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11. 发明申请

US20100130912A1 Patches and methods for the transdermal delivery of a therapeutically effective amount of iron 有权
标题翻译：用于透皮递送治疗有效量的铁的补片和方法
公开(公告)号：US20100130912A1
公开(公告)日：2010-05-27
申请号：US12459186
申请日：2009-06-25
申请人： Ronald J. Berenson
发明人： Ronald J. Berenson
IPC分类号： A61N1/30
CPC分类号： A61K9/703 , A61K9/0009 , A61K9/0021 , A61K9/7023 , A61K31/295 , A61K33/26 , A61K38/1816 , A61K45/06 , A61N1/0444 , A61N1/0448 , A61N1/303 , A61K2300/00
摘要： Embodiments of the invention provide patches for the transdermal delivery of iron-containing compositions to an individual suffering from an iron deficiency. Many embodiments provide an iontophoretic patch for the transdermal delivery of a therapeutically effective amount of iron. The patch comprises an electrode and a reservoir containing a composition comprising ionic iron for the delivery of the therapeutically effective amount of iron. Various embodiments provide methods of using embodiments of the iontophoretic patch for delivering a therapeutically effective amount of iron to an individual suffering from one more forms of iron deficiency including iron deficiency anemia. Such methods can be used for treating and/or preventing the iron deficiency. The amount of delivered iron can be adjusted depending upon various treatment parameters such as patient weight and type and amount of iron deficiency.
摘要翻译：本发明的实施方案提供了将含铁组合物透皮递送给患有铁缺乏症的个体的补片。许多实施方案提供用于透皮递送治疗有效量的铁的离子电渗贴剂。贴剂包括电极和含有用于递送治疗有效量的铁的包含离子铁的组合物的储存器。各种实施方案提供使用离子电渗贴剂的实施方案的方法，用于将治疗有效量的铁递送至患有一种更多形式的铁缺乏症（包括缺铁性贫血）的个体。这些方法可用于治疗和/或预防缺铁。输送铁的量可以根据各种治疗参数（如患者体重，铁缺乏的类型和量）进行调整。

12. 发明申请

US20080267972A1 Donor Lymphocyte Infusion of T Cells For the Treatment of Cancer 审中-公开
标题翻译：供体淋巴细胞输注T细胞治疗癌症
公开(公告)号：US20080267972A1
公开(公告)日：2008-10-30
申请号：US11815964
申请日：2006-02-10
申请人： Ronald J. Berenson
发明人： Ronald J. Berenson
IPC分类号： A61K35/14 , A61K39/395 , A61P35/00
CPC分类号： A61K35/17 , A61K2035/124 , A61K2039/505 , C07K16/2809 , C07K16/2818
摘要： The present invention relates generally to the treatment of cancer using donor lymphocyte infusions of T cells. Further, the present invention relates generally to methods for stimulating and activating allogeneic and/or xenogeneic cells which can then be used in a DLI setting.
摘要翻译：本发明一般涉及使用T细胞供体淋巴细胞输注治疗癌症。此外，本发明一般涉及用于刺激和激活同种异体和/或异种细胞的方法，其然后可以在DLI设置中使用。

13. 发明公开

US20230263523A1 FORCE MODULATING DEEP SKIN STAPLES AND INSTRUMENTS 审中-公开
公开(公告)号：US20230263523A1
公开(公告)日：2023-08-24
申请号：US18111080
申请日：2023-02-17
申请人： Ronald J. Berenson , Cheuk Yin Paul Leung
发明人： Ronald J. Berenson , Cheuk Yin Paul Leung
IPC分类号： A61B17/072
CPC分类号： A61B17/07207 , A61B2017/07214 , A61B2017/00526
摘要： A wound closure device in the form of a force modulating deep skin staple. The deep skin staple includes a bridge portion extending along a longitudinal axis to support a first set of staple legs and an opposing second set of staple legs. Each staple leg coupled to the bridge portion via a spring arm. Each staple leg angled towards a middle section of the bridge portion. The staple legs designed to modulate forces with a wound down into the reticular dermis layer when applied to the wound.

