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11. 发明申请

US20090069800A1 SURFACE ELECTRODE MULTIPLE MODE OPERATION 失效
标题翻译：表面电极多模式操作
公开(公告)号：US20090069800A1
公开(公告)日：2009-03-12
申请号：US12271738
申请日：2008-11-14
申请人： Amy C. Kelly , Steven K. Landreville , Robert J. Garabedian
发明人： Amy C. Kelly , Steven K. Landreville , Robert J. Garabedian
IPC分类号： A61B18/18 , A61B18/14
CPC分类号： A61B18/1477 , A61B2018/00023 , A61B2018/00029 , A61B2018/00083 , A61B2018/0016 , A61B2018/00196 , A61B2018/1425 , A61B2018/143 , A61B2018/1475
摘要： A surface electrode for ablating tissue is provided. The surface electrode comprises a base, a plurality of tissue penetrating needle electrodes extending from the surface of the base an adjustable distance, and an electrical interface coupled to the plurality of needle electrodes. The adjustability of the needle electrodes allows the depth that the needle electrodes penetrate through tissue to be adjusted.
摘要翻译：提供用于烧伤组织的表面电极。所述表面电极包括基底，从所述基底的表面延伸可调节距离的多个组织穿透针电极以及耦合到所述多个针电极的电接口。针电极的可调性允许针电极穿透组织的深度被调整。

12. 发明授权

US09757188B2 Tissue treatment system and method for tissue perfusion using feedback control 有权
公开(公告)号：US09757188B2
公开(公告)日：2017-09-12
申请号：US12037882
申请日：2008-02-26
申请人： Robert J. Garabedian , Amy C. Kelly , Steve K. Landreville
发明人： Robert J. Garabedian , Amy C. Kelly , Steve K. Landreville
IPC分类号： A61B18/14 , A61B18/00
CPC分类号： A61B18/0206 , A61B18/12 , A61B18/1477 , A61B18/148 , A61B2018/00005 , A61B2018/00035 , A61B2018/00071 , A61B2018/00577 , A61B2018/00595 , A61B2018/00702 , A61B2018/00875 , A61B2018/00916 , A61B2018/00934 , A61B2018/1425 , A61B2018/143 , A61B2018/1432 , A61B2018/1472 , A61B2018/1475 , A61B2218/002
摘要： A system, ablation probe, and method is provided for treating tissue, e.g., tissue having tumors. The treatment system is configured to automatically deliver infusaid to tissue when needed and comprises an ablation probe having an ablative element and at least one perfusion exit port. The system further comprises an ablation source operably coupled to the ablative element, and a pump assembly operably coupled to the perfusion exit pots). The pump assembly is configured for pumping infusaid out through the perfusion exit port(s), preferably during the ablation process. The system further comprises a feedback device configured for controlling the amount of infusaid displaced by the pump assembly based on a sensed tissue parameter, e.g., tissue temperature or tissue impedance.

