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11. 发明申请

US20110033506A1 COMBINATION DOSAGE FORM OF LOW-DOSE MODAFINIL AND LOW-DOSE SILDENAFIL 审中-公开
标题翻译：低剂量阿司匹林和低剂量硅藻的组合剂量形式
公开(公告)号：US20110033506A1
公开(公告)日：2011-02-10
申请号：US12865727
申请日：2009-02-08
申请人： Adel Penhasi , Janina Gauchman , Amanda Shauli , Marina Ruderman , Avi Avramoff
发明人： Adel Penhasi , Janina Gauchman , Amanda Shauli , Marina Ruderman , Avi Avramoff
IPC分类号： A61K9/00 , A61K31/165 , A61K31/496 , A61P25/00 , A61P29/00
CPC分类号： A61K9/2866 , A61K9/284 , A61K9/4808 , A61K31/165 , A61K31/519
摘要： Modified release formulations comprising at least one of modafinil and sildenafil, and combinations thereof, and a time-controlled delivery system coating.
摘要翻译：包含莫达非尼和西地那非或其组合中的至少一种的调释释放制剂和时间控制的递送系统涂层。

12. 发明申请

US20130323362A1 COMPOSITION AND METHOD FOR IMPROVING STABILITY AND EXTENDING SHELF LIFE OF PROBIOTIC BACTERIA AND FOOD PRODUCTS THEREOF 审中-公开
标题翻译：用于改善生物细菌和食品的稳定性和延长寿命的组合物和方法
公开(公告)号：US20130323362A1
公开(公告)日：2013-12-05
申请号：US13991911
申请日：2011-12-05
申请人： Adel Penhasi
发明人： Adel Penhasi
IPC分类号： A23L1/30 , C12N1/04
CPC分类号： A23L33/135 , A21D8/045 , A23P10/30 , A23P10/35 , A23V2002/00 , A61K9/4858 , A61K9/5015 , A61K9/5031 , A61K9/5036 , A61K9/5042 , A61K9/5073 , A61K35/745 , A61K2035/115 , C12N1/04 , A23V2200/3204 , A23V2250/0616 , A23V2250/5114 , A23V2250/636
摘要： A composition comprising probiotic bacteria, the composition comprising: (a) a core composition containing the probiotic bacteria and a stabilizer, wherein the total amount of probiotics in the mixture is from about 10% to about 90% by weight of the core composition; (b) an innermost coating layer, layered on said core composition, comprising at least one hydrophobic solid fat or fatty acid having a melting point lower than 60° C.; (c) an intermediate coating layer layered on said innermost coating layer, which when present in an aqueous solution in the amount of 0.1% weight/weight over the weight of the solution, has a surface tension lower than 60 mN/m, when measured at 25° C.; and (d) an outer coating layer, layered on said intermediate coating layer; wherein the composition is in the form of particles; food products containing the composition and methods of preparation thereof.
摘要翻译：一种包含益生菌的组合物，所述组合物包含：（a）含有益生菌和核心组合物的核心组合物，其中混合物中益生菌的总量为核心组合物重量的约10％至约90％; （b）层叠在所述芯组合物上的最内层，包含至少一种熔点低于60℃的疏水固体脂肪或脂肪酸; （c）层叠在所述最内层的中间涂层，当以溶液重量计为0.1重量/重量的量存在于水溶液中时，其表面张力低于60mN / m 在25°C。和（d）层叠在所述中间涂层上的外涂层; 其中所述组合物为颗粒形式; 含有组合物的食品及其制备方法。

