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11. 发明申请

US20050014232A1 Novel tetronic acid derivative 失效
标题翻译：新型四氢酸衍生物
公开(公告)号：US20050014232A1
公开(公告)日：2005-01-20
申请号：US10852766
申请日：2004-05-21
申请人： Kazuo Shinya , Takashi Tsuruo , Akihiro Tomida , Hae-Ryong Park
发明人： Kazuo Shinya , Takashi Tsuruo , Akihiro Tomida , Hae-Ryong Park
IPC分类号： A61K31/7048 , A61P35/00 , A61P43/00 , C07H17/08 , C12P19/62 , C12P19/60
CPC分类号： C07H17/08 , A61K31/7048 , C12P19/62 , C12R1/465
摘要： The present inventors intended to search for substances that can regulate the expression of a molecular chaperone, GRP78, using the expression of GRP78 as an indicator. As a result, a novel tetronic acid derivative, versipelostatin compound (also known as JL68) shown in formula (I) having the activity of suppressing GRP78 expression was isolated from the metabolite of Streptomyces versipellis strain 4083-SVS6. Versipelostatin can be obtained from the culture supernatant by culturing the above-mentioned Streptomyces versipellis strain 4083-SVS6.
摘要翻译：本发明人意图使用GRP78的表达作为指标来搜索可以调节分子伴侣GRP78表达的物质。结果，从Streptomyces versipellis株4083-SVS6的代谢物中分离出具有抑制GRP78表达活性的式（I）所示的新型tetronic酸衍生物（也称为JL68）。通过培养上述的链霉菌菌株4083-SVS6可以从培养上清液中获得多糖嵌合抑制素。

12. 发明申请

US20090155241A1 Prophylactic/therapeutic agent for cancer 审中-公开
标题翻译：癌症预防/治疗剂
公开(公告)号：US20090155241A1
公开(公告)日：2009-06-18
申请号：US11988995
申请日：2005-07-22
申请人： Tetsuo Mashima , Takashi Tsuruo
发明人： Tetsuo Mashima , Takashi Tsuruo
IPC分类号： A61K39/395 , C07H21/02 , C07K16/18 , G01N33/53 , C12Q1/68 , C12Q1/00 , A61K31/7088 , C12N9/96 , C07C245/00
CPC分类号： G01N33/573 , A61K38/00 , A61K49/0008 , C12N9/93 , C12Y602/01003 , G01N33/574 , G01N2333/91051 , G01N2800/52
摘要： A compound or its salt that inhibits the activity of a protein having the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 1; a compound or its salt that inhibits the expression of a gene for the protein; an antisense polynucleotide comprising a nucleotide sequence complementary or substantially complementary to the nucleotide sequence of a polynucleotide encoding the protein or a partial peptide thereof or a part of the nucleotide sequence; an antibody against the protein; etc. are useful as preventive/therapeutic agents for cancer, apoptosis promoters for cancer cells, or the like.
摘要翻译：抑制与SEQ ID NO：1所示的氨基酸序列具有相同或基本相同的氨基酸序列的蛋白质的活性的化合物或其盐; 抑制蛋白质基因表达的化合物或其盐; 反义多核苷酸，其包含与编码所述蛋白质或其部分肽或所述核苷酸序列的一部分的多核苷酸的核苷酸序列互补或基本互补的核苷酸序列; 抗蛋白的抗体; 等可用作癌症的预防/治疗剂，癌细胞的凋亡启动子等。

13. 发明授权

US07358233B2 Tetronic acid derivative 失效
标题翻译：季戊酸衍生物
公开(公告)号：US07358233B2
公开(公告)日：2008-04-15
申请号：US10852766
申请日：2004-05-21
申请人： Kazuo Shinya , Takashi Tsuruo , Akihiro Tomida , Hae-Ryong Park
发明人： Kazuo Shinya , Takashi Tsuruo , Akihiro Tomida , Hae-Ryong Park
IPC分类号： A61K31/70 , C07H17/08 , C12P17/00
CPC分类号： C07H17/08 , A61K31/7048 , C12P19/62 , C12R1/465
摘要： The present inventors intended to search for substances that can regulate the expression of a molecular chaperone, GRP78, using the expression of GRP78 as an indicator. As a result, a novel tetronic acid derivative, versipelostatin compound (also known as JL68) shown in formula (I) having the activity of suppressing GRP78 expression was isolated from the metabolite of Streptomyces versipellis strain 4083-SVS6. Versipelostatin can be obtained from the culture supernatant by culturing the above-mentioned Streptomyces versipellis strain 4083-SVS6
摘要翻译：本发明人意图使用GRP78的表达作为指标来搜索可以调节分子伴侣GRP78表达的物质。结果，从Streptomyces versipellis菌株4083-SVS6的代谢物中分离出具有抑制GRP78表达活性的式（I）所示的新型tetronic酸衍生物（也称为JL68）。通过培养上述的链霉菌菌株4083-SVS6可以从培养上清液中获得多糖前列腺素