13. 发明申请

US20080221562A1 TISSUE TREATMENT SYSTEM AND METHOD FOR TISSUE PERFUSION USING FEEDBACK CONTROL 有权
公开(公告)号：US20080221562A1
公开(公告)日：2008-09-11
申请号：US12037882
申请日：2008-02-26
申请人： Robert J. Garabedian , Amy C. Kelly , Steve K. Landreville
发明人： Robert J. Garabedian , Amy C. Kelly , Steve K. Landreville
IPC分类号： A61B18/14 , A61B18/12
CPC分类号： A61B18/0206 , A61B18/12 , A61B18/1477 , A61B18/148 , A61B2018/00005 , A61B2018/00035 , A61B2018/00071 , A61B2018/00577 , A61B2018/00595 , A61B2018/00702 , A61B2018/00875 , A61B2018/00916 , A61B2018/00934 , A61B2018/1425 , A61B2018/143 , A61B2018/1432 , A61B2018/1472 , A61B2018/1475 , A61B2218/002
摘要： A system, ablation probe, and method is provided for treating tissue, e.g., tissue having tumors. The treatment system is configured to automatically deliver infusaid to tissue when needed and comprises an ablation probe having an ablative element and at least one perfusion exit port. The system further comprises an ablation source operably coupled to the ablative element, and a pump assembly operably coupled to the perfusion exit port(s). The pump assembly is configured for pumping infusaid out through the perfusion exit port(s), preferably during the ablation process. The system further comprises a feedback device configured for controlling the amount of infusaid displaced by the pump assembly based on a sensed tissue parameter, e.g., tissue temperature or tissue impedance. For example, the feedback device can comprise a sensor configured for sensing the tissue parameter, and a perfusion controller configured for controlling the pump assembly based on the sensed tissue parameter. As another example, the feedback device can comprise a perfusion valve associated with the distal end of the shaft. In this case, the perfusion valve forms the perfusion exit port, wherein the perfusion valve changes the size of the perfusion exit port based on tissue temperature.An ablation probe is provided for treating tissue, e.g., tissue having a tumor. The ablation comprises an elongated shaft, an ablative element, a perfusion lumen that extends through the probe shaft, and a perfusion control valve associated with the distal end of the shaft. The perfusion control valve has a port, the size of which changes with temperature. In one embodiment, the perfusion control valve comprises a reed valve having at least one reed, e.g., a pair of opposing reeds, or even four reeds. The reeds are configured change shape in order to control the size of the port. For example, each reed can comprise a bimetallic flange or a nitinol flange that bends in the presence of a temperature change.Ablation probes and systems are provided for treating tissue, e.g., tissue having a tumor. The ablation comprises an elongated shaft, an ablative element, a perfusion lumen that extends through the probe shaft, and at least one perfusion exit port in fluid communication with the perfusion lumen. The perfusion lumen can be used to deliver an infusaid to the perfusion exit port(s) for perfusion of the surrounding tissue. The ablation probe further comprises a wicking material, e.g., cotton or fabric, disposed in the perfusion lumen. In this manner, the infusaid that travels through the perfusion lumen can be controlled without regard to the size of the perfusion exit port(s).An ablation probe is provided for treating tissue, e.g., tissue having a tumor. The ablation probe comprises an elongated shaft, an ablative element, a perfusion lumen that extends through the probe shaft, and at least one perfusion exit port in fluid communication with the perfusion lumen. The ablation probe further comprises a pump assembly carried by the proximal end of the shaft. The pump assembly is configured for pumping infusaid through the perfusion lumen and out the perfusion exit port(s). In one embodiment, the pump assembly comprises a reservoir for storing the infusaid, and a perfusion inlet port configured for transferring infusaid from an external source into the reservoir. The pump assembly can be variously configured. For example, the pump assembly may comprise a diaphragm adjacent the reservoir. In this case, the diaphragm has pumping stroke that displaces the infusaid from the reservoir into the perfusion lumen. As another example, the pump assembly comprises a diaphragm adjacent the reservoir, wherein the diaphragm is configured for expanding to pressurize the reservoir in response to the conveyance of infusaid into the reservoir. As still another example, the pump assembly comprises a plunger disposed in the reservoir and a spring configured to urge the plunger within the reservoir in one direction to pressurize the reservoir.

14. 发明授权

US07347859B2 Tissue treatment system and method for tissue perfusion using feedback control 有权
标题翻译：使用反馈控制的组织灌注组织治疗系统和方法
公开(公告)号：US07347859B2
公开(公告)日：2008-03-25
申请号：US10740692
申请日：2003-12-18
申请人： Robert J. Garabedian , Amy C. Kelly , Steve K. Landreville
发明人： Robert J. Garabedian , Amy C. Kelly , Steve K. Landreville
IPC分类号： A61B18/18
CPC分类号： A61B18/0206 , A61B18/12 , A61B18/1477 , A61B18/148 , A61B2018/00005 , A61B2018/00035 , A61B2018/00071 , A61B2018/00577 , A61B2018/00595 , A61B2018/00702 , A61B2018/00875 , A61B2018/00916 , A61B2018/00934 , A61B2018/1425 , A61B2018/143 , A61B2018/1432 , A61B2018/1472 , A61B2018/1475 , A61B2218/002
摘要： A system, ablation probe, and method is provided for treating tissue, e.g., tissue having tumors. The treatment system is configured to automatically deliver infusaid to tissue when needed and comprises an ablation probe having an ablative element and at least one perfusion exit port. The system further comprises an ablation source operably coupled to the ablative element, and a pump assembly operably coupled to the perfusion exit port(s). The pump assembly is configured for pumping infusaid out through the perfusion exit port(s), preferably during the ablation process. The system further comprises a feedback device configured for controlling the amount of infusaid displaced by the pump assembly based on a sensed tissue parameter, e.g., tissue temperature or tissue impedance.
摘要翻译：提供了一种用于治疗组织，例如具有肿瘤的组织的系统，消融探针和方法。治疗系统被配置为在需要时自动地输送到组织，并且包括具有消融元件和至少一个灌注出口的消融探针。该系统还包括可操作地联接到消融元件的消融源，以及可操作地连接到灌注出口的泵组件。泵组件被配置为优选在消融过程期间通过灌注出口端口进行泵送。该系统还包括反馈装置，该反馈装置被配置为基于感测到的组织参数（例如组织温度或组织阻抗）来控制由泵组件移位的内注量。

