专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

11. 发明授权

US4855302A Certain azaspirodecane compounds and a method of inducing an anxiolytic activity 失效
标题翻译：某些azaspirodecane化合物和诱导抗焦虑活性的方法
公开(公告)号：US4855302A
公开(公告)日：1989-08-08
申请号：US131186
申请日：1987-12-10
申请人： Jean-Claude Gasc , Lucien Nedelec , Daniel Humbert , Ana Maria Boaventura
发明人： Jean-Claude Gasc , Lucien Nedelec , Daniel Humbert , Ana Maria Boaventura
IPC分类号： A61K31/4427 , A61K31/445 , A61P25/20 , C07D401/14
CPC分类号： C07D401/14
摘要： A compound selected from the group consisting of azaspirodecane derivatives of the formula ##STR1## wherein R is selected from the group consisting of hydrogen, fluorine, chlorine, bromine, alkoxy of 1 to 3 carbon atoms, --NO.sub.2, --NH.sub.2 and CH.sub.3 S-- in the 4,5 or 6 position of the ring, R' is oxo or hydrogen or --OH or alkyl of 1 to 3 carbon atoms and the dotted line indicates a carbon-carbon bond in the 2,3-position, n is 2,3,4 or 5 and the dotted line in the piperidyl ring is an optional carbon-carbon bond and their non-toxic, pharmaceutically acceptable acid addition salts having remarkable anxiolytic activity.
摘要翻译：选自下式的化合物的化合物其中R选自氢，氟，氯，溴，1至3个碳原子的烷氧基，-NO 2，-NH 2和CH 3 S - 的烷基硫代十一烷衍生物，在环的4,5或6位，R'是氧代或氢或-OH或1至3个碳原子的烷基，虚线表示2,3位上的碳 - 碳键，n是2 ，3,4或5，哌啶环中的虚线是任选的碳 - 碳键及其无毒的药学上可接受的酸加成盐，具有显着的抗焦虑活性。

12. 发明授权

US4661482A Use of pyrazolobenzoxazines in method of treating cerebral senescence and cerebral hypoxin 失效
标题翻译：在治疗脑衰老和脑缺氧的方法中使用吡唑并苯恶嗪
公开(公告)号：US4661482A
公开(公告)日：1987-04-28
申请号：US833347
申请日：1986-02-25
申请人： Lucien Nedelec , Patrick Fauveau , Gilles Hamon , Claude Oberlander
发明人： Lucien Nedelec , Patrick Fauveau , Gilles Hamon , Claude Oberlander
IPC分类号： A61K31/535 , A61P3/04 , A61P3/08 , A61P3/10 , A61P5/00 , A61P7/00 , A61P9/12 , A61P25/00 , A61P25/28 , C07D265/36 , C07D498/04 , C07D265/34
CPC分类号： C07D265/36
摘要： Novel pyrazolobenzoxazines of the formula ##STR1## wherein R is selected from the group consisting of hydrogen, alkyl of 1 to 5 carbon atoms, cycloalkylalkyl or 4 to 7 carbon atoms, alkenyl and alkynyl of 3 to 5 carbon atoms with the proviso that the multiple bond is not between the carbon .alpha.- and .beta.- to the nitrogen atom, aralkyl of 7 to 12 carbon atoms and aralkyl of 7 to 12 carbon atoms substituted with at least one member of the group consisting of alkyl and alkoxy of 1 to 5 carbon atoms, amino, -OH and halogen, X is selected from the group consisting of hydrogen and --CH.sub.2 --S--Alk, Alk is alkyl of 1 to 5 carbon atoms, the wavy line indicates the .alpha.- or .beta.-position and their non-toxic, pharmaceutically acceptable acid addition salts having dopaminergic agonistic, hypotensive, antihypertensive and antianoxic properties and their preparation.
摘要翻译：新颖的式（Ⅰ）的吡唑并苯并恶嗪其中R选自氢，1至5个碳原子的烷基，环烷基烷基或4至7个碳原子，3至5个碳原子的链烯基和炔基，条件是多个键不在与氮原子的碳原子和β之间，7-12个碳原子的芳烷基和7至12个碳原子的芳烷基被至少一个由1至5个碳原子的烷基和烷氧基组成的组取代的芳烷基碳原子，氨基，-OH和卤素，X选自氢和-CH 2 -S-Alk，Alk是1至5个碳原子的烷基，波浪线表示α或β位，它们的具有多巴胺能激动，降血压，抗高血压和抗痉挛性质的无毒，药学上可接受的酸加成盐及其制备。

