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11. 发明授权

US07404808B2 Needleless syringe comprising an optimized injector-receptacle 有权
标题翻译：无针注射器包括优化的注射器 - 容器
公开(公告)号：US07404808B2
公开(公告)日：2008-07-29
申请号：US10546251
申请日：2004-04-09
申请人： Patrick Alexandre , Georges Baud , Bernard Brouquieres
发明人： Patrick Alexandre , Georges Baud , Bernard Brouquieres
IPC分类号： A61M5/30
CPC分类号： A61M5/3007 , A61M5/2046 , A61M5/30 , A61M2005/2013 , A61M2005/3132
摘要： The invention relates to the realm of needleless syringes used for injecting liquid active substances. Said syringe comprises a reservoir that is enclosed by means of displaceable plugs which trap the liquid. The reservoir is initially isolated from an injector-receptacle (37) which is provided with at least two peripheral injection conduits (38) that are arranged outside the receptacle (37). Said receptacle (37) encompasses a pocket bore (31) which accommodates the plug located downstream such that the optimized inlets (39) of the conduits are unobstructed. The face of the receptacle (37), which is located upstream, comprises a multilobed sealing joint (34) which is disposed parallel to and as close as possible to the edges of the bore (31) and the inlets (39). The aim of the invention is to create an injector-receptacle (37) that is optimized regarding discharging and the resistance thereof to the injection pressure.
摘要翻译：本发明涉及用于注射液体活性物质的无针注射器领域。所述注射器包括通过捕获液体的可移动塞子封闭的储存器。储存器最初与注射器 - 容器（37）隔离，所述注射器 - 容器（37）设置有布置在容器（37）外部的至少两个周边注射导管（38）。所述容器（37）包围一口袋孔（31），其容纳位于下游的塞子，使得导管的优化入口（39）畅通无阻。位于上游的容器（37）的表面包括多孔密封接头（34），其平行于并尽可能靠近孔（31）和入口（39）的边缘设置。本发明的目的是创建一种针对放电和针对注射压力的抵抗而优化的注射器 - 容器（37）。

12. 发明申请

US20060089595A1 Needleless injection device comprising means for regulating the gas pressure level in the combustion chamber 有权
标题翻译：无针注射装置包括用于调节燃烧室中的气体压力水平的装置
公开(公告)号：US20060089595A1
公开(公告)日：2006-04-27
申请号：US10547997
申请日：2004-03-18
申请人： Patrick Alexandre , Bernard Brouquieres , David Desailly
发明人： Patrick Alexandre , Bernard Brouquieres , David Desailly
IPC分类号： A61M5/30
CPC分类号： A61M5/30 , A61M5/2046 , A61M5/46 , A61M5/484
摘要： The invention relates to a needleless injection device (1) comprising a body (2) which supports and/or defines a plurality of elements that form a circuit of elements. The aforementioned circuit comprises, from upstream towards downstream, an initiation device which is associated with a pyrotechnic gas generator, a receptacle (5) housing a liquid system. According to the invention, the pyrotechnic gas generator comprises a pyrotechnic charge (62) which is placed in a combustion chamber (4). The inventive device is characterised in that it comprises at least one device for regulating the gas pressure level in the combustion chamber (4).
摘要翻译：本发明涉及一种无针注射装置（1），其包括主体（2），其支撑和/或限定形成元件电路的多个元件。上述电路从上游到下游包括与烟火气体发生器相关联的启动装置，容纳液体系统的容器（5）。根据本发明，烟火气体发生器包括放置在燃烧室（4）中的烟火装置（62）。本发明的装置的特征在于它包括用于调节燃烧室（4）中的气体压力水平的至少一个装置。

