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11. 发明授权

US4988208A Method of and apparatus for mixing or dispersing particles 失效
标题翻译：混合或分散颗粒的方法和设备
公开(公告)号：US4988208A
公开(公告)日：1991-01-29
申请号：US252248
申请日：1988-09-30
申请人： Akira Shibuya , Michio Aoyama , Isao Kimura
发明人： Akira Shibuya , Michio Aoyama , Isao Kimura
IPC分类号： B01F13/00
CPC分类号： B01F13/0001
摘要： A method of and an apparatus for mixing or dispersing particles using a gradient force produced by a contact type electric field curtain. The particles are mixed or dispersed by permitting them to be put in a dielectric container and passing them through the area of influence of the electric field curtain.
摘要翻译：使用由接触式电场帘产生的梯度力混合或分散颗粒的方法和装置。颗粒通过允许它们放入电介质容器中并将其通过电场帘的影响区域而混合或分散。

12. 发明授权

US5076706A Method of mixing of dispersing particles with an electrode assembly 失效
标题翻译：分散粒子与电极组件的混合方法
公开(公告)号：US5076706A
公开(公告)日：1991-12-31
申请号：US605903
申请日：1990-10-30
申请人： Akira Shibuya , Michio Aoyama , Isao Kimura
发明人： Akira Shibuya , Michio Aoyama , Isao Kimura
IPC分类号： B01F13/00
CPC分类号： B01F13/0001
摘要： A method of and an apparatus for mixing or dispersing particles with use of gradient force produced by a contact type electric field curtain. The particles are mixed or dispersed by permitting them to be put in a dielectric container and pass through the action area of the electric field curtain.

13. 发明授权

US4018577A Particle charging device for use in an electric dust collecting apparatus 失效
标题翻译：用于电动除尘装置的颗粒充电装置
公开(公告)号：US4018577A
公开(公告)日：1977-04-19
申请号：US460762
申请日：1974-04-15
申请人： Akira Shibuya , Yoshifumi Nitta
发明人： Akira Shibuya , Yoshifumi Nitta
IPC分类号： B05B5/00 , B03C3/38 , B03C3/41
CPC分类号： B03C3/38
摘要： A particle charging device for use in a two-stage type of electric dust collecting apparatus, including opposite electrodes disposed at such positions that an intermittent ion generating zone is established between the opposite electrodes and ion generating electrodes, and that uneven, non-uniform electric fields are established between said opposite electrodes and transfer electrodes; a dust containing gas is ionized in the intermittent ion generating zone, and upon transferring the ions by means of the uneven electric field, said ions are brought in contact with a flow of particles in said dust containing gas to thereby charge said particles.
摘要翻译：一种用于两级式电除尘装置的粒子充电装置，包括设置在相对电极和离子产生电极之间建立间歇离子产生区的位置处的相对电极，以及不均匀的不均匀电在所述相对电极和转移电极之间建立场; 在间歇离子产生区域中，含有尘埃的气体被离子化，在通过不均匀电场传递离子时，使离子与含尘气体中的粒子流接触，从而对所述粒子进行充电。

14. 发明授权

US08603754B2 Graft-versus-host disease predicting marker and use thereof 有权
标题翻译：移植物抗宿主病预测标记及其用途
公开(公告)号：US08603754B2
公开(公告)日：2013-12-10
申请号：US13204799
申请日：2011-08-08
申请人： Akira Shibuya , Hiroshi Kojima
发明人： Akira Shibuya , Hiroshi Kojima
IPC分类号： G01N33/53
CPC分类号： G01N33/573 , A61K39/3955 , A61K2039/505 , C07K16/2803 , G01N2333/91245 , G01N2800/245
摘要： A test method that provides data useful in predicting the probability of onset of acute graft-versus-host disease (GVHD) is described along with a kit for performing the method, and a pharmaceutical preparation and a molecular targeted therapy for treating or preventing GVHD. The test method includes measuring the blood DNAM-1 concentration of a patient of hematopoietic stem cell transplantation from bone marrow or the like over a period after the transplantation to provide data concerning the transition of the concentration to an abnormally high level deviating from the normal range, whereby the probability of the development of acute graft-versus-host disease is predicted, the risk of the development is estimated, or therapeutic effects after the development are evaluated. Concerning the molecular targeted therapy and pharmaceutical preparation used therefor wherein blood DNAM-1 of a GVHD patient or a graft recipient that is a possible patient is used as a target molecule, GVHD is treated or prevented by administering an anti-DNAM-1 antibody that is a neutralizing antibody.
摘要翻译：描述了提供用于预测急性移植物抗宿主病（GVHD）发病概率的数据的测试方法以及用于进行该方法的试剂盒以及用于治疗或预防GVHD的药物制剂和分子靶向治疗。测试方法包括在移植后的一段时间内测量来自骨髓等的造血干细胞移植患者的血液DNAM-1浓度，以提供关于浓度向偏离正常范围的异常高水平转变的数据预测急性移植物抗宿主病发展的可能性，估计发展的风险，或发展后的治疗效果。关于其中使用的分子靶向治疗和药物制剂，其中GVHD患者的血液DNAM-1或作为可能患者的移植物接受体用作靶分子，通过施用抗-DNAM-1抗体来治疗或预防GVHD，是中和抗体。

