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11. 发明授权

US5469867A Cast-in place thermoplastic channel occluder 失效
标题翻译：嵌入式热塑性通道封堵器
公开(公告)号：US5469867A
公开(公告)日：1995-11-28
申请号：US939110
申请日：1992-09-02
申请人： Edward E. Schmitt
发明人： Edward E. Schmitt
IPC分类号： A61B17/12 , A61F2/36 , A61F2/46 , A61F6/02 , A61F6/06 , A61F6/20 , A61F6/22 , A61F9/007 , A61L31/00 , A61L31/04 , A61L31/18 , A61B19/00
CPC分类号： A61B17/8802 , A61B17/12022 , A61B17/12099 , A61B17/12186 , A61F2/3607 , A61F6/20 , A61F6/22 , A61F9/007 , A61F9/00772 , A61L31/048 , A61L31/18 , A61B2017/1205 , A61F2/36 , A61F2002/4631
摘要： A method of blocking channels in a mammal which channels normally carry a material from one point to another is carried out by injecting a heated flowable polymer into the channel and allowing the polymer to cool and solidify, thus creating a plug or channel occluder. The plug can be later removed physically in its solid form or removed gradually by softening and/or fluidizing it by heating and/or chemical means. The channel occluder is preferably comprised of a main chain or side-chain crystallizable polymer but may be comprised of other polymers provided the polymers are formulated to have certain characteristics. The polymers must be solid and/or non-flowable at body temperature or lower and flowable when heated slightly above body temperature, i.e., 10 centigrade degrees or less above body temperature. The polymer is capable of changing quickly from a flowable state to a non-flowable state by moving through only a few centigrade degrees of temperature and is a non-immunogenic, biocompatible material. Typical channels which may be reversibly occluded via the present invention include the vas deferens, the mature sperm excretory channel of the testis; the fallopian tube or oviduct, the viaduct conveying the ovum from the ovary to the uterus; the canaliculus lacrimalis, the passageway that allows excess tears to flow from the puncta of the eye to the lacrimal sac; and the cavity of the femoral shaft to fix the stem of replacement hip joint (ball and neck).
摘要翻译：通过将加热的可流动聚合物注入通道并允许聚合物冷却和固化，从而产生塞子或通道封堵器来进行阻塞哺乳动物通道的方法，该通道通常将物质从一个点携带到另一个点。该塞子可以随后以其固体形式物理移除或通过软化和/或通过加热和/或化学方式使其流化而逐渐除去。通道阻塞剂优选由主链或侧链可结晶聚合物组成，但是可以由其它聚合物组成，只要聚合物配制成具有某些特性即可。聚合物在体温下必须是固体和/或不可流动的或较低的，并且在加热时稍微超过体温即在体温以上10摄氏度以下时可流动。聚合物能够通过仅通过几摄氏度的温度而从可流动状态快速变化到不可流动状态，并且是非免疫原性的生物相容性材料。通过本发明可以可逆地闭塞的典型通道包括输精管，睾丸的成熟精子排泄通道; 输卵管或输卵管，高架桥将卵子从卵巢输送到子宫; 泪小管，允许多余的眼泪从眼睛的泪点流到泪囊的通道; 和股骨轴的腔体，以固定替换髋关节（球和颈部）的杆。

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