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11. 发明授权

US10583296B2 Implantable pulse generator system and method for vagal nerve stimulation 有权
公开(公告)号：US10583296B2
公开(公告)日：2020-03-10
申请号：US15489829
申请日：2017-04-18
申请人： BIOTRONIK SE & Co. KG
发明人： Jie Lian , Lauren Kraiter , Andrew B. Kibler
IPC分类号： A61N1/36
摘要： An implantable pulse generator system includes a nerve stimulation unit providing vagal nerve stimulation (VNS) pulses; an autonomic tone sensor which determines the patient's autonomic status; and a control unit connected to the nerve stimulation unit and the autonomic tone sensor. The control unit controls the nerve stimulation unit to generate VNS with varying intensity, depending on the autonomic status (which is evaluated in a moving window). The control unit gradually increases VNS intensity when the autonomic status indicates a shift toward more sympathetic dominance, and it gradually decreases VNS intensity when the autonomic status indicates a shift toward more parasympathetic dominance, wherein the gradual increase and the gradual decrease of the VNS intensity follow two different paths.

12. 发明申请

US20190030339A1 Neural Stimulation and Recording, Particularly for Neuromodulation Closed-Loop Control 审中-公开
公开(公告)号：US20190030339A1
公开(公告)日：2019-01-31
申请号：US16032701
申请日：2018-07-11
申请人： BIOTRONIK SE & Co. KG
发明人： Marcelo Baru , Andrew B. Kibler
IPC分类号： A61N1/36 , A61B5/04
摘要： A device for neurostimulation including an electrode structure for delivering stimulation pulses to a nerve as well as for processing and extracting evoked compound action potentials, wherein the electrode structure comprises at least a first anode, at least a second anode opposing the first anode and a plurality of cathodes arranged between said anodes, wherein said cathodes are asymmetrically arranged with respect to said at least first and second anode to permit evoked compound action potential sensing via the anode electrodes simultaneously with stimulation.

13. 发明授权

US09895542B2 Device and method for selective nerve stimulation 有权
公开(公告)号：US09895542B2
公开(公告)日：2018-02-20
申请号：US15090690
申请日：2016-04-05
申请人： BIOTRONIK SE & Co. KG
发明人： Marcelo Baru , Andrew B. Kibler
IPC分类号： A61N1/36 , A61N1/05
CPC分类号： A61N1/36114 , A61N1/0556 , A61N1/36053 , A61N1/36185
摘要： An implantable pulse generator (106) provides electric stimulation pulses for nerve stimulation via a stimulation lead (100) having stimulation electrodes (102, 104). The electric stimulation pulses form a pulse train including (i) an initial selective-arrest phase for the large-diameter fibers in the vicinity of selected electrodes; (ii) followed by a charge-balanced phase where a charge-balanced alternating current (AC) is applied between the same or other selected electrodes; and (iii) a therapy phase where the charge-balanced alternating current (AC) is briefly unbalanced to deliver nerve stimulation therapy pulses, with the pulse train returning to the charge-balanced phase in between therapy pulses.

14. 发明申请

US20160175595A1 IMPLANTABLE PULSE GENERATOR SYSTEM FOR VAGAL NERVE STIMULATION 有权
标题翻译：用于VAGAL NERVE刺激的可植入脉冲发生器系统
公开(公告)号：US20160175595A1
公开(公告)日：2016-06-23
申请号：US14962065
申请日：2015-12-08
申请人： BIOTRONIK SE & Co. KG
发明人： Jie Lian , Lauren Kraiter , Alan Fryer , Andrew B. Kibler , Dirk Muessig , Larry Stotts , Warren Dabney , Jeffrey A. von Arx
IPC分类号： A61N1/36 , A61N1/05
CPC分类号： A61N1/36139 , A61N1/0556 , A61N1/36053 , A61N1/36114
摘要： An implantable pulse generator system includes a stimulation unit delivering vagal nerve stimulation pulses, an activity sensor determining an exertion level of the user and generating a signal representing metabolic demand, an autonomic tone sensor determining an autonomic status of the user and generating a signal representing autonomic status, and a control unit in communication with the foregoing components, and which is adapted to control the stimulation unit depending on both the signal representing metabolic demand and the signal representing autonomic status.
摘要翻译：植入式脉冲发生器系统包括：输送迷走神经刺激脉冲的刺激单元，确定使用者的运动水平并产生表示代谢需求的信号的活动传感器，确定使用者的自主状态并产生表示自主神经的信号的自主音调传感器状态和与前述组件通信的控制单元，其适于根据表示代谢需求的信号和表示自主状态的信号来控制刺激单元。

