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    • 14. 发明授权
    • Compositions and method for relaxing smooth muscles
    • 放松平滑肌肉的组合和方法
    • US5811463A
    • 1998-09-22
    • US770559
    • 1996-12-20
    • Peter LegzdinsCatherine C. Y. PangMichael J. Shaw
    • Peter LegzdinsCatherine C. Y. PangMichael J. Shaw
    • A61K31/28A61K31/445A61K31/4453A61K33/24A61K31/13A61K31/04
    • A61K33/24A61K31/28A61K31/445A61K31/4453
    • Compositions and methods for relaxing smooth muscle in a warm-blooded animal are provided, comprising the step of administering to the animal a transition-metal nitrosyl complex. In one aspect, the transition-metal nitrosyl complex is represented by the formula L.sub.3 M(NO).sub.y X.sub.3-y where L is a two-electron Lewis base or L.sub.3 is a six-electron Lewis base, M is a Group 6 or 8 transition-metal, and when y is 1, X is carbon monoxide, and when y is 2, X is a halide or pseudohalide. In another aspect, the transition-metal nitrosyl complex is represented by the formula �M(NO).sub.2 X.sub.y !.sub.2 where X is a halide or pseudohalide, and when M is a Group 6 transition-metal, y is 2, and when M is a Group 8 transition-metal, y is 1. Methods are also described for treating hypertension, angina pectoris, congestive heart disease, and impotence utilizing pharmaceutical compositions comprising the above-described transition-metal nitrosyl complexes.
    • 提供了用于在温血动物中放松平滑肌的组合物和方法,包括向动物施用过渡金属亚硝酰基络合物的步骤。 一方面,过渡金属亚硝酰基络合物由式L3M(NO)yX3-y表示,其中L是双电子路易斯碱,或L3是六电子路易斯碱,M是第6或8族过渡金属络合物, 金属,当y为1时,X为一氧化碳,当y为2时,X为卤化物或拟卤化物。 另一方面,过渡金属亚硝酰基络合物由式[M(NO)2 Xy] 2表示,其中X是卤化物或拟卤化物,当M是第6族过渡金属时,y是2,当M是 8族过渡金属,y为1.还描述了使用包含上述过渡金属亚硝酰基络合物的药物组合物治疗高血压,心绞痛,充血性心脏病和阳。的方法。