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    • 11. 发明申请
    • Neoadjuvant genetic compositions and methods
    • 新辅助遗传成分和方法
    • US20060120995A1
    • 2006-06-08
    • US11002839
    • 2004-12-02
    • Maulik Shah
    • Maulik Shah
    • A61K48/00A61K38/19A61K38/17
    • A61K38/193A61K38/1709A61K38/2013A61K38/208A61K39/0011A61K39/39A61K2039/53A61K2039/545A61K2039/55516C12N2710/10343A61K2300/00
    • The present invention relates to a method and composition for the use of a neoadjuvant to be used in with existing therapies to break host immune tolerance to tumor cells or other types of diseased cells. More precisely the present invention is directed to a vaccine which delivers a polypeptide adjuvant such as HSP72, or a cytokine molecule such as GMCSF, which is encoded in a polynucleotide that will be expressed at high levels within tumor cells and may also bind to tumor cell antigens. The vaccine may be administered alone, or in conjunction with a known tumor antigen or vaccine. After a period of time sufficient for expression of the polynucleotide and for the binding of adjuvant to cancer antigens, the cancer will be treated with conventional therapies, allowing the adjuvant/antigen complex to be released to the interstitial fluids where they will be accessible to antigen presenting cells of the host immune system. The presentation of the cancer antigen complexed with adjuvant as well as cytokine stimulation of the host immune system will cause the host to mount a heightened immune response against all remaining cancer cells or tumors which share these antigens.
    • 本发明涉及用于新辅助化合物的方法和组合物,其用于与现有疗法相结合以破坏对肿瘤细胞或其它类型的患病细胞的宿主免疫耐受性。 更精确地,本发明涉及递送多肽佐剂例如HSP72或细胞因子分子如GMCSF的疫苗,其编码在将在肿瘤细胞内以高水平表达并且还可以结合肿瘤细胞的多核苷酸 抗原。 疫苗可以单独施用,也可以与已知的肿瘤抗原或疫苗结合使用。 经过足以表达多核苷酸和用于将癌症抗原结合的足够时间,癌症将用常规疗法治疗,允许佐剂/抗原复合物释放到间质液体中,在那里它们将被抗原接触 呈递宿主免疫系统的细胞。 与佐剂复合的癌症抗原的呈递以及宿主免疫系统的细胞因子刺激将导致宿主对所有剩余的癌细胞或共享这些抗原的肿瘤产生更高的免疫应答。
    • 12. 发明授权
    • Intelligent specification of forward-link rate-control
    • 前向链路速率控制的智能规范
    • US08576737B1
    • 2013-11-05
    • US13010093
    • 2011-01-20
    • Manoj ShettySachin R. VargantwarMaulik Shah
    • Manoj ShettySachin R. VargantwarMaulik Shah
    • G06F11/00
    • H04L1/0002
    • A method and system is disclosed for dynamic adjustment of forward-link rate-control parameters. An access terminal in a wireless communication system that includes a base station will determine a requested forward-link data rate by measuring a signal-to-noise ratio (SNR) of the forward link, and looking up a corresponding forward-link data rate in one of three different tabulations of SNR threshold values against forward-link data rates. The AT will operate in a first state in which the access terminal uses a single tabulation for both increasing and decreasing measurements of SNR, and upon receiving a message from the base station indicating high time slot utilization on the forward link, the AT will transition to operating in a second state in which the access terminal uses a dual tabulation, wherein one of the dual tabulations is used for increasing measurement of SNR, and the other is used for decreasing measures of SNR.
    • 公开了用于前向链路速率控制参数的动态调整的方法和系统。 包括基站的无线通信系统中的接入终端将通过测量前向链路的信噪比(SNR)并查找相应的前向链路数据速率来确定所请求的前向链路数据速率 SNR阈值与前向链路数据速率的三个不同格式之一。 AT将处于第一状态,其中接入终端使用单个表格来增加和减少SNR的测量,并且在从基站接收到指示前向链路上的高时隙利用的消息时,AT将转换到 在接入终端使用双列表的第二状态下操作,其中双列表中的一个用于增加SNR的测量,另一个用于减小SNR的测量。
    • 16. 发明授权
    • Mobile-station-initiated removal of a high-congestion sector from the active set
    • 移动台从活动集中移除高拥塞扇区
    • US08363622B1
    • 2013-01-29
    • US12756041
    • 2010-04-07
    • Siddharth OroskarSrikanth PulugurtaMaulik Shah
    • Siddharth OroskarSrikanth PulugurtaMaulik Shah
    • H04W4/00G08C17/00H04W36/00
    • H04W36/18
    • Exemplary methods and systems may be used by a mobile station to request that a sector be removed from its active set, and by a radio access network (RAN) to facilitate such a request. An exemplary method involves (a) a mobile station receiving a congestion indicator in each active sector of an active set of the mobile station, wherein the congestion indicators are received from a RAN; (b) the mobile station using the received congestion indicators as a basis for selecting at least one high-congestion sector from the active set; and (c) the mobile station providing an indication of the at least one high-congestion sector to the RAN. Further, the mobile station may perform steps (b)-(c) in response to a determination that the battery power for the mobile station is below the threshold level.
    • 移动台可以使用示例性方法和系统来请求从其活动集中以及由无线电接入网络(RAN)去除扇区以促进这种请求。 一种示例性方法包括:(a)移动站在移动站的活动集合的每个活动扇区中接收拥塞指示符,其中从RAN接收拥塞指示符; (b)使用所接收的拥塞指示符作为从所述活动集中选择至少一个高拥塞扇区的基础的移动站; 以及(c)所述移动站向所述RAN提供所述至少一个高拥塞扇区的指示。 此外,移动台可以响应于移动台的电池电力低于阈值水平的确定而执行步骤(b) - (c)。