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11. 发明授权

US08452363B2 Device for measuring an analyte in an eye fluid 有权
标题翻译：用于测量眼液中分析物的装置
公开(公告)号：US08452363B2
公开(公告)日：2013-05-28
申请号：US12374866
申请日：2007-07-23
申请人： Achim Müller , Peter Herbrechtsmeier , Klaus Haberstroh , Roman Gruler
发明人： Achim Müller , Peter Herbrechtsmeier , Klaus Haberstroh , Roman Gruler
IPC分类号： A61B5/00 , A61B3/00 , A61B3/10
CPC分类号： A61B5/1455 , A61B5/14532 , A61B2560/0223
摘要： The invention proposes a manual measuring appliance (112) and an analytical measuring system (110) which can be used to measure at least one analyte in an eye fluid of an eye (114). The handheld measuring appliance (112) comprises a measuring system (120) and a positioning system (122). The measuring system (120) can measure at least one property of the at least one analyte and/or at least one analyte-dependent change of property of at least one ocular sensor (116) in the eye fluid, and this can be used to infer a concentration of the analyte in the eye fluid. The positioning system (122) is set up to measure a spatial positioning, wherein the spatial positioning comprises a distance between at least one measurement location in the eye (114) and the handheld measuring appliance (112) and also furthermore at least one further positioning co-ordinate. Furthermore, the handheld measuring appliance comprises a calibration system (128), wherein the calibration system (128) is set up to perform a comparison measurement of at least one analyte concentration in a body fluid and/or to adopt measurement data from a comparison measurement performed using a separate measuring appliance and to take them into account when determining the concentration of the at least one analyte.
摘要翻译：本发明提出了一种手动测量仪器（112）和分析测量系统（110），其可用于测量眼睛（114）的眼睛液体中的至少一种分析物。手持式测量仪器（112）包括测量系统（120）和定位系统（122）。测量系统（120）可以测量眼液中至少一种分析物的至少一种性质和/或至少一种分析物依赖的至少一种眼睛传感器（116）的性质变化，并且这可以用于推断眼液中分析物的浓度。定位系统（122）被设置为测量空间定位，其中空间定位包括眼睛（114）中的至少一个测量位置与手持式测量仪器（112）之间的距离，此外还包括至少一个另外的定位坐标。此外，手持式测量仪器包括校准系统（128），其中设置校准系统（128）以对体液中的至少一种分析物浓度进行比较测量和/或采用来自比较测量的测量数据使用单独的测量仪器执行，并在确定至少一种分析物的浓度时考虑它们。

12. 发明申请

US20100331634A1 HYDROGEL IMPLANT FOR SENSING METABOLITES IN BODY TISSUE 有权
标题翻译：用于感染身体组织中代谢物的HYDROGEL植入物
公开(公告)号：US20100331634A1
公开(公告)日：2010-12-30
申请号：US12601524
申请日：2008-05-23
申请人： Achim Müller , Peter Herbrechtsmeier , Monika Knuth , Katharina Nikolaus
发明人： Achim Müller , Peter Herbrechtsmeier , Monika Knuth , Katharina Nikolaus
IPC分类号： A61B5/145
CPC分类号： A61B5/1459 , A61B5/14532 , G01N21/77 , G01N2021/773 , G01N2021/7786
摘要： An implant (110) for detecting at least one analyte (126) in a body fluid, in particular an eye fluid, is proposed. The implant (110) is designed to be implanted in a tissue layer and/or a chamber of an eye of a patient, the implant (110) having a hydrogel matrix (110) with at least one hydrogel (114). The implant (110) also has sensor particles (116) dispersed in the hydrogel matrix (110), the sensor particles (116) having at least one sensor matrix (120) with a sensor matrix material (122) and at least one sensor material (124).
摘要翻译：提出了用于检测体液中的至少一种分析物（126）的植入物（110），特别是眼液。植入物（110）设计成植入患者眼睛的组织层和/或腔室中，植入物（110）具有至少一种水凝胶（114）的水凝胶基体（110）。植入物（110）还具有分散在水凝胶基质（110）中的传感器颗粒（116），传感器颗粒（116）具有至少一个具有传感器基体材料（122）的传感器矩阵（120）和至少一个传感器材料（124）。

