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11. 发明申请

US20190084927A1 1-[1-(BENZOYL)-PYRROLIDINE-2-CARBONYL]-PYRROLIDINE-2-CARBONITRILE DERIVATIVES 审中-公开
公开(公告)号：US20190084927A1
公开(公告)日：2019-03-21
申请号：US16142907
申请日：2018-09-26
申请人： UNIVERSITAT DE BARCELONA , FUNDACIÓ INSTITUT DE RECERCA BIOMÈDICA (IRB BARCELONA) , IPROTEOS S.L.
发明人： Ernest Giralt Lledó , Teresa Tarragó Clua , Roger Prades Cosano , Soledad Royo Gracia
IPC分类号： C07D207/16 , C07D403/06
摘要： The present invention relates to 1-[1-(benzoyl )-pyrrolidine-2-carbonyl]-pyrrolidine-2-carbonitrile derivatives having pharmacological activity formula (I) to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy and/or prophylaxis of a cognitive disorder.

12. 发明申请

US20180313688A1 SIGNAL PROCESSING METHOD FOR HISTOGRAM GENERATION, AND CORRESPONDING DEVICE AND USE 审中-公开
公开(公告)号：US20180313688A1
公开(公告)日：2018-11-01
申请号：US15768084
申请日：2016-10-20
申请人： UNIVERSITAT DE BARCELONA
发明人： Angel DIEGUEZ BARRIENTOS , Oscar ALONSO CASANOVAS , Joan CANALS GIL , Eva VILELLA FIGUERAS
IPC分类号： G01J1/02 , G01J1/46
CPC分类号： G01J1/0238 , G01J1/46 , G01J2001/442 , G01J2001/4466 , H03K5/1534 , H03K5/19
摘要： Signal processing method for histogram generation, and corresponding device and use. The method generates the histogram from a plurality of event detectors that generate event signals as a response to external events, and are connected to a current injection module which is connected to a plurality of capacitors, wherein each histogram bin is univocally assigned to a capacitor. The method includes: during an event time interval corresponding to a bin, the event detectors generate event signals as a response to external events; the current injection module detects said event signals and, for each event signal, generates a corresponding current signal, which is injected in a capacitor assigned to said bin, and stored therein; repeating steps for each successive bin of said histogram; and reading the charge accumulated in each of said capacitors.

13. 发明申请

US20180154106A1 Physiological Response 审中-公开
公开(公告)号：US20180154106A1
公开(公告)日：2018-06-07
申请号：US15883692
申请日：2018-01-30
申请人： UNIVERSITAT DE BARCELONA , INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS , INSTITUT D'INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER (IDIBAPS)
发明人： Mavi SÁNCHEZ VIVES , Mel SLATER , Jorge ARROYO PALACIOS
IPC分类号： A61M21/02
CPC分类号： A61M21/02 , A61B5/1114 , A61B5/16 , A61B5/6814 , A61B5/744 , A61M2021/0027 , A61M2021/005 , A61M2205/50 , A61M2205/582 , A61M2209/088 , A61M2230/06 , A61M2230/42 , A61M2230/50 , A61M2230/63 , A61M2230/65 , G06F3/012 , G06F3/016 , G06T13/40
摘要： Methods for provoking a physiological response in a subject comprising: receiving from sensors an orientation of an HMD of the subject and a parameter indicative of a physiological state of the subject, determining a video signal representing an avatar of the subject in a virtual reality scenario to be displayed on the head mounted display taking into account the orientation of the head mounted display, wherein the video signal includes an indication of a physiological state of the avatar, and sending the video signal to the head mounted display for visualization, optionally accompanied by a suitable audio signal. During a first period, the indication of the physiological state of the avatar substantially corresponds to the measured physiological state, and during a second period the indication of the physiological state of the avatar does not correspond to the measured physiological state. Related computer program and computing systems are also disclosed.

