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11. 发明授权

US08329208B2 Pharmacokinetics of S-adenosylmethionine formulations 有权
标题翻译： S-腺苷甲硫氨酸制剂的药代动力学
公开(公告)号：US08329208B2
公开(公告)日：2012-12-11
申请号：US12845600
申请日：2010-07-28
申请人： Nancy Harrison , I. David MacDonald , Aniko Takacs-Cox , Robert Miller
发明人： Nancy Harrison , I. David MacDonald , Aniko Takacs-Cox , Robert Miller
IPC分类号： A61K47/00 , A61K9/00 , A61K31/70
CPC分类号： A61K31/7076 , A61K9/0002 , A61K9/0053 , A61K9/2054 , A61K9/2095 , A61K9/28 , A61K9/2886 , A61K9/50 , A61K47/38
摘要： Compositions and methods to improve the pharmacokinetic profile of S-Adenosylmethionine (SAMe) are provided, as are methods of treating various disorders using SAMe formulations with improved pharmacokinetic profiles. More specifically, the invention is directed to methods of treating a disease or disorder in a subject and/or improving the nutritional status of a subject by administering formulations exhibiting improved pharmacokinetic profiles of exogenous SAMe. The method also includes the step of orally administering compositions of the invention to the subject once per day after overnight fast; that is prior to food intake in the morning.
摘要翻译：提供了改善S-腺苷甲硫氨酸（SAMe）的药代动力学特征的组合物和方法，以及使用具有改善的药代动力学特征的SAMe制剂治疗各种疾病的方法。更具体地，本发明涉及通过施用表现出改善的外源SAMe的药代动力学特征的制剂来治疗受试者的疾病或病症和/或改善受试者的营养状态的方法。该方法还包括将抗生素治疗本发明组合物一天一次快速过夜的步骤; 那是在早上食物摄入之前。

12. 发明授权

US08031637B2 Ineligible group member status 失效
标题翻译：不合格的团体成员身份
公开(公告)号：US08031637B2
公开(公告)日：2011-10-04
申请号：US12405478
申请日：2009-03-17
申请人： Michael James McDermott , Robert Miller , Michael John Snyder , Kiswanto Thayib
发明人： Michael James McDermott , Robert Miller , Michael John Snyder , Kiswanto Thayib
IPC分类号： H04L12/28
CPC分类号： H04L41/0893
摘要： A computing system group member, signal bearing medium, and method. A configuration of a computing system group member is determined to be able to assume a role of a primary member of the computing system group and, in response thereto, a first status is assigned in the member. All members of the computing system group receive, in order, all messages directed to group members. A second status is assigned in response to determining that the configuration of the member is not able to support performance as a primary member. The member then processes, within the member, all messages that are transmitted to all members of the group when the member is assigned the first status and when the member is assigned the second status. The configuration of the member, while assigned either the first status or the second status, is adjusted based upon contents of the messages.
摘要翻译：计算系统组成员，信号承载介质和方法。确定计算系统组成员的配置能够承担计算系统组的主要成员的角色，并且作为响应，在该成员中分配第一状态。计算系统组的所有成员按顺序接收指向组成员的所有消息。响应于确定成员的配置不能支持作为主要成员的性能而分配第二状态。然后，成员在成员分配第一个状态和成员被分配第二个状态时，在成员内处理发送给组中所有成员的所有消息。在分配了第一状态或第二状态的情况下，成员的配置根据消息的内容进行调整。

