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11. 发明授权

US4647445A Radiolabelled lipoproteins and method for making same 失效
标题翻译：放射性标记的脂蛋白及其制备方法
公开(公告)号：US4647445A
公开(公告)日：1987-03-03
申请号：US594244
申请日：1984-03-28
申请人： Robert S. Lees
发明人： Robert S. Lees
IPC分类号： A61K51/00 , A61K51/12 , A61K43/00 , A61K37/00 , A61K49/00
CPC分类号： A61K51/1224 , A61K2123/00
摘要： Lipoproteins radiolabelled with an isotope of technetium substantially retain their native structure and biological function. The lipoproteins can be radiolabelled by simultaneous reduction of pertechnetate and lipoprotein with sodium dithionite at pH 8-9. The resulting radiolabelled lipoproteins can be used as probes for extracorporeal imaging to analyze lipoprotein metabolism.
摘要翻译：用锝同位素放射性标记的脂蛋白基本上保留了其天然结构和生物学功能。脂蛋白可以通过在pH8-9下与连二亚硫酸钠同时还原高锝酸盐和脂蛋白进行放射性标记。所得放射性标记的脂蛋白可用作体外成像的探针，以分析脂蛋白代谢。

12. 发明授权

US06605588B1 Low density lipoprotein binding proteins and their use in diagnosing and treating atherosclerosis 失效
公开(公告)号：US06605588B1
公开(公告)日：2003-08-12
申请号：US09517849
申请日：2000-03-02
申请人： Ann M. Lees , Robert S. Lees , Simon W. Law , Anibal A. Arjona
发明人： Ann M. Lees , Robert S. Lees , Simon W. Law , Anibal A. Arjona
IPC分类号： A01N3718
CPC分类号： A61K49/0004 , A61K38/00 , A61K39/00 , C07K14/47 , C07K14/705 , G01N33/6893 , G01N33/92 , G01N2800/044 , G01N2800/323 , Y10S514/814
摘要： Isolated polynucleotides encoding novel polypeptides which are capable of binding to native and methylated LDL (low density lipoprotein), the isolated polypeptides, called LBPs (LDL binding proteins), and biologically active fragments and analogs thereof, are described. Also described are methods for determining if an animal is at risk for atherosclerosis, methods for evaluating an agent for use in treating atherosclerosis, methods for treating atherosclerosis, and methods for treating a cell having an abnormality in structure or metabolism of LBP. Pharmaceutical compositions and vaccine compositions are also provided.

13. 发明授权

US5989519A Technetium-99m labeled peptides for imaging inflammation 失效
标题翻译：锝-99m标记的肽用于成像炎症
公开(公告)号：US5989519A
公开(公告)日：1999-11-23
申请号：US290853
申请日：1994-10-11
申请人： Richard T. Dean , Robert S. Lees , Scott Buttram , John Lister-James
发明人： Richard T. Dean , Robert S. Lees , Scott Buttram , John Lister-James
IPC分类号： A61K51/08 , A61K51/00 , A61M36/14
CPC分类号： A61K51/08 , A61K51/088 , A61K2121/00 , A61K2123/00
摘要： This invention relates to radiolabeled peptides and methods for producing such peptides. Specifically, the invention relates to technetium-99m (Tc-99m) labeled leukocyte-binding peptides, methods and kits for making such peptides, and methods for using such peptides to image sites of infection and inflammation in a mammalian body.
摘要翻译： PCT No.PCT / US93 / 02320 Sec。 371日期：1994年10月11日 102（e）日期1994年10月11日PCT 1993年3月12日PCT公布。出版物WO93 / 17719 日期1993年9月16日本发明涉及放射性标记肽及其生产方法。具体地，本发明涉及锝-99m（Tc-99m）标记的白细胞结合肽，用于制备这些肽的方法和试剂盒，以及使用这些肽来成像哺乳动物体内的感染和炎症部位的方法。

14. 发明授权

US5726153A Synthetic peptides for arterial imaging 失效
公开(公告)号：US5726153A
公开(公告)日：1998-03-10
申请号：US468543
申请日：1995-06-06
申请人： Robert S. Lees , Ann M. Lees , Allan Fischman , Ing-Lung Shih , Mark A. Findeis
发明人： Robert S. Lees , Ann M. Lees , Allan Fischman , Ing-Lung Shih , Mark A. Findeis
IPC分类号： A61K38/00 , A61K49/14 , A61K51/08 , A61K51/12 , C07K14/775 , C07K14/78 , A61K38/04 , C07K5/00 , C07K7/00
CPC分类号： A61K49/085 , A61K49/14 , A61K51/08 , C07K14/775 , C07K14/78 , A61K2123/00 , A61K38/00
摘要： Vascular disease including asymptomatic atherosclerosis can be diagnosed by administering a synthetic peptide or peptide analog having an affinity for, and propensity to accumulate at, a site of vascular injury to a patient, and then detecting the location of the peptide or peptide analog within the patient's vascular system. The synthetic peptide or peptide analog may include an amino acid sequence sufficiently duplicative of the amino acid sequence of a region of either the apolipoprotein B, apolipoprotein A-I, or elastin proteins such that the peptide or peptide analog accumulates at a site of vascular injury.

