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11. 发明申请

US20080175881A1 Blood-contacting medical devices for the release of nitric oxide and anti-restenotic agents 审中-公开
标题翻译：用于释放一氧化氮和抗再狭窄剂的血液接触医疗装置
公开(公告)号：US20080175881A1
公开(公告)日：2008-07-24
申请号：US11654884
申请日：2007-01-18
申请人： J. Thomas Ippoliti , Scott Schewe , Michele Zoromski , Robert W. Warner , Liliana Atanasoska , Jan Weber
发明人： J. Thomas Ippoliti , Scott Schewe , Michele Zoromski , Robert W. Warner , Liliana Atanasoska , Jan Weber
IPC分类号： A61L31/16 , A61L31/10 , A61F2/82
CPC分类号： A61L31/10 , A61L31/16 , A61L2300/114 , A61L2300/416 , A61L2300/45
摘要： According to an aspect of the present invention, implantable or insertable blood-contacting devices are provided, which contain one or more release regions that release nitric oxide and one or more anti-restenotic agents. The release region contains one or more polymeric components. The release region also optionally contains one or more inorganic components. Nitric oxide producing groups may be attached to the polymeric component(s), to the optional inorganic component(s), or both. The one or more anti-restenotic agents may be admixed with the polymeric and optional inorganic components, attached to the polymeric component(s), attached to the optional inorganic component(s), or a combination thereof.
摘要翻译：根据本发明的一个方面，提供了可植入或可插入的血液接触装置，其包含一个或多个释放一氧化氮的释放区域和一种或多种抗再狭窄剂。释放区域包含一种或多种聚合物组分。释放区域还任选地含有一种或多种无机组分。一氧化碳生成基团可以连接到聚合物组分，任选的无机组分或两者。一种或多种抗再狭窄剂可以与附着于任选的无机组分的一种或多种聚合物组分的聚合物和任选的无机组分或其组合物混合。

12. 发明申请

US20060282156A1 Medical devices and related methods 有权
标题翻译：医疗器械及相关方法
公开(公告)号：US20060282156A1
公开(公告)日：2006-12-14
申请号：US11152555
申请日：2005-06-14
申请人： Jan Weber , Thomas Holman , Scott Schewe
发明人： Jan Weber , Thomas Holman , Scott Schewe
IPC分类号： A61F2/06
CPC分类号： A61F2/95 , A61F2/91 , A61F2/958 , A61F2210/0033 , A61F2220/005 , A61F2220/0058 , A61F2250/0018 , A61F2250/0068 , A61M25/09 , A61M25/1006 , A61M25/10186 , A61M2025/1015 , A61M2025/105 , A61M2025/1056 , A61M2025/1068 , A61M2025/1086 , A61M2025/1093
摘要： A medical system including an elongate member and an elongate element associated with the elongate member so that a shape of the elongate member can be altered upon applying energy to the element.
摘要翻译：一种医疗系统，包括细长构件和与细长构件相关联的细长元件，使得在向元件施加能量时可以改变细长构件的形状。

13. 发明申请

US20060184092A1 Internal medical devices for delivery of therapeutic agent in conjunction with a source of electrical power 失效
公开(公告)号：US20060184092A1
公开(公告)日：2006-08-17
申请号：US11055930
申请日：2005-02-11
申请人： Liliana Atanasoska , Thomas Holman , Jan Weber , Robert Warner , Scott Schewe
发明人： Liliana Atanasoska , Thomas Holman , Jan Weber , Robert Warner , Scott Schewe
IPC分类号： A61N1/30
CPC分类号： A61N1/325 , A61N1/05 , A61N1/306 , A61N1/327
摘要： The invention generally relates to internal (e.g., implantable, insertable, etc.) drug delivery devices which contain the following: (a) one or more sources of one or more therapeutic agents; (b) one or more first electrodes, (c) one or more second electrodes and (d) one or more power sources for applying voltages across the first and second electrodes. The power sources may be adapted, for example, to promote electrically assisted therapeutic agent delivery within a subject, including electroporation and/or iontophoresis. In one aspect of the invention, the first and second electrodes are adapted to have tissue of a subject positioned between them upon deployment of the medical device within the subject, such that an electric field may be generated, which is directed into the tissue. Furthermore, the therapeutic agent sources are adapted to introduce the therapeutic agents into the electric field. In another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of ion-conductive polymers and one or more types of charged therapeutic agents. In yet another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of electrically conductive polymers and one or more types of charged therapeutic agents.

