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11. 发明申请

US20150038494A1 Thiazolopyrimidine Modulators as Immunosuppressive Agents 有权
标题翻译：噻唑并嘧啶调节剂作为免疫抑制剂
公开(公告)号：US20150038494A1
公开(公告)日：2015-02-05
申请号：US14518480
申请日：2014-10-20
申请人： Piet Herdewijn , Steven De Jonghe , Ling-Jie Gao , Mi-Yeon Jang , Bart Vanderhoydonck , Mark Jozef Albert Waer , Yuan Lin , Jean Ferdinand Herman , Thierry Andre Michel Louat
发明人： Piet Herdewijn , Steven De Jonghe , Ling-Jie Gao , Mi-Yeon Jang , Bart Vanderhoydonck , Mark Jozef Albert Waer , Yuan Lin , Jean Ferdinand Herman , Thierry Andre Michel Louat
IPC分类号： C07D473/32 , A61K31/5513 , C07D473/18 , A61K31/5377 , A61K31/517 , A61K45/06
CPC分类号： C07D473/32 , A61K31/517 , A61K31/519 , A61K31/5377 , A61K31/5513 , A61K45/06 , C07D473/18 , C07D513/04
摘要： The present invention relates to compound of formula I, II, III, or IV, and/or a pharmaceutical acceptable addition salt thereof and/or a stereoisomer thereof and/or a solvate thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R11, and R12 are as defined in the claim 1. The present invention also relates to a method for their preparation, as well as to pharmaceutical compositions thereof. The present invention further relates to the use of said compounds as biologically active ingredients, more specifically as medicaments for the treatment of disorders and pathologic conditions such as, but not limited to, immune and auto-immune disorders, organ and cells transplant rejections.
摘要翻译：本发明涉及式I，II，III或IV化合物和/或其药学上可接受的加成盐和/或其立体异构体和/或其溶剂合物，其中R1，R2，R3，R4，R5， R6，R7，R8，R9，R11和R12如权利要求1中所定义。本发明还涉及其制备方法及其药物组合物。本发明还涉及所述化合物作为生物活性成分的用途，更具体地说，作为用于治疗疾病和病理状况的药物，例如但不限于免疫和自身免疫病症，器官和细胞移植排斥。

12. 发明授权

US08901132B2 Thiazolopyrimidine modulators as immunosuppressive agents 有权
标题翻译：噻唑并嘧啶调节剂作为免疫抑制剂
公开(公告)号：US08901132B2
公开(公告)日：2014-12-02
申请号：US13255429
申请日：2010-03-15
申请人： Piet Herdewijn , Steven De Jonghe , Ling-Jie Gao , Mi-Yeon Jang , Bart Vanderhoydonck , Mark Jozef Albert Waer , Yuan Lin , Jean Ferdinand Herman , Thierry Andre Michel Louat
发明人： Piet Herdewijn , Steven De Jonghe , Ling-Jie Gao , Mi-Yeon Jang , Bart Vanderhoydonck , Mark Jozef Albert Waer , Yuan Lin , Jean Ferdinand Herman , Thierry Andre Michel Louat
IPC分类号： A61K31/519 , C07D495/02 , C07D513/22 , C07D513/04
CPC分类号： C07D473/32 , A61K31/517 , A61K31/519 , A61K31/5377 , A61K31/5513 , A61K45/06 , C07D473/18 , C07D513/04
摘要： The present invention relates to compound of formula I, II, III, or IV, and/or a pharmaceutical acceptable addition salt thereof and/or a stereoisomer thereof and/or a solvate thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R11, and R12 are as defined in the claim 1. The present invention also relates to a method for their preparation, as well as to pharmaceutical compositions thereof. The present invention further relates to the use of said compounds as biologically active ingredients, more specifically as medicaments for the treatment of disorders and pathologic conditions such as, but not limited to, immune and auto-immune disorders, organ and cells transplant rejections.
摘要翻译：本发明涉及式I，II，III或IV化合物和/或其药学上可接受的加成盐和/或其立体异构体和/或其溶剂合物，其中R1，R2，R3，R4，R5， R6，R7，R8，R9，R11和R12如权利要求1中所定义。本发明还涉及其制备方法及其药物组合物。本发明还涉及所述化合物作为生物活性成分的用途，更具体地说，作为用于治疗疾病和病理状况的药物，例如但不限于免疫和自身免疫病症，器官和细胞移植排斥。