13. 发明申请

US20100303962A1 PROCESS FOR PREPARING BAKEABLE PROBIOTIC FOOD 审中-公开
标题翻译：制备可食用的生物食品的方法
公开(公告)号：US20100303962A1
公开(公告)日：2010-12-02
申请号：US12788176
申请日：2010-05-26
申请人： Adel Penhasi , Yohai Zorea , Carmit Zorea
发明人： Adel Penhasi , Yohai Zorea , Carmit Zorea
IPC分类号： A23L1/30 , A23L3/44
CPC分类号： A21D8/045 , A21D10/005 , A23G1/42 , A23L3/44 , A23L33/135 , A23L33/30 , A23P10/30 , A23P10/35 , A23V2002/00 , A61K35/741 , A61K35/744 , A61K35/745 , A61K35/747 , A61K2035/115 , A23V2200/224 , A23V2200/3204 , A23V2250/194 , A23V2250/5026 , A23V2250/511 , A23V2200/3202 , A23V2200/32 , A23V2250/5114 , A23V2250/51084 , A23V2250/636
摘要： Heat-processed health food is provided, as well as a process for making it, the food being particularly probiotic pastry which comprises a probiotic component capable of resisting baking heat, and so it beneficially affects the consumer's intestinal microbial balance.
摘要翻译：提供热加工的保健食品以及其制备方法，该食品特别是益生菌糕点，其包含能够抵抗烘烤热的益生菌成分，因此有利地影响消费者的肠微生物平衡。

14. 发明申请

US20090196889A1 CONTROLLED ABSORPTION OF STATINS IN THE INTESTINE 审中-公开
标题翻译：控制在INTESTINE中吸收统计数据
公开(公告)号：US20090196889A1
公开(公告)日：2009-08-06
申请号：US11719786
申请日：2005-11-22
申请人： Adel Penhasi
发明人： Adel Penhasi
IPC分类号： A61K9/00 , A61K9/28 , A61K31/351
CPC分类号： A61K9/2886 , A61K9/2013 , A61K9/2846 , A61K9/2866 , A61K31/401
摘要： The present invention provides a controlled absorption formulation in which modified release of active ingredient preferentially occurs in the lower gastrointestinal tract, including the colon. The formulation supports a significantly higher bioavailability of the active ingredient into the body of the subject than can be achieved from the currently used conventional formulation, such that therapeutically significant plasma levels of statin are maintained for an extended period after administration. The formulation preferably features a core over which an outer coating is layered. The core is optionally and preferentially in the form of a tablet.
摘要翻译：本发明提供了受控吸收制剂，其中活性成分的改性释放优先发生在下胃肠道，包括结肠中。制剂支持活性成分比目前使用的常规制剂可以获得的活性成分显着更高的生物利用度，使得他汀在施用后长时间内维持治疗上显着的血浆水平。制剂优选具有芯，其上层叠有外涂层。核心可选地且优选为片剂形式。

15. 发明授权

US06531152B1 Immediate release gastrointestinal drug delivery system 失效
标题翻译：延迟总释放胃肠道药物输送系统
公开(公告)号：US06531152B1
公开(公告)日：2003-03-11
申请号：US09694314
申请日：2000-10-24
申请人： E. Itzhak Lerner , Moshe Flashner , Adel Penhasi
发明人： E. Itzhak Lerner , Moshe Flashner , Adel Penhasi
IPC分类号： A61K920
CPC分类号： A61K9/286 , A61K9/205 , A61K9/2866
摘要： A gastrointestinal delivery system is provided. The system comprises a drug in combination with a swellable core material, the core being surrounded by a water-insoluble or relatively water-insoluble coating material in which particulate water-insoluble material is embedded. When the delivery device enters the gastrointestinal tract, the particulate matter takes up liquid, thus forming channels interconnecting the drug-containing core with the outside of the delivery device. Through these channels liquid enters the core which then swells to the point at which the coating is broken. When the integrity of the coating is destroyed, the core then disintegrates immediately releasing all or most of the drug at a specific site. By controlling parameters in the device, such as the core material, carrier material in the coating, and particulate matter, the location of release of the drug can be carefully controlled. Thus, the invention is also directed to a method of using the device for the treatment of disease by the release of drugs in the gastrointestinal tract in a location- and time-dependent manner.
摘要翻译：提供胃肠输送系统。该系统包括与可溶胀核心材料组合的药物，该核心被水不溶性或相对不溶于水的不溶性材料包围，其中嵌入有颗粒状水不溶性材料。当输送装置进入胃肠道时，颗粒物质吸收液体，从而形成将含药物核心与输送装置的外部相互连接的通道。通过这些通道，液体进入芯，然后膨胀到涂层破裂的点。当涂层的完整性被破坏时，核心然后在特定部位立即分解所有或大部分药物。通过控制装置中的参数，例如芯材料，涂层中的载体材料和颗粒物质，可以仔细地控制药物的释放位置。因此，本发明还涉及一种使用该装置通过以位置和时间依赖的方式在胃肠道中释放药物来治疗疾病的方法。

