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11. 发明申请

US20090098106A1 PHARMACEUTICAL COMPOSITIONS FOR TREATING DISEASES ASSOCIATED WITH NF-kB ACTIVITY 有权
标题翻译：用于治疗与NF-kB活性相关的疾病的药物组合物
公开(公告)号：US20090098106A1
公开(公告)日：2009-04-16
申请号：US11722898
申请日：2005-12-11
申请人： David Wallach , Parameswaran Ramakrishnan , Taisa Shmushkovich
发明人： David Wallach , Parameswaran Ramakrishnan , Taisa Shmushkovich
IPC分类号： A61K39/395 , A61K31/7088 , A61K38/02 , C07K16/00 , C07K14/00
CPC分类号： C07K16/18 , C07K14/47 , C12N9/1205 , G01N2500/02
摘要： A method of treating a disease associated with NF-κB activity. The method is effected by providing to a subject in need thereof a therapeutically effective amount of an agent capable of modulating NIK-HC8 binding.
摘要翻译：治疗与NF-κB活性相关的疾病的方法。该方法通过向有需要的受试者提供治疗有效量的能够调节NIK-HC8结合的试剂来实现。

12. 发明授权

US07485456B1 Modulators of TNF receptor associated factor (TRAF), their preparation and use 失效
标题翻译： TNF受体相关因子（TRAF）的调节剂，其制备和用途
公开(公告)号：US07485456B1
公开(公告)日：2009-02-03
申请号：US09155676
申请日：1997-04-01
申请人： David Wallach , Nikolai Malinin , Mark Boldin , Andrei Kovalenko , Igor Mett
发明人： David Wallach , Nikolai Malinin , Mark Boldin , Andrei Kovalenko , Igor Mett
IPC分类号： C07K1/00 , C12Q1/68 , C12P21/06 , C12N15/00 , A61K39/395 , C07H21/00 , C07H21/02
CPC分类号： C12N9/1205 , A61K38/00 , A61K48/00 , C07K14/4702 , C07K2319/00 , C12N2799/021
摘要： A DNA sequence encoding a protein capable of binding to a tumor necrosis factor receptor-associated factor (TRAF) molecule, TRAF-binding proteins, their isoforms, analogs, fragments and derivatives encoded by the DNA sequence, their methods for the production of the DNA sequences and proteins, and the uses for the DNA sequence and proteins.
摘要翻译：编码能够结合肿瘤坏死因子受体相关因子（TRAF）分子的蛋白质的DNA序列，由所述DNA序列编码的TRAF结合蛋白，其同工型，类似物，片段和衍生物，其生产DNA的方法序列和蛋白质，以及DNA序列和蛋白质的用途。

13. 发明授权

US07416730B2 Derivatives of the IL-2 receptor gamma chain, their production and use 有权
标题翻译： IL-2受体γ链的衍生物，其生产和使用
公开(公告)号：US07416730B2
公开(公告)日：2008-08-26
申请号：US10511722
申请日：2003-04-15
申请人： David Wallach , Parameswaran Ramakrishnan , Taisia Shmushkovich
发明人： David Wallach , Parameswaran Ramakrishnan , Taisia Shmushkovich
IPC分类号： C07K14/00
CPC分类号： C12N9/1205 , A61K38/00 , C07K14/7155 , C12N2799/022
摘要： This invention relates to the use of the IL-2 common gamma chain (cγc) and related molecules for the modulation of signal activities controlled by NIK, and some new such molecules.
摘要翻译：本发明涉及IL-2常见γ链（cgammac）和相关分子用于调节由NIK控制的信号活性的用途，以及一些新的这样的分子。

14. 发明授权

US07354736B2 Caspase-8 binding protein, its preparation and use 失效
标题翻译：胱天蛋白酶-8结合蛋白，其制备及应用
公开(公告)号：US07354736B2
公开(公告)日：2008-04-08
申请号：US10488614
申请日：2002-09-04
申请人： David Wallach , Tania Goncharov , Ganesh Kolumam , Akhil Rajput
发明人： David Wallach , Tania Goncharov , Ganesh Kolumam , Akhil Rajput
IPC分类号： C12P21/06 , C12N15/00 , C12N5/00 , C07H21/04 , C07K14/00
CPC分类号： C07K14/47 , A01K2217/05
摘要： The present invention relates to a caspase-8 interacting polypeptide (Cari), methods for its preparation, and its use.
摘要翻译：本发明涉及半胱天冬酶-8相互作用多肽（Cari），其制备方法及其应用。