13. 发明授权

US4503053A C-Homo-9-oxa-ergolines 失效
标题翻译： C-同-9-氧杂 - 麦角碱
公开(公告)号：US4503053A
公开(公告)日：1985-03-05
申请号：US532740
申请日：1983-09-15
申请人： Lucien Nedelec , Jean-Claude Gasc , Patrick Fauveau
发明人： Lucien Nedelec , Jean-Claude Gasc , Patrick Fauveau
IPC分类号： A61K31/535 , A61P25/00 , A61P43/00 , C07D209/00 , C07D265/00 , C07D498/06
CPC分类号： C07D209/94 , C07D498/06
摘要： Novel C-homo-9-oxa-ergolines of the formula ##STR1## wherein R is selected from the group consisting of hydrogen and alkyl of 1 to 4 carbon atoms, R.sub.1 is selected from the group consisting of hydrogen, chlorine and bromine or taken with b forms .dbd.0, a and b form a carbon-carbon bond or a is hydrogen when R.sub.1 and b form .dbd.0, R.sub.2 is selected from the group consisting of hydrogen, alkyl of 1 to 4 carbon atoms, aralkyl of 7 to 12 carbon atoms and cycloalkylalkyl of 4 to 7 carbon atoms, R.sub.3 is selected from the group consisting of hydroxymethyl, alkylthiomethyl of 1 to 5 alkyl carbon atoms, cyanomethyl, carboxy optionally esterified with an aliphatic alcohol of 1 to 5 carbon atoms and ##STR2## R.sub.4 is selected from the group consisting of hydrogen and alkyl of 1 to 4 carbon atoms, R.sub.5 is alkyl of 1 to 4 carbon atoms or R.sub.4 and R.sub.5 taken with the nitrogen atom form a saturated heterocycle optionally containing a second heteroatom having dopaminergic agonist, serotoninergic and antihypertensive activity as well as prolactin secretion inhibition and antianoxic activities and their preparation and intermediates.
摘要翻译：式（Ⅰ）的新型C-高-9-氧杂 - 麦角醇其中R选自氢和1至4个碳原子的烷基，R 1选自氢，氯和溴或以b形式= 0取代，a和b形成碳 - 碳键，或者当R 1和b形成= 0时，a为氢，R 2选自氢，1至4个碳原子的烷基，7至 12个碳原子和4至7个碳原子的环烷基烷基，R 3选自羟甲基，1至5个烷基碳原子的烷基硫甲基，氰基甲基，任选被1至5个碳原子的脂族醇酯化的羧基， R4选自氢和1-4个碳原子的烷基，R5是1-4个碳原子的烷基或R4和R5与氮原子一起形成饱和杂环，任选地含有具有多巴胺能激动剂的第二个杂原子，5-羟色胺能和抗高血压活动以及催乳素分泌抑制和抗氧化活性及其制备和中间体。