15. 发明授权

US4877599A Detection of vascular disease with labelled antibodies 失效
标题翻译：用标记抗体检测血管疾病
公开(公告)号：US4877599A
公开(公告)日：1989-10-31
申请号：US220376
申请日：1988-07-11
申请人： Robert S. Lees
发明人： Robert S. Lees
IPC分类号： A61K49/16 , A61K51/10
CPC分类号： A61K49/16 , A61K51/1018 , A61K2123/00 , Y10S514/824
摘要： Vascular diseases including asymptomatic atherosclerosis can be diagnosed by administering a conjugate diagnostic reagent to a patient and then detecting the location and concentration of the conjugate reagent within the patient's vascular system. The conjugate reagents have a target-seeking, biologically active molecule as one component and a labeling means capable of extracorporeal detection as the other component. The biologically active molecules (BAMs) are chosen to have affinity for structural elements of the arterial wall which are either not present in the normal wall but are found in atherosclerotic or arteritic lesions, or which are not available to the blood-borne reagent within normal arterial walls, but are exposed to the reagent in atherosclerotic or arteriotic lesions.
摘要翻译：包括无症状动脉粥样硬化的血管疾病可以通过向患者施用缀合物诊断试剂，然后检测患者血管系统内缀合物的位置和浓度来诊断。缀合物试剂具有作为一个成分的靶寻求的生物活性分子和能够作为其他组分进行体外检测的标记装置。选择生物活性分子（BAM）对动脉壁的结构元件具有亲和性，所述结构元件不存在于正常壁中，但存在于动脉粥样硬化或动脉病变中，或者在正常情况下不能用于血液载体试剂动脉壁，但暴露于动脉粥样硬化或动脉病变的试剂。

16. 发明申请

US20100028327A1 NOVEL LOW DENSITY LIPOPROTEIN BINDING PROTEINS AND THEIR USE IN DIAGNOSING AND TREATING ATHEROSCLEROSIS 失效
标题翻译：新型低密度脂蛋白结合蛋白及其在诊断和治疗甲状腺功能亢进中的应用
公开(公告)号：US20100028327A1
公开(公告)日：2010-02-04
申请号：US12137832
申请日：2008-06-12
申请人： ANN M. LEES , ROBERT S. LEES , SIMON W. LAW , ANIBAL A. ARJONA
发明人： ANN M. LEES , ROBERT S. LEES , SIMON W. LAW , ANIBAL A. ARJONA
IPC分类号： A61K39/395 , G01N33/566 , G01N33/53 , C12Q1/68 , A61K31/7088 , A61K31/70 , A61K38/16
CPC分类号： A61K49/0004 , A61K38/00 , A61K39/00 , A61K48/00 , C07K14/47 , C07K14/705 , G01N33/6893 , G01N33/92 , G01N2800/044 , G01N2800/323
摘要： Isolated polynucleotides encoding novel polypeptides which are capable of binding to native and methylated LDL (low density lipoprotein), the isolated polypeptides, called LBPs (LDL binding proteins), and biologically active fragments and analogs thereof, are described. Also described are methods for determining if an animal is at risk for atherosclerosis, methods for evaluating an agent for use in treating atherosclerosis, methods for treating atherosclerosis, and methods for treating a cell having an abnormality in structure or metabolism of LBP. Pharmaceutical compositions and vaccine compositions are also provided.
摘要翻译：描述了编码能够结合天然和甲基化的LDL（低密度脂蛋白），所述分离的多肽（称为LBP（LDL结合蛋白））及其生物活性片段及其类似物的分离的多核苷酸的分离的多核苷酸。还描述了用于确定动物是否处于动脉粥样硬化风险的方法，用于评估用于治疗动脉粥样硬化的药剂的方法，治疗动脉粥样硬化的方法，以及用于治疗LBP的结构或代谢异常的细胞的方法。还提供药物组合物和疫苗组合物。

