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11. 发明授权

US07300945B2 Benzimidazole and pyridylimidazole derivatives 失效
标题翻译：苯并咪唑和吡啶基咪唑衍生物
公开(公告)号：US07300945B2
公开(公告)日：2007-11-27
申请号：US11179458
申请日：2005-07-12
申请人： Guiying Li , Pamela Albaugh , Kevin S. Currie , Guolin Cai , Linda M. Gustavson , Kyungae Lee , Alan Hutchison , George D. Maynard , Jun Yuan , Ling Hong Xie , Manuka Ghosh , Nian Liu , George P. Luke , Scott Mitchell , Martin Patrick Allen , Spiros Liras
发明人： Guiying Li , Pamela Albaugh , Kevin S. Currie , Guolin Cai , Linda M. Gustavson , Kyungae Lee , Alan Hutchison , George D. Maynard , Jun Yuan , Ling Hong Xie , Manuka Ghosh , Nian Liu , George P. Luke , Scott Mitchell , Martin Patrick Allen , Spiros Liras
IPC分类号： C07D471/04 , A61K31/437
CPC分类号： C07D401/04 , C07D233/20 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/06 , C07D413/14 , C07D417/04 , C07D417/06 , C07D417/14 , C07D471/04 , C07D473/00 , C07D491/08 , C07D491/10
摘要： This invention relates to benzimidazoles, pyridylimidazoles and related bicyclic heteroaryl compounds, all of which may be described by of Formula I The invention is particularly related to such compounds that bind with high selectivity and high affinity to the benzodiazepine site of GABAA receptors. This invention also relates to pharmaceutical compositions comprising such compounds and to the use of such compounds in treatment of certain central nervous system (CNS) diseases. Novel processes for preparing compounds of Formula I are disclosed.This invention also relates to the use of benzimidazoles, pyridylimidazoles and related bicyclic heteroaryl compounds of Formula I in combination with one or more other CNS agents to potentiate the effects of the other CNS agents. Additionally this invention relates to the use such compounds as probes for the localization of GABAA receptors in tissue sections.
摘要翻译：本发明涉及苯并咪唑，吡啶基咪唑和相关双环杂芳基化合物，所有这些可以由式I描述。本发明特别涉及以高选择性和高亲和力结合GABA A的苯并二氮杂部位的化合物， / SUB>受体。本发明还涉及包含这些化合物的药物组合物以及这些化合物在治疗某些中枢神经系统（CNS）疾病中的用途。公开了制备式I化合物的新方法。本发明还涉及式I的苯并咪唑，吡啶基咪唑和相关的双环杂芳基化合物与一种或多种其它CNS剂的组合用于增强其它CNS剂的作用。此外，本发明涉及使用这些化合物作为组织切片中GABA A A受体定位的探针。

12. 发明申请

US20060025425A1 Benzimidazole and pyridylimidazole derivatives 失效
标题翻译：苯并咪唑和吡啶基咪唑衍生物
公开(公告)号：US20060025425A1
公开(公告)日：2006-02-02
申请号：US11179458
申请日：2005-07-12
申请人： Guiying Li , Pamela Albaugh , Kevin Currie , Guolin Cai , Linda Gustavson , Kyungae Lee , Alan Hutchison , George Maynard , Jun Yuan , Ling Xie , Manuka Ghosh , Nian Liu , George Luke , Scott Mitchell , Martin Allen , Spiros Liras
发明人： Guiying Li , Pamela Albaugh , Kevin Currie , Guolin Cai , Linda Gustavson , Kyungae Lee , Alan Hutchison , George Maynard , Jun Yuan , Ling Xie , Manuka Ghosh , Nian Liu , George Luke , Scott Mitchell , Martin Allen , Spiros Liras
IPC分类号： A61K31/506 , A61K31/4745 , A61K31/427 , A61K31/4184 , C07D471/02 , C07D403/02 , C07D417/02 , C07D413/02
CPC分类号： C07D401/04 , C07D233/20 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/06 , C07D413/14 , C07D417/04 , C07D417/06 , C07D417/14 , C07D471/04 , C07D473/00 , C07D491/08 , C07D491/10
摘要： This invention relates to benzimidazoles, pyridylimidazoles and related bicyclic heteroaryl compounds, all of which may be described by of Formula I The invention is particularly related to such compounds that bind with high selectivity and high affinity to the benzodiazepine site of GABAA receptors. This invention also relates to pharmaceutical compositions comprising such compounds and to the use of such compounds in treatment of certain central nervous system (CNS) diseases. Novel processes for preparing compounds of Formula I are disclosed. This invention also relates to the use of benzimidazoles, pyridylimidazoles and related bicyclic heteroaryl compounds of Formula I in combination with one or more other CNS agents to potentiate the effects of the other CNS agents. Additionally this invention relates to the use such compounds as probes for the localization of GABAA receptors in tissue sections.
摘要翻译：本发明涉及苯并咪唑，吡啶基咪唑和相关双环杂芳基化合物，所有这些可以由式I描述。本发明特别涉及以高选择性和高亲和力结合GABA A的苯并二氮杂部位的化合物， / SUB>受体。本发明还涉及包含这些化合物的药物组合物以及这些化合物在治疗某些中枢神经系统（CNS）疾病中的用途。公开了制备式I化合物的新方法。本发明还涉及式I的苯并咪唑，吡啶基咪唑和相关的双环杂芳基化合物与一种或多种其它CNS剂的组合用于增强其它CNS剂的作用。此外，本发明涉及使用这些化合物作为组织切片中GABA A A受体定位的探针。

