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    • 11. 发明申请
    • ANALYTE SENSOR
    • 分析传感器
    • US20110024307A1
    • 2011-02-03
    • US12829264
    • 2010-07-01
    • Peter C. SimpsonRobert BoockApurv Ullas KamathMatthew WightlinMichael J. Estes
    • Peter C. SimpsonRobert BoockApurv Ullas KamathMatthew WightlinMichael J. Estes
    • G01N27/26G01N33/50G01N27/416
    • Devices and methods are provided for continuous measurement of an analyte concentration. The device can include a sensor having a plurality of sensor elements, each having at least one characteristic that is different from other sensor(s) of the device. In some embodiments, the plurality of sensor elements are each tuned to measure a different range of analyte concentration, thereby providing the device with the capability of achieving a substantially consistent level of measurement accuracy across a physiologically relevant range. In other embodiments, the device includes a plurality of sensor elements each tuned to measure during different time periods after insertion or implantation, thereby providing the sensor with the capability to continuously and accurately measure analyte concentrations across a wide range of time periods. For example, a sensor system 180 is provided having a first working electrode 150 comprising a first sensor element 102 and a second working electrode 160 comprising a second sensor element 104, and a reference electrode 108 for providing a reference value for measuring the working electrode potential of the sensor elements 102, 104.
    • 提供了用于连续测量分析物浓度的装置和方法。 该装置可以包括具有多个传感器元件的传感器,每个传感器元件具有与装置的其它传感器不同的至少一个特性。 在一些实施例中,多个传感器元件各自被调谐以测量分析物浓度的不同范围,从而为器件提供在生理学相关范围内实现基本一致的测量精度水平的能力。 在其他实施例中,该装置包括多个传感器元件,每个传感器元件在插入或植入之后的不同时间期间被调整以测量,从而为传感器提供在宽范围的时间段内连续且精确地测量分析物浓度的能力。 例如,传感器系统180被提供有具有包括第一传感器元件102的第一工作电极150和包括第二传感器元件104的第二工作电极160以及用于提供用于测量工作电极电位的参考值的参考电极108 的传感器元件102,104。
    • 18. 发明授权
    • Surface plasmon devices
    • 表面等离子体激元器件
    • US07177515B2
    • 2007-02-13
    • US10140535
    • 2002-05-06
    • Michael J. EstesGarret Moddel
    • Michael J. EstesGarret Moddel
    • G02B6/10G02B6/26
    • G02B6/12B82Y20/00G02B6/10G02B6/1226
    • A device including an input port configured to receive an input signal is described. The device also includes an output port and a structure, which structure includes a tunneling junction connected with the input port and the output port. The tunneling junction is configured in a way (i) which provides electrons in a particular energy state within the structure, (ii) which produces surface plasmons in response to the input signal, (iii) which causes the structure to act as a waveguide for directing at least a portion of the surface plasmons along a predetermined path toward the output port such that the surface plasmons so directed interact with the electrons in a particular way, and (iv) which produces at the output port an output signal resulting from the particular interaction between the electrons and the surface plasmons.
    • 描述了包括被配置为接收输入信号的输入端口的装置。 该装置还包括输出端口和结构,该结构包括与输入端口和输出端口连接的隧道结。 以(i)的方式配置隧道结,(i)在结构内提供特定能量状态的电子,(ii)响应于输入信号产生表面等离子体激元,(iii)其导致该结构用作波导 将表面等离子体激元的至少一部分沿着预定路径引向输出端口,使得如此定向的表面等离子体激元以特定方式与电子相互作用,以及(iv)在输出端口处产生由特定的输出信号产生的输出信号 电子与表面等离子体相互作用。