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11. 发明授权

US06989897B2 Metal coated nanocrystalline silicon as an active surface enhanced Raman spectroscopy (SERS) substrate 有权
标题翻译：金属涂层纳米晶硅作为活性表面增强拉曼光谱（SERS）底物
公开(公告)号：US06989897B2
公开(公告)日：2006-01-24
申请号：US10680583
申请日：2003-10-07
申请人： Selena Chan , Andrew A. Berlin , Sunghoon Kwon , Narayanan Sundararajan , Mineo Yamakawa
发明人： Selena Chan , Andrew A. Berlin , Sunghoon Kwon , Narayanan Sundararajan , Mineo Yamakawa
IPC分类号： G01J3/44
CPC分类号： C12Q1/6825 , B82Y15/00 , B82Y30/00 , G01J3/44 , G01N21/658 , G01N2021/6439 , G01N2021/653 , G01N2021/655 , G01N2021/656 , C12Q2565/632 , C12Q2563/155
摘要： The disclosed methods and apparatus concern Raman spectroscopy using metal coated nanocrystalline porous silicon substrates. Porous silicon substrates may be formed by anodic etching in dilute hydrofluoric acid. A thin coating of a Raman active metal, such as gold or silver, may be coated onto the porous silicon by cathodic electromigration or any known technique. In certain alternatives, the metal coated porous silicon substrate comprises a plasma-oxidized, dip and decomposed porous silicon substrate. The metal-coated substrate provides an extensive, metal rich environment for SERS, SERRS, hyper-Raman and/or CARS Raman spectroscopy. In certain alternatives, metal nanoparticles may be added to the metal-coated substrate to further enhance the Raman signals. Raman spectroscopy may be used to detect, identify and/or quantify a wide variety of analytes, using the disclosed methods and apparatus. In some disclosed methods, Raman spectroscopy may be used to detect nucleotides, purines or pyrimidines at the single molecule level.
摘要翻译：所公开的方法和装置涉及使用金属涂覆的纳米晶体多孔硅衬底的拉曼光谱。多孔硅衬底可以通过在稀氢氟酸中的阳极蚀刻形成。拉曼活性金属如金或银的薄涂层可以通过阴极电迁移或任何已知技术涂覆在多孔硅上。在某些替代方案中，金属涂覆的多孔硅衬底包括等离子体氧化的，浸渍和分解的多孔硅衬底。金属涂层的基底为SERS，SERRS，超拉曼和/或CARS拉曼光谱提供了广泛的金属丰富的环境。在某些替代方案中，可以将金属纳米颗粒加入到金属涂覆的基底中以进一步增强拉曼信号。使用所公开的方法和装置，可以使用拉曼光谱来检测，鉴定和/或定量各种分析物。在一些公开的方法中，可以使用拉曼光谱法在单一分子水平检测核苷酸，嘌呤或嘧啶。

12. 发明申请

US20130243656A1 METHODS FOR UNIFORM METAL IMPREGNATION INTO A NANOPOROUS MATERIAL 有权
标题翻译：将金属均匀分解成纳米材料的方法
公开(公告)号：US20130243656A1
公开(公告)日：2013-09-19
申请号：US13730431
申请日：2012-12-28
申请人： Selena CHAN , Sunghoon Kwon , Narayan Sundararajan
发明人： Selena CHAN , Sunghoon Kwon , Narayan Sundararajan
IPC分类号： G01N21/65
CPC分类号： G01N21/658 , B01D67/0062 , B01D67/0086 , B01D67/0088 , B01D71/02 , B82Y15/00 , B82Y30/00 , C12Q1/6825 , G01J3/44 , G01N21/65 , G01N2021/6439 , G01N2021/655 , G01N2021/656 , C12Q2565/632 , C12Q2563/155
摘要： The methods, systems 400 and apparatus disclosed herein concern metal 150 impregnated porous substrates 110, 210, Certain embodiments of the invention concern methods for producing metal-coated porous silicon substrates 110, 210 that exhibit greatly improved uniformity and depth of penetration of metal 150 deposition. The increased uniformity and depth allow improved and more reproducible Raman detection of analytes. In exemplary embodiments of the invention, the methods may comprise oxidation of porous silicon 110, immersion in a metal salt solution, 130, drying and thermal decomposition of the metal salt 140 to form a metal deposit 150. In other exemplary embodiments of the invention, the methods may comprise microfluidic impregnation of porous silicon substrates 210 with one or more metal salt solutions 130. Other embodiments of the invention concern apparatus and/or systems 400 for Raman detection of analytes, comprising metal-coated porous silicon substrates 110, 210 prepared by the disclosed methods.
摘要翻译：本文公开的方法，系统400和装置涉及金属150浸渍的多孔基材110,210。本发明的某些实施方案涉及用于制造金属涂覆的多孔硅基板110,210的方法，其显示出显着改善金属150沉积物的均匀性和深度的渗透。增加的均匀性和深度允许分析物的改进和更可重复的拉曼检测。在本发明的示例性实施方案中，所述方法可以包括多孔硅110的氧化，浸入金属盐溶液130，金属盐140的干燥和热分解以形成金属沉积物150.在本发明的其它示例性实施方案中，该方法可以包括多孔硅衬底210与一种或多种金属盐溶液130的微流体浸渍。本发明的其它实施方案涉及用于分析物的拉曼检测的装置和/或系统400，包括金属涂覆的多孔硅衬底110,210，由公开的方法。

