by papilloma virus. The method includes an initial step of constructing one or more recombinant DNA molecules which each encode papilloma virus L1 protein or a combination of papilloma virus L1 protein and papilloma virus L2 protein followed by a further step of transfecting a suitable host cell with one or more of the recombinant DNA molecules so that virus like particles (VLPs) are produced within the cell after expression of the L1 or combination of L1 and L2 proteins. The VLPs are also claimed per se as well as vaccines incorporating the VLPs.
摘要翻译：提供乳头瘤病毒样颗粒的方法，其可用于诊断目的或用于结合用于与由乳头状瘤病毒引起的感染有关的疫苗。该方法包括构建一个或多个重组DNA分子的初始步骤，每个重组DNA分子编码乳头瘤病毒L1蛋白或乳头瘤病毒L1蛋白和乳头瘤病毒L2蛋白的组合，接着进一步将一个或多个重组DNA分子，使得在L1或L1和L2蛋白的组合表达之后，在细胞内产生病毒样颗粒（VLP）。本身还要求VLP以及结合VLP的疫苗。

16. 发明申请

US20070142252A1 Water Compatible Hydraulic Fluids 有权
标题翻译：水兼容液压油
公开(公告)号：US20070142252A1
公开(公告)日：2007-06-21
申请号：US11678738
申请日：2007-02-26
申请人： Alexander Zazovsky , Jian Zhou , Christopher Del Campo , Golchehreh Salamat , Diankui Fu , Jese Lee
发明人： Alexander Zazovsky , Jian Zhou , Christopher Del Campo , Golchehreh Salamat , Diankui Fu , Jese Lee
IPC分类号： C10M107/34
CPC分类号： C10M161/00 , C10M2207/281 , C10M2207/34 , C10M2209/084 , C10M2209/104 , C10M2209/106 , C10M2209/108 , C10M2215/04 , C10M2219/044 , C10M2221/043 , C10M2229/041 , C10N2230/12 , C10N2230/26 , C10N2240/08 , C10N2250/022 , Y10S166/902
摘要： A composition for use in an oil chamber of a tool includes a hydraulic oil; and a surfactant, wherein the surfactant is present at an amount sufficient to form micelles in the hydraulic oil. The composition may further include an amphiphilic copolymer. A method includes providing a hydraulic fluid composition comprising a hydraulic oil and a surfactant capable of forming micelles in the hydraulic oil; and filling a hydraulic chamber in the tool with the hydraulic fluid composition. The hydraulic fluid composition may further include an amphiphilic copolymer.
摘要翻译：用于工具的油室中的组合物包括液压油; 和表面活性剂，其中表面活性剂以足以在液压油中形成胶束的量存在。组合物还可以包括两亲性共聚物。一种方法包括提供包括液压油和能够在液压油中形成胶束的表面活性剂的液压流体组合物; 并用液压流体组合物在工具中填充液压室。液压流体组合物还可以包括两亲共聚物。

17. 发明申请

US20070050859A1 Method of making a geneticaly modified mammalian cell 失效
标题翻译：制备遗传修饰的哺乳动物细胞的方法
公开(公告)号：US20070050859A1
公开(公告)日：2007-03-01
申请号：US11591969
申请日：2006-11-02
申请人： Ian Frazer , Jian Zhou , Xiao Sun
发明人： Ian Frazer , Jian Zhou , Xiao Sun
IPC分类号： A01K67/027 , C12N5/06 , C12N15/85
CPC分类号： C12N7/00 , A61K2039/5258 , C07K14/005 , C07K14/43595 , C12N15/67 , C12N15/85 , C12N2710/20022 , C12N2710/20023 , C12N2710/20051 , C12N2830/00 , C12N2830/60 , C12Q1/6897
摘要： A method of making a genetically modified mammalian cell, the method including selecting a first codon of a parent polynucleotide that encodes a polypeptide for replacement with a synonymous codon, wherein the synonymous codon is selected on the basis that it exhibits a higher translational efficiency in a first type of mammalian cell than the first codon in a comparison of translational efficiencies of codons in cells of the first type, replacing the first codon with the synonymous codon to form a synthetic polynucleotide, and introducing the synthetic polynucleotide into a mammalian cell to produce the genetically modified mammalian cell.
摘要翻译：一种制备遗传修饰的哺乳动物细胞的方法，所述方法包括选择编码用于替代同义密码子的多肽的亲本多核苷酸的第一密码子，其中所述同义密码子是基于其在第一类型的哺乳动物细胞比第一密码子的细胞的密码子的翻译效率的比较，用同义密码子替换第一密码子以形成合成的多核苷酸，并将合成的多核苷酸引入到哺乳动物细胞中以产生遗传修饰的哺乳动物细胞。

