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11. 发明授权

US06875435B2 In vivo CTL elicitation by heat shock protein fusion proteins maps to a discrete domain and is CD4+ T cell-independent 失效
公开(公告)号：US06875435B2
公开(公告)日：2005-04-05
申请号：US09761534
申请日：2001-01-16
申请人： Qian Huang , Joan F. L. Richmond , Bryan K. Cho , Deborah Palliser , Jianzhu Chen , Herman N. Eisen , Richard A. Young
发明人： Qian Huang , Joan F. L. Richmond , Bryan K. Cho , Deborah Palliser , Jianzhu Chen , Herman N. Eisen , Richard A. Young
IPC分类号： A61K45/00 , A61K38/00 , A61K39/00 , A61K39/02 , A61K39/04 , A61K39/12 , A61K39/21 , A61K47/48 , A61P31/04 , A61P31/18 , A61P35/00 , A61P37/04 , C07K14/35 , A61K38/04 , A61K39/385
CPC分类号： C07K14/35 , A61K39/00 , A61K47/62 , A61K47/6425 , A61K2039/57 , C07K2319/00
摘要： The present invention relates to a method of inducing a CD8+ CTL response to a molecule in an individual deficient in CD4+ T cells comprising administering to the individual an hsp or a portion of an ATP binding domain of an hsp joined to the molecule. In one embodiment, the present invention relates to a method of treating HIV in an individual deficient in CD4+ T cells comprising administering to the individual an hsp or a portion of an ATP binding domain of an hsp joined to the molecule. Also encompassed by the present invention is a method of inducing a CD4+ independent CTL response in an individual comprising administering to the individual a portion of an ATP binding domain of an hsp joined to the molecule. The present invention also relates to a method of inducing a CD8+ CTL response in an individual comprising administering to the individual a portion of an ATP binding domain of an hsp joined to the molecule. In addition, the present invention relates to a composition characterized by a portion of an ATP biding domain of an hsp joined to a molecule.

12. 发明授权

US06270776B1 Recombinant mycobacterial vaccine 失效
标题翻译：重组分枝杆菌疫苗
公开(公告)号：US06270776B1
公开(公告)日：2001-08-07
申请号：US08454075
申请日：1995-05-30
申请人： Barry R. Bloom , Ronald W. Davis , William R. Jacobs, Jr. , Richard A. Young , Robert N. Husson
发明人： Barry R. Bloom , Ronald W. Davis , William R. Jacobs, Jr. , Richard A. Young , Robert N. Husson
IPC分类号： A61K3500
CPC分类号： A61K39/04 , A61K39/00 , C07K14/005 , C07K14/35 , C12N15/74 , C12N15/87 , C12N2795/10022 , C12R1/32 , Y02A50/412 , Y02A50/476
摘要： Recombinant mycobacterial vaccine vehicles capable of expressing DNA of interest which encodes at least one protein antigen for at least one pathogen against which an immune response is desired and which can be incorporated into the mycobacteria or stably integrated into the mycobacterial genome. The vaccine vehicles are useful for administration to mammalian hosts for purposes of immunization. A recombinant vector which replicates in E. coli but not in mycobacteria is also disclosed. The recombinant vector includes 1) a mycobacterial gene or portions thereof, necessary for recombination with homologous sequences in the genome of mycobacteria transformed with the recombinant plasmid; 2) all or a portion of a gene which encodes a polypeptide or protein whose expression is desired in mycobacteria transformed with the recombinant plasmid; 3) DNA sequences necessary for replication and selection in E. coli; and 4) DNA sequences necessary for selection in mycobacteria (e.g., drug resistance). The present invention also relates to two types of recombinant vectors useful in introducing DNA of interest into mycobacteria, where it is expressed. One type of vector is a recombinant phasmid capable of replicating as a plasmid in E. coli and of lysogenizing a mycobacterial host. The other type of vector is a recombinant plasmid which can be introduced into mycobacteria, where it is stably maintained extrachromosomally.
摘要翻译：能够表达目的的DNA的重组分枝杆菌疫苗载体，其编码针对至少一种需要免疫应答的至少一种病原体的至少一种蛋白质抗原并且可以并入分枝杆菌中或稳定整合到分枝杆菌基因组中。疫苗载体用于哺乳动物宿主用于免疫的目的。还公开了在大肠杆菌中但不在分枝杆菌中复制的重组载体。重组载体包括1）与用重组质粒转化的分枝杆菌基因组中与同源序列重组所必需的分枝杆菌基因或其部分; 2）编码在用重组质粒转化的分枝杆菌中表达所需的多肽或蛋白质的基因的全部或部分; 3）在大肠杆菌中复制和选择所需的DNA序列; 和4）在分枝杆菌中选择所需的DNA序列（例如耐药性）。本发明还涉及可用于将感兴趣的DNA引入分枝杆菌的两种类型的重组载体，其中它被表达。一种载体是能够在大肠杆菌中作为质粒复制并使分枝杆菌宿主溶解的重组噬菌粒。另一种载体是可以引入分枝杆菌的重组质粒，其在染色体外稳定地保持。