15. 发明申请

US20150328468A1 INNER PACKAGING FOR A STERILIZABLE CONTAINMENT AND STERILIZABLE CONTAINMENT 审中-公开
标题翻译：无菌包装和无菌包装的内包装
公开(公告)号：US20150328468A1
公开(公告)日：2015-11-19
申请号：US14703192
申请日：2015-05-04
申请人： BIOTRONIK SE & Co. KG
发明人： J. Christopher Moulder , Andrew B. Kibler
IPC分类号： A61N1/375 , A61N1/362 , B65B55/02 , B65B5/04 , B65B7/28 , A61N1/372 , A61N1/39
CPC分类号： A61N1/3758 , A61N1/362 , A61N1/37217 , A61N1/37235 , A61N1/3756 , A61N1/3968 , A61N2001/37294 , B65B5/04 , B65B7/28 , B65B55/02
摘要： A sterilizable container for an implantable medical device, including an inner packaging and an outer packaging that encloses said inner packaging. The inner packaging includes an enclosure and at least two electric contacts that are arranged inside the enclosure and that are placed so as to contact an implantable medical device electrode when such implantable medical device is placed in said inner packaging. Each electric contact of said inner packaging is electrically connected to a respective planar electrode arranged at or close to an outer surface of said inner packaging so as to provide a capacitive communication interface. The inner packaging further includes fixture means that are configured to securely hold an implantable medical device in place to ensure electric contact between the at least two electric contacts and a respective implantable medical device electrode when such implantable medical device is placed in the inner packaging.
摘要翻译：一种用于可植入医疗装置的可灭菌容器，包括内包装和封装所述内包装的外包装。内部包装包括外壳和至少两个电触点，其布置在外壳内部，并且当将这种可植入医疗器械放置在所述内包装中时，所述至少两个电触头被放置成接触可植入医疗装置电极。所述内包装的每个电接触电连接到布置在所述内包装的外表面处或靠近所述内包装的外表面的相应平面电极，以便提供电容性通信接口。内部包装还包括固定装置，其被构造成将可植入医疗装置牢固地保持在适当位置，以确保当将这种可植入医疗装置放置在内包装中时，该至少两个电触点和相应的可植入医疗装置电极之间的电接触。

16. 发明授权

US11357990B2 Method for programming an implantable medical device and system for configuring stimulation parameters of an implantable medical device 有权
公开(公告)号：US11357990B2
公开(公告)日：2022-06-14
申请号：US16825665
申请日：2020-03-20
申请人： BIOTRONIK SE & CO. KG
发明人： Andrew B. Kibler , Lauren Kraiter , Larry Stotts
IPC分类号： A61N1/02 , A61N1/05 , A61N1/36 , A61N1/372
摘要： A method programs an implantable medical device to configure the implantable medical device for stimulating neural tissue by at least one electrode. The method includes: performing, by the implantable medical device, an evoked compound action potential (eCAP) threshold search by stimulating the neural tissue with test stimulation pulses; determining, based on the eCAP threshold search, an eCAP threshold amplitude and a coupling factor that is indicative of a coupling between the at least one electrode and the neural tissue; and generating a first set of stimulation parameters containing at least a stimulation amplitude that is determined in dependence on the eCAP threshold amplitude and the coupling factor.