13. 发明授权

US06936617B2 Heteroaryl substituted fused bicyclic heteroaryl compound as GABAA receptor ligands 失效
标题翻译：杂芳基取代的稠合双环杂芳基化合物作为GABA A受体配体
公开(公告)号：US06936617B2
公开(公告)日：2005-08-30
申请号：US10194852
申请日：2002-07-12
申请人： Alan Hutchison , George Maynard , Pamela Albaugh , Linghong Xie , Jun Yuan , Scott Mitchell , Vinod Singh , Manuka Ghosh , Guiying Li , Nian Liu
发明人： Alan Hutchison , George Maynard , Pamela Albaugh , Linghong Xie , Jun Yuan , Scott Mitchell , Vinod Singh , Manuka Ghosh , Guiying Li , Nian Liu
IPC分类号： G01N33/48 , A61K31/4355 , A61K31/4439 , A61K31/444 , A61K31/4985 , A61K31/5025 , A61K31/506 , A61K31/519 , A61P25/00 , A61P25/14 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P43/00 , C07D471/04 , C07D487/04 , C07D513/04 , C12N15/09 , C12Q1/02 , G01N33/58 , G01N33/60 , A61K31/437
CPC分类号： C07D487/04 , C07D471/04 , C07D513/04
摘要： This invention relates to heteroaryl substituted fused bicyclic heteroaryl compounds, such as heteroaryl substituted imidazopyridines, imidazopyrazines, imidazopyridizines, imidazopyrimidines, and imidazothiazoles, which may be described by Formula I or Formula II: The invention is particularly related to such compounds that bind with high selectivity and high affinity to the benzodiazepine site of GABAA receptors. This invention also relates to pharmaceutical compositions comprising such compounds and to the use of such compounds in treatment of certain central nervous system (CNS) diseases. Processes for preparing compounds of Formula I and Formula II are disclosed.This invention also relates to the use of benzimidazoles, pyridylimidazoles and related bicyclic heteroaryl compounds of Formula I or Formula II in combination with one or more other CNS agents to potentiate the effects of the other CNS agents. Additionally this invention relates to the use such compounds as probes for the localization of GABAA receptors in tissue sections.
摘要翻译：本发明涉及可以由式I或式II描述的杂芳基取代的稠合双环杂芳基化合物，例如杂芳基取代的咪唑并吡啶，咪唑并吡嗪，咪唑并吡啶，咪唑并嘧啶和咪唑并噻唑。本发明特别涉及以高选择性结合的这些化合物并且对GABA A A受体的苯并二氮杂位点具有高亲和力。本发明还涉及包含这些化合物的药物组合物以及这些化合物在治疗某些中枢神经系统（CNS）疾病中的用途。公开了制备式I和式II化合物的方法。本发明还涉及式I或式II的苯并咪唑，吡啶基咪唑和相关双环杂芳基化合物与一种或多种其它CNS剂的组合用于增强其它CNS剂的作用。此外，本发明涉及使用这些化合物作为组织切片中GABA A A受体定位的探针。

14. 发明申请

US20060014746A1 Heteroaryl substituted fused bicyclic heteroaryl compounds as GABAA receptor ligands 审中-公开
标题翻译：杂芳基取代的稠合双环杂芳基化合物作为GABA A受体配体
公开(公告)号：US20060014746A1
公开(公告)日：2006-01-19
申请号：US11214345
申请日：2005-08-29
申请人： Alan Hutchison , George Maynard , Pamela Albaugh , Linghong Xie , Jun Yuan , Scott Mitchell , Vinod Singh , Manuka Ghosh , Guiying Li , Nian Liu
发明人： Alan Hutchison , George Maynard , Pamela Albaugh , Linghong Xie , Jun Yuan , Scott Mitchell , Vinod Singh , Manuka Ghosh , Guiying Li , Nian Liu
IPC分类号： C07D487/04 , C07D471/02 , A61K31/519 , A61K31/503 , A61K31/4745
CPC分类号： C07D487/04 , C07D471/04 , C07D513/04
摘要： This invention relates to heteroaryl substituted fused bicyclic heteroaryl compounds, such as heteroaryl substituted imidazopyridines, imidazopyrazines, imidazopyridizines, imidazopyrimidines, and imidazothiazoles, which may be described by Formula I or Formula II: The invention is particularly related to such compounds that bind with high selectivity and high affinity to the benzodiazepine site of GABAA receptors. This invention also relates to pharmaceutical compositions comprising such compounds and to the use of such compounds in treatment of certain central nervous system (CNS) diseases. Processes for preparing compounds of Formula I and Formula II are disclosed. This invention also relates to the use of benzimidazoles, pyridylimidazoles and related bicyclic heteroaryl compounds of Formula I or Formula II in combination with one or more other CNS agents to potentiate the effects of the other CNS agents. Additionally this invention relates to the use such compounds as probes for the localization of GABAA receptors in tissue sections.
摘要翻译：本发明涉及可以由式I或式II描述的杂芳基取代的稠合双环杂芳基化合物，例如杂芳基取代的咪唑并吡啶，咪唑并吡嗪，咪唑并吡啶，咪唑并嘧啶和咪唑并噻唑。本发明特别涉及以高选择性结合的这些化合物并且对GABA A A受体的苯并二氮杂位点具有高亲和力。本发明还涉及包含这些化合物的药物组合物以及这些化合物在治疗某些中枢神经系统（CNS）疾病中的用途。公开了制备式I和式II化合物的方法。本发明还涉及式I或式II的苯并咪唑，吡啶基咪唑和相关双环杂芳基化合物与一种或多种其它CNS剂的组合用于增强其它CNS剂的作用。此外，本发明涉及使用这些化合物作为组织切片中GABA A A受体定位的探针。

