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11. 发明授权

US12073957B2 Conductor material 有权
公开(公告)号：US12073957B2
公开(公告)日：2024-08-27
申请号：US17922108
申请日：2021-04-27
申请人： THE UNIVERSITY OF TOKYO , DAICEL CORPORATION
发明人： Toshihiro Okamoto , Tadanori Kurosawa , Yu Yamashita , Junichi Takeya , Daiji Ikeda , Takeshi Yokoo , Yasuyuki Akai
IPC分类号： H01B1/00 , H01B1/12
CPC分类号： H01B1/127
摘要： Provided is a conductor material having high conductivity. The conductor material according to an embodiment of the present disclosure has a configuration in which a conjugated polymeric compound having an electron donating group containing a heteroatom in a side chain is doped with a dopant containing an anion selected from a nitrogen anion, a boron anion, a phosphorus anion and an antimony anion, and a counter cation. The anion is preferably an anion represented by Formula (1) below: where R1 and R2 are identical or different, and each represent an electron withdrawing group; and R1 and R2 may be bonded to each other to form a ring with an adjacent nitrogen atom.

12. 发明公开

US20240277853A1 MEDIUM-MOLECULAR-WEIGHT COMPOUND CONJUGATE FOR IMPROVING PHARMACOKINETIC PROFILE OF MEDIUM-MOLECULAR-WEIGHT COMPOUND AND METHOD OF PRODUCING THE SAME 审中-公开
公开(公告)号：US20240277853A1
公开(公告)日：2024-08-22
申请号：US18566971
申请日：2022-06-03
申请人： TAGCYK Biotechnologies Inc. , The University of Tokyo
发明人： Susumu MUTO , Shinsuke SANDO , Miyuki HORI , Haishun PIAO , Kensuke OWARI , Kazunobu FUTAMI , Ryosuke UEKI , Yutaro SAITO , Seojung CHO
IPC分类号： A61K47/58 , A61K47/22 , C12N15/115
CPC分类号： A61K47/58 , A61K47/22 , C12N15/115
摘要： Provided is a medium-molecular-weight compound conjugate capable of improving pharmacokinetic profile of a medium-molecular-weight compound, that is easy to obtain, safer to a biological body, and useful in vivo such as a nucleic acid aptamer, and a method of producing the same. The PMPC-medium-molecular-weight compound conjugate of the present invention is obtained by conjugating PMPC (poly-2-(methacryloyloxy)ethyl phosphoryicholine) to a medium-molecular-weight compound.

13. 发明公开

US20240271880A1 HEAT ABSORPTION AND RADIATION SYSTEM 审中-公开
公开(公告)号：US20240271880A1
公开(公告)日：2024-08-15
申请号：US18565291
申请日：2022-03-18
申请人： AISIN CORPORATION , THE UNIVERSITY OF TOKYO
发明人： Ryu HATANO , Kazuhiko MOTODOHI , Kazuo ISOGAI , Takashi MOMIKI , Shin-ichi OHKOSHI
IPC分类号： F28D20/02
CPC分类号： F28D20/025 , F28D20/028
摘要： A heat absorption and radiation system uses a heat medium containing a rubidium-manganese-iron cyano complex, and is configured to release heat from the heat medium by applying a pressure to the heat medium and causing phase transition of the rubidium-manganese-iron cyano complex from a high-temperature phase to a low-temperature phase, absorb heat into the heat medium by releasing the pressure applied to the heat medium and causing phase transition of the rubidium-manganese-iron cyano complex from the low-temperature phase to the high-temperature phase, and repeat application of the pressure to and release of the pressure from the heat medium. Thus, it is possible to efficiently absorb and release heat through effective utilization of the characteristics of the rubidium-manganese-iron cyano complex.