14. 发明授权

US08703168B2 Medical devices for releasing therapeutic agent and methods of making the same 有权
标题翻译：用于释放治疗剂的医疗装置及其制造方法
公开(公告)号：US08703168B2
公开(公告)日：2014-04-22
申请号：US12109677
申请日：2008-04-25
申请人： Aiden Flanagan , Robert Herrmann , Ken Merdan , Michael Kuehling , Barry O'Brien , Rajesh Radhakishnan , Torsten Scheuermann , Scott Schewe , Anurag Singhal , Young-Ho Song , Mary Joe Timm , Jan Weber , Yixin Xu
发明人： Aiden Flanagan , Robert Herrmann , Ken Merdan , Michael Kuehling , Barry O'Brien , Rajesh Radhakishnan , Torsten Scheuermann , Scott Schewe , Anurag Singhal , Young-Ho Song , Mary Joe Timm , Jan Weber , Yixin Xu
IPC分类号： A61F2/00
CPC分类号： A61F2/91 , A61F2/3094 , A61F2002/30677 , A61F2002/3068 , A61F2210/0076 , A61F2230/0013 , A61F2240/001 , A61F2250/0067 , A61F2250/0068
摘要： An implantable medical device for releasing therapeutic agent having a medical device body and a plurality of reservoir-defining structures disposed on a surface of the body. A reservoir can be defined by the reservoir-defining structures and therapeutic agent may be located in the reservoir. A cover may extend over the reservoir so that the therapeutic agent is released from the reservoir when the medical device implanted. Methods for making the medical device may also include providing a medical device body, positioning a plurality of reservoir-defining structures on a surface of the body to form a reservoir, loading therapeutic agent into the reservoir, and covering the reservoir so that the therapeutic agent may release when the medical device is implanted. Alternatively, the reservoir may be covered with a cover and an opening formed in the cover so that the therapeutic agent may release when the medical device is implanted.
摘要翻译：一种用于释放具有医疗装置主体的治疗剂的可植入医疗装置和设置在身体表面上的多个储存器限定结构。储存器可以由储存器限定结构限定，并且治疗剂可以位于储存器中。覆盖物可以延伸到储存器上方，使得当植入医疗装置时治疗剂从储存器释放。用于制造医疗装置的方法还可以包括提供医疗装置主体，在身体的表面上定位多个储存器限定结构以形成储存器，将治疗剂装载到储存器中并覆盖储存器，使得治疗剂当植入医疗器械时可能释放。或者，储存器可覆盖有形成在盖中的盖和开口，使得治疗剂可以在植入医疗装置时释放。

