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11. 发明申请

US20070038380A1 Crystal structure of E.coli GDP-fucose synthetase (and complexes thereof) and methods of identifying agonists and antagonists using same 审中-公开
标题翻译：大肠杆菌GDP-岩藻糖合成酶（及其复合物）的晶体结构以及使用其鉴定激动剂和拮抗剂的方法
公开(公告)号：US20070038380A1
公开(公告)日：2007-02-15
申请号：US10090879
申请日：2002-03-04
申请人： William Somers , Mark Stahl , Francis Sullivan
发明人： William Somers , Mark Stahl , Francis Sullivan
IPC分类号： C07K14/475 , G06F19/00
CPC分类号： C12N9/0006 , C12N9/90
摘要： The present invention provides for crystalline GFS. The crystal structure of GFS has also been solved using such material. Models based upon such crystal structure are also provided. Methods of identifying inhibitors of GFS activity using such models are also disclosed.
摘要翻译：本发明提供了结晶GFS。 GFS的晶体结构也使用这种材料得到解决。还提供了基于这种晶体结构的模型。还公开了使用这些模型鉴定GFS活性抑制剂的方法。

12. 发明申请

US20060003431A1 Structure of protein kinase C theta 失效
标题翻译：蛋白激酶Cθ的结构
公开(公告)号：US20060003431A1
公开(公告)日：2006-01-05
申请号：US11099958
申请日：2005-04-06
申请人： Zhang Xu , Stephane Olland , Scott Wolfrom , Karl Malakian , Laura Lin , Mark Stahl , Julie Lee , Lori Fitz , Rita Greco , Divya Chaudhary , William Somers , Lidia Mosyak
发明人： Zhang Xu , Stephane Olland , Scott Wolfrom , Karl Malakian , Laura Lin , Mark Stahl , Julie Lee , Lori Fitz , Rita Greco , Divya Chaudhary , William Somers , Lidia Mosyak
IPC分类号： G06F19/00 , G01N33/48 , G01N33/50 , C12N9/12 , A61K31/553
CPC分类号： C12N9/1205 , C07K2299/00 , C12Q1/485 , G01N33/564 , G01N33/57426 , G01N2500/04
摘要： A three-dimensional structure of protein kinase C theta (PKCθ) can be used in methods of designing an agent that interacts with PKCθ. The agent can be an inhibitor of PKCθ activity.
摘要翻译：蛋白激酶Cθ（PKCθ）的三维结构可用于设计与PKCθ相互作用的试剂的方法。该药物可以是PKCθ活性的抑制剂。

13. 发明申请

US20110086351A1 ELIMINATION OF PATHOGENIC INFECTION IN FARMED ANIMAL POPULATIONS 审中-公开
公开(公告)号：US20110086351A1
公开(公告)日：2011-04-14
申请号：US12856434
申请日：2010-08-13
申请人： MARK STAHL , JOHN STAHL , RICHARD STAHL
发明人： MARK STAHL , JOHN STAHL , RICHARD STAHL
IPC分类号： C12Q1/68
CPC分类号： C12Q1/701
摘要： Animal husbandry has always been susceptible to the ravages of pathogenic infections. Poultry flus and cattle diseases are but two examples that have dire consequences for animals and adversely affect the economic fortunes of farmers. A testing and culling methodology is presented that can eliminate pathogens from an infected herd. The sensitivity of PCR to detect very low levels of nucleic acid of an infecting pathogen is utilized to identify infected animals. In addition, it has been discovered that PCR analysis of manure samples can accurately identify infected animals and offspring for those species that consume placental remains after birth. Mink Aleutian Disease Virus (mADV) is one of several deadly DNA parvoviruses that can quickly reach epidemic proportions in a mink herd. PCR primers have been developed that generate amplicons to detect and identify the mADV. In addition, a previously unidentified strain of mADV has been discovered, genomically sequenced, and substantially detailed.