13. 发明授权

US5922585A RNA polymerase II holoenzyme from Saccharomyces cerevisiae 失效
标题翻译：来自酿酒酵母的RNA聚合酶II全酶
公开(公告)号：US5922585A
公开(公告)日：1999-07-13
申请号：US218265
申请日：1994-03-25
申请人： Richard A. Young , Anthony J. Koleske , Craig M. Thompson
发明人： Richard A. Young , Anthony J. Koleske , Craig M. Thompson
IPC分类号： C07K14/395 , C07K14/47 , C07K16/14 , C12N9/12 , C12N15/54 , G01N33/573 , C12N15/31
CPC分类号： C12N9/1247 , C07K14/395 , C07K14/4702 , C07K16/14 , G01N33/573
摘要： An RNA polymerase II holoenzyme that contains, in addition to RNA polymerase, a subset of the general transcription factors together with nine SRB proteins is described. This holoenzyme will selectively initiate transcription in vitro when supplemented with TATA-binding protein (TBP) and factor a (TFIIE). The SRB proteins act positively and negatively to regulate transcription initiation, at least in part, via functional interactions with RNA polymerase II.
摘要翻译：描述了RNA聚合酶II全酶，其除RNA聚合酶外还包含一些一般转录因子的子集以及九种SRB蛋白。当补充有TATA结合蛋白（TBP）和因子a（TFIIE）时，该全酶将在体外选择性地启动转录。至少部分通过与RNA聚合酶II的功能相互作用，SRB蛋白质正向和负向地起调节转录起始作用。

14. 发明授权

US5776465A Recombinant mycobacterial vaccines 失效
标题翻译：重组分枝杆菌疫苗
公开(公告)号：US5776465A
公开(公告)日：1998-07-07
申请号：US461725
申请日：1995-06-05
申请人： Michael A. O'Donnell , Rosemary B. Duda , William C. DeWolf , Anna Aldovini , Richard A. Young
发明人： Michael A. O'Donnell , Rosemary B. Duda , William C. DeWolf , Anna Aldovini , Richard A. Young
IPC分类号： A61K38/00 , A61K39/00 , A61K39/04 , C07K14/16 , C07K14/35 , C07K14/52 , C07K14/55 , C12N1/21 , C12N15/74 , C12N15/87 , A61K45/05
CPC分类号： A61K39/04 , C07K14/005 , C07K14/35 , C07K14/52 , C07K14/55 , C12N15/74 , C12N15/87 , C12R1/32 , A61K38/00 , A61K39/00 , C12N2740/16022 , C12N2740/16122 , C12N2740/16222 , Y10S435/863 , Y10S435/864 , Y10S435/865 , Y10S435/866
摘要： The present invention relates to recombinant mycobacteria, particularly recombinant M. bovis BCG, which express heterologous DNA encoding a product (protein or polypeptide) of interest, such a protein or polypeptide (e.g., an antigen) against which an immune response is desired, or a cytokine.
摘要翻译：本发明涉及重组分枝杆菌，特别是重组牛分枝杆菌BCG，其表达编码目标产物（蛋白质或多肽）的异源DNA，例如需要免疫应答的蛋白质或多肽（例如抗原），或一种细胞因子。