13. 发明授权

US07928010B2 Method for producing portable memory devices 有权
标题翻译：便携式存储装置的制造方法
公开(公告)号：US07928010B2
公开(公告)日：2011-04-19
申请号：US11551402
申请日：2006-10-20
申请人： Warren Middlekauff , Robert Miller , Charlie Centofante
发明人： Warren Middlekauff , Robert Miller , Charlie Centofante
IPC分类号： H01L21/44
CPC分类号： H05K1/0268 , H01L2224/48091 , H05K3/0052 , H05K3/28 , H05K3/284 , H05K2201/09909 , H05K2203/013 , H01L2924/00014
摘要： Improved techniques to produce integrated circuit products are disclosed. The improved techniques permit smaller and less costly production of integrated circuit products. One aspect of the invention concerns covering test contacts (e.g., test pins) provided with the integrated circuit products using printed ink. Once covered with the ink, the test contacts are no longer electrically exposed. Hence, the integrated circuit products are not susceptible to accidental access or electrostatic discharge. Moreover, the integrated circuit products can be efficiently produced in a small form factor without any need for additional packaging or labels to electrically isolate the test contacts.
摘要翻译：公开了用于生产集成电路产品的改进的技术。改进的技术允许集成电路产品的生产更小且成本更低。本发明的一个方面涉及提供使用印刷油墨的集成电路产品的测试接触（例如测试引脚）。一旦被油墨覆盖，测试触点就不再被电镀。因此，集成电路产品不易意外进入或静电放电。此外，集成电路产品可以以小尺寸有效地生产，而不需要额外的封装或标签来电隔离测试触点。

14. 发明申请

US20110027360A1 PHARMACOKINETICS OF S-ADENOSYLMETHIONINE FORMULATIONS 有权
标题翻译： S-腺苷甲硫氨酸配方的药代动力学
公开(公告)号：US20110027360A1
公开(公告)日：2011-02-03
申请号：US12845600
申请日：2010-07-28
申请人： Nancy Harrison , I. David MacDonald , Aniko Takacs-Cox , Robert Miller
发明人： Nancy Harrison , I. David MacDonald , Aniko Takacs-Cox , Robert Miller
IPC分类号： A61K9/28 , C07H19/167 , A61K31/7076 , A61K9/00 , A61P1/16 , A61P19/02 , A61P25/24
CPC分类号： A61K31/7076 , A61K9/0002 , A61K9/0053 , A61K9/2054 , A61K9/2095 , A61K9/28 , A61K9/2886 , A61K9/50 , A61K47/38
摘要： Compositions and methods to improve the pharmacokinetic profile of S-Adenosylmethionine (SAMe) are provided, as are methods of treating various disorders using SAMe formulations with improved pharmacokinetic profiles. More specifically, the invention is directed to methods of treating a disease or disorder in a subject and/or improving the nutritional status of a subject by administering formulations exhibiting improved pharmacokinetic profiles of exogenous SAMe. The method also includes the step of orally administering compositions of the invention to the subject once per day after overnight fast; that is prior to food intake in the morning.
摘要翻译：提供了改善S-腺苷甲硫氨酸（SAMe）的药代动力学特征的组合物和方法，以及使用具有改善的药代动力学特征的SAMe制剂治疗各种疾病的方法。更具体地，本发明涉及通过施用表现出改善的外源SAMe的药代动力学特征的制剂来治疗受试者的疾病或病症和/或改善受试者的营养状态的方法。该方法还包括将抗生素治疗本发明组合物一天一次快速过夜的步骤; 那是在早上食物摄入之前。