14. 发明申请

US20170283927A1 METHOD FOR THE DETERMINATION OF THE REPRESENTATIVE HOMOTOP OF A BINARY METALLIC NANOPARTICLE (AxB1-x)N AND METHOD FOR MANUFACTURING THE CORRESPONDING NANOPARTICLE 审中-公开
公开(公告)号：US20170283927A1
公开(公告)日：2017-10-05
申请号：US15086772
申请日：2016-03-31
申请人： UNIVERSITAT DE BARCELONA , INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS
发明人： Sergey M. KOZLOV , Konstantin M. NEYMAN
IPC分类号： C22F1/14 , B22F9/20 , B22F9/16 , C23C14/48 , C25C1/20 , C22C5/02 , C22C5/06 , C22C5/04 , B22F9/30 , B22F1/00
CPC分类号： C22F1/14 , B22F1/0018 , B22F9/16 , B22F9/24 , B22F9/30 , B22F2202/01 , C22C5/02 , C22C5/04 , C22C5/06 , C25C1/20
摘要： A method for the manufacturing a representative homotop of a binary metallic nanoparticle (AxB1-x)N with a given composition AxB1-x, number of atoms N and shape, and at a given temperature, including generating a plurality of homotops, calculating an energy of the generate homotops using formula: E TOP = E 0  ( x , N ) + ɛ BOND A  -  B  ( x )  N BOND A  -  B + ∑ i   ɛ CORNER , i A  ( x )  N CORNER , i A + ∑ j   ɛ EDGE , j A  ( x )  N EDGE , j A + ∑ { LMN }  ɛ { LMN } A  ( x )  N { LMN } A ( 1 ) where E0(x, N) is constant for a given particle, εBONDA-B(x) is related to an energy gain caused by the mixing of both metals, NBONDA-B is a number of heteroatomic bonds, εCORNER,iA(x) is an energy required for or gained from an exchange of an atom of type A on a corner of type i with an atom of type B in the nanoparticle interior, εEDGE,jA(x) is an energy required for or gained from an exchange of an atom A on the nanoparticle edge of type j with an atom B in the nanoparticle interior, ε{LMN}A(x) is an energy required for or gained from an exchange of an atom A on a terrace on a nanoparticle facet with Miller indices {LMN} with an atom B in the nanoparticle interior, NCORNER,iA, NEDGE,jA, and N{LMN}A are numbers of atoms of type A on the respective corners, edges and terraces, determining the representative homotop, and manufacturing the nanoparticle.

15. 发明申请

US20170137881A1 MITOCHONDRIAL MARKERS OF NEURODEGENERATIVE DISEASES 审中-公开
公开(公告)号：US20170137881A1
公开(公告)日：2017-05-18
申请号：US15300248
申请日：2015-03-27
申请人： FUNDACIÓ INSTITUT D'INVESTIGACIÓ BIOMÈDICA DE BELLVITGE (IDIBELL) , UNIVERSITAT DE BARCELONA
发明人： Marta BARRACHINA CASTILLO , Isidre FERRER ABIZANDA , Marta BLANCH LOZANO
IPC分类号： C12Q1/68
摘要： Disclosed is an in vitro method to diagnose or determine the risk of developing a neurodegenerative disease in a subject based on the determination of the methylation pattern in certain regions of mitochondrial DNA from the subject or the determination of the nucleotide at the polymorphic position 16519 in the mitochondrial DNA of the subject. Also, disclosed are nucleic acids suitable for the in vitro method to diagnose or determine the risk of developing a neurodegenerative disease in a subject.

