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11. 发明授权

US4264706A Dichromated hydrophilic colloid-latex copolymer compositions 失效
标题翻译：重铬酸化亲水胶体 - 胶乳共聚物组合物
公开(公告)号：US4264706A
公开(公告)日：1981-04-28
申请号：US129523
申请日：1980-03-12
申请人： Richard C. Sutton , Thomas W. Martin
发明人： Richard C. Sutton , Thomas W. Martin
IPC分类号： G03C1/66 , C08L33/00 , C08L33/24 , G02B5/22 , G03F7/00 , G03F7/038 , G03F7/04 , H01J29/20 , G03C5/00 , H01J1/52
CPC分类号： G03F7/04 , G03F7/0007 , Y10S430/163
摘要： The properties of a dichromated hydrophilic colloid photosensitive composition are improved by the incorporation of certain copolymer latices. More particularly, the copolymer particles in the latex conform to the structure:--A).sub. (B --.phi.-awherein A is a polymerized monomer or monomers having the structure: ##STR1## and B is a polymerized monomer or monomers having the structure: ##STR2## wherein each R.sup.1 is independently hydrogen or methyl;R.sup.2 is phenyl, substituted phenyl or a straight- or branched-chain alkoxycarbonyl group of about 2-8 carbon atoms;R.sup.3 is --NR.sup.4 R.sup.5 or --OR.sup.6 wherein R.sup.4 and R.sup.5 are independently selected from hydrogen, alkyl of about 1-8 carbon atoms including substituted alkyl, and alkyl containing hetero atoms in the alkyl chain, and R.sup.6 is hydroxyalkyl of about 1-8 carbon atoms; anda represents a weight percent of about 75-95.
摘要翻译：通过掺入某些共聚物胶乳改善了重铬酸酯亲水胶体感光组合物的性能。更具体地说，乳液中的共聚物颗粒符合以下结构：-A）（B-phi -a其中A是聚合单体或具有以下结构的单体：＆lt; IMAGE＆gt;和B是聚合单体或具有以下结构的单体：其中每个R 1独立地是氢或甲基; R 2是苯基，取代的苯基或约2-8个碳原子的直链或支链烷氧基羰基; R 3是-NR 4 R 5或-OR 6，其中R 4和R 5独立地选自氢原子，含有取代烷基的约1-8个碳原子的烷基和烷基链中含有杂原子的烷基，R 6是约1-8个碳原子的羟基烷基; a代表约75-95的重量百分比。

12. 发明授权

US4181526A Interpolymer protective overcoats for electrophotographic elements 失效
标题翻译：电子照相元件的共聚物保护性外涂层
公开(公告)号：US4181526A
公开(公告)日：1980-01-01
申请号：US916174
申请日：1978-06-16
申请人： Cathy L. Blakey , Richard C. Sutton
发明人： Cathy L. Blakey , Richard C. Sutton
IPC分类号： G03G5/147 , G03G5/14
CPC分类号： G03G5/14734 , Y10S526/934
摘要： Overcoats for electrophotographic elements are provided. The overcoats comprise a polymer having recurring units of the structure: ##STR1## in which R represents phenyl, tolyl, xylyl, or a ##STR2## group; R.sub.1, R.sub.5 and R.sub.6, which may be the same or different represent hydrogen or methyl;R.sub.2 represents alkyl or aryl;R.sub.3 represents carboxyl, alkyl ester, aryl ester, alkylamide or arylamide group having at least one carboxyl or hydroxyl or carboxylic anhydride substituent;R.sub.4 represents a group containing an active methylene group;a is about 29 to about 96 weight percent of said polymer;b is about 2 to about 25 weight percent of said polymer; andc is about 2 to about 46 weight percent of said polymer.
摘要翻译：提供电子照相元件的大衣。外涂层包含具有以下结构的重复单元的聚合物：其中R表示苯基，甲苯基，二甲苯基或者IMAGE基团; R1，R5和R6可以相同或不同，表示氢或甲基; R2代表烷基或芳基; R3表示具有至少一个羧基或羟基或羧酸酐取代基的羧基，烷基酯，芳基酯，烷基酰胺或芳基酰胺基团; R4表示含有活性亚甲基的基团; a为约29至约96重量％的所述聚合物; b是约2至约25重量％的所述聚合物; 和c为约2至约46重量％的所述聚合物。