15. 发明授权

US5733011A Multiple position tool caddy seat 失效
标题翻译：多位置工具球童座椅
公开(公告)号：US5733011A
公开(公告)日：1998-03-31
申请号：US796820
申请日：1997-02-06
申请人： Richard A. Young , Michael F. Drzewiecki
发明人： Richard A. Young , Michael F. Drzewiecki
IPC分类号： A47C7/62 , A47C9/02 , A47C7/50
CPC分类号： A47C9/002 , A47C16/00 , A47C9/005 , A47C9/027
摘要： A multiple position work is disclosed caddy seat or stool which has a base and at least two rest surfaces to support a worker. The stool and rest surfaces are constructed and arranged to properly balance the worker's weight and relieve stress and strain on a worker's neck, upper body, and back and to provide comfort to a worker. The work stool also includes a storage compartment for caddying tools and which is easily accessible when used in any of the positions. Additionally, the stool may have limb rests for when the worker is working in a kneeling position. Cushions are provided on the rest surfaces to provide maximum comfort for the worker. The work stool is designed for use by heating, ventilating, and air conditioning technicians, but is readily adaptable to for use by plumbers, electricians, masons, mechanics, janitors, gardeners, and the like.
摘要翻译：公开了一种多位置工作的座椅或凳子，其具有基座和至少两个支撑工人的休息面。粪便和休息表面被构造和布置成适当地平衡工人的体重，并且减轻工作者的脖子，上身和背部的压力和压力，并为工人提供舒适感。工作凳子还包括一个用于夹紧工具的储物箱，当用于任何位置时，该容器易于接近。此外，当工人在跪下的时候，凳子可能有肢体休息。在休息表面上提供靠垫，为工人提供最大的舒适度。工作凳设计用于加热，通风和空调技术人员使用，但易于适用于水管工，电工，泥瓦匠，机械师，管理者，园丁等。

16. 发明授权

US5504005A Recombinant mycobacterial vaccine 失效
标题翻译：重组分枝杆菌疫苗
公开(公告)号：US5504005A
公开(公告)日：1996-04-02
申请号：US361944
申请日：1989-06-05
申请人： Barry R. Bloom , Ronald W. Davis , William R. Jacobs, Jr. , Richard A. Young , Robert N. Husson
发明人： Barry R. Bloom , Ronald W. Davis , William R. Jacobs, Jr. , Richard A. Young , Robert N. Husson
IPC分类号： G01N33/53 , A61K39/00 , A61K39/04 , A61K39/39 , A61P31/04 , A61P31/06 , A61P31/08 , A61P31/12 , A61P31/16 , A61P31/18 , A61P31/22 , A61P37/04 , A61P39/02 , C07K14/01 , C07K14/35 , C12N1/21 , C12N15/09 , C12N15/74 , C12N15/87 , C12P21/02 , C12R1/19 , C12R1/32 , C12R1/325 , C12R1/33 , C12R1/34 , G01N33/50 , C12N15/64 , C12N15/66
CPC分类号： A61K39/04 , C07K14/005 , C07K14/35 , C12N15/74 , C12N15/87 , C12R1/32 , A61K39/00 , C12N2795/10022
摘要： Recombinant mycobacterial vaccine vehicles capable of expressing DNA of interest which encodes at least one protein antigen for at least one pathogen against which an immune response is desired and which can be incorporated into the mycobacteria or stably integrated into the mycobacterial genome. The vaccine vehicles are useful for administration to mammalian hosts for purposes of immunization. A recombinant vector which replicates in E. coli but not in mycobacteria is also disclosed. The recombinant vector includes 1) a mycobacterial gene or portions thereof, necessary for recombination with homologous sequences in the genome of mycobacteria transformed with the recombinant plasmid; 2) all or a portion of a gene which encodes a polypeptide or protein whose expression is desired in mycobacteria transformed with the recombinant plasmid; 3) DNA sequences necessary for replication and selection in E. coli; and 4) DNA sequences necessary for selection in mycobacteria (e.g., drug resistance). The present invention also relates to two types of recombinant vectors useful in introducing DNA of interest into mycobacteria, where it is expressed. One type of vector is a recombinant phasmid capable of replicating as a plasmid in E. coli and of lysogenizing a mycobacterial host. The other type of vector is a recombinant plasmid which can be introduced into mycobacteria, where it is stably maintained extrachromosomally.
摘要翻译：能够表达目的的DNA的重组分枝杆菌疫苗载体，其编码针对至少一种需要免疫应答的至少一种病原体的至少一种蛋白质抗原并且可以并入分枝杆菌中或稳定整合到分枝杆菌基因组中。疫苗载体用于哺乳动物宿主用于免疫的目的。还公开了在大肠杆菌中但不在分枝杆菌中复制的重组载体。重组载体包括1）与用重组质粒转化的分枝杆菌基因组中与同源序列重组所必需的分枝杆菌基因或其部分; 2）编码在用重组质粒转化的分枝杆菌中表达所需的多肽或蛋白质的基因的全部或部分; 3）在大肠杆菌中复制和选择所需的DNA序列; 和4）在分枝杆菌中选择所需的DNA序列（例如耐药性）。本发明还涉及可用于将感兴趣的DNA引入分枝杆菌的两种类型的重组载体，其中它被表达。一种载体是能够在大肠杆菌中作为质粒复制并使分枝杆菌宿主溶解的重组噬菌粒。另一种载体是可以引入分枝杆菌的重组质粒，其在染色体外稳定地保持。