16. 发明授权

US09961910B2 Process for preparing bakeable probiotic food 有权
公开(公告)号：US09961910B2
公开(公告)日：2018-05-08
申请号：US12788176
申请日：2010-05-26
申请人： Adel Penhasi , Yohai Zorea , Carmit Zorea
发明人： Adel Penhasi , Yohai Zorea , Carmit Zorea
IPC分类号： A61K35/741 , A23L33/135 , A21D8/04 , A23L3/44 , A23L33/00 , A23L33/15
CPC分类号： A21D8/045 , A21D10/005 , A23G1/42 , A23L3/44 , A23L33/135 , A23L33/30 , A23P10/30 , A23P10/35 , A23V2002/00 , A61K35/741 , A61K35/744 , A61K35/745 , A61K35/747 , A61K2035/115 , A23V2200/224 , A23V2200/3204 , A23V2250/194 , A23V2250/5026 , A23V2250/511 , A23V2200/3202 , A23V2200/32 , A23V2250/5114 , A23V2250/51084 , A23V2250/636
摘要： Heat-processed health food is provided, as well as a process for making it, the food being particularly probiotic pastry which comprises a probiotic component capable of resisting baking heat, and so it beneficially affects the consumer's intestinal microbial balance.

17. 发明申请

US20110111026A1 HUMIDITY-RESISTANT DRUG FORMULATIONS AND METHODS OF PREPARATION THEREOF 审中-公开
标题翻译：抗湿性药物制剂及其制备方法
公开(公告)号：US20110111026A1
公开(公告)日：2011-05-12
申请号：US12933843
申请日：2009-03-10
申请人： Adel Penhasi , Yaakov Stephane Attali
发明人： Adel Penhasi , Yaakov Stephane Attali
IPC分类号： A61K9/30 , A61K9/32 , A61K9/40 , A61K9/36 , A61K31/40 , A61P9/00 , B05D1/36
CPC分类号： A61K9/2886 , A61K9/5073 , A61K31/40
摘要： The invention relates to a pharmaceutical composition of a humidity-sensitive core comprising an active ingredient or pharmaceutically acceptable salt thereof; a coating over the core, the coating containing a cationic polymer; and an additional coating over the cationic polymer-containing coating, with the additional coating including an acidifying agent. Also, methods for preparing such compositions wherein a cationic polymer containing coating is applied over a humidity-sensitive core that contains the active ingredient or pharmaceutically acceptable salt thereof; and then an additional coating is applied over the cationic polymer containing coating.
摘要翻译：本发明涉及包含活性成分或其药学上可接受的盐的湿敏性核心的药物组合物; 在芯上的涂层，所述涂层含有阳离子聚合物; 以及在含阳离子聚合物的涂层上的另外的涂层，附加涂层包括酸化剂。此外，制备这种组合物的方法，其中将含阳离子聚合物的涂层施用于含有活性成分或其药学上可接受的盐的湿度敏感的核心上; 然后在包含阳离子聚合物的涂层上施加另外的涂层。

