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11. 发明授权

US07123958B1 Methods and devices for reducing integrated circuit power consumption in implantable cardiac stimulation devices 有权
标题翻译：用于降低植入式心脏刺激装置中集成电路功耗的方法和装置
公开(公告)号：US07123958B1
公开(公告)日：2006-10-17
申请号：US10011018
申请日：2001-12-04
申请人： Louis Wong
发明人： Louis Wong
IPC分类号： A61N1/362
CPC分类号： A61N1/378 , A61N1/3975
摘要： A voltage step-down circuit reduces the amount of power drawn from the battery of an implantable cardiac stimulation device (ICD) to supply an integrated circuit (IC) within the ICD. The ICD battery supply voltage is reduced to a level that maintains proper operation of the IC. The reduced battery supply voltage is also regulated such that the IC is supplied with a constant voltage source. The IC consumes less power when supplied by the reduced battery supply voltage than when supplied directly by the battery supply voltage. The present invention promotes ICD battery longevity and reduces the need for frequent ICD battery replacements.
摘要翻译：电压降压电路减少从可植入心脏刺激装置（ICD）的电池中提取的电力量，以在ICD内提供集成电路（IC）。 ICD电池电源电压降低到保持IC正常工作的水平。减小的电池电源电压也被调节，使得IC被提供有恒定电压源。当通过电池电源供电电压供电时，与通过电池电源电压直接供电时，IC的功耗较低。本发明促进了ICD电池的使用寿命，并且减少了频繁的ICD电池更换的需要。

12. 发明授权

US09107585B1 Tissue characterization using intracardiac impedances with an implantable lead system 有权
标题翻译：使用可植入引导系统的心内阻抗的组织表征
公开(公告)号：US09107585B1
公开(公告)日：2015-08-18
申请号：US11684664
申请日：2007-03-12
申请人： Louis Wong , Cem Shaquer , Gene A. Bornzin , Euljoon Park , Andre Walker , Dorin Panescu
发明人： Louis Wong , Cem Shaquer , Gene A. Bornzin , Euljoon Park , Andre Walker , Dorin Panescu
IPC分类号： A61N1/18 , A61B5/02 , A61B5/053 , A61N1/37 , A61B5/029 , A61B5/08 , A61B5/00
CPC分类号： A61B5/02028 , A61B5/0031 , A61B5/029 , A61B5/0538 , A61B5/08 , A61B5/4878 , A61N1/3627 , A61N1/36521 , A61N1/3702
摘要： An implantable system acquires intracardiac impedance with an implantable lead system. In one implementation, the system generates frequency-rich, low energy, multi-phasic waveforms that provide a net-zero charge and a net-zero voltage. When applied to bodily tissues, current pulses or voltage pulses having the multi-phasic waveform provide increased specificity and sensitivity in probing tissue. The effects of the applied pulses are sensed as a corresponding waveform. The waveforms of the applied and sensed pulses can be integrated to obtain corresponding area values that represent the current and voltage across a spectrum of frequencies. These areas can be compared to obtain a reliable impedance value for the tissue. Frequency response, phase delay, and response to modulated pulse width can also be measured to determine a relative capacitance of the tissue, indicative of infarcted tissue, blood to tissue ratio, degree of edema, and other physiological parameters.
摘要翻译：可植入系统采用可植入引线系统获得心内阻抗。在一个实现中，该系统产生提供净零电荷和净零电压的富频率，低能量，多相波形。当应用于身体组织时，具有多相波形的电流脉冲或电压脉冲在探测组织中提供增加的特异性和灵敏度。所施加的脉冲的影响被感测为对应的波形。施加和感测的脉冲的波形可以被积分，以获得表示频谱范围内的电流和电压的相应面积值。可以比较这些区域以获得组织的可靠的阻抗值。还可以测量频率响应，相位延迟和对调制脉冲宽度的响应，以确定组织的相对电容，指示梗死组织，血液与组织之比，水肿程度和其他生理参数。

