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11. 发明授权

US06325102B1 Servo driving pilot-type solenoid valve 有权
标题翻译：伺服驱动先导式电磁阀
公开(公告)号：US06325102B1
公开(公告)日：2001-12-04
申请号：US09545457
申请日：2000-04-07
申请人： Keiji Misumi , Makoto Ishikawa
发明人： Keiji Misumi , Makoto Ishikawa
IPC分类号： F15B13043
CPC分类号： F15B13/0402 , F15B11/0365 , F15B13/0431 , F15B2211/30525 , F15B2211/355 , Y10T137/86614 , Y10T137/8663
摘要： A pilot-type solenoid valve capable of driving a valve member by increasing a pilot fluid pressure from a pilot valve and reliably switching valve member. The pilot-type solenoid valve includes a main valve portion having a valve member capable of sliding in a valve hole to which ports P, A, B, EA and EB in a valve body are opened, a pilot driving mechanism for applying a pilot fluid pressure to a pushing member which pushes one end of the valve member, and a returning mechanism for applying a returning force to the valve member. The pushing member includes a first piston for applying the pilot fluid pressure, and a second piston which is pushed by the first piston and which pushes the valve member. A shaft of the first piston passes through a partition wall in a sealing manner and abuts against the second piston. The shaft is provided therein with a guide hole for guiding the pilot fluid pressure to a pressure chamber of the second piston.
摘要翻译：一种先导式电磁阀，其能够通过增加来自先导阀的先导流体压力和可靠地切换阀构件来驱动阀构件。先导式电磁阀包括主阀部分，其具有能够在阀体中的端口P，A，B，EA和EB打开的阀孔中滑动的阀构件，用于施加先导流体的先导驱动机构推压构件的压力推动阀构件的一端，以及用于向阀构件施加返回力的返回机构。推动构件包括用于施加先导流体压力的第一活塞和由第一活塞推动并推动阀构件的第二活塞。第一活塞的轴以密封方式穿过分隔壁并抵靠第二活塞。轴在其中设置有用于将先导流体压力引导到第二活塞的压力室的引导孔。

12. 发明授权

US07129232B2 Cephem compounds 有权
标题翻译：头孢烯化合物
公开(公告)号：US07129232B2
公开(公告)日：2006-10-31
申请号：US10695895
申请日：2003-10-30
申请人： Hidenori Ohki , Shinya Okuda , Toshio Yamanaka , Masaru Ohgaki , Ayako Toda , Kohji Kawabata , Satoshi Inoue , Keiji Misumi , Kenji Itoh , Kenji Satoh
发明人： Hidenori Ohki , Shinya Okuda , Toshio Yamanaka , Masaru Ohgaki , Ayako Toda , Kohji Kawabata , Satoshi Inoue , Keiji Misumi , Kenji Itoh , Kenji Satoh
IPC分类号： C07D501/46 , C07D501/38 , A61K31/546 , A61P31/04
CPC分类号： C07D501/00 , Y02P20/55
摘要： The present invention relates to a compound of the formula [I]: wherein R1 is lower alkyl, hydroxy(lower)alkyl or halo(lower)alkyl, and R2 is hydrogen or amino protecting group, or R1 and R2 are bonded together and form lower alkylene or lower alkenylene; R3 is hydrogen or lower alkyl; R4 is R5 is carboxy or protected carboxy; and R6 is amino or protected amino, or a pharmaceutically acceptable salt thereof, a process for preparing a compound of the formula [I], and a pharmaceutical composition comprising a compound of the formula [I] in admixture with a pharmaceutically acceptable carrier.
摘要翻译：本发明涉及式[I]化合物：其中R 1是低级烷基，羟基（低级）烷基或卤代（低级）烷基，R 2是是氢或氨基保护基，或R 1和R 2结合在一起形成低级亚烷基或低级亚烯基; R 3是氢或低级烷基; R 4是R 5是羧基或被保护的羧基; 和R 6是氨基或被保护的氨基或其药学上可接受的盐，制备式[I]化合物的方法，以及药物组合物，其包含式[I]化合物与药学上可接受的载体混合。

13. 发明授权

US6127361A 5,11-dihydrodibenzo[b,e][1,4]oxazepine derivatives and pharmaceutical compositions containing the same 失效
标题翻译： 5,11-二氢二苯并[b，e] [1,4]氧氮杂衍生物和含有它们的药物组合物
公开(公告)号：US6127361A
公开(公告)日：2000-10-03
申请号：US147012
申请日：1998-09-11
申请人： Yuji Tanaka , Keiji Misumi , Yoshinari Kawakami , Masahiko Moriguchi , Kazuyoshi Takahashi , Hiroki Okamoto , Toshiaki Kamisaki , Kimihiro Inoue , Makoto Sato
发明人： Yuji Tanaka , Keiji Misumi , Yoshinari Kawakami , Masahiko Moriguchi , Kazuyoshi Takahashi , Hiroki Okamoto , Toshiaki Kamisaki , Kimihiro Inoue , Makoto Sato
IPC分类号： A61P1/00 , C07D413/06 , C07D413/14 , A61K31/553 , C07D267/18
CPC分类号： C07D413/06 , C07D413/14
摘要： Disclosed are 5,11-Dihydrodibenzo[b,e][1,4]oxazepine derivatives such as (R)-(+)-5,11-dihydro-5-[1-(4-methoxyphenethyl)-2-pyrrolidinylmethyl]dibenzo[b,e][1,4]oxazepine and (R)-(+)-5,11-dihydro-5-[1-(4-fluorophenethyl)-2-pyrrolidinylmethyl]dibenzo[b,e][1,4]oxazepine, stereoisomers thereof, pharmacologically acceptable salts thereof, or hydrates thereof and a phramaceutical composition conating the 5,11-Dihydrodibenzo[b,e][1,4]oxazepine derivatives. The derivatives have an excellent activity of improving a digestive tract moving function and are free of side effect.
摘要翻译： PCT No.PCT / JP97 / 00754 Sec。 371日期：1998年9月11日 102（e）日期1998年9月11日PCT 1997年3月11日PCT公布。公开号WO97 / 33885 PCT 日期：1997年9月18日公开了5,11-二氢二苯并[b，e] [1,4]氧氮杂衍生物如（R） - （+） - 5,11-二氢-5- [1-（4-甲氧基苯乙基） -2-吡咯烷基甲基]二苯并[b，e] [1,4]氧氮杂和（R） - （+） - 5,11-二氢-5- [1-（4-氟苯乙基）-2-吡咯烷基甲基]二苯并[b ，e] [1,4]氧氮杂，其立体异构体，其药理学上可接受的盐或其水合物和赋予5,11-二氢二苯并[b，e] [1,4]氧氮杂衍生物的药物组合物。该衍生物具有改善消化道移动功能的优异活性，无副作用。

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