15. 发明授权

US08258340B2 Method for producing β-mercapto carboxylic acids 失效
标题翻译： - 巯基羧酸的生产方法
公开(公告)号：US08258340B2
公开(公告)日：2012-09-04
申请号：US12921495
申请日：2009-03-11
申请人： Hidemasa Aoki , Akio Kuroiwa , Akira Shibuya
发明人： Hidemasa Aoki , Akio Kuroiwa , Akira Shibuya
IPC分类号： C07B53/00
CPC分类号： C07C319/04 , C07C323/56 , C07C323/52
摘要： An object of the present invention is to provide a method for industrially producing β-mercapto carboxylic acids that are useful as synthetic raw materials for medicines and agrochemicals or as additives for polymer compounds from easily available α,β-unsaturated carboxylic acids in high yields and productivity.The present invention is characterized in that a solvent having an amide group and represented by the formula (1) is used when the α,β-unsaturated carboxylic acids are reacted with hydrogen sulfides to produce the β-mercapto carboxylic acids. Particularly, it is more preferable to carry out the reaction at a pH range of 6.0 to 8.5: (In the formula (1), R1 represents any one of a hydrogen atom, an alkoxy group having 1 to 5 carbon atoms, an alkyl group having 1 to 5 carbon atoms, an amino group, and an alkylamino group having 1 to 5 carbon atoms; R2 and R3 each represents independently any one of a hydrogen atom and an alkyl group having 1 to 5 carbon atoms; when both R2 and R3 are not a hydrogen atom, R2 and R3 may together form a ring structure through an alkylene group; and when both R1 and R2 are not a hydrogen atom, R1 and R2 may form a ring structure through an alkylene group).
摘要翻译：本发明的一个目的是提供一种工业上生产和/或巯基羧酸的方法，其可用作药物和农用化学品的合成原料或作为高分子化合物的添加剂，其易于获得的α，β-不饱和羧酸在高产量和生产力。本发明的特征在于，当α，bgr-不饱和羧酸与硫化氢反应以制备β-巯基羧酸时，使用具有酰胺基并由式（1）表示的溶剂。特别优选在6.0〜8.5的pH范围进行反应（式（1）中，R 1表示氢原子，碳原子数1〜5的烷氧基，烷基具有1至5个碳原子，氨基和具有1至5个碳原子的烷基氨基; R 2和R 3各自独立地表示氢原子和具有1至5个碳原子的烷基中的任一个;当R 2和R 3均为不是氢原子，R2和R3可以一起通过亚烷基形成环结构;当R1和R2都不是氢原子时，R1和R2可以通过亚烷基形成环结构）。

16. 发明申请

US20110318762A1 Graft-Versus-Host Disease Predicting Marker and Use Thereof 有权
标题翻译：移植物抗宿主病预测标记及其用途
公开(公告)号：US20110318762A1
公开(公告)日：2011-12-29
申请号：US13204799
申请日：2011-08-08
申请人： Akira Shibuya , Hiroshi Kojima
发明人： Akira Shibuya , Hiroshi Kojima
IPC分类号： G01N33/577
CPC分类号： G01N33/573 , A61K39/3955 , A61K2039/505 , C07K16/2803 , G01N2333/91245 , G01N2800/245
摘要： A test method that provides data useful in predicting the probability of onset of acute graft-versus-host disease (GVHD) is described along with a kit for performing the method, and a pharmaceutical preparation and a molecular targeted therapy for treating or preventing GVHD. The test method includes measuring the blood DNAM-1 concentration of a patient of hematopoietic stem cell transplantation from bone marrow or the like over a period after the transplantation to provide data concerning the transition of the concentration to an abnormally high level deviating from the normal range, whereby the probability of the development of acute graft-versus-host disease is predicted, the risk of the development is estimated, or therapeutic effects after the development are evaluated. Concerning the molecular targeted therapy and pharmaceutical preparation used therefor wherein blood DNAM-1 of a GVHD patient or a graft recipient that is a possible patient is used as a target molecule, GVHD is treated or prevented by administering an anti-DNAM-1 antibody that is a neutralizing antibody.
摘要翻译：描述了提供用于预测急性移植物抗宿主病（GVHD）发病概率的数据的测试方法以及用于进行该方法的试剂盒以及用于治疗或预防GVHD的药物制剂和分子靶向治疗。测试方法包括在移植后的一段时间内测量来自骨髓等的造血干细胞移植患者的血液DNAM-1浓度，以提供关于浓度向偏离正常范围的异常高水平转变的数据预测急性移植物抗宿主病发展的可能性，估计发展的风险，或发展后的治疗效果。关于其中使用的分子靶向治疗和药物制剂，其中GVHD患者的血液DNAM-1或作为可能患者的移植物接受体用作靶分子，通过施用抗-DNAM-1抗体来治疗或预防GVHD，是中和抗体。