13. 发明授权

US07925349B1 Tissue characterization using intracardiac impedances with an implantable lead system 有权
公开(公告)号：US07925349B1
公开(公告)日：2011-04-12
申请号：US11684681
申请日：2007-03-12
申请人： Louis Wong , Cem Shaquer , Gene A. Bornzin , Euljoon Park , Andre Walker , Dorin Panescu , Jiong Xia
发明人： Louis Wong , Cem Shaquer , Gene A. Bornzin , Euljoon Park , Andre Walker , Dorin Panescu , Jiong Xia
IPC分类号： A61N1/37
CPC分类号： A61B5/02028 , A61B5/0031 , A61B5/029 , A61B5/0538 , A61B5/08 , A61B5/4878 , A61N1/3627 , A61N1/36521 , A61N1/3702
摘要： An implantable system acquires intracardiac impedance with an implantable lead system. In one implementation, the system generates frequency-rich, low energy, multi-phasic waveforms that provide a net-zero charge and a net-zero voltage. When applied to bodily tissues, current pulses or voltage pulses having the multi-phasic waveform provide increased specificity and sensitivity in probing tissue. The effects of the applied pulses are sensed as a corresponding waveform. The waveforms of the applied and sensed pulses can be integrated to obtain corresponding area values that represent the current and voltage across a spectrum of frequencies. These areas can be compared to obtain a reliable impedance value for the tissue. Frequency response, phase delay, and response to modulated pulse width can also be measured to determine a relative capacitance of the tissue, indicative of infarcted tissue, blood to tissue ratio, degree of edema, and other physiological parameters.

14. 发明授权

US06934584B1 Enhanced power efficiency in implantable cardiac stimulation devices 有权
标题翻译：在植入式心脏刺激装置中提高功率效率
公开(公告)号：US06934584B1
公开(公告)日：2005-08-23
申请号：US10113706
申请日：2002-03-27
申请人： Louis Wong , Weiqun Yang
发明人： Louis Wong , Weiqun Yang
IPC分类号： A61N1/365 , A61N1/37 , A61N1/39
CPC分类号： A61N1/37 , A61N1/3981
摘要： Pacing pulse power efficiency is increased in an implantable cardiac stimulation device. The invention includes a cardiac function sensor for sensing cardiac functions. A controller is coupled to the sensor for determining a required cardiac pacing pulse voltage level. A determining means is coupled to the controller for determining a desired battery voltage multiplication factor as a function of the required pacing pulse voltage level. A setting means is coupled to the determining means for setting a battery voltage multiplier to multiply the battery voltage to a level as close as possible to the required pacing pulse voltage level.
摘要翻译：可植入心脏刺激装置中起搏脉冲功率效率增加。本发明包括用于感测心脏功能的心脏功能传感器。控制器耦合到传感器以确定所需的心脏起搏脉冲电压电平。确定装置耦合到控制器，用于根据所需的起搏脉冲电压电平确定期望的电池电压倍增因子。一个设置装置耦合到确定装置，用于设置电池电压倍增器以将电池电压乘以尽可能接近所需的起搏脉冲电压电平的电平。

15. 发明授权

US06636083B1 Leakage current cancellation technique for low power switched-capacitor circuits 失效
标题翻译：低功耗开关电容电路的泄漏电流消除技术
公开(公告)号：US06636083B1
公开(公告)日：2003-10-21
申请号：US09970630
申请日：2001-10-03
申请人： Louis Wong , Shohan Hossain , Andre Walker
发明人： Louis Wong , Shohan Hossain , Andre Walker
IPC分类号： H03K500
CPC分类号： G11C27/026 , H03F1/02 , H03F3/005 , H03F2200/331
摘要： An active feedback loop is provided in a switched-capacitor circuit to automatically cancel both junction and sub-Vth channel leakage. Low power consumption that is crucial for implantable medical devices is achieved. The circuit technique largely minimizes the effective leakage current when the switch is turned off. This circuit technique of the invention can be used in many different circuit applications.
摘要翻译：在开关电容电路中提供有源反馈回路，以自动消除结和子Vth通道泄漏。实现了对植入式医疗设备至关重要的低功耗。当开关断开时，电路技术大大减少了有效的漏电流。本发明的该电路技术可用于许多不同的电路应用中。