15. 发明授权

US07278993B2 Surface electrode multiple mode operation 失效
标题翻译：表面电极多模式操作
公开(公告)号：US07278993B2
公开(公告)日：2007-10-09
申请号：US11144848
申请日：2005-06-03
申请人： Amy C. Kelly , Steve K. Landreville , Robert J. Garabedian
发明人： Amy C. Kelly , Steve K. Landreville , Robert J. Garabedian
IPC分类号： A61B18/14
CPC分类号： A61B18/1477 , A61B2018/00023 , A61B2018/00029 , A61B2018/00083 , A61B2018/0016 , A61B2018/00196 , A61B2018/1425 , A61B2018/143 , A61B2018/1475
摘要： A surface electrode for ablating tissue is provided. The surface electrode comprises a base, a plurality of tissue penetrating needle electrodes extending from the surface of the base an adjustable distance, and an electrical interface coupled to the plurality of needle electrodes. The adjustability of the needle electrodes allows the depth that the needle electrodes penetrate through tissue to be adjusted.
摘要翻译：提供用于烧伤组织的表面电极。所述表面电极包括基底，从所述基底的表面延伸可调节距离的多个组织穿透针电极以及耦合到所述多个针电极的电接口。针电极的可调性允许针电极穿透组织的深度被调整。

16. 发明申请

US20110022044A1 RADIO FREQUENCY ABLATION COOLING SHIELD 失效
标题翻译：无线电频率冷却屏蔽
公开(公告)号：US20110022044A1
公开(公告)日：2011-01-27
申请号：US12849699
申请日：2010-08-03
申请人： Robert J. Garabedian , Robert F. Rioux
发明人： Robert J. Garabedian , Robert F. Rioux
IPC分类号： A61B18/14
CPC分类号： A61B18/1477 , A61B18/14 , A61B90/04 , A61B2018/00005 , A61B2018/00017 , A61B2018/00023 , A61B2018/00029 , A61B2018/00577 , A61B2090/0445 , A61B2090/0481
摘要： A medical assembly and method are provided to effectively treat abnormal tissue, such as, a tumor. The target tissue is thermally ablated using a suitable source, such as RF or laser energy. A cooling shield is placed in contact with non-target tissue adjacent the target tissue, and actively cooled to conduct thermal energy away from the non-target tissue. In one method, the cooling shield can be placed between two organs, in which case, one of the two organs can comprise the target tissue, and the other of the two organs can comprise the non-target tissue. In this case, the cooling shield may comprise an actively cooled inflatable balloon, which can be disposed between the two organs when deflated, and then inflated. The inflatable balloon can be actively cooled by pumping a cooling medium through it. In another method, the cooling shield can be embedded within the non-target tissue. In this case, the cooling shield can comprise one or more needles. If a plurality of needles is used, they can be embedded into the non-target tissue in a series, e.g., a rectilinear or curvilinear arrangement. The needle(s) can be actively cooled by pumping a cooling medium through them.
摘要翻译：提供医疗组件和方法来有效地治疗诸如肿瘤的异常组织。使用适当的来源（例如RF或激光能量）将靶组织热消融。将冷却屏蔽物放置成与目标组织相邻的非靶组织接触，并且主动冷却以将热能从非目标组织传导出去。在一种方法中，冷却屏蔽可以放置在两个器官之间，在这种情况下，两个器官中的一个可以包括靶组织，并且两个器官中的另一个可以包括非靶组织。在这种情况下，冷却屏蔽件可以包括主动冷却的可膨胀气囊，当气体放气时可以将气囊放置在两个器官之间，然后膨胀。可以通过泵送冷却介质来主动冷却可充气球囊。在另一种方法中，冷却屏蔽可以嵌入在非目标组织内。在这种情况下，冷却罩可以包括一个或多个针。如果使用多个针，则它们可以以一系列例如直线或曲线布置被嵌入到非目标组织中。可以通过将冷却介质泵送通过它们来主动冷却针。