13. 发明申请

US20130146788A1 METHOD OF CREATING COLORED MATERIALS BY FIXING ORDERED STRUCTURES OF MAGNETITE NANOPARTICLES WITHIN A SOLID MEDIA 审中-公开
标题翻译：通过在固体介质中固定磁性纳米粒子的有序结构来形成彩色材料的方法
公开(公告)号：US20130146788A1
公开(公告)日：2013-06-13
申请号：US13264411
申请日：2010-04-14
申请人： Yadong Yin , Jianping Ge , Sunghoon Kwon
发明人： Yadong Yin , Jianping Ge , Sunghoon Kwon
IPC分类号： B01J19/12 , G02F1/29 , G02F1/09
CPC分类号： B01J19/12 , B01J19/123 , B82Y20/00 , B82Y25/00 , C01P2006/42 , C08K3/22 , C08K9/08 , C08K2201/01 , C08K2201/011 , C09C1/24 , C09C3/10 , C09D7/62 , C09D7/69 , C09D11/50 , G02B1/005 , G02B5/201 , G02B2207/101 , G02F1/09 , G02F1/29 , H01F1/0063 , H01F1/344 , Y10T428/24802
摘要： Compositions and methods wherein ordered structures of photonic nanocrystals are created in a liquid medium and then such structures are fixed by converting the liquid medium to a solid. In addition, compositions and methods of reversibly fixing such structures, so that ordered structures can be reversibly created in a liquid medium, converted to solid, and then converted back to liquid, wherein new ordered structures can be created and again fixed.
摘要翻译：组合物和方法，其中在液体介质中产生光子纳米晶体的有序结构，然后通过将液体介质转化为固体来固定这些结构。此外，可逆地固定这种结构的组合物和方法，使得有序结构可以在液体介质中可逆地产生，转化为固体，然后转化回液体，其中可以产生并再次固定新的有序结构。

14. 发明授权

US08367017B2 Methods for uniform metal impregnation into a nanoporous material 有权
公开(公告)号：US08367017B2
公开(公告)日：2013-02-05
申请号：US12575369
申请日：2009-10-07
申请人： Selena Chan , Sunghoon Kwon , Narayan Sundararajan
发明人： Selena Chan , Sunghoon Kwon , Narayan Sundararajan
IPC分类号： G01N21/65 , G01J3/44
CPC分类号： G01N21/658 , B01D67/0062 , B01D67/0086 , B01D67/0088 , B01D71/02 , B82Y15/00 , B82Y30/00 , C12Q1/6825 , G01J3/44 , G01N21/65 , G01N2021/6439 , G01N2021/655 , G01N2021/656 , C12Q2565/632 , C12Q2563/155
摘要： The methods, systems 400 and apparatus disclosed herein concern metal 150 impregnated porous substrates 110, 210. Certain embodiments of the invention concern methods for producing metal-coated porous silicon substrates 110, 210 that exhibit greatly improved uniformity and depth of penetration of metal 150 deposition. The increased uniformity and depth allow improved and more reproducible Raman detection of analytes. In exemplary embodiments of the invention, the methods may comprise oxidation of porous silicon 110, immersion in a metal salt solution 130, drying and thermal decomposition of the metal salt 140 to form a metal deposit 150. In other exemplary embodiments of the invention, the methods may comprise microfluidic impregnation of porous silicon substrates 210 with one or more metal salt solutions 130. Other embodiments of the invention concern apparatus and/or systems 400 for Raman detection of analytes, comprising metal-coated porous silicon substrates 110, 210 prepared by the disclosed methods.