15. 发明授权

US07797429B2 Method for establishing peer-to-peer connection 有权
标题翻译：建立点对点连接的方法
公开(公告)号：US07797429B2
公开(公告)日：2010-09-14
申请号：US11691546
申请日：2007-03-27
申请人： Zhu Liang , Fuzhong Sheng , Baohe Zhang , Nian Liu
发明人： Zhu Liang , Fuzhong Sheng , Baohe Zhang , Nian Liu
IPC分类号： G06F15/16 , G06F15/173 , H04L12/28
CPC分类号： H04L67/104 , H04L29/12377 , H04L29/12452 , H04L61/2517 , H04L61/2546 , H04L67/1044 , H04L67/1063
摘要： The embodiment of the present invention provides a method for establishing P2P connection, comprising the steps of: a first terminal initiating connection sends a message to a second terminal to be connected, wherein the message contains the address of the first terminal; the second terminal reads the address of the first terminal initiating connection upon receiving the message, and initiates a P2P connection to the address of the first terminal. The embodiment of the present invention also provides another method for establishing P2P connection, through which both UDP P2P connection and TCP P2P connection can be established. Through the methods provided by the embodiments of the present invention, the terminal to be connected may initiate P2P connection, hence a P2P connection can be initiated by both ends of the connection; furthermore, a P2P connection can be established by using multiple policies through the multiple policy P2P connection establishment method provided by the embodiment of the present invention, thus the P2P connection rate is improved.
摘要翻译：本发明的实施例提供了一种建立P2P连接的方法，包括以下步骤：第一终端发起连接向要连接的第二终端发送消息，其中消息包含第一终端的地址; 第二终端在接收到消息时读取第一终端发起连接的地址，并且发起到第一终端的地址的P2P连接。本发明的实施例还提供了另一种用于建立P2P连接的方法，通过该方法可以建立UDP P2P连接和TCP P2P连接。通过本发明实施例提供的方法，要连接的终端可以发起P2P连接，因此P2P连接可以由连接的两端发起; 此外，通过本发明实施例提供的多策略P2P连接建立方法，可以通过使用多个策略来建立P2P连接，从而提高P2P连接速率。

16. 外观设计

USD841880S1 Multifunction foldable eyebrow stencil makeup apparatus 有权
公开(公告)号：USD841880S1
公开(公告)日：2019-02-26
申请号：US29610831
申请日：2017-07-17
申请人： Jing Jing , Nian Liu
设计人： Jing Jing , Nian Liu
摘要： FIG. 1 is a front elevational view of a multifunction foldable eyebrow stencil makeup apparatus showing my new design;
FIG. 2 is a rear elevational view thereof;
FIG. 3 is a left side view thereof;
FIG. 4 is a right side view thereof;
FIG. 5 is a top plan view thereof;
FIG. 6 is a bottom plan view thereof;
FIG. 7 is a perspective view thereof; and,
FIG. 8 is a perspective view in folded state.

17. 发明申请

US20170333192A1 Non-metal Ball-headed Hip Joint Prosthesis 审中-公开
公开(公告)号：US20170333192A1
公开(公告)日：2017-11-23
申请号：US15405333
申请日：2017-01-13
申请人： Diange Zhou , Nian Liu
发明人： Diange Zhou , Nian Liu
IPC分类号： A61F2/34 , A61F2/36 , A61F2/32 , A61F2/30
CPC分类号： A61F2/34 , A61F2/32 , A61F2/3609 , A61F2/3672 , A61F2002/3065 , A61F2002/30654 , A61F2002/3225 , A61F2002/3429 , A61F2002/3446 , A61F2002/345 , A61F2002/3611 , A61F2002/3619 , A61F2002/3654 , A61F2310/00005 , A61F2310/00179
摘要： This invention revolves around medical devices, especially the non-metal ball-headed hip joint prosthesis, including acetabular cup, non-metal femoral head and femoral stem prostheses. In this invention, the acetabular cup is combined with the lining as a metal cup, and the traditional metal or ceramic ball head is replaced by non-metal femoral head prosthesis with metal inner core.

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