13. 发明授权

US4176008A Method, composition and element for the detection of nitrogen-containing compounds 失效
标题翻译：用于检测含氮化合物的方法，组成和元素
公开(公告)号：US4176008A
公开(公告)日：1979-11-27
申请号：US880828
申请日：1978-02-24
申请人： John Figueras , Roger W. Nelson , Richard C. Sutton
发明人： John Figueras , Roger W. Nelson , Richard C. Sutton
IPC分类号： C12Q1/58 , G01N33/16
CPC分类号： C12Q1/58
摘要： Methods, compositions and elements for detecting a nitrogen-containing compound capable of releasing ammonia upon enzymatic action are described. The method comprises contacting in an aqueous medium a sample suspected of containing such a compound and a novel assay composition comprising at least one enzyme which catalyzes the decomposition of the compound to ammonia and detecting the ammonia by condensation with a diketone and measuring the color or fluorescence produced by the resulting dihydropyridine.The foregoing assay composition can be incorporated into single-layer or multilayer analytical elements of the type known in the prior art. A preferred such element comprises an isotropically porous spreading layer in fluid contact with a reagent layer. The spreading layer is most preferably non-fibrous.
摘要翻译：描述了用于检测酶促作用时能够释放氨的含氮化合物的方法，组合物和元件。该方法包括在水性介质中接触怀疑含有这种化合物的样品和新的测定组合物，其包含至少一种催化化合物分解成氨的酶，并通过与二酮缩合并测量颜色或荧光检测氨由所得二氢吡啶生成。上述测定组合物可以结合到现有技术中已知的类型的单层或多层分析元件中。优选的这种元件包括与试剂层流体接触的各向同性的多孔扩散层。铺展层最优选非纤维状。

14. 发明授权

US06432296B1 Polymeric compositions for ion-selective electrodes 有权
标题翻译：用于离子选择性电极的聚合物组合物
公开(公告)号：US06432296B1
公开(公告)日：2002-08-13
申请号：US09651048
申请日：2000-08-30
申请人： Daniel S. Daniel , Richard L. Detwiler , Andrew M. Kirsch , James E. Love, Jr. , Richard C. Sutton
发明人： Daniel S. Daniel , Richard L. Detwiler , Andrew M. Kirsch , James E. Love, Jr. , Richard C. Sutton
IPC分类号： G01N2731
CPC分类号： G01N27/4035 , G01N27/3335
摘要： Improved dry-operative ion-selective electrodes and their use are described. The dry-operative ion-selective electrodes include an internal reference electrode comprising a water-soluble salt dispersed in a polymer binder consisting essentially of a monomer having at least one carboxyl group and a hydrophobic monomer. The polymer provides reduced brittleness, good interlayer adhesion and high salt tolerance.
摘要翻译：描述了改进的干式离子选择性电极及其用途。干手术离子选择性电极包括内部参比电极，其包含分散在基本上由具有至少一个羧基的单体和疏水性单体组成的聚合物粘合剂中的水溶性盐。该聚合物具有降低的脆性，良好的层间粘附性和高耐盐性。

15. 发明授权

US5401633A Biologically active reagent prepared from aldehyde-containing polymer, test kit, analytical element and methods of use 失效
标题翻译：由含醛聚合物，试剂盒，分析元素和使用方法制备的生物活性试剂
公开(公告)号：US5401633A
公开(公告)日：1995-03-28
申请号：US955167
申请日：1992-10-01
申请人： Richard C. Sutton , Ignazio S. Ponticello , Susan J. Danielson
发明人： Richard C. Sutton , Ignazio S. Ponticello , Susan J. Danielson
IPC分类号： G01N33/50 , C12Q1/68 , G01N33/543 , G01N33/545 , G01N33/68 , G01N33/546
CPC分类号： C12Q1/6834 , G01N33/54313 , G01N33/54386 , G01N33/545
摘要： A biologically active reagent is prepared by reacting a biologically active substance covalently to a polymeric particle having pendant aldehyde groups. Such groups are provided by a polymerizable monomer represented by the structure: ##STR1## wherein Ar is arylene, R and R.sup.1 are independently hydrogen, halo or lower alkyl, R.sup.2 and R.sup.3 are independently alkylene of 1 to 4 carbon atoms in the chain, R.sup.4 is arylene, m is 0 or 1, and n is an integer of 1 to 4. These reagents can be used in a variety of specific binding and affinity purification methods, and in both solution assays and dry analytical elements.
摘要翻译：通过将生物活性物质共价反应到具有侧基醛基的聚合物颗粒来制备生物活性试剂。这样的基团由以下结构表示的可聚合单体提供：其中Ar是亚芳基，R和R 1独立地是氢，卤素或低级烷基，R 2和R 3独立地是链中具有1至4个碳原子的亚烷基，R 4 是亚芳基，m是0或1，n是1至4的整数。这些试剂可以用于各种特异性结合和亲和纯化方法，以及在溶液测定和干燥分析元件中。