14. 发明申请

US20110086350A1 ELIMINATION OF PATHOGENIC INFECTION IN FARMED ANIMAL POPULATIONS 审中-公开
标题翻译：消除动物疫病在恶性动物群体中的发病
公开(公告)号：US20110086350A1
公开(公告)日：2011-04-14
申请号：US12856422
申请日：2010-08-13
申请人： MARK STAHL , JOHN STAHL , RICHARD STAHL
发明人： MARK STAHL , JOHN STAHL , RICHARD STAHL
IPC分类号： C12Q1/68
CPC分类号： C12Q1/701
摘要： Animal husbandry has always been susceptible to the ravages of pathogenic infections. Poultry flus and cattle diseases are but two examples that have dire consequences for animals and adversely affect the economic fortunes of farmers. A testing and culling methodology is presented that can eliminate pathogens from an infected herd. The sensitivity of PCR to detect very low levels of nucleic acid of an infecting pathogen is utilized to identify infected animals. In addition, it has been discovered that PCR analysis of manure samples can accurately identify infected animals and offspring for those species that consume placental remains after birth. Mink Aleutian Disease Virus (mADV) is one of several deadly DNA parvoviruses that can quickly reach epidemic proportions in a mink herd. PCR primers have been developed that generate amplicons to detect and identify the mADV. In addition, a previously unidentified strain of mADV has been discovered, genomically sequenced, and substantially detailed.
摘要翻译：畜牧业一直容易受到致病感染的蹂躏。禽流感和牛病只是对动物造成严重后果的两个例子，对农民的经济命运产生不利影响。提出了可以消除受感染群体病原体的测试和剔除方法。利用PCR检测感染病原体的非常低水平的核酸的灵敏度来鉴定受感染的动物。此外，已经发现，粪便样品的PCR分析可以准确地识别出生后消耗胎盘遗留物质的受感染动物和后代。貂阿留申病病毒（mADV）是几种致命的DNA细小病毒之一，可以在貂群中迅速达到流行的比例。已经开发了产生扩增子以检测和鉴定mADV的PCR引物。此外，已经发现以前不明的mADV菌株，基因组测序并且基本上详细。

15. 发明授权

US07584087B2 Structure of protein kinase C theta 失效
标题翻译：蛋白激酶Cθ的结构
公开(公告)号：US07584087B2
公开(公告)日：2009-09-01
申请号：US11099958
申请日：2005-04-06
申请人： Zhang Bao Xu , Stephane Olland , Scott Wolfrom , Karl Malakian , Laura Lin , Mark Stahl , Julie Lee , Lori Fitz , Rita Greco , Divya Chaudhary , William Stuart Somers , Lidia Mosyak
发明人： Zhang Bao Xu , Stephane Olland , Scott Wolfrom , Karl Malakian , Laura Lin , Mark Stahl , Julie Lee , Lori Fitz , Rita Greco , Divya Chaudhary , William Stuart Somers , Lidia Mosyak
IPC分类号： G06G7/58 , G01N31/00 , G01N33/573 , G01N33/53 , C12Q1/00 , C12Q1/48 , C12N9/99 , C12N9/12
CPC分类号： C12N9/1205 , C07K2299/00 , C12Q1/485 , G01N33/564 , G01N33/57426 , G01N2500/04
摘要： A three-dimensional structure of human protein kinase C theta (PKCθ) can be used in methods of designing an agent that interacts with PKCθ. The agent can be an inhibitor of PKCθ activity.
摘要翻译：人蛋白激酶Cθ（PKCθ）的三维结构可用于设计与PKCθ相互作用的试剂的方法中。该药物可以是PKCθ活性的抑制剂。

16. 发明授权

US07555415B2 Methods for the design of estrogen receptor ligands 失效
标题翻译：设计雌激素受体配体的方法
公开(公告)号：US07555415B2
公开(公告)日：2009-06-30
申请号：US11334982
申请日：2006-01-18
申请人： Lidia Mosyak , Zhang Bao Xu , Mark Stahl , Wah-Tung Hum , William Stuart Somers , Eric Steven Manas
发明人： Lidia Mosyak , Zhang Bao Xu , Mark Stahl , Wah-Tung Hum , William Stuart Somers , Eric Steven Manas
IPC分类号： G06G7/48 , G01N33/50 , G06F19/00
CPC分类号： C07K14/721 , C07K2299/00
摘要： Estrogen receptor ligands, estrogen receptor polypeptide/ligand complexes, crystals of estrogen receptor polypeptide/ligand complexes, and related methods and software systems are disclosed.
摘要翻译：雌激素受体配体，雌激素受体多肽/配体配合物，雌激素受体多肽/配体复合物的晶体以及相关方法和软件系统。

17. 发明申请

US20060160836A1 Estrogen receptor structure 失效
标题翻译：雌激素受体结构
公开(公告)号：US20060160836A1
公开(公告)日：2006-07-20
申请号：US11334982
申请日：2006-01-18
申请人： Lidia Mosyak , Zhang Xu , Mark Stahl , Wah-Tung Hum , William Somers , Eric Manas
发明人： Lidia Mosyak , Zhang Xu , Mark Stahl , Wah-Tung Hum , William Somers , Eric Manas
IPC分类号： A61K31/473 , A61K31/416 , C07K14/72 , G06F19/00
CPC分类号： C07K14/721 , C07K2299/00
摘要： Estrogen receptor ligands, estrogen receptor polypeptide/ligand complexes, crystals of estrogen receptor polypeptide/ligand complexes, and related methods and software systems are disclosed.
摘要翻译：雌激素受体配体，雌激素受体多肽/配体配合物，雌激素受体多肽/配体复合物的晶体以及相关方法和软件系统。