15. 发明授权

US08152759B2 Internal medical devices for delivery of therapeutic agent in conjunction with a source of electrical power 有权
标题翻译：用于与电力源一起递送治疗剂的内部医疗装置
公开(公告)号：US08152759B2
公开(公告)日：2012-04-10
申请号：US12077603
申请日：2008-03-20
申请人： Liliana Atanasoska , Thomas J. Holman , Jan Weber , Robert Warner , Scott Schewe
发明人： Liliana Atanasoska , Thomas J. Holman , Jan Weber , Robert Warner , Scott Schewe
IPC分类号： A61M29/00
CPC分类号： A61N1/325 , A61N1/05 , A61N1/306 , A61N1/327
摘要： The invention generally relates to internal (e.g., implantable, insertable, etc.) drug delivery devices which contain the following: (a) one or more sources of one or more therapeutic agents; (b) one or more first electrodes, (c) one or more second electrodes and (d) one or more power sources for applying voltages across the first and second electrodes. The power sources may be adapted, for example, to promote electrically assisted therapeutic agent delivery within a subject, including electroporation and/or iontophoresis. In one aspect of the invention, the first and second electrodes are adapted to have tissue of a subject positioned between them upon deployment of the medical device within the subject, such that an electric field may be generated, which is directed into the tissue. Furthermore, the therapeutic agent sources are adapted to introduce the therapeutic agents into the electric field. In another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of ion-conductive polymers and one or more types of charged therapeutic agents. In yet another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of electrically conductive polymers and one or more types of charged therapeutic agents.
摘要翻译：本发明一般涉及含有以下物质的内部（例如，可植入，可插入等）药物递送装置：（a）一种或多种一种或多种治疗剂来源; （b）一个或多个第一电极，（c）一个或多个第二电极和（d）用于在第一和第二电极上施加电压的一个或多个电源。电源可以适应于例如促进受试者内的电辅助治疗剂递送，包括电穿孔和/或离子电渗疗法。在本发明的一个方面中，第一和第二电极适于在医疗装置在受试者内展开时使被检体的组织位于它们之间，使得可以产生被引导到组织中的电场。此外，治疗剂源适于将治疗剂引入电场。另一方面，治疗剂来源是含有一种或多种类型的离子导电聚合物和一种或多种类型的带电治疗剂的聚合物区域。在另一方面，治疗剂来源是含有一种或多种类型的导电聚合物和一种或多种类型的带电治疗剂的聚合物区域。

16. 发明授权

US08070718B2 Medical devices formed with a sacrificial structure and processes of forming the same 有权
标题翻译：用牺牲结构形成的医疗器械及其形成方法
公开(公告)号：US08070718B2
公开(公告)日：2011-12-06
申请号：US11010810
申请日：2004-12-13
申请人： Jan Weber , Scott Schewe , Thomas J. Holman
发明人： Jan Weber , Scott Schewe , Thomas J. Holman
IPC分类号： A61M29/00 , B29C33/40
CPC分类号： A61M25/1029 , A61M25/0009 , A61M25/0045 , A61M25/1036 , A61M25/104 , A61M2025/1075 , A61M2025/1086
摘要： Medical devices formed using a sacrificial structure, and processes of forming the devices therefrom.
摘要翻译：使用牺牲结构形成的医疗器械，以及由其形成器件的工艺。

17. 发明申请

US20110251653A1 IMPLANTABLE ELECTRODES CONTAINING POLYOXOMETALATE ANIONS AND METHODS OF MANUFACTURE AND USE 审中-公开
标题翻译：含有聚羟基乙酸酯阴离子的可植入电极及其制造和使用方法
公开(公告)号：US20110251653A1
公开(公告)日：2011-10-13
申请号：US13166528
申请日：2011-06-22
申请人： Liliana Atanasoska , Jan Weber , Scott Schewe , Robert W. Warner
发明人： Liliana Atanasoska , Jan Weber , Scott Schewe , Robert W. Warner
IPC分类号： A61N1/05 , A61N1/36
CPC分类号： A61N1/372 , A61N1/05 , A61N1/0551 , A61N1/0553 , A61N1/36 , A61N1/37205
摘要： An implantable device includes at least one electrode comprising a conductive base and polyoxometalate anions disposed on or within the conductive base; and at least one conductor attached to the at least one electrode for conducting electrical energy to the at least one electrode.
摘要翻译：可植入装置包括至少一个电极，其包括设置在导电基底上或内部的导电基底和多金属氧酸盐阴离子; 以及至少一个连接到所述至少一个电极的导体，用于将电能传导到所述至少一个电极。