18. 发明申请

US20110052648A1 ORAL MODIFIED-RELEASE FORMULATIONS CONTAINING THIAZEPINES 审中-公开
标题翻译：含有THIAZEPINES的口服修饰释放配方
公开(公告)号：US20110052648A1
公开(公告)日：2011-03-03
申请号：US12921168
申请日：2009-03-09
申请人： Avi Avramoff , Adel Penhasi , Orly Einav-Rubashkin , Ron Schlinger
发明人： Avi Avramoff , Adel Penhasi , Orly Einav-Rubashkin , Ron Schlinger
IPC分类号： A61K31/554 , A61K9/00 , A61P25/22 , A61P25/18 , A61P25/24
CPC分类号： A61K9/1635 , A61K9/284 , A61K9/2846 , A61K31/554
摘要： An oral modified-release formulation using Quetiapine or pharmaceutically acceptable salts thereof as an active ingredient, while avoiding the use of a gelling material. As used herein, the term “modified release” includes but is not limited to one or more of controlled release, sustained release, prolonged release and extended release.
摘要翻译：使用喹硫平或其药学上可接受的盐作为活性成分的口服改良释放制剂，同时避免使用胶凝材料。如本文所用，术语“修饰释放”包括但不限于控制释放，缓释，延长释放和延长释放中的一种或多种。

19. 发明授权

US07410498B2 Polymeric stents and other surgical articles 失效
标题翻译：聚合物支架和其他外科用品
公开(公告)号：US07410498B2
公开(公告)日：2008-08-12
申请号：US10312712
申请日：2001-06-26
申请人： Adel Penhasi
发明人： Adel Penhasi
IPC分类号： A61F2/06
CPC分类号： A61L31/148 , A61F2/86 , A61F2/91 , A61L31/146
摘要： A biocompatible non-memory expandable polymeric article selected from stents, implantable prostheses, catheters, other surgical articles and sealants for implantable prostheses, and which is at least in part biodegradable and includes a combination where hollow cylindrical element (2) is depicted in cutaway form to reveal helical element (4), terminated schematically at (6) and where a combination of at least one thermoplastic elastomeric component and at least one thermoplastic non-elastomeric component, the article being either porous articles or having the potential to become porous by action of body fluids in situ), the thermoplastic non-elastomeric component being present in such an amount as will provide mechanical strength and rigidity to the article when in an expanded mode.
摘要翻译：选自支架，可植入假体，导管，其他手术用品和用于可植入假体的密封剂的生物相容性非记忆可扩张聚合物制品，并且其至少部分可生物降解且包括中空圆柱形元件（2）以剖面形式描绘的组合以揭示螺旋元件（4），其在（6）处示意性地终止，并且其中至少一种热塑性弹性体组分和至少一种热塑性非弹性体组分的组合，所述制品是多孔制品或具有通过作用变得多孔的潜力的体液），所述热塑性非弹性体组分以这样的量存在，当处于膨胀模式时将为制品提供机械强度和刚度。

20. 发明授权

US06231888B1 Local delivery of non steroidal anti inflammatory drugs (NSAIDS) to the colon as a treatment for colonic polyps 失效
标题翻译：将非甾体抗炎药（NSAIDS）局部递送至结肠作为结肠息肉的治疗
公开(公告)号：US06231888B1
公开(公告)日：2001-05-15
申请号：US09190127
申请日：1998-11-12
申请人： E. Itzhak Lerner , Moshe Flashner , Adel Penhasi
发明人： E. Itzhak Lerner , Moshe Flashner , Adel Penhasi
IPC分类号： A61K920
CPC分类号： A61K31/606 , A61K9/2027 , A61K9/205 , A61K9/284 , A61K9/2846 , A61K9/286 , A61K31/192 , A61K31/196
摘要： A composition and method for the treatment of polyp and colon cancer is described, such composition and method providing for the colonic delivery and/or preferential metabolism of a drug or desired agent, especially an NSAID, in the colon of the patient in need such treatment.
摘要翻译：描述了用于治疗息肉和结肠癌的组合物和方法，所述组合物和方法提供了在需要这种治疗的患者的结肠中药物或所需试剂，特别是NSAID的结肠递送和/或优先代谢。

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