14. 发明公开

US20230255630A1 WOUND CLOSURE DEVICE FOR WIDE TREATMENT AREAS 审中-公开
公开(公告)号：US20230255630A1
公开(公告)日：2023-08-17
申请号：US18140822
申请日：2023-04-28
申请人： Cheuk Yin Paul Leung , Ronald J. Berenson
发明人： Cheuk Yin Paul Leung , Ronald J. Berenson
IPC分类号： A61B17/08 , A61B17/064
CPC分类号： A61B17/085 , A61B17/064 , A61B2017/00862
摘要： A wound closure device includes an elastic substrate and a plurality of microstructure arrays coupled to the elastic substrate via an adhesive layer. The device is long enough or wide enough to treat large wounds with the plurality of microstructure arrays distributed along a length of the wound.

15. 发明授权

US09913806B2 Patches and methods for the transdermal delivery of a therapeutically effective amount of iron 有权
公开(公告)号：US09913806B2
公开(公告)日：2018-03-13
申请号：US12459186
申请日：2009-06-25
申请人： Ronald J. Berenson
发明人： Ronald J. Berenson
IPC分类号： A61N1/30 , A61K9/70 , A61K9/00 , A61K31/295 , A61K33/26 , A61K38/18 , A61K45/06 , A61N1/04
CPC分类号： A61K9/703 , A61K9/0009 , A61K9/0021 , A61K9/7023 , A61K31/295 , A61K33/26 , A61K38/1816 , A61K45/06 , A61N1/0444 , A61N1/0448 , A61N1/303 , A61K2300/00
摘要： Embodiments of the invention provide patches for the transdermal delivery of iron-containing compositions to an individual suffering from an iron deficiency. Many embodiments provide an iontophoretic patch for the transdermal delivery of a therapeutically effective amount of iron. The patch comprises an electrode and a reservoir containing a composition comprising ionic iron for the delivery of the therapeutically effective amount of iron. Various embodiments provide methods of using embodiments of the iontophoretic patch for delivering a therapeutically effective amount of iron to an individual suffering from one more forms of iron deficiency including iron deficiency anemia. Such methods can be used for treating and/or preventing the iron deficiency. The amount of delivered iron can be adjusted depending upon various treatment parameters such as patient weight and type and amount of iron deficiency.

16. 发明授权

US08996104B2 Patches and method for the transdermal delivery of a therapeutically effective amount of iron 有权
标题翻译：用于透皮递送治疗有效量的铁的补片和方法
公开(公告)号：US08996104B2
公开(公告)日：2015-03-31
申请号：US12459183
申请日：2009-06-25
申请人： Ronald J. Berenson
发明人： Ronald J. Berenson
IPC分类号： A61N1/30 , A61K9/00 , A61K9/70 , A61K31/295 , A61K33/26 , A61K38/18 , A61N1/04
CPC分类号： A61K9/703 , A61K9/0009 , A61K9/0021 , A61K9/7023 , A61K31/295 , A61K33/26 , A61K38/1816 , A61K45/06 , A61N1/0444 , A61N1/0448 , A61N1/303 , A61K2300/00
摘要： Embodiments of the invention provide patches for the transdermal delivery of iron-containing compositions to an individual suffering from an iron deficiency. Many embodiments provide an iontophoretic patch for the transdermal delivery of a therapeutically effective amount of iron. The patch comprises an electrode and a reservoir containing a composition comprising ionic iron for the delivery of the therapeutically effective amount of iron. Various embodiments provide methods of using embodiments of the iontophoretic patch for delivering a therapeutically effective amount of iron to an individual suffering from one more forms of iron deficiency including iron deficiency anemia. Such methods can be used for treating and/or preventing the iron deficiency. The amount of delivered iron can be adjusted depending upon various treatment parameters such as patient weight and type and amount of iron deficiency.
摘要翻译：本发明的实施方案提供了将含铁组合物透皮递送给患有铁缺乏症的个体的补片。许多实施方案提供用于透皮递送治疗有效量的铁的离子电渗贴剂。贴剂包括电极和含有用于递送治疗有效量的铁的包含离子铁的组合物的储存器。各种实施方案提供使用离子电渗贴剂的实施方案的方法，用于将治疗有效量的铁递送至患有一种更多形式的铁缺乏症（包括缺铁性贫血）的个体。这些方法可用于治疗和/或预防缺铁。输送铁的量可以根据各种治疗参数（如患者体重，铁缺乏的类型和量）进行调整。