17. 发明授权

US4647716A Article having heat expandable sealing member 失效
标题翻译：物品具有热膨胀密封件
公开(公告)号：US4647716A
公开(公告)日：1987-03-03
申请号：US668740
申请日：1984-11-06
申请人： James K. Akiyama , Klaus D. Freysing , Richard A. Young
发明人： James K. Akiyama , Klaus D. Freysing , Richard A. Young
IPC分类号： H01R4/72 , H02G15/013 , H02G15/04 , F16B4/00
CPC分类号： H01R4/72 , H02G15/013 , Y10S174/08 , Y10S264/71 , Y10T403/48
摘要： An article comprising a generally axially extending outer, tubular member, a plurality of generally axially extending cylindrical members, and a heat expandable foam sealing member. The outer tubular member has at least one opening and occupies a predetermined volume. Each of the cylindrical members is received by outer tubular member in an axially extending, parallel fashion such that the cylindrical members occupy a volume that is less than the volume of the outer tubular member. The sealing member, capable of sealing the opening of outer tubular member, occupies a volume that is generally equal to the difference between the volume of the outer tubular member and the volume of the cylindrical members.
摘要翻译：包括大致轴向延伸的外部管状构件，多个大致轴向延伸的圆柱形构件和热膨胀泡沫密封构件的制品。外管状构件具有至少一个开口并占据预定的体积。圆柱形构件中的每一个以外部管状构件以轴向延伸的平行方式容纳，使得圆柱形构件占据的体积小于外部管状构件的体积。能够密封外部管状构件的开口的密封构件占据的体积通常等于外部管状构件的体积与圆柱形构件的体积之间的差异。

