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11. 发明授权

US09518032B2 Small molecule inhibitors of USP1 deubiquitinating enzyme activity 有权
标题翻译： USP1去分支酶活性的小分子抑制剂
公开(公告)号：US09518032B2
公开(公告)日：2016-12-13
申请号：US13695036
申请日：2011-04-29
申请人： Alan D. D'Andrea , Gregory D. Cuny , Ross L. Stein , Marcie Glicksman , April Case , Jun Xian , David Wilson , Min Huang
发明人： Alan D. D'Andrea , Gregory D. Cuny , Ross L. Stein , Marcie Glicksman , April Case , Jun Xian , David Wilson , Min Huang
IPC分类号： C07D263/60 , A61K45/06 , C07D405/06 , A61K31/136 , C07D217/24 , A61K31/472 , C07C225/30 , A61K31/423 , A61K31/4725
CPC分类号： A61K31/423 , A61K31/136 , A61K31/472 , A61K31/4725 , A61K45/06 , C07C225/30 , C07D217/24 , C07D263/60 , C07D405/06
摘要： Provided are small molecule inhibitors of ubiquitin specific protease 1 (USP1) activity and methods for their use in treating and characterizing cancers. The small molecule USP1 inhibitors of the invention are particularly useful in the treatment of cancers that are resistant to DNA cross-linking agents.
摘要翻译：提供泛素特异性蛋白酶1（USP1）活性的小分子抑制剂及其用于治疗和表征癌症的方法。本发明的小分子USP1抑制剂特别可用于治疗对DNA交联剂有抗性的癌症。

12. 发明申请

US20130253005A1 SMALL MOLECULE INHIBITORS OF USP1 DEUBIQUITINATING ENZYME ACTIVITY 有权
标题翻译： USP1分子酶活性的小分子抑制剂
公开(公告)号：US20130253005A1
公开(公告)日：2013-09-26
申请号：US13695036
申请日：2011-04-29
申请人： Alan D. D'Andrea , Gregory D. Cuny , Ross L. Stein , Marcie Glicksman , April Case , Jun Xian , David Wilson , Min Huang
发明人： Alan D. D'Andrea , Gregory D. Cuny , Ross L. Stein , Marcie Glicksman , April Case , Jun Xian , David Wilson , Min Huang
IPC分类号： C07D263/60 , A61K45/06 , C07D405/06 , A61K31/136 , C07D217/24 , A61K31/472 , C07C225/30 , A61K31/423 , A61K31/4725
CPC分类号： A61K31/423 , A61K31/136 , A61K31/472 , A61K31/4725 , A61K45/06 , C07C225/30 , C07D217/24 , C07D263/60 , C07D405/06
摘要： Provided are small molecule inhibitors of ubiquitin specific protease 1 (USP1) activity and methods for their use in treating and characterizing cancers. The small molecule USP1 inhibitors of the invention are particularly useful in the treatment of cancers that are resistant to DNA cross-linking agents.
摘要翻译：提供泛素特异性蛋白酶1（USP1）活性的小分子抑制剂及其用于治疗和表征癌症的方法。本发明的小分子USP1抑制剂特别可用于治疗对DNA交联剂有抗性的癌症。

13. 发明授权

US08541198B2 Method for determination and quantification of radiation or genotoxin exposure 有权
公开(公告)号：US08541198B2
公开(公告)日：2013-09-24
申请号：US13023201
申请日：2011-02-08
申请人： Alan D. D'Andrea
发明人： Alan D. D'Andrea
IPC分类号： G01N33/533 , G01N33/53
CPC分类号： C07K14/47 , C07K16/18 , G01N33/5014 , G01N2800/52
摘要： The present invention discloses methods for detecting exposure of a living subject to genotoxic agents, testing sensitivity to a genotoxic agent, and determining DNA damage caused by exposure to an agent, comprising detecting the presence of FANCD2-containing foci from a sample collected from said subject. The presence of concentrated foci is indicative of DNA damage, and the degree of foci formation is correlated with degree of exposure. Diagnostic reagents contain a ligand that binds to human FANCD2 associated with a detectable label. Kits for detecting DNA damage in a biological sample contain such diagnostic reagents and signal detection components. The invention further discloses methods for identifying agents which modulate the ability of FANCD2-containing foci to form. Among other things, such agents are potentially useful chemosensitizing agents or may confer protection against damage caused by genotoxic agents.

14. 发明授权

US07459287B2 Method for determination and quantification of radiation or genotoxin exposure 有权
标题翻译：辐射或基因毒素暴露的测定和定量方法
公开(公告)号：US07459287B2
公开(公告)日：2008-12-02
申请号：US11046346
申请日：2005-01-28
申请人： Alan D. D'Andrea
发明人： Alan D. D'Andrea
IPC分类号： G01N33/533
CPC分类号： C07K14/47 , C07K16/18 , G01N33/5014 , G01N2800/52
摘要： The present invention discloses methods for detecting exposure of a living subject to genotoxic agents, testing sensitivity to a genotoxic agent, and determining DNA damage caused by exposure to an agent, comprising detecting the presence of FANCD2-containing foci from a sample collected from said subject. The presence of concentrated foci is indicative of DNA damage, and the degree of foci formation is correlated with degree of exposure. Diagnostic reagents contain a ligand that binds to human FANCD2 associated with a detectable label. Kits for detecting DNA damage in a biological sample contain such diagnostic reagents and signal detection components. The invention further discloses methods for identifying agents which modulate the ability of FANCD2-containing foci to form. Among other things, such agents are potentially useful chemosensitizing agents or may confer protection against damage caused by genotoxic agents.
摘要翻译：本发明公开了一种用于检测活体受体对基因毒物的暴露的方法，检测对遗传毒性试剂的敏感性，以及确定由暴露于药剂引起的DNA损伤的方法，包括从所述受试者收集的样品中检测含FANCD2的病灶的存在。浓缩灶的存在表明DNA损伤，并且病灶形成程度与暴露程度相关。诊断试剂含有与可检测标记物相关的人FANCD2结合的配体。用于检测生物样品中DNA损伤的试剂盒含有这样的诊断试剂和信号检测组分。本发明还公开了用于鉴定调节含FANCD2的灶的形成能力的试剂的方法。除其他之外，这些试剂是潜在有用的化学增感剂或可以赋予针对由遗传毒性物质引起的损伤的保护。

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