13. 发明授权

US07500960B2 Needleless injection device comprising a pyrotechnic cartridge, and method of assembling such a device 有权
标题翻译：包括烟火药筒的无针注射装置和组装这种装置的方法
公开(公告)号：US07500960B2
公开(公告)日：2009-03-10
申请号：US10551652
申请日：2004-03-18
申请人： Patrick Alexandre , Georges Baud , Bernard Brouquieres , Philippe Gautier
发明人： Patrick Alexandre , Georges Baud , Bernard Brouquieres , Philippe Gautier
IPC分类号： A61M5/30
CPC分类号： A61M5/30 , A61M5/2046 , A61M5/3129 , A61M5/484
摘要： The invention relates to a method of assembling a needleless injection device (1), whereby a plurality of elements forming a circuit of elements is assembled to a body (2). The aforementioned circuit comprises elements such as an initiation device, a receptacle (5) containing an active agent to be injected, and an active agent injection system. The inventive method is characterised in that it comprises a step in which a gas-generating cartridge (6), which is adapted to the nature and/or quantity of active agent to be injected as well as to the skin penetration depth desired for same, is inserted directly into the circuit of elements, independently of said elements, from outside the body (2). The invention also relates to a needleless injection device (1).
摘要翻译：本发明涉及组装无针注射装置（1）的方法，由此将形成元件电路的多个元件组装到主体（2）上。上述电路包括诸如引发装置，包含待注射的活性剂的容器（5）和活性剂注射系统的元件。本发明的方法的特征在于它包括一个气体发生筒（6），其适于要注射的活性剂的性质和/或数量以及与其相同的皮肤渗透深度，独立于元件的元件的电路直接插入到主体（2）的外部。本发明还涉及无针注射装置（1）。

14. 发明申请

US20080039780A1 Needleless Syringe Provided with a Damping Injector Receptacle 有权
标题翻译：带有阻尼注射器插座的无针注射器
公开(公告)号：US20080039780A1
公开(公告)日：2008-02-14
申请号：US10585574
申请日：2005-01-11
申请人： Patrick Alexandre , Georges Baud , Bernard Brouquieres , Laurent D'Emmanuelle , Denis Roller
发明人： Patrick Alexandre , Georges Baud , Bernard Brouquieres , Laurent D'Emmanuelle , Denis Roller
IPC分类号： A61M5/30
CPC分类号： A61M5/30 , A61M5/2459 , A61M2005/3132
摘要： The invention relates to needleless syringe for injecting an active liquid principle. The inventive syringe comprises a container (3) closed by a movable shutter and containing the injectable liquid. Said container is initially insulated from an injector-receptacle provided with a cylinder bore (10) in which a downstream shutter is arranged and which comprises at least one protuberance reducing the section with respect to the upstream opening of the bore. The aim of said invention is to damp and prevent the downstream shutter bounce when it is disposed in the bore (10) of the receptacle.
摘要翻译：本发明涉及用于注射活性液体原理的无针注射器。本发明的注射器包括由活动快门封闭并容纳可注射液体的容器（3）。所述容器最初与设置有气缸孔（10）的注射器 - 容器绝缘，其中下游闸门布置在其中，并且包括至少一个突起，其相对于孔的上游开口减小截面。所述发明的目的是在其设置在容器的孔（10）中时阻止和防止下游快门反弹。

15. 发明申请

US20070167906A1 Needleless syringe comprising an optimized injector-receptacle 有权
标题翻译：无针注射器包括优化的注射器 - 容器
公开(公告)号：US20070167906A1
公开(公告)日：2007-07-19
申请号：US10546251
申请日：2004-04-09
申请人： Patrick Alexandre , Georges Baud , Bernard Brouquieres
发明人： Patrick Alexandre , Georges Baud , Bernard Brouquieres
IPC分类号： A61M5/30
CPC分类号： A61M5/3007 , A61M5/2046 , A61M5/30 , A61M2005/2013 , A61M2005/3132
摘要： The invention relates to the realm of needleless syringes used for injecting liquid active substances. Said syringe comprises a reservoir that is enclosed by means of displaceable plugs which trap the liquid. The reservoir is initially isolated from an injector-receptacle (37) which is provided with at least two peripheral injection conduits (38) that are arranged outside the receptacle (37). Said receptacle (37) encompasses a pocket bore (31) which accommodates the plug located downstream such that the optimized inlets (39) of the conduits are unobstructed. The face of the receptacle (37), which is located upstream, comprises a multilobed sealing joint (34) which is disposed parallel to and as close as possible to the edges of the bore (31) and the inlets (39). The aim of the invention is to create an injector-receptacle (37) that is optimized regarding discharging and the resistance thereof to the injection pressure.
摘要翻译：本发明涉及用于注射液体活性物质的无针注射器领域。所述注射器包括通过捕获液体的可移动塞子封闭的储存器。储存器最初与注射器 - 容器（37）隔离，所述注射器 - 容器（37）设置有布置在容器（37）外部的至少两个周边注射导管（38）。所述容器（37）包围一口袋孔（31），其容纳位于下游的塞子，使得导管的优化入口（39）畅通无阻。位于上游的容器（37）的表面包括多孔密封接头（34），其平行于并尽可能靠近孔（31）和入口（39）的边缘设置。本发明的目的是创建一种针对放电和针对注射压力的抵抗而优化的注射器 - 容器（37）。

