专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

11. 发明授权

US06299374B1 Instruments for producing edible colored indicia on food substrates and medicaments 有权
标题翻译：在食品基质和药物上生产食用色标的仪器
公开(公告)号：US06299374B1
公开(公告)日：2001-10-09
申请号：US09796115
申请日：2001-02-28
申请人： David Naor , James Michael
发明人： David Naor , James Michael
IPC分类号： B43K500
CPC分类号： B43K29/00 , B43K5/00 , B43K8/06 , B43M11/08
摘要： Novel capillary feed marking instruments capable of producing edible colored indicia directly on food substrates and medicaments are disclosed. The marking instruments are used to write or decorate directly on porous and non-porous food substrates in a controlled fashions and without the need to pre-mix colors or handle dyes. Kits comprising a plurality of such marking instruments in various colors and, optionally, edible substances or artistic aids, are also disclosed. The marking instruments of the invention may also be employed in a system for classifying solid, oral medicaments such as pills, tablets or capsules, for identification and easy detection.
摘要翻译：公开了能够直接在食品基材和药物上生产可食用彩色标记的新型毛细管饲料标记仪器。标记仪器用于以受控制的方式直接在多孔和无孔食品基材上书写或装饰，无需预混颜色或处理染料。还公开了包括多种这样的各种颜色的标记装置和任选的可食用物质或艺术助剂的试剂盒。本发明的标记装置也可以用于将固体，口服药物如丸剂，片剂或胶囊分类的系统中，用于鉴别和容易检测。

12. 发明授权

US5776970A Tryptophan derivatives as protein tyrosine kinase blockers and their use in the treatment of neoplastic diseases 失效
标题翻译：色氨酸衍生物作为蛋白酪氨酸激酶阻断剂及其在治疗肿瘤疾病中的应用
公开(公告)号：US5776970A
公开(公告)日：1998-07-07
申请号：US234159
申请日：1994-04-28
申请人： Yoram Shechter , David Naor
发明人： Yoram Shechter , David Naor
IPC分类号： C07D209/20 , C07D209/30 , C07D401/02 , A61K31/405 , A61K31/47 , C07D209/10
CPC分类号： C07D209/20 , C07D209/30
摘要： Tryptophan derivatives substituted by a hydrophobic group, e.g. carbobenzoxy, at the N-terminus, and a hydrophilic group, e.g. --COOH, --SO.sub.3 H or --PO.sub.3 H, at the C-terminus, were found to be cell-permeable blockers of protein tyrosine kinases (PTKs). These PTK blockers are useful in basic research and in the treatment of neoplastic diseases.
摘要翻译：被疏水基取代的色氨酸衍生物，例如 N-苯甲氧基，N-末端，和亲水基团，例如 -COOH，-SO 3 H或-PO 3 H在C末端被发现是蛋白酪氨酸激酶（PTK）的细胞可渗透阻断剂。这些PTK阻断剂可用于基础研究和肿瘤疾病的治疗。

13. 发明申请

US20050215464A1 Binding agents for cd44 glycoproteins and methods of use 审中-公开
标题翻译： cd44糖蛋白的结合剂及其使用方法
公开(公告)号：US20050215464A1
公开(公告)日：2005-09-29
申请号：US10505769
申请日：2003-02-27
申请人： Lora Melnik , Itehak Golan , David Naor , Yehiel Zick
发明人： Lora Melnik , Itehak Golan , David Naor , Yehiel Zick
IPC分类号： A61K38/17 , G01N33/50 , G01N33/566 , G01N33/68
CPC分类号： G01N33/5008 , A61K38/1709 , G01N33/5005 , G01N33/502 , G01N33/566 , G01N33/68
摘要： The present invention is based on the finding that Gal-8 binds to carbohydrates of cell surface CD44std and CD44v and activates a chain of biological events within the cells. A specific effect exhibited was the induction of apoptosis in the CD44std and CD44v expressing cells. Thus, the present invention concerns the use of an active agent for achieving a therapeutic effect on a target cell, the therapeutic effect comprises binding of said active agent to a standard CD44 (CD44std) glycoprotein or to a CD44 variant (CD44v) expressed by said target cell, the active agent being galectin-8 (Gal-8) or a functional derivative thereof. The active ingredient may be used for the preparation of a pharmaceutical composition, for the treatment of a disease or a disorder or for diagnostic purposes.
摘要翻译：本发明基于Gal-8与细胞表面CD44std和CD44v的碳水化合物结合并激活细胞内生物学事件链的发现。具体表现为CD44std和CD44v表达细胞凋亡诱导。因此，本发明涉及活性剂用于实现对靶细胞的治疗作用的用途，治疗效果包括将所述活性剂与标准CD44（CD44std）糖蛋白或由所述的CD44（CD44std）糖蛋白表达的CD44变体（CD44v）的结合靶细胞，活性剂是半乳凝素-8（Gal-8）或其功能性衍生物。活性成分可用于制备药物组合物，用于治疗疾病或病症或用于诊断目的。

14. 发明申请

US20110163539A1 Connector for pipe-line 审中-公开
标题翻译：管线连接器
公开(公告)号：US20110163539A1
公开(公告)日：2011-07-07
申请号：US13065063
申请日：2011-03-14
申请人： David Naor
发明人： David Naor
IPC分类号： F16L19/00
CPC分类号： E03C1/0409 , F16L37/0915
摘要： A connector that enables fast connection and disconnection of a pipe to/from another pipe and accessories that are designed to be connected to a pipe, such as a bathroom or shower pipe. The connector comprises a hollow main body, a spring ring with flexible prongs that can be bent by applying force, and a compression ring that protrudes out from the main body and whose bottom part is shaped like an up-side-down truncated cone, enabling it to penetrate into the spring ring. When the compression ring is pressed, it penetrates into the main body. The conic part of the compression ring widens the hole in the compression ring by bending the prongs downward, enabling the pipe to penetrate into the flexible pronged ring. When application of pressure on the compression ring is ceased, the pipe can not be extracted from the connector. The connector can an integral part of an accessory or a pipe.
摘要翻译：一个连接器，可以快速连接和断开管道与另一个管道的连接，以及设计为连接到管道（如浴室或淋浴管道）的附件。连接器包括中空主体，具有能够通过施加力弯曲的柔性叉头的弹簧环和从主体突出并且其底部形状像上侧截锥体的压缩环，使得能够它渗透到弹簧环。当压缩环被按压时，它会渗入主体。压缩环的圆锥部分通过向下弯曲插脚来加宽压缩环中的孔，使得管能够穿透柔性插脚环。当压缩环上施加压力停止时，管道不能从连接器中拔出。连接器可以是附件或管道的组成部分。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式