17. 发明授权

US07402395B2 Low density lipoprotein binding proteins and their use in diagnosing and treating atherosclerosis 失效
标题翻译：低密度脂蛋白结合蛋白及其在诊断和治疗动脉粥样硬化中的应用
公开(公告)号：US07402395B2
公开(公告)日：2008-07-22
申请号：US10671242
申请日：2003-09-24
申请人： Ann M. Lees , Robert S. Lees , Simon W. Law , Anibal A. Arjona
发明人： Ann M. Lees , Robert S. Lees , Simon W. Law , Anibal A. Arjona
IPC分类号： G01N33/53 , C07K14/00
CPC分类号： A61K49/0004 , A61K38/00 , A61K39/00 , A61K48/00 , C07K14/47 , C07K14/705 , G01N33/6893 , G01N33/92 , G01N2800/044 , G01N2800/323
摘要： Isolated polynucleotides encoding novel polypeptides which are capable of binding to native and methylated LDL (low density lipoprotein), the isolated polypeptides, called LBPs (LDL binding proteins), and biologically active fragments and analogs thereof, are described. Also described are methods for determining if an animal is at risk for atherosclerosis, methods for evaluating an agent for use in treating atherosclerosis, methods for treating atherosclerosis, and methods for treating a cell having an abnormality in structure or metabolism of LBP. Pharmaceutical compositions and vaccine compositions are also provided.
摘要翻译：描述了编码能够结合天然和甲基化的LDL（低密度脂蛋白），所述分离的多肽（称为LBP（LDL结合蛋白））及其生物活性片段及其类似物的分离的多核苷酸的分离多核苷酸。还描述了用于确定动物是否处于动脉粥样硬化风险的方法，用于评估用于治疗动脉粥样硬化的药剂的方法，治疗动脉粥样硬化的方法，以及用于治疗LBP的结构或代谢异常的细胞的方法。还提供药物组合物和疫苗组合物。

18. 发明授权

US5495852A Method and apparatus for estimating diameter of an artery using B-mode ultrasonic images 失效
标题翻译：使用B模式超声图像估计动脉直径的方法和装置
公开(公告)号：US5495852A
公开(公告)日：1996-03-05
申请号：US379852
申请日：1995-01-27
申请人： Robert W. Stadler , W. Clem Karl , Robert S. Lees
发明人： Robert W. Stadler , W. Clem Karl , Robert S. Lees
IPC分类号： A61B5/107 , A61B8/08 , A61B8/00
CPC分类号： A61B8/0858 , A61B5/1076
摘要： An improved apparatus and method for measuring the diameter of an artery utilizes an ultrasonic imaging plane that is rotated slightly from the centerline of an artery to produce a "skew" image of the artery. The invention detects edge points on the image of near and far walls of the artery. It fits curves to the near and far end edge points and measures distances between the curves. Alternatively, it fits one curve to all the edge points and measures a parameter (such as minor diameter of an ellipse) of the curve. Finally, it estimates arterial diameter from the measurement.
摘要翻译：用于测量动脉直径的改进的装置和方法利用从动脉中心线稍微旋转的超声成像平面，以产生动脉的“歪斜”图像。本发明检测动脉近壁和远壁的图像上的边缘点。它适合曲线到近端和远端边缘点，并测量曲线之间的距离。或者，它适合于所有边缘点的一条曲线，并测量曲线的参数（如椭圆的小直径）。最后，从测量中估计动脉直径。

19. 发明授权

US5232696A Reduction of low density lipoproteins in biological fluids 失效
标题翻译：减少生物流体中低密度脂蛋白
公开(公告)号：US5232696A
公开(公告)日：1993-08-03
申请号：US101262
申请日：1987-09-25
申请人： Robert S. Lees , Robert S. Langer, Jr. , Claudy J. P. Mullon , Hugh D. Conlon
发明人： Robert S. Lees , Robert S. Langer, Jr. , Claudy J. P. Mullon , Hugh D. Conlon
IPC分类号： A61K38/43 , A61K35/14 , A61K38/46 , A61M1/16 , A61M1/34 , A61M1/36 , A61P3/06 , C12N11/10
CPC分类号： A61K38/465 , A61M1/3687 , A61M1/1678 , A61M2202/046
摘要： A method and apparatus for reducing the levels of low density lipoproteins (LDL) in blood is disclosed. The LDL is contacted with an enzyme which modifies it in a manner such that the LDL is rapidly removed endogenously by the patients' own metabolic processes. The enzyme may be introduced into the patient by injection, transdermal transport, nasal insufflation and ingestion. Additionally, the enzyme may be contained in a reactor for both in vivo and extracorporeal use.
摘要翻译：公开了一种降低血液中低密度脂蛋白（LDL）水平的方法和装置。使LDL与以其使得LDL被患者自身的代谢过程内源性快速去除的方式接触的酶接触。可以通过注射，透皮转运，鼻吹入和摄取将酶引入患者。此外，酶可以包含在用于体内和体外使用的反应器中。

20. 发明授权

US5178864A Lipoprotein removal by soluble enzymes 失效
标题翻译： LIPOPROTEIN可溶性酶除去
公开(公告)号：US5178864A
公开(公告)日：1993-01-12
申请号：US567261
申请日：1990-08-14
申请人： Robert S. Lees , Robert S. Langer, Jr. , Regine Labeque , Claudy J. P. Mullon
发明人： Robert S. Lees , Robert S. Langer, Jr. , Regine Labeque , Claudy J. P. Mullon
IPC分类号： A61K38/46 , A61P3/06
CPC分类号： A61K38/465
摘要： A therapeutically effective amount of soluble phospholipase A.sub.2 is administered into a subject for lowering the low density lipoproteins ("LDL") in the blood. Phospholipase A.sub.2 modifies the plasma LDL by hydrolyzing the phospholipids present in LDL. As a result, the modified LDL is rapidly removed from the bloodstream by the catabolic processes.

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