14. 发明公开

US20240241130A1 BIOMARKER FOR PREDICTING RESPONSE TO IMMUNE CHECKPOINT INHIBITOR 审中-公开
公开(公告)号：US20240241130A1
公开(公告)日：2024-07-18
申请号：US18684272
申请日：2022-08-18
申请人： The University of Tokyo
发明人： Takahiro AMEMIYA , Masashi HONMA , Yoshiaki KARIYA , Hiroshi SUZUKI
IPC分类号： G01N33/68
CPC分类号： G01N33/68 , G01N2800/52
摘要： An object of the present invention is to provide a method for predicting responsiveness to an immune checkpoint inhibitor and a method for predicting prognosis of a cancer patient who has received treatment with an immune checkpoint inhibitor. According to the present invention, there is provided a method for predicting responsiveness to an immune checkpoint inhibitor by using an amount of an IL-1 signaling pathway molecule in a subject in need of treatment of cancer as an indicator. According to the present invention, there is also provided a method for predicting prognosis of a cancer patient who has received treatment with an immune checkpoint inhibitor, the method comprising predicting prognosis by using an amount of an IL-1 signaling pathway molecule of the subject as an indicator.

15. 发明授权

US12033318B2 Estimation apparatus, estimation system, and computer-readable non-transitory medium storing estimation program 有权
公开(公告)号：US12033318B2
公开(公告)日：2024-07-09
申请号：US17274757
申请日：2019-09-10
申请人： KYOCERA Corporation , The University of Tokyo
发明人： Kenichi Watanabe , Masayuki Kyomoto , Shintaro Honda , Toru Moro , Sakae Tanaka
IPC分类号： G06T7/00 , A61B6/50 , G06T7/11
CPC分类号： G06T7/0012 , A61B6/505 , G06T7/11 , G06T2207/10116 , G06T2207/20081 , G06T2207/20084 , G06T2207/30008 , G06T2207/30096
摘要： An estimation apparatus includes an input unit and an approximator. Input information including an image in which a bone appears is input into the input unit. The approximator is configured to determine an estimation result related to bone density of the bone from the input information. The approximator includes a learned parameter to obtain the estimation result.

16. 发明公开

US20240218384A1 METHOD FOR EDITING PLANT GENOME 审中-公开
公开(公告)号：US20240218384A1
公开(公告)日：2024-07-04
申请号：US18272978
申请日：2022-01-21
申请人： The University of Tokyo
发明人： Shin-ichi ARIMURA , Issei NAKAZATO , Nobuhiro TSUTSUMI , Ayako HOSODA
IPC分类号： C12N15/82 , C12N9/78 , C12N15/62
CPC分类号： C12N15/8213 , C12N9/78 , C12N15/62 , C07K2319/02 , C07K2319/07 , C07K2319/09 , C12Y305/04005
摘要： It is an object of the present invention to provide a method for editing or modifying plant genomes (a nuclear genome, a plastid genome, and a mitochondrial genome), and in particular, the editing or modification of a single nucleotide. Specifically, the present invention relates to a method for editing genomic DNAs in plant cells, namely, a nuclear genomic DNA, a plastid genomic DNA and a mitochondrial genomic DNA, wherein the method comprises converting target nucleotides on these genomic DNAs to other nucleotides. This conversion is carried out, for example, with cytidine deaminase, and in particular, with the aforementioned enzyme using a double-stranded DNA as a substrate.

17. 发明授权

US12024717B2 Method for reconstructing immune function using pluripotent stem cells 有权
公开(公告)号：US12024717B2
公开(公告)日：2024-07-02
申请号：US16991758
申请日：2020-08-12
申请人： The University of Tokyo
发明人： Hiromitsu Nakauchi , Shin Kaneko , Toshinobu Nishimura
IPC分类号： C12N5/0783 , A61K35/17 , A61K39/00 , A61K39/21 , C12N5/074
CPC分类号： C12N5/0636 , A61K35/17 , A61K39/00 , A61K39/21 , C12N5/0638 , C12N5/0696 , A61K2039/5158 , C12N2500/02 , C12N2501/065 , C12N2501/2302 , C12N2501/2307 , C12N2501/2315 , C12N2501/415 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/605 , C12N2501/606 , C12N2501/608 , C12N2501/727 , C12N2506/11 , C12N2506/45 , C12N2510/00
摘要： According to the present invention, there are provided a method for producing a human T cell, which comprises the steps of inducing an iPS cell from a human T cell, and differentiating the iPS cell into a T cell; a pharmaceutical composition comprising the T cell produced by the method; and a method for cell-based immunotherapy using the method.