14. 发明授权

US4313944A Cycloheptindoles, compositions and use 失效
标题翻译： Cycloheptindoles，组成和用途
公开(公告)号：US4313944A
公开(公告)日：1982-02-02
申请号：US237062
申请日：1981-02-23
申请人： Lucien Nedelec , Daniel Frechet , Claude Dumont
发明人： Lucien Nedelec , Daniel Frechet , Claude Dumont
IPC分类号： A61K31/40 , A61K31/403 , A61K31/535 , A61P1/04 , A61P9/12 , A61P25/00 , C07D209/94 , C07D498/06 , C07D498/04
CPC分类号： C07D209/94
摘要： Novel compounds selected from the group consisting of optically active isomers and racemic mixtures of cycloheptindoles of the formula ##STR1## wherein R is selected from the group consisting of hydrogen, alkyl of 1 to 5 carbon atoms and optionally substituted aralkyl of 7 to 12 carbon atoms, R.sub.1 is selected from the group consisting of hydrogen, chlorine and bromine and R.sub.2 is selected from the group consisting of hydrogen, alkyl of 1 to 5 carbon atoms, cycloalkylalkyl of 4 to 7 carbon atoms, alkenyl and alkynyl of 3 to 7 carbon atoms and optionally substituted aralkyl of 7 to 12 carbon atoms and their non-toxic, pharmaceutically acceptable acid addition salts having dopaminergic agonist and antianoxic properties and a process for their preparation and novel intermediates.
摘要翻译：新型化合物，其选自光学活性异构体和式Ⅺ的环庚啶的外消旋混合物，其中R选自氢，1至5个碳原子的烷基和7至12个碳的任选取代的芳烷基原子，R 1选自氢，氯和溴，R 2选自氢，1至5个碳原子的烷基，4至7个碳原子的环烷基烷基，3至7个碳的链烯基和炔基原子和任选取代的7-12个碳原子的芳烷基及其无毒的药学上可接受的具有多巴胺能激动剂和抗氧化性质的酸加成盐及其制备方法和新型中间体。

15. 发明授权

US4296126A 3-Aryloxy-3-aryl-propaneamines and their method of use 失效
标题翻译： 3-芳氧基-3-芳基 - 丙胺及其使用方法
公开(公告)号：US4296126A
公开(公告)日：1981-10-20
申请号：US13831
申请日：1979-02-22
申请人： Lucien Nedelec , Daniel Frechet , Claude Dumont
发明人： Lucien Nedelec , Daniel Frechet , Claude Dumont
IPC分类号： A61K31/135 , A61K31/16 , A61K31/165 , A61P3/04 , C07C67/00 , C07C213/00 , C07C217/48 , C07C233/16 , C07C233/25 , A01N37/30 , C07C93/02
CPC分类号： A61K31/135 , C07C233/16
摘要： Novel benzene-propanamines of the formula ##STR1## wherein X is selected from the group consisting of hydrogen, chlorine, fluorine and bromine, R.sub.1 is selected from the group consisting of hydrogen and alkyl of 1 to 5 carbon atoms, R.sub.2 is alkyl of 1 to 5 carbon atoms, R.sub.3 is selected from the group consisting of hydrogen, chlorine, bromine, --CF.sub.3, methyl and methoxy when R.sub.4 is nitro and R.sub.3 is selected from the group consisting of amino and acetamido when R.sub.4 is hydrogen and their non-toxic, pharmaceutically acceptable acid addition salts having anorexigenic activity and inhibit serotonine uptake in vivo and in vitro and their preparation.
摘要翻译：具有式“IMAGE”I'的新型苯丙胺，其中X选自氢，氯，氟和溴，R 1选自氢和1至5个碳原子的烷基，R 2是烷基当R 4为硝基时，R 3选自氢，氯，溴，-CF 3，甲基和甲氧基，当R 4为氢时，R 3选自氨基和乙酰氨基，具有厌食活性的药学上可接受的酸加成盐，并且在体内和体外抑制血清素摄取及其制备。