16. 发明授权

US5397695A Attachment of compounds to polymeric particles using carbamoylonium compounds and a kit containing same 失效
标题翻译：使用氨基甲酸铵化合物将化合物与聚合物颗粒附着，以及含有它们的试剂盒
公开(公告)号：US5397695A
公开(公告)日：1995-03-14
申请号：US373304
申请日：1989-06-29
申请人： Richard C. Sutton , Susan J. Danielson , Pranab Bagchi , Patricia M. Scensny
发明人： Richard C. Sutton , Susan J. Danielson , Pranab Bagchi , Patricia M. Scensny
IPC分类号： B01D61/18 , B01D67/00 , B01D69/12 , G01N33/53 , G01N33/543 , C12Q1/70 , C12N11/08 , C07K3/00
CPC分类号： B01D67/0088 , B01D61/18 , B01D69/12 , G01N33/5302 , G01N33/54366 , Y10S435/81 , Y10S435/975
摘要： Useful materials for diagnostic tests, affinity chromatography, enzymatic reactions and immunoassays are prepared by covalently attaching reactive compounds containing reactive amino or sulfhydryl groups to polymeric particles having pendant carboxyl groups on the outer surfaces. Such reactive compounds include biologically reactive species, such as enzymes, polypeptides and proteins. This attachment is carried out using carbamoylonium compounds which react with the carboxyl groups to form intermediate reactive groups which then react with the amino or sulfhydryl groups to form a covalent linkage between particle and reactive compound. A kit comprises polymeric particles having carboxyl groups on the outer surfaces, and a carbamoylonium compound.
摘要翻译：用于诊断测试，亲和层析，酶促反应和免疫测定的有用材料通过将包含反应性氨基或巯基的反应性化合物共价连接到在外表面上具有侧基羧基的聚合物颗粒来制备。这种反应性化合物包括生物反应性物质，例如酶，多肽和蛋白质。该连接使用与羧基反应形成中间反应基团的氨基甲酰胺化合物进行，然后与氨基或巯基反应形成颗粒和反应性化合物之间的共价连接。试剂盒包括在外表面上具有羧基的聚合物颗粒和氨基甲酰胺化合物。

17. 发明授权

US5330891A Method for detection of a nucleic acid using particulate reagent having polyoxyalkylene side chains 失效
标题翻译：使用具有聚氧化烯侧链的颗粒试剂检测核酸的方法
公开(公告)号：US5330891A
公开(公告)日：1994-07-19
申请号：US968936
申请日：1992-10-30
申请人： Richard C. Sutton , Marsha B. Oenick
发明人： Richard C. Sutton , Marsha B. Oenick
IPC分类号： C07K17/02 , C12Q1/68 , G01N31/22 , G01N33/48 , G01N33/543 , G01N33/545 , C12Q1/70 , C08F12/16 , C08L33/00 , G01N21/00
CPC分类号： G01N33/54313 , C07K17/02 , C12Q1/6834 , Y10S435/962 , Y10S435/969 , Y10S435/97 , Y10S435/974 , Y10S435/975
摘要： Biologically active reagents are prepared from particles of copolymers having polyoxyalkylene side chains, each of which side chains has a molecular weight of at least about 88. The reagents are prepared by covalently attaching biologically active substances, for example antibodies, to the particles, directly or indirectly through reactive groups on the particle surface. These reagents are used to advantage in analytical elements and methods for the detection of specific binding ligands (such as immunological species) and immunoassays, and in purification methods as affinity chromatography reagents. Adsorption of undesirable proteins on the particles of the reagents was considerably reduced because of the specific composition of the particles.
摘要翻译：生物活性试剂由具有聚氧化烯侧链的共聚物颗粒制备，每个侧链具有至少约88的分子量。试剂通过将生物活性物质，例如抗体直接或间接地附着到颗粒上而制备，间接地通过颗粒表面上的反应性基团。这些试剂用于检测特异性结合配体（如免疫物质）和免疫测定的分析元件和方法，以及作为亲和层析试剂的纯化方法。由于颗粒的特定组成，吸附不需要的蛋白质在试剂颗粒上显着降低。

18. 发明授权

US5200315A Particulate biologically active reagent containing polyoxyalkylene side chains, analytical element and methods for use of the reagent 失效
标题翻译：含有聚氧亚基链的生物活性试剂，分析元素和使用试剂的方法
公开(公告)号：US5200315A
公开(公告)日：1993-04-06
申请号：US558272
申请日：1990-07-25
申请人： Richard C. Sutton , Marsha B. Oenick
发明人： Richard C. Sutton , Marsha B. Oenick
IPC分类号： C07K17/02 , C12Q1/68 , G01N31/22 , G01N33/48 , G01N33/543 , G01N33/545
CPC分类号： G01N33/54313 , C07K17/02 , C12Q1/6834 , Y10S435/962 , Y10S435/969 , Y10S435/97 , Y10S435/974 , Y10S435/975
摘要： Biologically active reactive are prepared from particles of copolymers having polyoxyalkylene side chains, each of which side chains has a molecular weight of at least about 88. The reagents are prepared by covalently attaching biologically active substances, for example antibodies, to the particles, directly or indirectly through reactive groups on the particle surface. These reagents are used to advantage in analytical elements and methods for the detection of specific binding ligands (such as immunological species) and immunoassays, and in purification methods as affinity chromatography reagents. Adsorption of undesirable proteins on the particles of the reagents was considerably reduced because of the specific composition of the particles.