16. 发明申请

US20170009192A1 BIOREACTOR FOR CELL CO-CULTURE 审中-公开
标题翻译：细胞培养物的生物反应器
公开(公告)号：US20170009192A1
公开(公告)日：2017-01-12
申请号：US15120562
申请日：2015-03-05
申请人： INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER (IDIBAPS) , CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS , CIBER CENTRO DE INVESTIGATIÓN BIOMÉDICA EN RED , HOSPITAL CLÍNIC DE BARCELONA , UNIVERSITAT DE BARCELONA CENTRO DE PATENTES UB
发明人： Carmen PERALTA UROZ , Jordi GRACIA SANCHO , Rosa VILLA SANZ , Javier ILLA VILA , Marta MASSIP SALCEDO , Jaime BOSCH GENOVER
IPC分类号： C12M1/12 , C12M1/42 , C12M1/00
CPC分类号： C12M25/06 , C12M23/04 , C12M23/40 , C12M25/02 , C12M25/04 , C12M29/10 , C12M29/20 , C12M35/04 , C12M35/08
摘要： A bioreactor for cell co-culture having at least first and second cell culture chambers which are separated by a porous membrane. The membrane has at least one sealing gasket integrated in the membrane and being integral therewith. The sealing gasket defines a closed perimeter delimiting a first cell culture area.
摘要翻译：用于细胞共培养的生物反应器，其具有由多孔膜分离的至少第一和第二细胞培养室。膜具有集成在膜中并与其成一体的至少一个密封垫片。密封垫圈限定了限定第一细胞培养区域的封闭周界。

17. 发明授权

US09475840B2 Protease-resistant compounds useful as shuttles through the blood-brain barrier and shuttle-cargo constructs 有权
标题翻译：蛋白酶抗性化合物可用作穿过血脑屏障和穿梭货物构造的梭子
公开(公告)号：US09475840B2
公开(公告)日：2016-10-25
申请号：US14379484
申请日：2013-02-27
申请人： UNIVERSITAT DE BARCELONA , FUNDACIÓ INSTITUT DE RECERCA BIOMÈDICA (IRB BARCELONA)
发明人： Ernest Giralt Lledó , Meritxell Teixidó Turà , Roger Prades Cosano
IPC分类号： C07K7/08 , A61K49/00 , A61K49/18 , A61K31/198 , A61K39/395 , A61K47/48
CPC分类号： C07K7/08 , A61K31/198 , A61K39/39533 , A61K47/62 , A61K47/64 , A61K49/0056 , A61K49/0093 , A61K49/1866
摘要： The peptides of formula (I) where: R1 is the group attached to the N-terminal of the first amino acid of the sequence P, optionally via the ligand X, and is selected from H, CH3C(═O)—, and maleimide; X is a biradical selected from —NH—(CH2)r—C(═O)—, —C(═O)—(CH2)r—C(═O)—, —S(CH2)r—, —S—(CH2)r—C(═O)—, —O—(CH2)r—, —S—CH—CH(NH2)—C(═O)—, —O—(CH2)r—C(═O)—, —(CH2)r—C(═O)—, —NH—O—CH2—C(═O)—NH—(CH2)r—CH(NH2)—C(═O)—, —(CH2)r—C(═O)—NH—(CH2)r—CH(NH2)—C(═O)—, and —NH—(CH2)r—CH(NHC(═O)CH2NH2)—C(═O)—; r is 1-5; P is a biradical of an amino acid sequence comprising the sequence D-Pro-D-Trp-D-Val-D-Pro-D-Ser-D-Trp-D-Met-D-Pro-D-Pro-D-Arg-D-His-D-Thr (SEQ ID NO: 1); Y is the group attached to the C-terminal of the last amino acid of the sequence P, and is selected from —NH2, —OH, —OR2 and —NHR2; R2 is a radical selected from (C1-C6)-alkyl and (CH2)2—NH—C(═O)—CH2—O—NH2; k is 0-2; m is 0-1; with the proviso that when the biradical X is —C(═O)(CH2)r—C(═O)—, then R1 is H; when the N of the amino acid of the sequence P to which is attached the biradical X is a biradical —NH—, then m is 1, and when is a biradical —N—, then m is 0; and when R1 is maleimide then the biradical X is —C(═O)—(CH2)r—C(═O)—, —(CH2)—C(═O)—, —(CH2)r—C(═O)—, and —(CH2)r—C(═O)—NH—(CH2)r—CH(NH2)—C(═O)—. The peptides are useful as shuttles through the blood brain barrier (BBB). The constructs BBB-shuttle-cargo, being the cargo of a biologically active substance or for use in a diagnostic method, are useful in therapy and diagnosis. R1—(X)K—P—Y (I)