17. 发明授权

US08153130B2 Graft-versus-host disease predicting marker and use thereof 有权
标题翻译：移植物抗宿主病预测标记及其用途
公开(公告)号：US08153130B2
公开(公告)日：2012-04-10
申请号：US12296345
申请日：2007-04-05
申请人： Akira Shibuya , Hiroshi Kojima
发明人： Akira Shibuya , Hiroshi Kojima
IPC分类号： A61K39/395
CPC分类号： G01N33/573 , A61K39/3955 , A61K2039/505 , C07K16/2803 , G01N2333/91245 , G01N2800/245
摘要： A test method that provides data useful in predicting the probability of onset of acute graft-versus-host disease (GVHD) is described along with a kit for performing the method, and a pharmaceutical preparation and a molecular targeted therapy for treating or preventing GVHD. The test method includes measuring the blood DNAM-1 concentration of a patient of hematopoietic stem cell transplantation from bone marrow or the like over a period after the transplantation to provide data concerning the transition of the concentration to an abnormally high level deviating from the normal range, whereby the probability of the development of acute graft-versus-host disease is predicted, the risk of the development is estimated, or therapeutic effects after the development are evaluated. Concerning the molecular targeted therapy and pharmaceutical preparation used therefor wherein blood DNAM-1 of a GVHD patient or a graft recipient that is a possible patient is used as a target molecule, GVHD is treated or prevented by administering an anti-DNAM-1 antibody that is a neutralizing antibody.
摘要翻译：描述了提供用于预测急性移植物抗宿主病（GVHD）发病概率的数据的测试方法以及用于进行该方法的试剂盒以及用于治疗或预防GVHD的药物制剂和分子靶向治疗。测试方法包括在移植后的一段时间内测量来自骨髓等的造血干细胞移植患者的血液DNAM-1浓度，以提供关于浓度向偏离正常范围的异常高水平转变的数据预测急性移植物抗宿主病发展的可能性，估计发展的风险，或发展后的治疗效果。关于其中使用的分子靶向治疗和药物制剂，其中GVHD患者的血液DNAM-1或作为可能患者的移植物接受体用作靶分子，通过施用抗-DNAM-1抗体来治疗或预防GVHD，是中和抗体。

18. 发明申请

US20090081147A1 PERMANENT WAVING AGENT 审中-公开
标题翻译：永久性摆动剂
公开(公告)号：US20090081147A1
公开(公告)日：2009-03-26
申请号：US11914172
申请日：2006-05-12
申请人： Akira Shibuya , Motoaki Kamachi
发明人： Akira Shibuya , Motoaki Kamachi
IPC分类号： A61K8/49 , A61Q5/04
CPC分类号： A61K8/4913 , A61K8/447 , A61K8/4933 , A61K8/4973 , A61K2800/884 , A61Q5/04 , A61Q5/10
摘要： A permanent waving agent is capable of permanent waving and coloring hair simultaneously.The permanent waving agent includes: (i) a perming first agent including at least one compound represented by Formula (1) below, and an acid dye and/or an oxidation dye: wherein X is a structure selected from the group consisting of —O—, —S—, —NH— and —NR1—; R1 is an alkyl group of 1 to 6 carbon atoms; R2 is a hydrogen atom or an alkyl group of 1 to 6 carbon atoms; Y is an oxygen atom or a sulfur atom; and R is a divalent organic residue optionally having a mercapto group; and (ii) a perming second agent including an oxidizing agent.
摘要翻译：永久性挥发剂能够同时烫发和着色头发。永久性挥发剂包括：（i）包含至少一种由下式（1）表示的化合物的烫发第一剂和酸性染料和/或氧化染料：其中X是选自-O - ， - S - ， - NH-和-NR 1 - ; R1是1-6个碳原子的烷基; R2是氢原子或1〜6个碳原子的烷基; Y是氧原子或硫原子; 并且R是任选具有巯基的二价有机残基; 和（ii）包含氧化剂的烫发第二剂。