15. 发明授权

US07828986B2 Forming surface features using self-assembling masks 有权
标题翻译：使用自组装掩模形成表面特征
公开(公告)号：US07828986B2
公开(公告)日：2010-11-09
申请号：US11926722
申请日：2007-10-29
申请人： Joy Cheng , Mark W. Hart , Hiroshi Ito , Ho-Cheol Kim , Robert Miller
发明人： Joy Cheng , Mark W. Hart , Hiroshi Ito , Ho-Cheol Kim , Robert Miller
IPC分类号： B44C1/22 , H01L21/302
CPC分类号： H01L21/0337 , B81C1/00031 , B81C2201/0149 , B81C2201/0198 , H01L21/0271 , H01L21/0332
摘要： A method. A combination is provided of a block copolymer and additional material. The copolymer includes a first block of a first polymer covalently bonded to a second block of a second polymer. The additional material is miscible with the first polymer. The first polymer includes polystyrene and the second polymer includes poly(ethylene oxide). A first layer including polydimethylglutarimide is adhered onto a surface of a substrate including a dielectric coated silicon wafer. A film is formed of the combination directly onto a surface of the first layer. Nanostructures of the additional material self-assemble within the first polymer block. The film and the first layer are simultaneously etched. The nanostructures have an etch rate lower than an etch rate of the block copolymer and lower than an etch rate of the first layer. Portions of the film are removed. Features remain on the surface of the first layer.
摘要翻译：一个方法。提供了一种嵌段共聚物和另外的材料的组合。共聚物包括共价键合到第二聚合物的第二嵌段的第一聚合物的第一嵌段。附加材料与第一聚合物混溶。第一聚合物包括聚苯乙烯，第二聚合物包括聚（环氧乙烷）。包括聚二甲基戊二酰亚胺的第一层粘附到包括电介质涂覆的硅晶片的基材的表面上。该组合物直接由第一层的表面形成。附加材料的纳米结构在第一聚合物嵌段内自组装。同时蚀刻膜和第一层。纳米结构的蚀刻速率低于嵌段共聚物的蚀刻速率，并且低于第一层的蚀刻速率。部分电影被删除。特征保留在第一层的表面上。

16. 发明申请

US20100242592A1 SHEAR STRESS SENSORS 有权
标题翻译：剪应变传感器
公开(公告)号：US20100242592A1
公开(公告)日：2010-09-30
申请号：US12739520
申请日：2008-10-24
申请人： Ibraheem Haneef , Howard P. Hodson , Robert Miller , Florin Udrea
发明人： Ibraheem Haneef , Howard P. Hodson , Robert Miller , Florin Udrea
IPC分类号： G01F1/692 , C03C15/00
CPC分类号： G01F1/6845 , G01F1/7084 , G01N3/24 , G01N2203/0226 , G01N2203/0623
摘要： This invention relates to hot film shear stress sensors and their fabrication. We describe a hot film shear stress sensor comprising a silicon substrate supporting a membrane having a cavity underneath, said membrane bearing a film of metal and having electrical contacts for heating said film, and wherein said membrane comprises a silicon oxide membrane, where in said metal comprises aluminium or tungsten, and wherein said membrane has a protective layer of a silicon-based material over said film of metal. In preferred embodiments the sensor is fabricated by a CMOS process and the metal comprises aluminium or tungsten.
摘要翻译：本发明涉及热膜剪切应力传感器及其制造。我们描述了一种热膜剪切应力传感器，其包括支撑具有下面空腔的膜的硅衬底，所述膜承载金属膜并具有用于加热所述膜的电触点，并且其中所述膜包括氧化硅膜，其中在所述金属包括铝或钨，并且其中所述膜在所述金属膜上具有硅基材料的保护层。在优选实施例中，传感器通过CMOS工艺制造，并且金属包括铝或钨。

17. 发明授权

US07766950B2 Hypothermia treatment sack 有权
标题翻译：低温治疗袋
公开(公告)号：US07766950B2
公开(公告)日：2010-08-03
申请号：US11491338
申请日：2006-07-21
申请人： Robert A. Castellani , Robert Miller
发明人： Robert A. Castellani , Robert Miller
IPC分类号： A61F7/00
CPC分类号： A61F7/03 , A61F7/0097 , A61F2007/0001 , A61F2007/0255 , A61F2007/038
摘要： A hypothermia treatment sack comprising a top sheet and a bottom sheet releasably connecting along their perimeters to form a patient receiving cavity between the top and bottom sheets while allowing for patient access from any location around the perimeter. The top and bottom sheets include a weatherproof exterior side for repelling wind and water, and a heat reflective interior side for preventing heat from escaping. A plurality of self-activating heating pads are carried in the top sheet for producing heat when exposed to air. The heating pads have a first side exposed on the weatherproof exterior side of the top sheet to provide for a generally unrestricted airflow to the heating pads, and a second side exposed on the heat reflective interior side of the top sheet for radiating heat directly into the patient receiving cavity.
摘要翻译：一种低温治疗袋，其包括顶片和底片，所述底片可沿其周边可释放地连接，以在顶片和底片之间形成患者容纳空腔，同时允许患者从周围任何位置进入。顶部和底部片材包括用于排斥风和水的防风雨外部侧面，以及用于防止热量逸出的热反射内侧。多个自激活加热垫被承载在顶片中，以在暴露于空气中时产生热量。加热垫具有暴露在顶片的防风雨外侧的第一面，以提供对加热垫的大致不受限制的气流，以及暴露在顶片的热反射内侧的第二侧，用于将热量直接辐射到患者接受腔。