17. 发明申请

US20110251149A1 METHODS AND LOW DOSE REGIMENS FOR TREATING RED BLOOD CELL DISORDERS 有权
标题翻译：用于治疗红血球细胞病的方法和低剂量方案
公开(公告)号：US20110251149A1
公开(公告)日：2011-10-13
申请号：US12963490
申请日：2010-12-08
申请人： Susan P. Perrine , Douglas V. Faller , Ronald J. Berenson
发明人： Susan P. Perrine , Douglas V. Faller , Ronald J. Berenson
IPC分类号： A61K31/19 , A61K31/706 , A61P7/06 , A61K31/4406
CPC分类号： A61K31/17 , A61K31/19 , A61K31/4406 , A61K31/7068 , A61K45/06 , A61K2300/00
摘要： Disclosed herein are methods and low dose regimens for increasing fetal hemoglobin levels in patients with red blood cell disorders, such as beta thalassemia, sickle cell disease, other anemias, or blood loss. Fetal and total hemoglobin levels and red blood cell counts are increased by administering 2,2-dimethylbutyrate (DMB) alone or in combination with hydroxyurea, decitabine or an HDAC inhibitor. Treatment can be continued for at least two weeks.
摘要翻译：本文公开了用于在患有红细胞病症的患者中增加胎儿血红蛋白水平的方法和低剂量方案，例如β地中海贫血，镰状细胞病，其他贫血或失血。通过单独施用2,2-二甲基丁酸酯（DMB）或与羟基脲，地西他滨或HDAC抑制剂组合来增加胎儿和总血红蛋白水平和红细胞计数。治疗可持续至少两周。

18. 发明申请

US20110245154A1 Methods and Compositions for Treating Viral or Virally-Induced Conditions 审中-公开
标题翻译：用于治疗病毒或病毒诱导条件的方法和组合物
公开(公告)号：US20110245154A1
公开(公告)日：2011-10-06
申请号：US13046555
申请日：2011-03-11
申请人： Ronald J. Berenson , Douglas V. Faller
发明人： Ronald J. Berenson , Douglas V. Faller
IPC分类号： A61K38/12 , A61K31/167 , A61K31/513 , A61K31/4045 , A61K31/27 , A61K31/19 , A61P31/12 , A61P29/00 , A61P31/22 , A61P31/20
CPC分类号： A61K31/506 , A61K9/0053 , A61K31/165 , A61K31/167 , A61K31/18 , A61K31/19 , A61K31/27 , A61K31/4045 , A61K31/4402 , A61K31/473 , A61K31/513 , A61K31/522 , A61K38/12 , A61K38/15 , A61K45/06 , Y02A50/467 , A61K2300/00
摘要： Provided are methods and compositions for the prevention and/or treatment of viral conditions, virally-induced conditions and inflammatory conditions. The methods can comprise administering to a subject a viral inducing agent with an antiviral agent, and optionally an additional agent. The viral inducing agent can be a HDAC inhibitor administered orally.
摘要翻译：提供了用于预防和/或治疗病毒状况，病毒诱导的病症和炎性病症的方法和组合物。所述方法可以包括用抗病毒剂和任选的另外的药剂向受试者施用病毒诱导剂。病毒诱导剂可以是口服给药的HDAC抑制剂。