14. 发明申请

US20060252056A1 Markers for responsiveness to an erbB receptor tyrosine kinase inhibitor 审中-公开
标题翻译：对erbB受体酪氨酸激酶抑制剂的反应的标记
公开(公告)号：US20060252056A1
公开(公告)日：2006-11-09
申请号：US11290173
申请日：2005-11-30
申请人： Takashi Tsuruo , Yusuke Nakamura , Saburo Sone , Masahiro Fukuoka
发明人： Takashi Tsuruo , Yusuke Nakamura , Saburo Sone , Masahiro Fukuoka
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C07K14/47 , C12Q1/6886 , C12Q2600/106 , C12Q2600/158
摘要： The invention relates to a set of isolated marker genes comprising at least one gene identified as having differential expression as between patients who are responders and non responders to an erbB receptor tyrosine kinase inhibitor; said gene set comprising one or more genes selected from at least the group consisting of the 51 genes listed herein including gene-specific oligonucleotides derived from said genes; and uses of such sets in diagnostic applications.
摘要翻译：本发明涉及一组分离的标记基因，其包含鉴定为具有差异表达的至少一个基因，所述差异表达在作为应答者的患者和对erbB受体酪氨酸激酶抑制剂的非应答者之间; 所述基因组包含一个或多个选自至少由本文所列的51个基因组成的组的基因，包括来源于所述基因的基因特异性寡核苷酸; 并在诊断应用中使用这样的组。

15. 发明申请

US20090202569A1 Prophylactic/Therapeutic Agent for Cancer 审中-公开
标题翻译：预防/治疗癌症治疗剂
公开(公告)号：US20090202569A1
公开(公告)日：2009-08-13
申请号：US12225882
申请日：2007-04-06
申请人： Tetsuo Mashima , Takashi Tsuruo , Hideaki Tojo , Hiroyuki Sumi
发明人： Tetsuo Mashima , Takashi Tsuruo , Hideaki Tojo , Hiroyuki Sumi
IPC分类号： A61K39/395 , C07K16/18 , C07H21/02 , A61K31/7088 , C12N5/06
CPC分类号： A61K45/06 , A61K31/7088 , A61K39/395 , A61K2300/00
摘要： The present invention provides a preventative/therapeutic agent for cancer capable of selectively and effectively killing cancer cells. A medicament of the present invention prepared by combining at least one selected from a substance that inhibits the activity of an enzyme belonging to the acyl-CoA synthase family and a substance that inhibits expression of a gene for an enzyme belonging to the acyl-CoA synthase family, with at least one selected from a substance that inhibits the activity of fatty acid synthase and a substance that inhibits expression of a fatty acid synthase gene and the like can be used as a preventative/therapeutic agent for cancer capable of selectively and effectively killing cancer cells.
摘要翻译：本发明提供了能够选择性且有效地杀死癌细胞的癌症预防/治疗剂。通过组合选自抑制属于酰基辅酶A合成酶家族的酶的活性的物质和抑制属于酰基辅酶A合成酶的酶的基因表达的物质中的至少一种而制备的本发明的药物可以使用选自抑制脂肪酸合酶活性的物质中的至少一种和抑制脂肪酸合酶基因表达的物质等作为能够选择性有效杀死的癌症的预防/治疗剂癌细胞。

16. 发明授权

US4628047A Agent for enhancing antitumor activity of antitumor agent 失效
标题翻译：用于增强抗肿瘤剂抗肿瘤活性的药剂
公开(公告)号：US4628047A
公开(公告)日：1986-12-09
申请号：US498639
申请日：1983-05-27
申请人： Yoshio Sakurai , Takashi Tsuruo
发明人： Yoshio Sakurai , Takashi Tsuruo
IPC分类号： C07D281/10 , A61K31/55 , A61K31/554 , A61P35/00 , A61P43/00 , A61K31/70 , A61K31/44
CPC分类号： A61K31/55
摘要： An agent for enhancing antitumor activity of antitumor agents comprising as the active ingredient diltiazem or a pharmaceutically acceptable acid addition salt thereof, an antitumor composition comprising the diltiazem or an acid addition salt thereof and a conventional antitumor agent, and further a method for treating tumors by administering diltiazem or an acid addition salt thereof together with a conventional antitumor agent in oral or parenteral route to patients suffering from various tumors. Said active diltiazem or a salt thereof is effective for enhancing the antitumor activity of antitumor agents because it can enhance sensitivity of tumor cells to antitumor agents regardless the tumor cells have resistance to the antitumor agents or not.
摘要翻译：包含作为活性成分的地尔硫卓或其药学上可接受的酸加成盐的抗肿瘤剂的抗肿瘤活性的药剂，包含地尔硫卓或其酸加成盐的抗肿瘤组合物和常规的抗肿瘤剂，以及进一步的治疗肿瘤的方法将经口服或肠胃外途径的地尔硫卓或其酸加成盐与常规抗肿瘤药物一起给予患有各种肿瘤的患者。所述活性地尔硫卓或其盐对于提高抗肿瘤剂的抗肿瘤活性是有效的，因为它可以增强肿瘤细胞对抗肿瘤剂的敏感性，而不管肿瘤细胞对抗肿瘤剂具有抗性。

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