16. 发明授权

US4263290A Novel 19-nor-steroids 失效
标题翻译：新型19-类固醇
公开(公告)号：US4263290A
公开(公告)日：1981-04-21
申请号：US98766
申请日：1979-11-30
申请人： Lucien Nedelec , Vesperto Torelli , Robert Fournex
发明人： Lucien Nedelec , Vesperto Torelli , Robert Fournex
IPC分类号： C07D317/14 , A61K31/57 , A61P5/38 , A61P9/12 , C07D317/72 , C07J5/00 , C07J7/00 , C07J17/00 , C07J43/00 , C07J51/00 , C07J53/00 , A61K31/56
CPC分类号： C07J7/002 , C07D317/72 , C07J17/00 , C07J43/006 , C07J5/0015 , C07J7/007
摘要： Novel 19-nor-steroids of the formula ##STR1## wherein R.sub.1 and R.sub.2 taken together form a cycloalkyl of 3 to 8 carbon atoms or are individually selected from the group consisting of hydrogen, alkyl of 1 to 4 carbon atoms and alkenyl and alkynyl of 2 to 6 carbon atoms with the proviso that both cannot be hydrogen, R.sub.3 is alkyl of 2 to 4 carbon atoms, R.sub.4 ' is selected from the group consisting of hydrogen, hydroxyl, acyloxy of an organic carboxylic acid of 1 to 18 carbon atoms and ##STR2## and M is selected from the group consisting of hydrogen and alkali metal, having antagonistic properties to aldosterone and increasing sodium-water diuresis with conservation of organic potassium and a novel process and novel intermediates for their preparation.
摘要翻译：式Ⅰ'的新型19-去甲甾类化合物，其中R 1和R 2一起形成3至8个碳原子的环烷基或分别选自氢，1至4个碳原子的烷基和烯基，和 2至6个碳原子的炔基，条件是两者不能是氢，R3是2至4个碳原子的烷基，R4'选自氢，羟基，1至18碳的有机羧酸的酰氧基原子和M选自氢和碱金属，对醛固酮具有拮抗作用，并增加钠 - 水利尿与保护有机钾的新方法和新的制备中间体。

17. 发明授权

US4232031A Process for preparation of piperidyl-indoles 失效
标题翻译：哌啶基 - 吲哚的制备方法
公开(公告)号：US4232031A
公开(公告)日：1980-11-04
申请号：US100909
申请日：1979-12-06
申请人： Claude Dumont , Jacques Guillaume , Lucien Nedelec
发明人： Claude Dumont , Jacques Guillaume , Lucien Nedelec
IPC分类号： C07D401/04 , A61K20060101 , A61K31/40 , A61K31/435 , A61K31/44 , A61K31/445 , A61K31/475 , A61P1/08 , A61P25/00 , A61P25/18 , A61P25/20 , B01J23/04 , C07D20060101 , C07D209/04 , C07D211/68 , C07D211/70 , C07D401/02
CPC分类号： C07D401/04
摘要： A novel process for the preparation of piperidylindoles of the formula ##STR1## wherein R is selected from the group consisting of hydrogen and alkyl of 1 to 3 carbon atoms and X is selected from the group consisting of hydrogen, nitro, fluorine, bromine, chlorine and alkoxy of 1 to 3 carbon atoms and their non-toxic, pharmaceutically acceptable acid addition salts thereof by reacting an indole of the formula ##STR2## with 4-piperidone hydrochloride in an alkaline medium to obtain the compound of formula I which is optionally salified and the novel product, 5-nitro-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole and its non-toxic, pharmaceutically acceptable acid addition salts.
摘要翻译：一种制备式Ia的哌啶子基吲哚的新方法，其中R选自氢和1至3个碳原子的烷基，X选自氢，硝基，氟，溴，氯和具有1至3个碳原子的烷氧基以及它们的无毒的药学上可接受的酸加成盐，其通过使式II的吲哚与4-哌啶酮盐酸盐在碱性介质中反应，得到式I化合物，其为任选地盐化，并且新产物5-硝基-3-（1,2,3,6-四氢吡啶-4-基）-1H-吲哚及其无毒的药学上可接受的酸加成盐。