18. 发明授权

US07850645B2 Internal medical devices for delivery of therapeutic agent in conjunction with a source of electrical power 失效
标题翻译：用于与电力源一起递送治疗剂的内部医疗装置
公开(公告)号：US07850645B2
公开(公告)日：2010-12-14
申请号：US11055930
申请日：2005-02-11
申请人： Liliana Atanasoska , Thomas J. Holman , Jan Weber , Robert Warner , Scott Schewe
发明人： Liliana Atanasoska , Thomas J. Holman , Jan Weber , Robert Warner , Scott Schewe
IPC分类号： A61M29/00
CPC分类号： A61N1/325 , A61N1/05 , A61N1/306 , A61N1/327
摘要： The invention generally relates to internal (e.g., implantable, insertable, etc.) drug delivery devices which contain the following: (a) one or more sources of one or more therapeutic agents; (b) one or more first electrodes, (c) one or more second electrodes and (d) one or more power sources for applying voltages across the first and second electrodes. The power sources may be adapted, for example, to promote electrically assisted therapeutic agent delivery within a subject, including electroporation and/or iontophoresis. In one aspect of the invention, the first and second electrodes are adapted to have tissue of a subject positioned between them upon deployment of the medical device within the subject, such that an electric field may be generated, which is directed into the tissue. Furthermore, the therapeutic agent sources are adapted to introduce the therapeutic agents into the electric field. In another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of ion-conductive polymers and one or more types of charged therapeutic agents. In yet another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of electrically conductive polymers and one or more types of charged therapeutic agents.
摘要翻译：本发明一般涉及含有以下物质的内部（例如，可植入，可插入等）药物递送装置：（a）一种或多种一种或多种治疗剂来源; （b）一个或多个第一电极，（c）一个或多个第二电极和（d）用于在第一和第二电极上施加电压的一个或多个电源。电源可以适应于例如促进受试者内的电辅助治疗剂递送，包括电穿孔和/或离子电渗疗法。在本发明的一个方面中，第一和第二电极适于在医疗装置在受试者内展开时使被检体的组织位于它们之间，使得可以产生被引导到组织中的电场。此外，治疗剂源适于将治疗剂引入电场。另一方面，治疗剂来源是含有一种或多种类型的离子导电聚合物和一种或多种类型的带电治疗剂的聚合物区域。在另一方面，治疗剂来源是含有一种或多种类型的导电聚合物和一种或多种类型的带电治疗剂的聚合物区域。

19. 发明申请

US20070244501A1 Medical balloons 审中-公开
标题翻译：医用气球
公开(公告)号：US20070244501A1
公开(公告)日：2007-10-18
申请号：US11406022
申请日：2006-04-18
申请人： Daniel Horn , John Jianhua Chen , John Blix , Jan Weber , Angela Volk , Richard Gunderson , Daniel Tomaschko , Scott Schewe
发明人： Daniel Horn , John Jianhua Chen , John Blix , Jan Weber , Angela Volk , Richard Gunderson , Daniel Tomaschko , Scott Schewe
IPC分类号： A61M29/00
CPC分类号： A61M25/10 , A61L29/085 , A61L29/123 , A61L29/126 , A61M25/1029 , A61M25/1038 , A61M2025/1031 , A61M2025/1075 , A61M2025/1088
摘要： Described herein are medical balloons which contain one or more material regions that are configured to cause the balloons to preferentially fold into predetermined orientations upon deflation.
摘要翻译：这里描述的是包含一个或多个材料区域的医疗气囊，其被构造成使得气囊在放气时优先折叠成预定取向。

20. 发明授权

US08852146B2 Reinforced medical balloon 有权
标题翻译：加强医疗气球
公开(公告)号：US08852146B2
公开(公告)日：2014-10-07
申请号：US13285518
申请日：2011-10-31
申请人： Daniel J. Horn , John Jianhua Chen , Jan Weber , Thomas J. Holman
发明人： Daniel J. Horn , John Jianhua Chen , Jan Weber , Thomas J. Holman
IPC分类号： A61M25/10 , A61L29/12 , A61F2/958
CPC分类号： A61M25/104 , A61F2002/9583 , A61F2250/0068 , A61L29/126 , A61M2025/1086
摘要： The invention relates to medical balloons, and methods of modifying said balloons by forming a void pattern in their exterior surfaces and filling the voids with a material, such as a fiber or a nanomaterial (e.g., nanotubes, such as carbon nanotubes) and a matrix material, e.g., a polymer.
摘要翻译：本发明涉及医用气囊，以及通过在其外表面上形成空隙图案并用诸如纤维或纳米材料（例如纳米管，例如碳纳米管）和基体材料，例如聚合物。

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