18. 发明授权

US4153747A Wrap around heat shrinkable closure 失效
标题翻译：缠绕热收缩闭合
公开(公告)号：US4153747A
公开(公告)日：1979-05-08
申请号：US892673
申请日：1978-04-03
申请人： Richard A. Young , Mark J. Stanek
发明人： Richard A. Young , Mark J. Stanek
IPC分类号： B65D65/14 , B29C51/00 , B29C61/10 , B29C63/00 , B29C63/40 , C09J7/02
CPC分类号： B29C61/10 , C09J7/0239 , B29L2009/00 , Y10S174/08 , Y10T428/1462 , Y10T428/2826 , Y10T428/2843 , Y10T428/2848 , Y10T428/31663
摘要： Wrap around closures for cables, pipes, splices, and junctions to effect repair, insulation, waterproofing and the like and a method for preparing such closures are described. The closures comprise generally rectangular sheets of heat shrinkable polymer having a large central section which has been hot stretched and cooled while in stretched condition and two small, flat unstretched end sections integral with the central section. Each end section has a layer of non-silicone adhesive covering one of its surfaces, optionally a layer of non-porous support material covering and adhering to the adhesive layer, a layer of silicone adhesive covering and adhering to the non-silicone support layer and a peelably removable cover layer covering the upper surface of the silicone adhesive layer. The several layers lie on the upper surface of one of the end sections and on the lower surface of the other end section.
摘要翻译：描述用于电缆，管道，接头和接头的闭合件以实现修复，绝缘，防水等，并且描述了制备这种闭合件的方法。封闭件包括大致矩形的热收缩聚合物片，其具有大的中心部分，其在拉伸状态下被热拉伸和冷却，以及与中心部分成一体的两个小的，平坦的未拉伸端部。每个端部具有覆盖其一个表面的任选的非硅氧烷粘合剂层，可选地覆盖并粘附到粘合剂层的一层无孔支撑材料，覆盖并附着到非硅氧烷支撑层的硅氧烷粘合剂层，覆盖有机硅粘合剂层的上表面的可剥离的覆盖层。几层位于一个端部的上表面上，另一端位于另一端部的下表面上。

19. 发明授权

US08912156B1 Markers for and methods of targeting tumor stem cells 有权
标题翻译：肿瘤干细胞的标志物和方法
公开(公告)号：US08912156B1
公开(公告)日：2014-12-16
申请号：US13365073
申请日：2012-02-02
申请人： Tan A. Ince , Tong Ihn Lee , Richard A. Young
发明人： Tan A. Ince , Tong Ihn Lee , Richard A. Young
IPC分类号： A61K48/00 , C07H21/02 , C07H21/04
CPC分类号： A61K31/165 , C12N5/0695 , C12N2501/065
摘要： The invention provides methods of targeting tumor stem cells that comprise inhibiting the level and/or activity of HDAC1, HDAC7 and phosphorylated HDAC7. The invention further provides methods for identifying tumor stem cells comprising detecting increased levels and/or activity of HDAC1, HDAC7 and phosphorylated HDAC7. Further provided are kits and articles of manufacture comprising inhibitors of the level and/or activity of HDAC1, HDAC7 and phosphorylated HDAC7. Methods for screening for inhibitors of the level and/or activity of HDAC1, HDAC7 and phosphorylated HDAC7 are also provided.
摘要翻译：本发明提供靶向肿瘤干细胞的方法，其包括抑制HDAC1，HDAC7和磷酸化HDAC7的水平和/或活性。本发明还提供用于鉴定肿瘤干细胞的方法，包括检测HDAC1，HDAC7和磷酸化HDAC7的增加的水平和/或活性。还提供了包含HDAC1，HDAC7和磷酸化HDAC7的水平和/或活性的抑制剂的试剂盒和制品。还提供了筛选HDAC1，HDAC7和磷酸化HDAC7的水平和/或活性抑制剂的方法。

20. 发明授权

US07556921B2 Methods for mapping signal transduction pathways to gene expression programs 有权
标题翻译：将信号转导途径映射到基因表达程序的方法
公开(公告)号：US07556921B2
公开(公告)日：2009-07-07
申请号：US11607478
申请日：2006-12-01
申请人： Dmitry K. Pokholok , Richard A. Young
发明人： Dmitry K. Pokholok , Richard A. Young
IPC分类号： C12Q1/68
CPC分类号： G01N33/5308 , C12Q1/6804 , C12Q1/6809 , C12Q1/6883 , C12Q2600/158 , C12Q2523/101 , C12Q2522/101
摘要： The invention relates to improved methods of identifying the gene expression programs that are regulated by a signal transduction pathway. The invention also provides methods of identifying agents which modulate signal transduction pathway. The invention also provides improved methods of isolating DNA fragments to which a protein of interest is bound, and genome-wide location analysis methods employing these improved isolation methods.
摘要翻译：本发明涉及鉴定由信号转导途径调节的基因表达程序的改进方法。本发明还提供鉴定调节信号转导途径的试剂的方法。本发明还提供了分离目的蛋白质结合的DNA片段的改进方法，以及使用这些改进的分离方法的全基因组位置分析方法。

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