16. 发明申请

US20120053470A1 TISSUE CHARACTERIZATION USING INTRACARDIAC IMPEDANCES WITH AN IMPLANTABLE LEAD SYSTEM 有权
标题翻译：使用具有可植入引导系统的入侵者抵抗的组织特征
公开(公告)号：US20120053470A1
公开(公告)日：2012-03-01
申请号：US13149507
申请日：2011-05-31
申请人： Louis Wong , Cem Shaquer , Gene A. Bornzin , Euljoon Park , Andre Walker , Dorin Panescu , Jiong Xia , Shahrooz Shahparnia
发明人： Louis Wong , Cem Shaquer , Gene A. Bornzin , Euljoon Park , Andre Walker , Dorin Panescu , Jiong Xia , Shahrooz Shahparnia
IPC分类号： A61B5/053 , A61B5/085
CPC分类号： A61B5/02028 , A61B5/0031 , A61B5/029 , A61B5/0538 , A61B5/08 , A61B5/4878 , A61N1/3627 , A61N1/36521 , A61N1/3702
摘要： An implantable system acquires intracardiac impedance with an implantable lead system. In one implementation, the system generates frequency-rich, low energy, multi-phasic waveforms that provide a net-zero charge and a net-zero voltage. When applied to bodily tissues, current pulses or voltage pulses having the multi-phasic waveform provide increased specificity and sensitivity in probing tissue. The effects of the applied pulses are sensed as a corresponding waveform. The waveforms of the applied and sensed pulses can be integrated to obtain corresponding area values that represent the current and voltage across a spectrum of frequencies. These areas can be compared to obtain a reliable impedance value for the tissue. Frequency response, phase delay, and response to modulated pulse width can also be measured to determine a relative capacitance of the tissue, indicative of infarcted tissue, blood to tissue ratio, degree of edema, and other physiological parameters.
摘要翻译：可植入系统采用可植入引线系统获得心内阻抗。在一个实现中，该系统产生提供净零电荷和净零电压的富频率，低能量，多相波形。当应用于身体组织时，具有多相波形的电流脉冲或电压脉冲在探测组织中提供增加的特异性和灵敏度。所施加的脉冲的影响被感测为对应的波形。施加和感测的脉冲的波形可以被积分，以获得表示频谱范围内的电流和电压的相应面积值。可以比较这些区域以获得组织的可靠的阻抗值。还可以测量频率响应，相位延迟和对调制脉冲宽度的响应，以确定组织的相对电容，指示梗死组织，血液与组织之比，水肿程度和其他生理参数。

17. 发明授权

US08065005B1 Tissue characterization using intracardiac impedances with an implantable lead system 有权
公开(公告)号：US08065005B1
公开(公告)日：2011-11-22
申请号：US11684688
申请日：2007-03-12
申请人： Louis Wong , Cem Shaquer , Gene A. Bornzin , Euljoon Park , Andre Walker , Dorin Panescu , Jiong Xia , Shahrooz Shahparnia
发明人： Louis Wong , Cem Shaquer , Gene A. Bornzin , Euljoon Park , Andre Walker , Dorin Panescu , Jiong Xia , Shahrooz Shahparnia
IPC分类号： A61N1/18
CPC分类号： A61B5/02028 , A61B5/0031 , A61B5/029 , A61B5/0538 , A61B5/08 , A61B5/4878 , A61N1/3627 , A61N1/36521 , A61N1/3702
摘要： An implantable system acquires intracardiac impedance with an implantable lead system. In one implementation, the system generates frequency-rich, low energy, multi-phasic waveforms that provide a net-zero charge and a net-zero voltage. When applied to bodily tissues, current pulses or voltage pulses having the multi-phasic waveform provide increased specificity and sensitivity in probing tissue. The effects of the applied pulses are sensed as a corresponding waveform. The waveforms of the applied and sensed pulses can be integrated to obtain corresponding area values that represent the current and voltage across a spectrum of frequencies. These areas can be compared to obtain a reliable impedance value for the tissue. Frequency response, phase delay, and response to modulated pulse width can also be measured to determine a relative capacitance of the tissue, indicative of infarcted tissue, blood to tissue ratio, degree of edema, and other physiological parameters.

18. 发明授权

US08010196B1 Tissue characterization using intracardiac impedances with an implantable lead system 有权
公开(公告)号：US08010196B1
公开(公告)日：2011-08-30
申请号：US11684671
申请日：2007-03-12
申请人： Louis Wong , Cem Shaquer , Gene A. Bornzin , Euljoon Park , Andre Walker , Dorin Panescu , Jiong Xia , Shahrooz Shahparnia
发明人： Louis Wong , Cem Shaquer , Gene A. Bornzin , Euljoon Park , Andre Walker , Dorin Panescu , Jiong Xia , Shahrooz Shahparnia
IPC分类号： A61N1/18
CPC分类号： A61B5/02028 , A61B5/0031 , A61B5/029 , A61B5/0538 , A61B5/08 , A61B5/4878 , A61N1/3627 , A61N1/36521 , A61N1/3702
摘要： An implantable system acquires intracardiac impedance with an implantable lead system. In one implementation, the system generates frequency-rich, low energy, multi-phasic waveforms that provide a net-zero charge and a net-zero voltage. When applied to bodily tissues, current pulses or voltage pulses having the multi-phasic waveform provide increased specificity and sensitivity in probing tissue. The effects of the applied pulses are sensed as a corresponding waveform. The waveforms of the applied and sensed pulses can be integrated to obtain corresponding area values that represent the current and voltage across a spectrum of frequencies. These areas can be compared to obtain a reliable impedance value for the tissue. Frequency response, phase delay, and response to modulated pulse width can also be measured to determine a relative capacitance of the tissue, indicative of infarcted tissue, blood to tissue ratio, degree of edema, and other physiological parameters.