17. 发明申请

US20100114084A1 PERCUTANEOUS PRINGLE OCCLUSION METHOD AND DEVICE 有权
标题翻译： PERCUTANEOUS PRESSLE OCCLUSION方法和设备
公开(公告)号：US20100114084A1
公开(公告)日：2010-05-06
申请号：US12685139
申请日：2010-01-11
申请人： David J. Sauvageau , Robert J. Garabedian , Robert F. Rioux
发明人： David J. Sauvageau , Robert J. Garabedian , Robert F. Rioux
IPC分类号： A61B18/04 , A61M29/00
CPC分类号： A61B17/12036 , A61B17/12022 , A61B17/12109 , A61B17/12136 , A61B17/1219 , A61B18/1477 , A61B18/1485 , A61B2017/00557 , A61B2017/22067 , A61B2018/00214 , A61B2018/00577
摘要： Methods and devices for occluding a vessel during a percutaneous ablation procedure. An elongated access device having a lumen and a tissue piercing, open distal end in communication with the lumen is used to percutaneously access a vessel that supplied blood to the tissue to be treated. An elongated balloon deployment device is used to deliver a balloon into the interior of the vessel. The balloon is inflated, resulting in the occlusion of the vessel. The tissue to be treated is ablated. Because there is little or no blood to transfer the thermal energy away from the heated tissue, the ablation procedure is performed more efficiently. The balloon may be subsequently deflated allowing normal flow through the vessel to return.
摘要翻译：在经皮消融手术期间闭塞血管的方法和装置。使用具有内腔和与内腔连通的组织刺穿的开放远端的细长的进入装置来经皮地进入供应待处理组织的血液的血管。使用细长的气囊展开装置将气囊输送到容器的内部。气球膨胀，导致血管闭塞。要治疗的组织被消融。因为很少或没有血液将热能转移到加热的组织之外，因此更有效地进行消融过程。气球可能随后放气，允许正常流过血管返回。

18. 发明授权

US07295875B2 Method of stimulating/sensing brain with combination of intravascularly and non-vascularly delivered leads 有权
标题翻译：通过血管内和非血管输送导联组合刺激/感觉脑的方法
公开(公告)号：US07295875B2
公开(公告)日：2007-11-13
申请号：US10783679
申请日：2004-02-20
申请人： Michael P. Wallace , Robert J. Garabedian
发明人： Michael P. Wallace , Robert J. Garabedian
IPC分类号： A61N1/36
CPC分类号： A61N1/36025 , A61N1/0529 , A61N1/0531 , A61N1/0534 , A61N1/36017 , A61N1/36064 , A61N1/36067 , A61N1/36082
摘要： A method of treating a neurological disorder in a patient is provided. The method comprises intravascularly delivering a first electrical lead within the head of the patient, and non-vascularly delivering a second electrical lead within the head the patient. The vascular and intravascular leads are placed adjacent brain tissue (e.g., cortical brain tissue or deep brain tissue). Optionally, the method comprises implanting a source of stimulation and/or recorder within the patient's body, and then electrically coupling the proximal ends of the electrical leads to the implanted device. Using the electrical leads, the brain tissue can then be stimulated and/or recorded in order to treat the neurological disorder.
摘要翻译：提供了治疗患者神经障碍的方法。该方法包括血管内传递患者头部内的第一电引线，并且在患者的头部内非血管输送第二电引线。血管和血管内引线被放置在脑组织（例如皮质脑组织或深部脑组织）附近。可选地，该方法包括在患者体内植入刺激源和/或记录器源，然后将电引线的近端电连接到植入装置。使用电引线，然后可以刺激和/或记录脑组织以治疗神经障碍。