18. 发明申请

US20100109948A1 Methods and Apparatuses For GPS Coordinates Extrapolation When GPS Signals Are Not Available 有权
标题翻译： GPS信号不可用时GPS坐标外推的方法和装置
公开(公告)号：US20100109948A1
公开(公告)日：2010-05-06
申请号：US12264564
申请日：2008-11-04
申请人： Leonid Razoumov , Saeed Ghassemzadeh , Robert Miller
发明人： Leonid Razoumov , Saeed Ghassemzadeh , Robert Miller
IPC分类号： G01S5/14
CPC分类号： G01S19/48
摘要： Systems and methods for extrapolating GPS coordinates beyond line of sight are disclosed. A coordinate extrapolation system (CES) can include a memory, a processor, and a GPS receiver. The CES can receive GPS signals and determine GPS coordinates corresponding to a location. If GPS signals are unavailable, the CES models the surface of the earth and extrapolates the GPS coordinates corresponding to the location at which GPS signals are unavailable. Methods for extrapolating the GPS coordinates and calibrating the CES are also disclosed.
摘要翻译：公开了将GPS坐标超出视线外推的系统和方法。坐标外插系统（CES）可以包括存储器，处理器和GPS接收器。 CES可以接收GPS信号并确定对应于一个位置的GPS坐标。如果GPS信号不可用，则CES对地球表面进行建模，并对与GPS信号不可用位置对应的GPS坐标进行外推。还公开了外推GPS坐标和校准CES的方法。