18. 发明申请

US20140358450A1 Method of Binding Site and Binding Energy Determination by Mixed Explicit Solvent Simulations 审中-公开
标题翻译：通过混合显式溶剂模拟的结合位点和结合能测定方法
公开(公告)号：US20140358450A1
公开(公告)日：2014-12-04
申请号：US14364039
申请日：2012-12-20
申请人： UNIVERSITAT DE BARCELONA , INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS
发明人： Xavier Barril Alonso , Daniel Alvarez Garcia , Peter Schmidtke
IPC分类号： G06F19/00
CPC分类号： G16C20/50 , G16B15/00 , G16C10/00 , G16C20/10
摘要： It is described a method of binding site and binding energy determination by mixed explicit solvent all-atoms molecular dynamics simulations. The macromolecular target for which high affinity binders are sought is simulated in several mixed solvent environments comprising water and at least one amphiphilic organic co-solvent. The simulations are run so that the mixture of solvents are free to react to the presence of the target without the addition of any forces other than those found in the original potential. A correction is applied that helps dissociating the distribution of the different chemical groups found in the amphiphilic organic solvents when calculating their free energies of binding. Additionally, a second correction can be applied accounting for the aggregation of said solvents. The correction helps determining more meaningful absolute, and more accurate relative free energies of binding that can be applied in the rational design of new binders to macromolecular targets.
摘要翻译：描述了通过混合显式溶剂全原子分子动力学模拟结合位点和结合能量测定的方法。在几个包含水和至少一种两亲性有机共溶剂的混合溶剂环境中模拟了寻求高亲和力粘合剂的大分子靶。运行模拟，使溶剂的混合物自由地与目标物的存在反应，而不添加除原始潜力以外的任何力。应用校正，当计算其结合的自由能时，有助于解离在两亲性有机溶剂中发现的不同化学基团的分布。另外，可以应用第二校正来计算所述溶剂的聚集。该校正有助于确定更有意义的绝对和更准确的结合自由能，可以在新粘合剂对大分子靶标的合理设计中应用。

19. 发明公开

US20240309366A1 COMPOSITIONS AND METHODS FOR TREATING METABOLIC DISORDERS 审中-公开
公开(公告)号：US20240309366A1
公开(公告)日：2024-09-19
申请号：US18260096
申请日：2021-12-30
申请人： Arcturus Therapeutics, Inc. , CONSORCIO CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED, M.P. , INSTITUT D’INVESTIGACIÓ BIOMÉDICA DE GIRONA DR JOSEP TRUETA , UNIVERSITAT DE BARCELONA
发明人： Ramón Díaz TRELLES , Kiyoshi TACHIKAWA , Priya Prakash KARMALI , Rajesh MUKTHAVARAM , Padmanabh CHIVUKULA , José María MORENO-NAVARRETE , Aleix Gavaldá NAVARRO , José Manuel FERNÁNDEZ-REAL , Marta Giralt OMS , Francesc Villarroya GOMBAU
IPC分类号： C12N15/113 , A61K9/51 , A61K31/713 , A61P3/04
CPC分类号： C12N15/113 , A61K9/5146 , A61K31/713 , A61P3/04
摘要： Provided herein are compositions and methods for treating metabolic disorders, such as hepatic steatosis, adipose tissue dysfunction, and insulin resistance. Small interfering RNAs (siRNAs) targeting LPS-binding protein (LBP) that include unlocked nucleotides (UNA) and their therapeutic applications for the treatment of metabolic disorders are provided herein.

20. 发明公开

US20240152572A1 QUANTUM CONTROL 审中-公开
公开(公告)号：US20240152572A1
公开(公告)日：2024-05-09
申请号：US18400709
申请日：2023-12-29
申请人： IDEADED, S.L , UNIVERSITAT DE BARCELONA
发明人： Lluc GARCIA I GONZALO , Josep Maria BOFILL VILLÀ , Ibério de Pinho RIBEIRO MOREIRA , Guillermo ALBAREDA PIQUER
IPC分类号： G06F17/11 , G06N10/60
CPC分类号： G06F17/11 , G06N10/60
摘要： A computer implemented method and a computer to determine a control protocol Hamiltonian for a quantum process is provided. Quantum systems driven according to the control protocol Hamiltonian are provided.

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