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11. 发明授权

US6007823A Simmondsin concentrate from jojoba 失效
标题翻译：辛莫辛浓缩荷荷荷巴
公开(公告)号：US6007823A
公开(公告)日：1999-12-28
申请号：US89104
申请日：1998-06-02
申请人： Thomas P. Abbott , Brian J. Plattner , Hal C. Purcell
发明人： Thomas P. Abbott , Brian J. Plattner , Hal C. Purcell
IPC分类号： A61K31/00 , A61K35/78
CPC分类号： A61K31/00
摘要： A process for the isolation of simmondsins from jojoba meal is disclosed. Simmondsins are first extracted from defatted jojoba meal with water. After separation from the meal, this water extract is subsequently dried, leaving the simmondsins in the resulting solid. The simmondsins may then be preferentially extracted from the dried water extract by contact with a first ethanolic solvent, forming a first solvent fraction containing simmondsins therein. The first solvent fraction, which is a substantially protein-free concentrate of simmondsins, may be separated from the solid phase, and the ethanolic solvent may then be readily removed, for example, by drying. Residual simmondsins remaining in the meal following extraction with the first ethanolic solvent may also be recovered by a second extraction with ethanolic solvent. Optionally, simmondsin and its analogs, simmondsin ferulate, demethylsimmondsin, and didemethyl simmondsin, may be separated in substantially pure form from the extracts by reverse-phase HPLC.
摘要翻译：公开了一种从霍霍巴粉中分离simmonds的方法。 Simmondsins首先从脱脂的霍霍巴餐中用水提取。从餐中分离后，将该水提取物随后干燥，留下所得固体中的茜素。然后可以通过与第一乙醇溶剂接触从干燥的水提取物中优先提取茜素，在其中形成含有茜素的第一溶剂馏分。作为基本上不含蛋白质的辛聚糖浓缩物的第一溶剂馏分可以与固相分离，然后可以容易地除去乙醇溶剂，例如通过干燥。用第一乙醇溶剂萃取后残留在餐中的残留茜素可以通过用乙醇溶剂的第二次萃取来回收。任选地，可以通过反相HPLC从提取物中分离simmondsin及其类似物，阿魏酸，去甲基辛明
菌素和didemethyl simmondsin基本上纯的形式。

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