16. 发明授权

US07056300B2 Needleless syringe for injecting a liquid contained in a prefilled ampule 有权
标题翻译：用于注射预充式安瓿中所含液体的无针注射器
公开(公告)号：US07056300B2
公开(公告)日：2006-06-06
申请号：US10169997
申请日：2001-01-26
申请人： Patrick Alexandre , Bernard Brouquieres , Xavière Castano , Philippe Gautier
发明人： Patrick Alexandre , Bernard Brouquieres , Xavière Castano , Philippe Gautier
IPC分类号： A61M5/30
CPC分类号： A61M5/30 , A61M2005/2013 , A61M2005/2086 , A61M2005/3132 , A61M2005/3143
摘要： A needleless syringe comprises a reservoir sealed with mobile closure elements enclosed the liquid, the reservoir being initially isolated from the injection system which is so designed that it comprises at least two peripheral injection conduits located outside a receptacle comprising a blind bore which receives the downstream closure element such that the inlets of the conduits are cleared.
摘要翻译：无针注射器包括用封闭液体的移动闭合元件密封的储存器，储存器最初与注射系统隔离，该注射系统被设计成使得其包括位于容器外部的至少两个外围注射导管，所述外围注射导管包括盲孔，所述盲孔接收下游封闭件元件，使得导管的入口被清除。

17. 发明授权

US08070714B2 Needleless syringe provided with modular reservoir 有权
标题翻译：无针注射器配有模块化储液器
公开(公告)号：US08070714B2
公开(公告)日：2011-12-06
申请号：US12073122
申请日：2008-02-29
申请人： Patrick Alexandre , Bernard Brouquieres , Denis Roller
发明人： Patrick Alexandre , Bernard Brouquieres , Denis Roller
IPC分类号： A61M37/00 , A61M5/30
CPC分类号： A61M5/30 , A61M5/2046 , A61M2005/3132
摘要： The technical field of the invention is that of needleless pre-filled disposable syringes, operating with a gas generator, and used for intradermal, subcutaneous and intramuscular injections, of a liquid active principle for therapeutic use in human and veterinary medicine. The inventive needleless syringes use a reservoir (5) consisting of a tube (6) closed by an upstream plug-piston (7) and a downstream plug-piston (8) between which is contained the liquid active principle. Said needleless syringes are characterized in that they are capable of injecting a variable amount of liquid active principle (9) by adapting, through displacement of the downstream plug-piston (8) in the tube (6) the volume included between the two plug-pistons (7,8) to the amount of active principle (9) to be injected.
摘要翻译：本发明的技术领域是针对用于人和兽医学治疗用途的液体活性成分的无针预填充一次性注射器，用气体发生器操作并用于皮内，皮下和肌内注射。本发明的无针注射器使用由上游塞子 - 活塞（7）封闭的管（6）和下游塞 - 活塞（8）组成的储存器（5），在其之间包含液体活性成分。所述无针注射器的特征在于，它们能够通过使包含在管（6）中的下游塞 - 活塞（8）的位移容纳在两个插塞式活塞（9）之间的体积，活塞（7,8）与待注射的活性成分（9）的量。