19. 发明授权

US4997772A Water-insoluble particle and immunoreactive reagent, analytical elements and methods of use 失效
标题翻译：水不溶性颗粒和免疫反应试剂，分析元素和使用方法
公开(公告)号：US4997772A
公开(公告)日：1991-03-05
申请号：US098583
申请日：1987-09-18
申请人： Richard C. Sutton , Susan B. Littlehale , Susan J. Danielson
发明人： Richard C. Sutton , Susan B. Littlehale , Susan J. Danielson
IPC分类号： C08J3/215 , G01N33/543 , G01N33/569 , G01N33/58
CPC分类号： G01N33/54386 , C08J3/215 , G01N33/54313 , G01N33/56911 , G01N33/585 , Y10S525/902
摘要： A water-insoluble polymeric particle has an inner core comprising a detectable tracer material distributed in a first polymer for which the tracer material has a high affinity. This first polymer has a glass transition temperature (Tg.sub.1) less than about 100.degree. C. The particle also has an outer shell comprising a second polymer for which the tracer material has substantially less affinity relative to said first polymer. This second polymer has a glass transition temperature (Tg.sub.2) which is greater than or equal to the term [Tg.sub.1 -10.degree. C.]. It also contains groups which are either reactive with free amino or sulfhydryl groups of an immunoreactive species or which can be activated for reaction with such groups. Such a species can be covalently attached to this particle to form an immunoreactive reagent which is useful in analytical elements and various analytical methods including immunological methods, for example, agglutination assays.
摘要翻译：水不溶性聚合物颗粒具有包含分布在第一聚合物中的可检测示踪剂材料的内核，其中示踪材料具有高亲和力。该第一聚合物具有小于约100℃的玻璃化转变温度（Tg1）。该颗粒还具有包含第二聚合物的外壳，其中示踪材料相对于所述第一聚合物具有显着更小的亲和力。该第二聚合物的玻璃化转变温度（Tg2）大于或等于术语[Tg1-10℃]。它还含有与免疫反应物质的游离氨基或巯基反应的基团，或者可以与这些基团反应而被活化。这种物质可以共价连接到该颗粒上以形成免疫反应性试剂，其可用于分析元件和各种分析方法，包括免疫学方法，例如凝集测定法。

20. 发明授权

US4482108A Tilt wing short takeoff aircraft and method 失效
标题翻译：倾斜翼短起飞飞机和方法
公开(公告)号：US4482108A
公开(公告)日：1984-11-13
申请号：US451654
申请日：1982-09-29
申请人： Richard C. Sutton
发明人： Richard C. Sutton
IPC分类号： B64C29/00 , B64C15/12 , B64C3/38 , B64C15/14
CPC分类号： B64C29/0083
摘要： A short takeoff and landing aircraft (10) and vertical/short takeoff and landing aircraft (10), having upper surface blowing engines (12, 14) on gull-shaped wings (24, 26) which may be tilted and translated by a variable incidence translation device (52). The translation means (80, 62, 64) is adapted to provide center of gravity travel trim and critical engine out moment trim. Thrust vectoring of the upper surface blowing engines is accomplished by a combination of the upper surface blowing and wing tilt, and vectoring of lower lift/boost engines (124, 126) is accomplished by swiveling nozzles (138, 140). Critical engine out lateral trim is accomplished by a combination of airplane bank and differential vectoring by the lower lift/boost engines (124, 126).
摘要翻译： PCT No.PCT / US82 / 01357 Sec。 371日期：1982年9月29日 102（e）1982年9月29日PCT PCT卷号1982年9月29日PCT公布。公开号WO84 / 01341 1984年4月12日，一架短起飞和着陆飞机（10）和垂直/短型起飞飞机（10），在海鸥形翼（24,26）上具有上表面喷气发动机（12,14）由可变入射平移装置（52）倾斜和平移。平移装置（80,62,64）适于提供重心行程修整和关键发动机出力修剪。上表面吹塑发动机的推力矢量通过上表面吹风和机翼倾斜的组合来实现，并且下升力/升压发动机（124,126）的向量化是通过旋转喷嘴（138,140）实现的。关键发动机外侧装饰通过飞机组和下部升力/升压发动机（124,126）的差分矢量的组合来实现。

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