15. 发明授权

US07101675B2 Modulators of regulatory proteins 失效
标题翻译：调节蛋白的调节剂
公开(公告)号：US07101675B2
公开(公告)日：2006-09-05
申请号：US10035408
申请日：2002-01-04
申请人： David Wallach , Mark P Boldin , Eugene E Varfolomeev , Zeev Pancer , Igor Mett , Tanya M Goncharov
发明人： David Wallach , Mark P Boldin , Eugene E Varfolomeev , Zeev Pancer , Igor Mett , Tanya M Goncharov
IPC分类号： G01N33/53 , C12N9/64 , C12P21/06 , C12Q1/68
CPC分类号： C07K14/70578 , A61K38/00 , C07K14/4747 , C07K14/705 , C07K14/7151 , C07K14/7155 , C07K16/18 , C07K16/2878
摘要： A modulator of regulatory cellular events occurring intracellularly which are mediated by regulatory proteins containing a ‘death domain’ motif is provided. The ‘death domain’ is a regulatory portion of the regulatory proteins, and the modulator is capable of interacting with one or more ‘death domain’ motifs contained in the regulatory proteins and affecting the regulatory action of one or more of the regulatory proteins. The modulator preferably is capable of interacting with ‘death domain’ motifs within p55-TNF-R, FAS/APO1-R, NGF-R, MORT-1, RIP, TRADD, or ankyrin. A method for producing the modulators is also provided. The modulators are useful for modulating functions mediated in cells by proteins containing the ‘death domain’.
摘要翻译：提供了由细胞内发生的调节性细胞事件的调节剂，其由含有“死亡域”基序的调节蛋白介导。 “死亡域”是调节蛋白的调节部分，并且调节剂能够与调节蛋白中包含的一个或多个“死亡域”基序相互作用并影响一种或多种调节蛋白的调节作用。调节剂优选能够与p55-TNF-R，FAS / APO1-R，NGF-R，MORT-1，RIP，TRADD或锚蛋白内的'死亡域'基序相互作用。还提供了一种制备调制剂的方法。调节剂可用于通过含有“死亡域”的蛋白调节细胞介导的功能。

16. 发明申请

US20050214886A1 TNF modulation 审中-公开
标题翻译： TNF调节
公开(公告)号：US20050214886A1
公开(公告)日：2005-09-29
申请号：US10968191
申请日：2004-10-20
申请人： David Wallach , Eva Pocsik , Erno Duda
发明人： David Wallach , Eva Pocsik , Erno Duda
IPC分类号： A61K38/00 , C07K14/47 , C12N15/12 , C12Q1/48
CPC分类号： C07K14/4702 , A61K38/00 , C07K2319/00
摘要： Modulators such as proteins, peptides, antibodies or analogs, fragments or derivatives of any of them are provided which are capable of interacting with, or binding to, the intracellular domain of the membrane-bound form of TNF (26 KD TNF). These modulators are capable of regulating the expression, proteolytic processing, bioactivity or intracellular signaling of the 26 KD TNF and may thus be used for the treatment of diseases in which TNF plays a central role.
摘要翻译：提供了能够与膜结合形式的TNF（26KD TNF）的细胞内结构域相互作用或结合的调节剂，例如蛋白质，肽，抗体或类似物，其任何的片段或衍生物。这些调节剂能够调节26KD TNF的表达，蛋白水解加工，生物活性或细胞内信号传导，因此可用于治疗TNF起主要作用的疾病。

17. 发明授权

US06275890B1 Low latency data path in a cross-bar switch providing dynamically prioritized bus arbitration 失效
标题翻译：交叉条交换机中的低延迟数据路径提供动态优先的总线仲裁
公开(公告)号：US06275890B1
公开(公告)日：2001-08-14
申请号：US09136595
申请日：1998-08-19
申请人： William Robert Lee , David Wallach
发明人： William Robert Lee , David Wallach
IPC分类号： G06F1300
CPC分类号： G06F13/36
摘要： The present invention provides a cross-bar switch which includes a plurality of master bus ports, the master bus ports adapted to receive a plurality of master buses; a plurality of slave bus ports, the slave bus ports adapted to receive a plurality of slave buses; a manner of switching for selectively coupling the plurality of master bus ports to the plurality of slave bus ports; and a manner of configuration for prioritizing access requests by the plurality of master buses to the plurality of slave buses via the switching means. The cross-bar switch of the present invention has the capability of prioritizing requests between multiple parallel high speed buses. In a preferred embodiment, this arbitration is accomplished through Configuration Registers on the cross-bar switch. The Configuration Registers are programmable through the Device Control Register bus, which allows the cross-bar switch to be dynamically programmed and changed by a processor in a larger system. The cross-bar switch of the present invention minimizes the latency between data transfers. This improves the bandwidth and throughput on the on-chip bus.
摘要翻译：本发明提供一种交叉开关，其包括多个主总线端口，主总线端口适于接收多个主总线; 多个从属总线端口，所述从属总线端口适于接收多个从属总线; 用于选择性地将多个主总线端口耦合到多个从属总线端口的切换方式; 以及用于经由切换装置将多个主总线的访问请求优先于多个从总线的配置方式。本发明的交叉开关具有在多个并行高速总线之间优先化请求的能力。在优选实施例中，该仲裁通过交叉开关上的配置寄存器来实现。配置寄存器可通过器件控制寄存器总线进行编程，允许跨系统开关由较大系统中的处理器进行动态编程和更改。本发明的交叉开关将数据传输之间的延迟最小化。这样可以提高片上总线的带宽和吞吐量。