18. 发明公开

US20240200037A1 METHOD FOR PRODUCING VIRUS PARTICLES 审中-公开
公开(公告)号：US20240200037A1
公开(公告)日：2024-06-20
申请号：US18286657
申请日：2022-04-14
申请人： The University of Tokyo
发明人： Takashi OKADA , Mikako WADA
IPC分类号： C12N7/00 , C12M3/04
CPC分类号： C12N7/00 , C12M27/10 , C12N2750/14123 , C12N2750/14151
摘要： It is an object of the present invention to provide a method for producing a virus to obtain high-purity virus particles, said method being more efficient than conventional methods. Specifically, the present invention relates to a method for producing full-genome virus particles, comprising steps of purifying full-genome virus particles from a virus particle mixed solution containing empty virus particles, intermediate virus particles and the full-genome virus particles, wherein the method comprises: a step (a) of rotating a zonal rotator at a low speed and arranging the virus particle mixed solution, a liquid having a lower density than the full-genome virus particles (liquid L), and a liquid having a higher density than the liquid L (liquid H1) in this order from the rotation axis side of the rotor toward the outside; a step (b) of operating the zonal rotor after the step (a) at an ultracentrifugation mode, so as to separate the empty virus particles, the intermediate virus particles and the full-genome virus particles from one another; and a step (c) of removing the contents of the zonal rotor after the step (b), while fractionating the contents, so as to recover a fraction comprising the full-genome virus particles.

19. 发明公开

US20240197964A1 GEL MATERIAL FOR OPHTHALMIC TREATMENT USE 审中-公开
公开(公告)号：US20240197964A1
公开(公告)日：2024-06-20
申请号：US18595720
申请日：2024-03-05
申请人： THE UNIVERSITY OF TOKYO , UNIVERSITY OF TSUKUBA
发明人： Takamasa SAKAI , Yuichi TEI , Fumiki OKAMOTO , Sujin HOSHI
IPC分类号： A61L27/52 , A61K9/00 , A61K9/06 , A61K47/10 , A61K47/18 , A61K47/32 , A61K47/34 , A61L27/14 , A61L27/54 , A61P27/02 , C08G65/329
CPC分类号： A61L27/52 , A61K9/0051 , A61K9/06 , A61K47/10 , A61K47/18 , A61K47/32 , A61K47/34 , A61L27/14 , A61L27/54 , A61P27/02 , C08G65/329
摘要： Provided is a gel material for ophthalmic treatment useful as a synthetic vitreous body which is a novel intraocular tamponade material having a low swelling pressure, an appropriate elastic force, and no toxicity to ocular tissues, specifically, to retinas, and which is capable of stably maintaining a long-term stable tamponade effect. A gel material for ophthalmic treatment including a hydrogel in which a gel precursor cluster crosslinks to form a three-dimensional network. The gel precursor cluster has a structure with crosslinked monomer units or crosslinked polymer units present at concentrations less than a critical gelation concentration, and the gel precursor cluster has a relationship of G′

20. 发明授权

US12009115B2 Conductor material 有权
公开(公告)号：US12009115B2
公开(公告)日：2024-06-11
申请号：US17922108
申请日：2021-04-27
申请人： THE UNIVERSITY OF TOKYO , DAICEL CORPORATION
发明人： Toshihiro Okamoto , Tadanori Kurosawa , Yu Yamashita , Junichi Takeya , Daiji Ikeda , Takeshi Yokoo , Yasuyuki Akai
IPC分类号： H01B1/00 , H01B1/12
CPC分类号： H01B1/127
摘要： Provided is a conductor material having high conductivity. The conductor material according to an embodiment of the present disclosure has a configuration in which a conjugated polymeric compound having an electron donating group containing a heteroatom in a side chain is doped with a dopant containing an anion selected from a nitrogen anion, a boron anion, a phosphorus anion and an antimony anion, and a counter cation. The anion is preferably an anion represented by Formula (1) below: where R1 and R2 are identical or different, and each represent an electron withdrawing group; and R1 and R2 may be bonded to each other to form a ring with an adjacent nitrogen atom.

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