18. 发明申请

US20150124091A1 DOOR VIEWING SYSTEM AND APPARATUS 审中-公开
标题翻译：门查看系统和装置
公开(公告)号：US20150124091A1
公开(公告)日：2015-05-07
申请号：US14528534
申请日：2014-10-30
申请人： Mark Stahl
发明人： Mark Stahl
IPC分类号： H04N7/18 , H04N5/232
CPC分类号： H04N7/183 , H04N5/33
摘要： A liquid crystal display door viewing apparatus. The door viewing apparatus includes a display panel (e.g., Liquid crystal display) that can be configured to align with an existing peephole lens coupled to a door of varying thickness. The display panel includes a viewing screen to view a clear non-distorted image (color or black and white) of various objects located on the other side of the door from any height and viewing angle. A touch button located in association with the display panel can be pressed to display the image on the display panel for easy and safe operation. The door viewer apparatus can also be removed and a peephole reviewer can be re-installed.
摘要翻译：一种液晶显示器门观赏装置。门观赏装置包括显示面板（例如，液晶显示器），其可以被配置为与连接到不同厚度的门的现有窥视孔透镜对准。显示面板包括观看屏幕，用于从任何高度和视角观察位于门的另一侧的各种物体的清晰的非失真图像（颜色或黑白）。可以按压与显示面板相关联的触摸按钮，以在显示面板上显示图像，以方便和安全地操作。还可以拆卸门查看器装置并重新安装窥视孔检查器。

19. 发明申请

US20070048785A1 Anti-IL-13 antibodies and complexes 审中-公开
标题翻译：抗IL-13抗体和复合物
公开(公告)号：US20070048785A1
公开(公告)日：2007-03-01
申请号：US11149025
申请日：2005-06-09
申请人： Laura Lin , Kevin Parris , Amy Sze Tam , Xiang-Yang Tan , Tania Shane , John Dumas , James Wilhelm , Mark Stahl , Lidia Mosyak , Zhixiang Hu
发明人： Laura Lin , Kevin Parris , Amy Sze Tam , Xiang-Yang Tan , Tania Shane , John Dumas , James Wilhelm , Mark Stahl , Lidia Mosyak , Zhixiang Hu
IPC分类号： C07K16/28 , G01N33/53 , G06F19/00
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/24 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： Anti-IL-13 antibodies, crystals of anti-IL-13 antibodies, IL-13 polypeptide/anti-IL-13 antibody complexes, crystals of IL-13 polypeptide/anti-IL-13 antibody complexes, IL-13Rα1 polypeptide/IL-13 polypeptide/anti-IL-13 antibody complexes, crystals of IL-13Rα1 polypeptide/IL-13 polypeptide/anti-IL-13 antibody complexes, and related methods and software systems are disclosed.
摘要翻译：抗IL-13抗体，抗IL-13抗体晶体，IL-13多肽/抗IL-13抗体复合物，IL-13多肽/抗IL-13抗体复合物的结晶，IL-13Rα1多肽/ IL -13多肽/抗IL-13抗体复合物，IL-13Rα1多肽/ IL-13多肽/抗IL-13抗体复合物的晶体，以及相关方法和软件系统。

20. 发明授权

US5684807A Adaptive distributed system and method for fault tolerance 失效
标题翻译：自适应分布式系统和容错方法
公开(公告)号：US5684807A
公开(公告)日：1997-11-04
申请号：US495871
申请日：1995-06-28
申请人： Ronald P. Bianchini, Jr. , Mark Stahl , Richard Buskens
发明人： Ronald P. Bianchini, Jr. , Mark Stahl , Richard Buskens
IPC分类号： H04L12/26 , H04L29/14 , G06F11/22
CPC分类号： H04L43/50 , H04L12/2697 , H04L69/40
摘要： An adaptive distributed diagnostic system and method for a network having at least a first, a second and a third nodes. Both the third and first nodes and the third and second nodes, respectively, are in communication with each other via the network. The first node can directly test a state of the third node and indirectly test through the third node a state of the second node. The second node can directly test a state of the third node and indirectly test through the third node a state of the first node. The third node can directly test both a state of the first node and a state of the second node. The third node has a testing assignment based on given circumstances at a corresponding time.
摘要翻译：一种用于具有至少第一，第二和第三节点的网络的自适应分布式诊断系统和方法。第三节点和第一节点以及第三节点和第二节点分别通过网络彼此通信。第一个节点可以直接测试第三个节点的状态，并通过第三个节点间接测试第二个节点的状态。第二节点可以直接测试第三节点的状态，并通过第三节点间接测试第一节点的状态。第三节点可以直接测试第一节点的状态和第二节点的状态。第三个节点根据给定的情况在相应的时间进行测试分配。

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