18. 发明授权

US07981075B2 Device for needleless injection operating with two concentric energetic materials 有权
标题翻译：两针同步高能材料无针注射装置
公开(公告)号：US07981075B2
公开(公告)日：2011-07-19
申请号：US11662226
申请日：2005-09-20
申请人： Patrick Alexandre , Bernard Brouquieres , Philippe Gautier , Christiane Reynaud
发明人： Patrick Alexandre , Bernard Brouquieres , Philippe Gautier , Christiane Reynaud
IPC分类号： A61M5/30
CPC分类号： A61M5/30 , A61M5/2046
摘要： A needleless injection device used for intradermal, subcutaneous and intramuscular injections is disclosed. The device includes a pyrotechnic gas generator, at least one piston, a reserve of liquid active principle and an injection nozzle. The generator includes a pyrotechnic charge composed of a central energetic material that is surrounded by a second peripheral energetic material. The entire outer surface of the central energetic material contacts the inner surface of the peripheral energetic material. The two energetic materials have different rates of combustion.
摘要翻译：公开了一种用于皮内，皮下和肌内注射的无针注射装置。该装置包括烟火气体发生器，至少一个活塞，液体有效原理储备和喷射喷嘴。该发生器包括由第二外围能量材料围绕的中心能量材料构成的烟火电荷。中心能量材料的整个外表面接触周边能量材料的内表面。两种高能材料的燃烧速率不同。

19. 发明授权

US07798989B2 Needleless syringe provided with a damping injector receptacle 有权
标题翻译：无针注射器配有阻尼注射器插座
公开(公告)号：US07798989B2
公开(公告)日：2010-09-21
申请号：US10585574
申请日：2005-01-11
申请人： Patrick Alexandre , Georges Baud , Bernard Brouquieres , Laurent D'Emmanuelle , Denis Roller
发明人： Patrick Alexandre , Georges Baud , Bernard Brouquieres , Laurent D'Emmanuelle , Denis Roller
IPC分类号： A61M5/30
CPC分类号： A61M5/30 , A61M5/2459 , A61M2005/3132
摘要： The invention relates to needleless syringe for injecting an active liquid principle. The inventive syringe comprises a container (3) closed by a movable shutter and containing the injectable liquid. Said container is initially insulated from an injector-receptacle provided with a cylinder bore (10) in which a downstream shutter is arranged and which comprises at least one protuberance reducing the section with respect to the upstream opening of the bore. The aim of said invention is to damp and prevent the downstream shutter bounce when it is disposed in the bore (10) of the receptacle.
摘要翻译：本发明涉及用于注射活性液体原理的无针注射器。本发明的注射器包括由活动快门封闭并容纳可注射液体的容器（3）。所述容器最初与设置有气缸孔（10）的注射器 - 容器绝缘，其中下游闸门布置在其中，并且包括至少一个突起，其相对于孔的上游开口减小截面。所述发明的目的是在其设置在容器的孔（10）中时阻止和防止下游快门反弹。

20. 发明申请

US20080154189A1 Needleless syringe provided with modular reservoir 有权
标题翻译：无针注射器配有模块化储液器
公开(公告)号：US20080154189A1
公开(公告)日：2008-06-26
申请号：US12073122
申请日：2008-02-29
申请人： Patrick Alexandre , Bernard Brouquieres , Denis Roller
发明人： Patrick Alexandre , Bernard Brouquieres , Denis Roller
IPC分类号： A61M5/303
CPC分类号： A61M5/30 , A61M5/2046 , A61M2005/3132
摘要： The technical field of the invention is that of needleless pre-filled disposable syringes, operating with a gas generator, and used for intradermal, subcutaneous and intramuscular injections, of a liquid active principle for therapeutic use in human and veterinary medicine. The inventive needleless syringes use a reservoir (5) consisting of a tube (6) closed by an upstream plug-piston (7) and a downstream plug-piston (8) between which is contained the liquid active principle. Said needleless syringes are characterized in that they are capable of injecting a variable amount of liquid active principle (9) by adapting, through displacement of the downstream plug-piston (8) in the tube (6) the volume included between the two plug-pistons (7,8) to the amount of active principle (9) to be injected.
摘要翻译：本发明的技术领域是针对用于人和兽医学治疗用途的液体活性成分的无针预填充一次性注射器，用气体发生器操作并用于皮内，皮下和肌内注射。本发明的无针注射器使用由上游塞子 - 活塞（7）封闭的管（6）和下游塞 - 活塞（8）组成的储存器（5），在其之间包含液体活性成分。所述无针注射器的特征在于，它们能够通过使包含在管（6）中的下游塞 - 活塞（8）的位移容纳在两个插塞式活塞（9）之间的体积，活塞（7,8）与待注射的活性成分（9）的量。

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