19. 发明授权

US5008552A Data recording and reproducing apparatus for an optical card 失效
标题翻译：用于光卡的数据记录和再现装置
公开(公告)号：US5008552A
公开(公告)日：1991-04-16
申请号：US274994
申请日：1988-10-07
申请人： Wataru Kuramochi , Yoshiaki Tsuruoka , Norikazu Saitou , Akira Shibuya , Shuichi Yamashita
发明人： Wataru Kuramochi , Yoshiaki Tsuruoka , Norikazu Saitou , Akira Shibuya , Shuichi Yamashita
IPC分类号： G11B7/0033 , G11B7/007 , G11B7/08 , G11B7/085 , G11B7/09 , G11B17/34 , G11B19/10 , G11B19/20 , G11B25/04 , G11B33/08 , G06K13/06 , G06K13/24
CPC分类号： G11B19/20 , G11B17/34 , G11B19/10 , G11B19/2018 , G11B25/04 , G11B33/08 , G11B7/0033 , G11B7/00745 , G11B7/08 , G11B7/08505 , G11B7/08523 , G11B7/0857 , G11B7/0904 , G11B7/0917 , G11B2007/0924
摘要： Data can be recorded onto an optical card (102; 200; 601; 800) on which a plurality of tracks are parallelly arranged and can be reproduced therefrom. The optical card is supported by card supporting means (101; 501). This card supporting means is reciprocated in a first direction by card drive means (109; 511). An optical head (103; 503; 603) is provided above the optical card to selectively provide access to tracks by a light beam. This optical head is reciprocated in a second direction perpendicular to the first direction by head drive means (108; 507). The reciprocating motion of the card supporting means is accelerated and decelerated when the optical head scans on guide sections (G) provided on both the sides of the optical card. Error correcting codes are added to data recorded onto the optical card. Thus, error correction is made by an error correction circuit (136). Motors of respective drive means are enclosed with vibration proof metal (321, 323) and vibration proof rubber (322). The card supporting means (101) comprises pressing means (423) for pressing the upper surface of the optical card and positioning means (425) which can be in contact with the side surface of the optical card and away therefrom, thus to carry out positioning of the optical card. The card supporting means (501) is provided with contact surface (501a). By roller means (506) having rotation shaft (505) slightly inclined with respect to perpendicular (505') set up on the plane including the contact surface, optical card inserted from the outside is introduced toward the contact surface. The optical head (103) is ordinarily controlled by feedback control.

20. 发明授权

US3994704A Electric dust collecting apparatus 失效
标题翻译：电动除尘装置
公开(公告)号：US3994704A
公开(公告)日：1976-11-30
申请号：US565821
申请日：1975-04-07
申请人： Akira Shibuya , Yoshifumi Nitta
发明人： Akira Shibuya , Yoshifumi Nitta
IPC分类号： B03C3/00 , B03C3/04 , B03C3/51 , B03C3/45
CPC分类号： B03C3/51 , B03C3/04
摘要： An improved dust collecting apparatus is described, in a first section of which are disposed a plurality of linear discharge electrodes and a plurality of planar dust collecting electrodes in an opposed relationship to each other within a casing that has an inlet port for introducing a dust-containing gas formed at one end and that has an outlet port for discharging a dust-free gas formed at the other end, so that the dust in the dust-containing gas may be charged and also collected in said first section. Downstream of said first section of the apparatus are aligned a plurality of rod-shaped driver electrodes spaced apart from each other along a plane transverse of a gas flow, and on the side surfaces of said driver electrodes are provided lengthwise channels having their openings directed to the outlet port side. Downstream of the gas spaces formed between adjacent ones of said driver electrodes are disposed a plurality of rod-shaped collector electrodes, and on the side surfaces of said collector electrodes are provided lengthwise channels having their openings directed to the inlet port side. A negative terminal of a D.C. power source is connected to said driver electrodes, while a positive terminal of a D.C. power source is connected to said collector electrodes, whereby the dust that has been charged in the space between said discharge electrodes and said dust collecting electrodes but has not adhered to the dust collecting electrodes and that has been respattered can be collected within the lengthwise channels of said collector electrodes.
摘要翻译：在第一部分中描述了一种改进的集尘装置，其中第一部分在壳体内彼此相对关系地设置有多个线性放电电极和多个平面集尘电极，该壳体具有用于引入除尘装置的入口，形成在一端的容纳气体，具有用于排出在另一端形成的无尘气体的出口，使得含尘气体中的灰尘可能被填充并收集在所述第一部分中。所述设备的所述第一部分的下游沿着沿着气流横向的平面彼此间隔开的多个杆状驱动器电极对准，并且在所述驱动电极的侧表面上设置有纵向通道，其开口指向出口侧。在相邻的所述驱动电极之间形成的气体空间的下游设置有多个棒状收集电极，并且在所述集电极的侧表面上设有纵向通道，其开口指向入口侧。直流电源的负端子连接到所述驱动电极，而直流电源的正极端子连接到所述集电极，由此已经充电在所述放电电极和所述集尘电极之间的空间的灰尘但是没有附着在集尘电极上，并且已经被重新分配的电极可以被收集在所述集电极的纵向通道内。

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