13. 发明授权

US10429380B2 Device comprising a hydrogel having a glucose-binding protein and a ligand of the glucose-binding protein incorporated therein 有权
公开(公告)号：US10429380B2
公开(公告)日：2019-10-01
申请号：US13993556
申请日：2011-12-13
申请人： Achim Müller , Peter Herbrechtsmeier , Monika Knuth , Katharina Nikolaus
发明人： Achim Müller , Peter Herbrechtsmeier , Monika Knuth , Katharina Nikolaus
IPC分类号： G01N33/543 , G01N33/542 , G01N33/66
摘要： The present invention relates to measures for determining glucose and for diagnosing diseases based on impaired glucose metabolism. In particular the present invention relates to a device comprising a hydrogel having a glucose-binding protein and a ligand of the glucose-binding protein incorporated therein, wherein the hydrogel comprises a first hydrogel matrix made of alginate and a second hydrogel matrix which forms an interpenetrating network within the first hydrogel matrix. The invention further relates to the use of such a device for determining the glucose content in a sample and to the use of the device for diagnosing impaired glucose metabolism in a test subject.

14. 发明授权

US08945942B2 Stabilization of bio-sensors for in vivo applications 有权
标题翻译：用于体内应用的生物传感器的稳定化
公开(公告)号：US08945942B2
公开(公告)日：2015-02-03
申请号：US13503599
申请日：2010-10-25
申请人： Peter Herbrechtsmeier , Achim Müller , Monika Knuth , Katharina Nikolaus
发明人： Peter Herbrechtsmeier , Achim Müller , Monika Knuth , Katharina Nikolaus
IPC分类号： G01N33/66 , C07K14/42
CPC分类号： C07K14/42 , C07K14/4726 , G01N33/66 , Y10S436/827
摘要： The present invention relates to the use of preparations for stabilizing isolated proteins. In particular, the use of such a preparation for stabilizing receptors in biochemical sensors is disclosed. The invention in addition relates to biochemical sensors containing such preparations.
摘要翻译：本发明涉及用于稳定分离的蛋白质的制剂的用途。特别地，公开了在生物化学传感器中使用这种用于稳定受体的制剂。本发明还涉及含有这种制剂的生化传感器。

15. 发明授权

US06627124B1 Single mould alignment 有权
标题翻译：单模对准
公开(公告)号：US06627124B1
公开(公告)日：2003-09-30
申请号：US09530073
申请日：2000-12-14
申请人： Peter Herbrechtsmeier , Peter Hagmann , Roger Biel , Axel Heinrich , Wilhelm Hörner , Egbert Jux , Anette Therese Lang-Schöll , Iris Jlona Leder-Brück , Achim Müller , Bernhard Seiferling , Werner Steffan
发明人： Peter Herbrechtsmeier , Peter Hagmann , Roger Biel , Axel Heinrich , Wilhelm Hörner , Egbert Jux , Anette Therese Lang-Schöll , Iris Jlona Leder-Brück , Achim Müller , Bernhard Seiferling , Werner Steffan
IPC分类号： B29D1100
CPC分类号： B29D11/00125 , B29C35/02 , B29C35/0888 , B29C2035/0827 , B29C2035/085 , B29C2035/0877 , B29K2909/08 , Y10S425/808
摘要： The invention tackles the problem of improving the production process for contact lenses further, so that the production costs for contact lenses can be reduced further and the production capacities can be increased. To this end, provision is made for the two mould halves, which together form the mould for producing a contact lens, to be fixed to each other and/or detachably connected to each other by means of individual half-mould guide. In conjunction with a cyclic production process, a high degree of automation can be achieved in this way.
摘要翻译：本发明还解决了进一步改进隐形眼镜的制造工艺的问题，能够进一步降低隐形眼镜的制造成本，提高生产能力。为此，为了通过单独的半模引导件彼此固定和/或可拆卸地彼此固定的两个半模一起形成用于制造隐形眼镜的模具。结合循环生产过程，可以以这种方式实现高度的自动化。