17. 发明授权

US11235153B2 Interleaved multi-contact neuromodulation therapy with reduced energy 有权
公开(公告)号：US11235153B2
公开(公告)日：2022-02-01
申请号：US16656120
申请日：2019-10-17
申请人： BIOTRONIK SE & CO. KG
发明人： Andrew B. Kibler , Sean Slee , Pamela Shamsie Victoria Riahi
IPC分类号： A61N1/36
摘要： A medical device for electrical stimulation of a patient. A pulse generator generates current pulses for the electrical stimulation. An electrode lead with a plurality of electrode contacts delivers the pulses to tissue of the patient. The pulse generator repeatedly delivers a current pulse between two electrodes forming a first group and delivers a charge balancing current pulse after each current pulse between the electrodes of the first group. The respective current pulse is separated from the succeeding charge balancing current pulse by an inter pulse interval. The respective current pulse has an amplitude with the same absolute magnitude as the succeeding charge balancing current pulse, but is of opposite sign. The pulse generator delivers between each current pulse and the succeeding charge balancing current pulse a current pulse between two further electrodes forming a second group of electrode contacts of the plurality of electrode contacts.

18. 发明申请

US20210387009A1 Dual-Module Motion Detection System for the Power Saving of Rate Adaption Algorithm in Leadless Pacemaker 有权
公开(公告)号：US20210387009A1
公开(公告)日：2021-12-16
申请号：US17288240
申请日：2019-09-11
申请人： BIOTRONIK SE & Co. KG
发明人： Min Qu , Andrew B. Kibler , Christopher S. de Voir
IPC分类号： A61N1/365 , A61N1/02
摘要： An implantable cardiac pacemaker, wherein the pacemaker is configured to apply pacing pulses to the heart of a person during operation of the pacemaker, and wherein the pacemaker comprises a motion detection system that comprises a first module and a second module. The first module is configured to continuously run during operation of the pacemaker. The second module is configured to receive a trigger signal to change from an idle state to an active state or to receive a further trigger signal to change from an active state to an idle state. An energy consumption per time unit of the second module in the active state is larger than in the idle state. When the second module is in its active state, the second module is configured to execute a rate adaptation algorithm that adapts a rate of the pacing pulses to meet a metabolic demand of the person.

19. 发明授权

US10928181B2 Method for relative lead offset determination 有权
公开(公告)号：US10928181B2
公开(公告)日：2021-02-23
申请号：US17071116
申请日：2020-10-15
申请人： BIOTRONIK SE & CO. KG
发明人： Pamela Shamsie Victoria Riahi , Andrew B. Kibler , Sean Slee , Christopher S. De Voir
IPC分类号： A61N1/36 , G01B7/31 , A61N1/05
摘要： A method for estimating an offset between a first group and a second group of contacts with respect to a longitudinal direction. Each group of contacts includes a plurality of electrodes arranged along a surface of a body of a lead. The method includes the steps of: (a) Selecting a number of electrode pairs, each electrode pair including an electrode of the first contact group and an electrode of the second contact group, and measuring the impedances between the electrodes of each selected electrode pair; (b) pre-conditioning the measured impedances for attenuating unwanted noise to generate pre-conditioned impedances, and (c) determining the lead offset using the pre-conditioned impedances.

20. 发明申请

US20170304628A1 IMPLANTABLE PULSE GENERATOR SYSTEM AND METHOD FOR VAGAL NERVE STIMULATION 审中-公开
公开(公告)号：US20170304628A1
公开(公告)日：2017-10-26
申请号：US15489829
申请日：2017-04-18
申请人： BIOTRONIK SE & Co. KG
发明人： Jie Lian , Lauren Kraiter , Andrew B. Kibler
IPC分类号： A61N1/36
CPC分类号： A61N1/36139 , A61N1/36053 , A61N1/36114 , A61N1/3615 , A61N1/36171 , A61N1/36175
摘要： An implantable pulse generator system includes a nerve stimulation unit providing vagal nerve stimulation (VNS) pulses; an autonomic tone sensor which determines the patient's autonomic status; and a control unit connected to the nerve stimulation unit and the autonomic tone sensor. The control unit controls the nerve stimulation unit to generate VNS with varying intensity, depending on the autonomic status (which is evaluated in a moving window). The control unit gradually increases VNS intensity when the autonomic status indicates a shift toward more sympathetic dominance, and it gradually decreases VNS intensity when the autonomic status indicates a shift toward more parasympathetic dominance, wherein the gradual increase and the gradual decrease of the VNS intensity follow two different paths.

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