19. 发明申请

US20100272827A1 Method for transdermal iontophoretic delivery of chelated agents 有权
标题翻译：螯合剂透皮离子电渗递送方法
公开(公告)号：US20100272827A1
公开(公告)日：2010-10-28
申请号：US12459862
申请日：2009-07-07
申请人： Mir Imran , Mir Hashim , Sanjay Patel , Ronald J. Berenson
发明人： Mir Imran , Mir Hashim , Sanjay Patel , Ronald J. Berenson
IPC分类号： A61K33/42 , A61K33/26 , A61P7/06
CPC分类号： A61K41/0047 , A61K9/0009 , A61K9/703 , A61K9/7084 , A61K33/26 , A61K33/42 , A61K41/00 , A61N1/0496 , A61N1/30 , A61N1/325
摘要： Embodiments provide devices, systems and methods for the transdermal delivery of chelated compounds. One embodiment provides a method for the iontophoretic transdermal delivery of a chelated iron complex for the treatment of anemia. A first patch comprising an active electrode and a chelated iron complex is applied to the skin; a second patch containing an electrode is also applied. An electrical current is then delivered to the skin from the active electrode. The chelated complex is transported across the skin via electromotive force from the current, with the iron being substantially chromogenically unreactive with the skin during transport so that there is little or no tattooing of the skin due to the formation of insoluble oxidative products. The complex is then dissociated by phagocytosis or related process to release the iron where it may be bound by transferrin or ferritin and carried to other sites for storage or metabolic use.
摘要翻译：实施方案提供用于经皮递送螯合化合物的装置，系统和方法。一个实施方案提供了用于治疗贫血的螯合铁络合物的离子电渗疗法透皮递送的方法。将包含活性电极和螯合铁络合物的第一贴片施加到皮肤上; 还应用了包含电极的第二贴片。然后从活性电极将电流输送到皮肤。螯合络合物通过电流从电流传递穿过皮肤，铁在运输过程中与皮肤基本上不发生色素反应，因此由于不溶性氧化产物的形成，皮肤几乎或没有纹身。然后通过吞噬作用或相关过程解离复合物以释放铁，其中它可被转铁蛋白或铁蛋白结合并携带到其它部位用于储存或代谢使用。

20. 发明授权

US07572631B2 Activation and expansion of T cells 有权
标题翻译： T细胞的活化和扩增
公开(公告)号：US07572631B2
公开(公告)日：2009-08-11
申请号：US11070841
申请日：2005-03-02
申请人： Ronald J Berenson , Che Law , Mark Bonyhadi , Zahbea Saund , Stewart Craig , Alan Hardwick , Dale Kalamasz , David McMillen , Harjinder Singh Chana
发明人： Ronald J Berenson , Che Law , Mark Bonyhadi , Zahbea Saund , Stewart Craig , Alan Hardwick , Dale Kalamasz , David McMillen , Harjinder Singh Chana
IPC分类号： C12N5/00
CPC分类号： C12N5/0636 , C12N2501/51 , C12N2501/515 , C12N2533/00
摘要： The present invention relates generally to methods for activating and expanding cells, and more particularly, to a novel method to activate and/or stimulate cells that maximizes the expansion of such cells to achieve dramatically high densities. In the various embodiments, cells are activated and expanded to very high densities in a short period of time. In certain embodiments, cells are activated and expanded to very high numbers of cells in a short period of time. Compositions of cells activated and expanded by the methods herein are further provided.
摘要翻译：本发明一般涉及用于激活和扩增细胞的方法，更具体地，涉及一种激活和/或刺激细胞的新方法，其使这种细胞的扩增最大化以达到显着高的密度。在各种实施例中，细胞被激活并在短时间内扩展到非常高的密度。在某些实施方案中，细胞在短时间内被激活并扩增至非常高数量的细胞。进一步提供通过本文方法激活和扩增的细胞的组成。

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