18. 发明授权

US06262239B1 TNF receptor-specific antibodies 失效
公开(公告)号：US06262239B1
公开(公告)日：2001-07-17
申请号：US08476862
申请日：1995-06-07
申请人： David Wallach , Jacek Bigda , Igor Beletsky , Igor Mett , Hartmut Engelmann
发明人： David Wallach , Jacek Bigda , Igor Beletsky , Igor Mett , Hartmut Engelmann
IPC分类号： C07K1628
CPC分类号： C07K16/2866 , A61K38/00 , C07K14/7151 , C07K16/4258 , C07K2319/00
摘要： Antibodies to Tumor Necrosis Factor receptors (TNF-Rs) which inhibit the cytocidal effect of TNF but not its binding to the TNF-Rs, and ligands interacting with other receptors of the TNF/NGF family, are provided together with methods of producing them. The antibodies preferably bind to the fourth cysteine rich domain of the p75 TNF receptor or to the region between said fourth cysteine rich domain and the cell membrane.

19. 发明授权

US5695953A DNA that encodes a tumor necrosis factor inhibitory protein and a recombinant method of production 失效
标题翻译：编码肿瘤坏死因子抑制蛋白的DNA和重组生产方法
公开(公告)号：US5695953A
公开(公告)日：1997-12-09
申请号：US876828
申请日：1992-04-30
申请人： David Wallach , Hartmut Engelmann , Dan Aderka , Menachem Rubinstein
发明人： David Wallach , Hartmut Engelmann , Dan Aderka , Menachem Rubinstein
IPC分类号： C12N15/09 , A61K38/00 , A61P9/00 , A61P37/06 , A61P37/08 , C07H21/04 , C07K1/16 , C07K1/20 , C07K14/00 , C07K14/47 , C07K14/52 , C07K14/525 , C07K14/715 , C07K16/00 , C07K16/18 , C07K16/24 , C07K16/28 , C07K19/00 , C12P21/00 , C12P21/08 , C12R1/19 , C12P21/06 , C07H21/00
CPC分类号： C07K14/7151 , C07K16/2866 , A61K38/00
摘要： Tumor Necrosis Factor (TNF) Inhibitory Protein is isolated and substantially purified and the DNA that encodes the TNF inhibitory protein, vectors, host cells, and a recombinant method for producing the encoded protein are also set forth. It has the ability to inhibit: (a) the binding of TNF to its receptors, and (b) the cytotoxic effect of TNF. TNF Inhibitory Protein and salts, functional derivatives and active fractions thereof can be used to antagonize the deleterious effects of TNF.
摘要翻译：分离并基本纯化肿瘤坏死因子（TNF）抑制蛋白，并且还阐述了编码TNF抑制蛋白的DNA，载体，宿主细胞和用于产生编码蛋白质的重组方法。它具有抑制：（a）TNF与其受体的结合，和（b）TNF的细胞毒性作用。 TNF抑制蛋白及其盐，功能衍生物及其活性成分可用于拮抗TNF的有害作用。

20. 发明授权

US5665859A Molecules influencing the shedding of the TNF receptor, their preparation and their use 失效
标题翻译：影响TNF受体脱落的分子，其制备及其用途
公开(公告)号：US5665859A
公开(公告)日：1997-09-09
申请号：US321668
申请日：1994-10-12
申请人： David Wallach , Cord Brakebusch , Eugene Varfolomeev , Michael Batkin
发明人： David Wallach , Cord Brakebusch , Eugene Varfolomeev , Michael Batkin
IPC分类号： C12N15/09 , A61K38/00 , A61K38/46 , A61K38/55 , A61K39/395 , A61P35/00 , A61P43/00 , C07H21/04 , C07K14/705 , C07K14/71 , C07K14/715 , C07K14/81 , C07K16/00 , C07K16/40 , C12N1/21 , C12N5/10 , C12N9/48 , C12N9/64 , C12N9/99 , C12N15/57 , C12P21/08 , C07K7/06
CPC分类号： C07K14/7151 , C07K14/71 , C12N9/6421 , A61K38/00 , C07K2319/00
摘要： Molecules which influence the shedding of the cell-bound p55 Tumor Necrosis Factor receptor (p55-TNF-R), are provided, together with methods of producing them.
摘要翻译：提供影响细胞结合的p55肿瘤坏死因子受体（p55-TNF-R）脱落的分子及其制备方法。

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