19. 发明授权

US08712519B1 Closed-loop adaptive adjustment of pacing therapy based on cardiogenic impedance signals detected by an implantable medical device 有权
标题翻译：基于由可植入医疗设备检测到的心源性阻抗信号的起搏治疗的闭环自适应调整
公开(公告)号：US08712519B1
公开(公告)日：2014-04-29
申请号：US11558194
申请日：2006-11-09
申请人： Dorin Panescu , Weiqun Yang , Louis Wong , Nils Holmstrom , Andre Walker
发明人： Dorin Panescu , Weiqun Yang , Louis Wong , Nils Holmstrom , Andre Walker
IPC分类号： A61N1/365
CPC分类号： A61N1/36521 , A61N1/3627 , A61N1/3684
摘要： Techniques are provided for controlling therapy provided by the implantable cardiac stimulation device based on cardiogenic impedance. A cardiogenic impedance signal (or intracardiac impedance signal) is an impedance signal representative of the beating of the heart of the patient in which the device is implanted. The cardiogenic impedance signal is sensed along a sensing vector passing through at least a portion of the heart so that the sensed impedance is affected by the mechanical beating of the heart along that sensing vector. Pacing therapy is automatically and adaptively adjusted based on the cardiogenic impedance signal. For example, pacing timing parameters such as the atrioventricular delay and the inter-ventricular delay may be adjusted. Preferably, the adjustments are adaptive, i.e. the adjustments are performed in a closed-loop so as to adapt the adjustments to changes in the cardiogenic impedance signal so as to optimize therapy. In one particular example, the adjustments are performed so as to reduce a degree of fractionation within a cardiogenic impedance waveform.
摘要翻译：提供技术用于基于心源性阻抗来控制由可植入心脏刺激装置提供的治疗。心源性阻抗信号（或心内阻抗信号）是表示装置植入的患者的心跳的阻抗信号。沿着通过心脏的至少一部分的感测矢量感测心源性阻抗信号，使得感测到的阻抗受到沿着该感测向量的心脏的机械跳动的影响。基于心源阻抗信号自动调整起搏治疗。例如，可以调整起搏定时参数，例如房室延迟和心室间延迟。优选地，调整是自适应的，即，在闭环中进行调整，以使调整适应于心源阻抗信号的变化，以便优化治疗。在一个具体示例中，执行调整以便降低心源阻抗波形内的分级程度。

20. 发明申请

US20100030294A1 IMPLANTABLE CARDIAC DEVICE WITH SATELLITE REFRESH 有权
标题翻译：具有卫星刷新功能的可携带心脏器具
公开(公告)号：US20100030294A1
公开(公告)日：2010-02-04
申请号：US12183438
申请日：2008-07-31
申请人： Louis Wong , Dorin Panescu
发明人： Louis Wong , Dorin Panescu
IPC分类号： A61N1/362
CPC分类号： A61N1/3627 , A61N1/37288 , A61N1/378
摘要： In one embodiment an implantable cardiac device is provided that includes an implantable cardiac stimulation device with an implantable satellite device coupled to it. The implantable satellite device has a charge storage device. The implantable stimulation device having a refresh generator configured to generate a charge and voltage balanced multi-phasic refresh signal with a duration less than a capacitive time constant of an electro-electrolyte interface of the implantable cardiac device and transmit the charge and voltage balanced multi-phasic refresh signal to the implantable satellite device for charging the charge storage device. In various embodiments, the charge and voltage balanced multi-phasic refresh signal having alternating phase signs and null durations between the alternating phases. In some embodiments, the refresh generator is configured to modulate the multi-phasic waveform refresh signal. The multi-phasic waveform refresh signal may be modulated to contain configuration information, status information, or other information.
摘要翻译：在一个实施例中，提供了可植入的心脏装置，其包括可植入的心脏刺激装置，其中可植入的卫星装置与其联接。可植入式卫星装置具有电荷存储装置。该可植入刺激装置具有刷新发生器，其被配置为产生具有小于可植入心脏装置的电解质界面的电容时间常数的持续时间的充电和电压平衡多相刷新信号，相位刷新信号到可植入式卫星装置，用于对电荷存储装置充电。在各种实施例中，充电和电压平衡的多相刷新信号在交替相位之间具有交替的相位符号和空持续时间。在一些实施例中，刷新发生器配置成调制多相波形刷新信号。可以调制多相波形刷新信号以包含配置信息，状态信息或其他信息。

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