16. 发明授权

US06342570B1 Cross-linkable copolymers and hydrogels 有权
标题翻译：可交联的共聚物和水凝胶
公开(公告)号：US06342570B1
公开(公告)日：2002-01-29
申请号：US09280789
申请日：1999-03-26
申请人： Harald Bothe , Achim Müller , Bernhard Seiferling , Sharla Borghorst , John Golby , Peter Hagmann , Peter Herbrechtsmeier , Otto Kretzschmar
发明人： Harald Bothe , Achim Müller , Bernhard Seiferling , Sharla Borghorst , John Golby , Peter Hagmann , Peter Herbrechtsmeier , Otto Kretzschmar
IPC分类号： C08F2608
CPC分类号： C08F293/005 , C08F8/00 , C08F226/06 , C08F226/10 , C08F2810/30 , C08F2220/281 , C08F2220/343 , C08F220/36 , C08F220/14 , C08F2220/325
摘要： The present invention describes novel statistical copolymers and the preparation and possible uses thereof. Copolymers are described that are water-soluble and cross-linkable and that comprise the copolymerization product of a monomer mixture consisting substantially of a vinyl lactam (a) and at least one further vinyl monomer (b) of a different type selected from the group consisting of hydrophobic, hydrophilic and functional vinyl monomers, wherein the monomers are present in the copolymer in the form of statistically distributed building blocks, and, if a functional vinyl monomer is present as a building block in the copolymer, that building block is, where appropriate, modified with a reactive vinyl monomer (c), the reactive vinyl monomer (c) being linked to a building block of a functional vinyl monomer with retention of its vinylic group and with the formation of a covalent bond.
摘要翻译：本发明描述了新的统计共聚物及其制备及其可能用途。描述了共聚物是水溶性和可交联的，并且包含基本上由乙烯基内酰胺（a）和至少一种另外的不同类型的乙烯基单体（b）组成的单体混合物的共聚产物，其选自的疏水性，亲水性和功能性的乙烯基单体，其中单体以统计分布的结构单元的形式存在于共聚物中，并且如果官能的乙烯基单体作为共聚物中的结构单元存在，则该结构单元在适当的情况下，用反应性乙烯基单体（c）改性，反应性乙烯基单体（c）与保持其乙烯基基团并形成共价键的官能乙烯基单体的结构单元连接。

17. 发明申请

US20120156361A1 METHOD FOR COATING SILICONE HYDROGELS 有权
标题翻译：涂层硅胶的方法
公开(公告)号：US20120156361A1
公开(公告)日：2012-06-21
申请号：US13403335
申请日：2012-02-23
申请人： Achim Müller , Monika Knuth , Ralf Pasternack , Jens Zotzel , Christine Reiff
发明人： Achim Müller , Monika Knuth , Ralf Pasternack , Jens Zotzel , Christine Reiff
IPC分类号： B05D3/10
CPC分类号： B29D11/00865 , G02B1/043 , Y10S514/839
摘要： The invention relates to a process for producing biomedical articles, in particular, silicone hydrogel contact lenses having durable hydrophilic chitosan coating. The chitosan coating is covalently attached to the medical device by performing a crosslinking reaction between chitosan and the carboxylic groups on the surface of a medical device directly in a sealed package during autoclave. The coated biomedical articles obtainable by the process of the invention have desirable characteristics regarding adherence to the substrate, durability, hydrophilicity, wettability, biocompatibility and permeability and are thus especially useful in the field of ophthalmic devices.
摘要翻译：本发明涉及一种用于生产生物医学制品的方法，特别是具有持久的亲水性壳聚糖涂层的硅酮水凝胶隐形眼镜。壳聚糖涂层通过在高压釜中直接在密封包装中在壳聚糖和医疗器械表面上的羧基之间进行交联反应而共价连接到医疗装置上。通过本发明的方法可获得的涂覆的生物医学制品具有关于对基底的粘附，耐久性，亲水性，润湿性，生物相容性和渗透性的期望特性，因此在眼科装置领域中特别有用。