15. 发明申请

US20120295297A1 ASSAY METHOD USING ENCODED PARTICLE-BASED PLATFORM 审中-公开
标题翻译：使用基于粒子的平台的测定方法
公开(公告)号：US20120295297A1
公开(公告)日：2012-11-22
申请号：US13473901
申请日：2012-05-17
申请人： Sunghoon KWON , Su Eun CHUNG , Sung Hoon LEE , Wook PARK , Young Hoon SONG , Ji Sung JANG , Hyoki KIM , Howon LEE
发明人： Sunghoon KWON , Su Eun CHUNG , Sung Hoon LEE , Wook PARK , Young Hoon SONG , Ji Sung JANG , Hyoki KIM , Howon LEE
IPC分类号： C12Q1/02 , G01N31/00
CPC分类号： G01N33/585 , G01N33/54313 , Y10T436/143333
摘要： Provided is an assay method using an encoded particle-based platform. In the assay method, first, a plurality of encoded particles having codes distinguishable from one another according to kinds of included target materials are prepared. The plurality of encoded particles are provided onto a plate including a plurality of wells by pipetting, and disposed in the plurality of wells by a self-assembly method. An analyte is provided into the plurality of wells. The codes of the plurality of encoded particles disposed in the plurality of wells are decoded. The target materials of the plurality of encoded particles are released to cause a reaction between the target materials and the analyte.
摘要翻译：提供了使用编码的基于粒子的平台的测定方法。在测定方法中，首先，准备具有根据所包含的目标材料的种类彼此可区分的代码的多个编码粒子。通过移液将多个编码粒子提供到包括多个孔的板上，并通过自组装方法设置在多个孔中。分析物被提供到多个孔中。解码设置在多个孔中的多个编码粒子的代码。多个编码粒子的目标材料被释放以引起目标材料和分析物之间的反应。

16. 发明授权

US08246889B2 Optofluidic lithography system, method of manufacturing two-layered microfluidic channel, and method of manufacturing three-dimensional microstructures 有权
标题翻译：光电光刻系统，双层微流体通道的制造方法和制造三维微结构的方法
公开(公告)号：US08246889B2
公开(公告)日：2012-08-21
申请号：US12555428
申请日：2009-09-08
申请人： Sunghoon Kwon , SeungAh Lee , Wook Park , SuEun Chung
发明人： Sunghoon Kwon , SeungAh Lee , Wook Park , SuEun Chung
IPC分类号： B28B7/30
CPC分类号： G03F7/70341 , B29C64/106 , B29L2031/756 , B33Y30/00 , B81C99/0095 , B81C2201/0159 , F15B7/08 , F15B15/10 , G03B27/54 , G03F7/20 , G03F7/70416
摘要： An optofluidic lithography system including a membrane, a microfluidic channel, and a pneumatic chamber is provided. The membrane may be positioned between a pneumatic chamber and a microfluidic channel. The microfluidic channel may have a height corresponding to a displacement of the membrane and have a fluid flowing therein, the fluid being cured by light irradiated from the bottom to form a microstructure. The pneumatic chamber may induce the displacement of the membrane depending on an internal atmospheric pressure thereof.
摘要翻译：提供了包括膜，微流体通道和气动室的光流体光刻系统。膜可以位于气动室和微流体通道之间。微流体通道可以具有对应于膜的位移的高度并且具有在其中流动的流体，流体由从底部照射的光固化以形成微结构。气动室可以根据其内部大气压力而引起膜的移位。