18. 发明授权

US4177292A Novel 5H-benzocyclohepten-7-amines 失效
标题翻译：新的5H-苯并环庚烯-7-胺
公开(公告)号：US4177292A
公开(公告)日：1979-12-04
申请号：US959943
申请日：1978-11-13
申请人： Lucien Nedelec , Daniel Frechet , Claude Dumont , Peter Hunt
发明人： Lucien Nedelec , Daniel Frechet , Claude Dumont , Peter Hunt
IPC分类号： A61K31/135 , A61K20060101 , A61K9/20 , A61K31/04 , A61P25/24 , A61P25/26 , B01J23/00 , B01J23/44 , C07B61/00 , C07C20060101 , C07C67/00 , C07C213/00 , C07C217/52 , C07C91/16 , C07C91/28 , C07C91/40
CPC分类号： C07C217/52 , C07C2102/12
摘要： Novel 5H-benzocyclohepten-7-amines of the formula ##STR1## wherein R.sub.1 is selected from the group consisting of hydrogen and methyl, R.sub.2 and R.sub.3 are individually selected from the group consisting of hydrogen, fluorine, chlorine, bromine, nitro, amino, --CF.sub.3 and methoxy, X is selected from the group consisting of hydrogen and halogen, and their non-toxic, pharmaceutically acceptable acid addition salts having remarkable in vivo and in vitro inhibiting properties for the capture of serotonine and their preparation.
摘要翻译：新颖的式“IMAGE”I'的5H-苯并环庚烯-7-胺其中R 1选自氢和甲基，R 2和R 3分别选自氢，氟，氯，溴，硝基，氨基，-CF 3和甲氧基，X选自氢和卤素，及其无毒的药学上可接受的酸加成盐，其具有显着的体内和体外抑制5-羟色胺的捕获性质及其制备。

19. 发明授权

US4175136A N-Phenethyl-N-propyl-3,4-dihydroxyphenethylamines and salts thereof 失效
标题翻译： N-苯乙基-N-丙基-3,4-二羟基苯乙胺及其盐
公开(公告)号：US4175136A
公开(公告)日：1979-11-20
申请号：US905535
申请日：1978-05-12
申请人： Lucien Nedelec , Daniel Frechet , Claude Dumont
发明人： Lucien Nedelec , Daniel Frechet , Claude Dumont
IPC分类号： A61K31/135 , A61P25/02 , A61P25/26 , C07C20060101 , C07C67/00 , C07C213/00 , C07C215/52 , A01N9/20 , A01N9/24 , C07C91/32
CPC分类号： C07D213/38
摘要： N-phenethyl-N-propyl-3,4-dihydroxyphenethylamine and its non-toxic, pharmaceutically acceptable acid addition salts possessing dopaminergic properties.
摘要翻译： N-苯乙基-N-丙基-3,4-二羟基苯乙胺及其无毒的药学上可接受的具有多巴胺能性质的酸加成盐。

20. 发明授权

US4136179A 2,2-Dimethyl-19-nor-steroids 失效
标题翻译： 2,2-二甲基-19-非 - 异唑烷酮
公开(公告)号：US4136179A
公开(公告)日：1979-01-23
申请号：US831254
申请日：1977-09-07
申请人： Lucien Nedelec , Vesperto Torelli , Robert Fournex
发明人： Lucien Nedelec , Vesperto Torelli , Robert Fournex
IPC分类号： A61K31/57 , A61P5/38 , A61P9/00 , C07J5/00 , C07J7/00 , C07J9/00 , C07J17/00 , C07J43/00 , A61K31/56
CPC分类号： C07J17/00 , C07J43/003 , C07J5/0015 , C07J7/002 , C07J9/00
摘要： 2,2-DIMETHYL-19-NOR-STEROIDS OF THE FORMULA ##STR1## wherein R.sub.1 is selected from the group consisting of hydrogen, ##STR2## and R.sub.2 is selected from the group consisting of hydrogen and hydrocarbon of 1 to 17 carbon atoms and the dotted lines indicate the optional presence of a double bond in 9(10) and 11(12) positions having antialdosteronic activity and an increased sodium diuresis with conservation of organic potassium and their preparation and novel intermediates.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式