18. 发明申请

US20110033147A1 Bearing Assembly 有权
标题翻译：轴承总成
公开(公告)号：US20110033147A1
公开(公告)日：2011-02-10
申请号：US12817056
申请日：2010-06-16
申请人： Rico Dittmar , Thilo Beck , Gerhard Haas , Michael Kummert , Achim Müller , Bernd Stephen , Arno Stubenrauch , Peter Volpert , Thomas Will
发明人： Rico Dittmar , Thilo Beck , Gerhard Haas , Michael Kummert , Achim Müller , Bernd Stephen , Arno Stubenrauch , Peter Volpert , Thomas Will
IPC分类号： F16C19/34
CPC分类号： F16C19/56 , F16C19/364 , F16C19/548 , F16C35/067 , F16C41/04 , F16C2229/00 , F16C2326/02
摘要： A bearing assembly includes a first bearing comprising a first inner ring and a second bearing comprising a second inner ring. A sleeve-shaped spacer is disposed between and axially separates the first and second inner rings. An adhesive connects the spacer to the first and second inner rings.
摘要翻译：轴承组件包括包括第一内圈的第一轴承和包括第二内圈的第二轴承。套筒形间隔件设置在第一和第二内圈之间并且轴向地分离第一和第二内圈。粘合剂将间隔件连接到第一和第二内圈。

19. 发明授权

US07429465B2 Process for analyzing tear fluid 有权
标题翻译：撕裂液分析方法
公开(公告)号：US07429465B2
公开(公告)日：2008-09-30
申请号：US10653866
申请日：2003-09-03
申请人： Achim Müller , Roland Schmieder , Katharina Schmid
发明人： Achim Müller , Roland Schmieder , Katharina Schmid
IPC分类号： G01N33/00 , A61B5/00
CPC分类号： G01N33/487 , A61B2010/0067
摘要： The present invention concerns a process for analyzing an analyte in a hydrogel contact lens following its wear on the eye, comprising the steps of (a) physically or chemically inducing a volume reduction of the hydrogel contact lens and thereby squeezing the analyte out of the polymer material making up the contact lens and (b) feeding the analyte obtained according to step (a) into an analyzer. The process of the invention provides a new concept for noninvasively measuring various analytes occurring in the tear fluid that is comfortable to the user.
摘要翻译：本发明涉及一种用于分析水凝胶隐形眼镜在眼睛上的磨损后的分析物的方法，包括以下步骤：（a）物理或化学诱导水凝胶隐形眼镜的体积减少，从而将分析物挤出聚合物构成隐形眼镜的材料和（b）将根据步骤（a）获得的分析物进料到分析器中。本发明的方法提供了用于非侵入性地测量在用户舒适的泪液中出现的各种分析物的新概念。

20. 发明授权

US08632255B2 Bearing assembly 有权
标题翻译：轴承总成
公开(公告)号：US08632255B2
公开(公告)日：2014-01-21
申请号：US12817056
申请日：2010-06-16
申请人： Rico Dittmar , Thilo Louis Beck , Gerhard Haas , Michael Kummert , Achim Müller , Bernd Stephan , Arno M. Stubenrauch , Peter Volpert , Thomas Will
发明人： Rico Dittmar , Thilo Louis Beck , Gerhard Haas , Michael Kummert , Achim Müller , Bernd Stephan , Arno M. Stubenrauch , Peter Volpert , Thomas Will
IPC分类号： F16C23/10 , F16C19/40 , F16C27/04
CPC分类号： F16C19/56 , F16C19/364 , F16C19/548 , F16C35/067 , F16C41/04 , F16C2229/00 , F16C2326/02
摘要： A bearing assembly includes a first bearing comprising a first inner ring and a second bearing comprising a second inner ring. A sleeve-shaped spacer is disposed between and axially separates the first and second inner rings. An adhesive connects the spacer to the first and second inner rings.
摘要翻译：轴承组件包括包括第一内圈的第一轴承和包括第二内圈的第二轴承。套筒形间隔件设置在第一和第二内圈之间并且轴向地分离第一和第二内圈。粘合剂将间隔件连接到第一和第二内圈。

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