17. 发明申请

US20100096447A1 OPTICAL IDENTIFICATION TAG, READER AND SYSTEM 审中-公开
标题翻译：光学识别标签，读取器和系统
公开(公告)号：US20100096447A1
公开(公告)日：2010-04-22
申请号：US12530367
申请日：2008-03-07
申请人： Sunghoon Kwon , Youngjune Park , Suhwan Kim
发明人： Sunghoon Kwon , Youngjune Park , Suhwan Kim
IPC分类号： G06F17/00 , G06K7/10 , G06K19/07 , H04B10/00
CPC分类号： G06K19/0723 , G06K19/0728
摘要： The present invention relates to an optical identification tag, a reader, and a system, and more particularly, to an optical identification tag which transmits its identification information using energy input in an optical form, and an optical identification system and reader using the optical identification tag. The present invention provides an optical identification tag and an optical identification reader. The optical identification tag includes a solar cell for converting incident light into an electrical energy, a circuit for providing a transmitted electrical signal corresponding to identification information, and a light emitter for providing a transmitted optical signal corresponding to the transmitted electrical signal, and the optical identification reader provides the incident light to the optical identification tag, and receives the transmitted optical signal from the optical identification tag.
摘要翻译：光学识别标签，读取器和系统技术领域本发明涉及光学识别标签，读取器和系统，更具体地，涉及使用光学形式的能量输入来发送其识别信息的光学识别标签，以及使用光学识别的光学识别系统和读取器标签。本发明提供一种光学识别标签和光学识别读取器。光学识别标签包括用于将入射光转换为电能的太阳能电池，用于提供与识别信息相对应的透射电信号的电路，以及用于提供对应于所发射的电信号的透射光信号的光发射器，识别读取器将入射光提供给光学识别标签，并从光学识别标签接收所发送的光信号。

18. 发明申请

US20100056720A1 SELF-ASSEMBLING METHOD AND STRUCTURE 审中-公开
标题翻译：自组装方法和结构
公开(公告)号：US20100056720A1
公开(公告)日：2010-03-04
申请号：US12199351
申请日：2008-08-27
申请人： Sunghoon Kwon , Sueun Chung
发明人： Sunghoon Kwon , Sueun Chung
IPC分类号： C08L89/00 , C08F291/00
CPC分类号： C08L53/025 , C08F297/04 , C08L2666/02 , C08L2666/04
摘要： Disclosed are compositions and methods for self-assembling polymeric particles by using biological binders attached to subunits of a multi-sectioned polymeric particle.
摘要翻译：公开了通过使用连接到多段聚合物颗粒的亚基的生物粘合剂自组装聚合物颗粒的组合物和方法。

19. 发明申请

US20100055620A1 NANOSTRUCTURE FABRICATION 审中-公开
标题翻译：纳米结构制造
公开(公告)号：US20100055620A1
公开(公告)日：2010-03-04
申请号：US12323372
申请日：2008-11-25
申请人： Sunghoon Kwon
发明人： Sunghoon Kwon
IPC分类号： G03F7/20 , B05D3/00 , C23C16/56 , B05D3/12 , C23C14/34
CPC分类号： B82B3/00 , B82Y10/00 , B82Y30/00 , B82Y40/00
摘要： Techniques for fabricating nanostructures are provided. In one embodiment a method includes forming a multilayer stack including at least one pair of a structural layer and a sacrificial layer on a substrate, patterning the multilayer stack in order to fabricate a nanostructure, and releasing the nanostructure from the patterned multilayer stack.
摘要翻译：提供了制造纳米结构的技术。在一个实施例中，一种方法包括在衬底上形成包括至少一对结构层和牺牲层的多层堆叠，图案化多层堆叠以制造纳米结构，以及从图案化的多层堆叠释放纳米结构。

20. 发明申请

US20100048025A1 NANOSTRUCTURES AND NANOSTRUCTURE FABRICATION 审中-公开
标题翻译：纳米结构和纳米结构制造
公开(公告)号：US20100048025A1
公开(公告)日：2010-02-25
申请号：US12197997
申请日：2008-08-25
申请人： Sunghoon Kwon
发明人： Sunghoon Kwon
IPC分类号： H01L21/3205
CPC分类号： B82Y40/00 , B82Y10/00 , H01L21/76251 , H01L29/0665 , H01L29/0669
摘要： Nanostructure and techniques for fabricating nanostructures are provided. In one embodiment, nanostructures may be formed by providing a Silicon-on-Insulator (SOI) substrate, forming a pattern on the SOI substrate, disposing a conformal layer over the pattern, etching the conformal layer, except for a sidewall portion, removing the pattern, transferring the sidewall pattern to the silicon layer of the SOI substrate to form the nanostructure, and releasing the nanostructure.
摘要翻译：提供纳米结构和制造纳米结构的技术。在一个实施例中，纳米结构可以通过提供绝缘体上硅（SOI）衬底形成，在SOI衬底上形成图案，在图案之上设置保形层，蚀刻除了侧壁部分之外的保形层，去除将侧壁图案转移到SOI衬底的硅层以形成纳米结构，并释放纳米结构。

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