19. 发明授权

US06171295B2 Intravascular catheter with composite reinforcement 有权
标题翻译：血管内导管与复合增强
公开(公告)号：US06171295B2
公开(公告)日：2001-01-09
申请号：US09234203
申请日：1999-01-20
申请人： Robert J. Garabedian , John Griego , Earl Bardsley , Dean A. Schaefer , Cang D. Dao , Steven M. Anderson
发明人： Robert J. Garabedian , John Griego , Earl Bardsley , Dean A. Schaefer , Cang D. Dao , Steven M. Anderson
IPC分类号： A61M2500
CPC分类号： A61M25/005 , A61M25/0053
摘要： An intravascular catheter that exhibits the combined features of superior flexibility, softness, radiopacity and oval/kink resistance. The catheter includes an elongate shaft having a proximal region, a distal region and a lumen extending therethrough. The proximal region of the shaft includes an inner lubricious polymer layer, a reinforcement layer and an outer layer. The reinforcement layer comprises a braid having one or more metallic members and a plurality of polymer members wherein each polymer member comprises a plurality of monofilaments, preferably formed of LCP. The polymer members of the braid provide improved flexibility and softness in addition to high burst pressure. The metallic member(s) of the braid provide improved radiopacity and oval/kink resistance. The catheter may also include a longitudinal member extending along the reinforcement layer.
摘要翻译：一种血管内导管，其具有优异的柔韧性，柔软性，不透射线性和椭圆形/扭结阻力的组合特征。导管包括细长轴，其具有近端区域，远侧区域和延伸穿过其中的内腔。轴的近侧区域包括内部光滑聚合物层，加强层和外层。加强层包括具有一个或多个金属构件和多个聚合物构件的编织物，其中每个聚合物构件包括多个单丝，优选由LCP形成。除了高爆裂压力之外，编织物的聚合物构件提供了改善的柔韧性和柔软性。编织物的金属构件提供了改善的射线不透性和椭圆形/扭结阻力。导管还可以包括沿加强层延伸的纵向构件。

20. 发明授权

US07937160B2 Methods for delivering cortical electrode leads into patient's head 有权
标题翻译：将皮质电极导入患者头部的方法
公开(公告)号：US07937160B2
公开(公告)日：2011-05-03
申请号：US11010232
申请日：2004-12-10
申请人： Robert J. Garabedian , Michael P. Wallace , Gary Heit
发明人： Robert J. Garabedian , Michael P. Wallace , Gary Heit
IPC分类号： A61N1/05
CPC分类号： A61N1/0531 , A61N1/0539 , A61N1/36082
摘要： Methods and kits for delivering an electrode lead into the head of a patient are provided. A burr hole is formed within the cranium of the patient, and an electrode lead is threaded through the burr hole. The electrode lead is then placed in a pre-shaped two-dimensional geometry between the cranium and cortical brain tissue of the patient. An access anchor may be mounted into the burr hole to facilitate introduction and removal of the electrode lead and other devices. In some circumstances, it may be desirable to separate the dura mater overlying the cortical brain tissue from the cortical brain tissue to create a pocket in which the electrode lead may be manipulated. In this case, a tissue layer dissection device can be introduced through the burr hole, operated to separate the dura mater from the cranium, and then removed from the burr hole. In one embodiment, the dissection device comprises a balloon that can be inflated to separate the dura mater and cranium, and then deflated prior to removing the dissection device from the burr hole.
摘要翻译：提供了用于将电极引线输送到患者头部的方法和套件。在患者的颅骨内形成有钻孔，电极引线穿过毛刺孔。然后将电极引线置于患者的颅骨和皮质脑组织之间的预先形状的二维几何形状中。可以将入口锚固件安装到钻孔中以便于引入和移除电极引线和其它装置。在某些情况下，可能需要将覆盖皮质脑组织的硬膜与皮层脑组织分离，以产生可以操纵电极引线的口袋。在这种情况下，可以通过毛刺孔引入组织层解剖装置，操作以将硬脑膜与头颅分开，然后从毛刺孔中取出。在一个实施例中，解剖装置包括可以充气以分离硬脑膜和颅骨的气囊，然后在从毛刺孔移除解剖装置之前放气。

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