19. 发明申请

US20090325853A1 DETERGENT AND LIQUID SOAP COMPOSITIONS COMPRISING BIOLOGICALLY-BASED MONO AND DI ESTERS 审中-公开
标题翻译：洗涤剂和液体包含基于生物学的单体和单体的皂组合物
公开(公告)号：US20090325853A1
公开(公告)日：2009-12-31
申请号：US12554056
申请日：2009-09-04
申请人： Gyorgyi Fenyvesi , Raja Hari Prasad R. Poladi , Ann Wehner , Robert Miller
发明人： Gyorgyi Fenyvesi , Raja Hari Prasad R. Poladi , Ann Wehner , Robert Miller
IPC分类号： C11D7/26 , C11D17/08
CPC分类号： A61K8/345 , A01N1/021 , A01N3/00 , A01N25/02 , A21D2/14 , A23B7/154 , A23K20/105 , A23L2/52 , A23L3/3463 , A23L29/035 , A23L29/04 , A23L29/10 , A23L33/10 , A23L33/12 , A23V2002/00 , A61K8/0208 , A61K8/375 , A61K8/92 , A61K9/0019 , A61K9/06 , A61K9/282 , A61K31/22 , A61K36/02 , A61K36/185 , A61K36/28 , A61K36/355 , A61K36/61 , A61K36/738 , A61K47/10 , A61K47/14 , A61K47/44 , A61K2800/10 , A61K2800/75 , A61Q1/02 , A61Q1/08 , A61Q1/10 , A61Q1/14 , A61Q5/00 , A61Q5/02 , A61Q5/065 , A61Q5/10 , A61Q5/12 , A61Q9/02 , A61Q9/04 , A61Q11/00 , A61Q13/00 , A61Q15/00 , A61Q17/00 , A61Q17/005 , A61Q17/04 , A61Q19/00 , A61Q19/002 , A61Q19/005 , A61Q19/007 , A61Q19/008 , A61Q19/04 , A61Q19/10 , B01D11/0288 , C02F5/10 , C07C67/08 , C07C69/16 , C07C69/28 , C07C69/44 , C07C69/58 , C07C69/60 , C07C69/78 , C08K5/053 , C08K5/103 , C08K2201/018 , C09D7/63 , C09D11/03 , C09D11/16 , C09D11/38 , C09G1/08 , C09K3/18 , C09K3/185 , C09K5/10 , C09K5/20 , C10M129/08 , C10M2207/022 , C10M2207/04 , C10M2207/283 , C10M2209/086 , C10M2215/042 , C10M2215/223 , C10M2229/0425 , C10N2230/64 , C10N2240/08 , C11C3/003 , C11D1/667 , C11D3/2003 , C11D3/2044 , C11D3/2068 , C11D3/2093 , C11D3/3418 , C11D3/38663 , C11D7/266 , C11D7/5022 , C11D11/0017 , C11D11/0023 , C12P7/18 , C12P7/42 , C12P7/62 , Y02W10/37 , C08L67/04
摘要： A process for providing detergent compositions comprising synthesizing mono and di esters from biologically derived 1,3-propanediol an incorporating said esters into detergent formulations. The basic process involves producing and purifying biologically derived 1,3-propanediol, synthesizing mono and di esters by the condensation of 1,3-propanediol with an acid using a catalyst, recovering the ester and incorporating said ester into a detergent formulation. The compositions made from the biologically derived 1,3-propanediol are also encompassed by the invention.
摘要翻译：一种用于提供洗涤剂组合物的方法，包括从生物衍生的1,3-丙二醇合成单酯和二酯，将所述酯掺入洗涤剂配方中。基本方法包括生产和纯化生物衍生的1,3-丙二醇，通过使用催化剂与1,3-丙二醇与酸的缩合合成单酯和二酯，回收酯并将所述酯并入洗涤剂配方中。由生物衍生的1,3-丙二醇制成的组合物也包括在本发明中。

20. 发明申请

US20090197824A1 Extended Release Pharmaceutical Formulations of S-Adenosylmethionine 审中-公开
标题翻译： S-腺苷甲硫氨酸的延长释放药物制剂
公开(公告)号：US20090197824A1
公开(公告)日：2009-08-06
申请号：US12175432
申请日：2008-07-17
申请人： Joshua Freedman , Aviva Revgev , Nancy Harrison , Robert Miller , David MacDonald
发明人： Joshua Freedman , Aviva Revgev , Nancy Harrison , Robert Miller , David MacDonald
IPC分类号： A61K31/7076 , A61P19/02 , A61P25/00 , A61P9/00 , A61P1/00 , A61P35/00
CPC分类号： A61K9/2009 , A61K9/2013 , A61K9/2095 , A61K9/2866 , A61K31/70
摘要： Extended release formulations of S-methyladenosylmethionine (SAMe) are provided, as are methods of treating various disorders using extended release SAMe formulations. The extended release formulations may be used to treat a variety of disorders, including liver disorders, psychiatric disorders and joint disorders. Thus, extended release SAMe formulations may be used to treat alcoholic liver disease, fatty liver disease, hepatitis, generalized anxiety disorder, obsessive compulsive disorder, post traumatic stress disorder, panic disorder, and depressive disorders such as depression (e.g. major clinical depression) and dysthymia.
摘要翻译：提供S-甲基腺苷甲硫氨酸（SAMe）的延长释放制剂，以及使用延长释放SAMe制剂治疗各种疾病的方法。延长释放制剂可用于治疗多种疾病，包括肝脏疾病，精神病学障碍和关节疾病。因此，延长释放的SAMe制剂可用于治疗酒精性肝病，脂肪肝疾病，肝炎，广泛性焦虑症，强迫症，创伤后应激障碍，恐慌症和抑郁障碍（例如主要临床抑郁症）和情绪恶化

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