18. 发明授权

US07169585B2 Papillomavirus vaccine 失效
标题翻译：乳头瘤病毒疫苗
公开(公告)号：US07169585B2
公开(公告)日：2007-01-30
申请号：US10732345
申请日：2003-12-11
申请人： Ian Frazer , Jian Zhou
发明人： Ian Frazer , Jian Zhou
IPC分类号： C12N15/64 , C12N15/37
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/5258 , C12N7/00 , C12N2710/20022 , C12N2710/20023 , C12N2710/20034 , C12N2710/20043 , C12Q1/701 , Y10S977/802
摘要： A method of providing papillomavirus like particles which may be used for diagnostic purposes or for incorporation in a vaccine for use in relation to infections causd by papillomavirus. The method includes an initial step of constructing one or more recombinant DNA molecules which each encode papillomavirus L1 protein or a combination of papillomavirus L1 protein and papillomavirus L2 protein followed by a further step of transfecting a suitable host cell with one or more of the recombinant DNA molecules so that virus like particles (VLPs) are produced within the cell after expression of the L1 or combination of L1 and L2 proteins. The VLPs are also claimed per se as well as vaccines incorporating the VLPs.
摘要翻译：提供乳头瘤病毒样颗粒的方法，其可用于诊断目的或用于结合用于与由乳头瘤病毒引起的感染有关的疫苗中。该方法包括构建一种或多种重组DNA分子的初始步骤，每个重组DNA分子编码乳头瘤病毒L1蛋白或乳头瘤病毒L1蛋白和乳头瘤病毒L2蛋白的组合，接着进一步用一种或多种重组DNA转染合适的宿主细胞分子，使得在表达L1或L1和L2蛋白的组合之后，在细胞内产生病毒样颗粒（VLP）。本身还要求VLP以及结合VLP的疫苗。

19. 发明申请

US20060055884A1 Soft contact lenses with stiffening rib features therein 审中-公开
标题翻译：柔软的隐形眼镜，其中具有加筋肋
公开(公告)号：US20060055884A1
公开(公告)日：2006-03-16
申请号：US11196908
申请日：2005-08-04
申请人： Jason Molinari , Courtney Morgan , Joseph Lindacher , Rafael Andino , S. Fisher , Tracy Snowden , Jian Zhou
发明人： Jason Molinari , Courtney Morgan , Joseph Lindacher , Rafael Andino , S. Fisher , Tracy Snowden , Jian Zhou
IPC分类号： G02C7/02
CPC分类号： G02C7/043 , G02C7/048 , G02C2202/04 , G02C2202/08
摘要： The present invention is related to a method for designing and making a contact lens which comprises stiffening rib features that provide even distribution of pressure from the lens over the cornea of an eye and/or allows the lens structure to maintain balance of forces for consistent and correct lens orientation on an eye during lens translation or eye lid movement. The invention also provides a soft contact lens comprising stiffening rib features that provides localized directional reinforcements to the lens structure to evenly distribute pressure from the lens over the cornea of an eye and/or to maintain balance of forces for consistent and correct lens orientation on an eye during lens translation or eye lid movement.
摘要翻译：本发明涉及一种用于设计和制造隐形眼镜的方法，其包括加强肋部特征，其提供来自透镜在眼睛的角膜上的均匀分布的压力和/或允许透镜结构保持力的平衡以保持一致和在镜头平移或眼睑移动过程中，眼睛上矫正镜片的方位。本发明还提供了一种柔性隐形眼镜，其包括加强肋特征，其向透镜结构提供局部方向加强件，以将透镜上的压力均匀地分布在眼睛的角膜上和/或维持平衡力以使一致和正确的透镜取向在透镜翻转或眼罩移动时的眼睛。

20. 发明申请

US20060047028A1 Hydrogel for use in downhole seal applications 审中-公开
标题翻译：水凝胶用于井下密封应用
公开(公告)号：US20060047028A1
公开(公告)日：2006-03-02
申请号：US11246864
申请日：2005-10-07
申请人： Yanmei Li , Jian Zhou
发明人： Yanmei Li , Jian Zhou
IPC分类号： C08L1/00
CPC分类号： C08L5/14 , C08L1/28 , C08L101/00 , C08L101/14 , C09K3/10 , C09K2200/06 , C09K2200/0617 , C09K2200/0627 , C09K2200/0632 , C09K2200/0657 , C09K2200/0685 , E21B33/12 , C08L2666/06 , C08L2666/02 , C08L2666/08 , C08L2666/26
摘要： The present invention is a composition for forming seals. The composition includes a base material and a hydrogel. The base material is preferably an elastomer or a thermoplastic. Seals formed with the composition are particularly suited for use in a wellbore environment. The inclusion of hydrogel in the seals allows the seals to be manipulated or altered through certain environmental factors. For instance, temperature, oil/water ratio, pH and the electronic field may all be used to alter the characteristics of the hydrogel. In this way, the seal may be caused to swell in response to a specific stimulus, thereby preventing or sealing a leak without requiring additional work or input from the operator.
摘要翻译：本发明是用于形成密封件的组合物。该组合物包括基础材料和水凝胶。基材优选为弹性体或热塑性材料。用该组合物形成的密封件特别适用于井眼环境。将水凝胶包括在密封件中可以通过某些环境因素来操纵或改变密封。例如，可以使用温度，油/水比，pH和电场来改变水凝胶的特性。以这种方式，密封可以响应于特定的刺激而膨胀，从而防止或密封泄漏，而不需要额外的工作或来自操作者的输入。

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