13. 发明申请

US20140192706A1 Method and System for Frequency Reuse in Wireless Relay Scenario 有权
标题翻译：无线中继方式频率重用方法及系统
公开(公告)号：US20140192706A1
公开(公告)日：2014-07-10
申请号：US14234730
申请日：2011-12-12
申请人： Yanlong Wang , Yongyu Chang , Jie Gao , Yun Zhu
发明人： Yanlong Wang , Yongyu Chang , Jie Gao , Yun Zhu
IPC分类号： H04W72/04
CPC分类号： H04W72/0486 , H04W16/04 , H04W74/0866 , H04W84/047
摘要： The disclosure provides a method for frequency reuse in a wireless relay scenario, wherein a center frequency spectrum, an edge frequency spectrum and a random access frequency spectrum are pre-allocated to a cell according to a scenario parameter in the cell; load conditions of all mobile stations (MSs) covered by each relay station (RS) in the cell is calculated and reported to a base station (BS); the BS allocates the random access frequency spectrum to an RS according to load conditions of all RSs and schedules MSs. The disclosure also provides a system for frequency reuse in a wireless relay scenario. With the method and system above, the frequency spectrum planning is configurable, the random access frequency spectrum is introduced, and both the load balancing and user fairness are taken into consideration, which improves the throughput at the edge of the cell, especially can increase the throughput for the users whose throughput ranks poorly.
摘要翻译：本公开提供了一种在无线中继场景中的频率重用的方法，其中根据小区中的场景参数将中心频谱，边缘频谱和随机接入频谱预先分配给小区; 计算小区中每个中继站（RS）覆盖的所有移动台（MS）的负载情况并将其报告给基站（BS）; BS根据所有RS和时间表MS的负载条件向RS分配随机接入频谱。本公开还提供了一种用于无线中继场景中的频率重用的系统。通过上述方法和系统，可以配置频谱规划，引入随机接入频谱，同时考虑负载均衡和用户公平性，提高小区边缘吞吐量，特别是可以增加吞吐量排名不佳的用户的吞吐量。

14. 发明申请

US20140095755A1 USING ADAPTIVE CHANNEL SELECTION TO ENHANCE THE PERFORMANCE OF WIRELESS DOCKING 有权
标题翻译：使用自适应通道选择，以提高无线锁定的性能
公开(公告)号：US20140095755A1
公开(公告)日：2014-04-03
申请号：US13631473
申请日：2012-09-28
申请人： Jie Gao , Ulun Karacaoglu , Lei Shao , Xintian E. Lin
发明人： Jie Gao , Ulun Karacaoglu , Lei Shao , Xintian E. Lin
IPC分类号： G06F13/14
CPC分类号： G06F13/387 , G06F1/1632 , G06F3/023 , G06F3/0231 , G06F3/038 , G06F2203/0384 , H04W72/02 , H04W72/08
摘要： An Adaptive Channel Selection (ACS) system is disclosed. A computing device uses wireless docking to provide a separate monitor and full-size input devices. The computing device requests docking, receives data wirelessly from the full-size input devices, and provides compressed video display data wirelessly for display on the separate monitor. An adaptive docking adapter receives and decodes compressed video display data and provides the decoded compressed video display data to a separate monitor for display. A wireless connection is disposed between the computing device and the adaptive docking adapter to provide wireless transmission of signals between the computing device and the adaptive docking adapter.
摘要翻译：公开了一种自适应信道选择（ACS）系统。计算设备使用无线对接来提供单独的监视器和全尺寸输入设备。计算设备请求对接，从全尺寸输入设备无线接收数据，并提供无线的压缩视频显示数据，以便在单独的监视器上显示。自适应对接适配器接收并解码压缩的视频显示数据，并将经解码的压缩视频显示数据提供给单独的监视器以进行显示。在计算设备和自适应对接适配器之间设置无线连接以在计算设备和自适应对接适配器之间提供信号的无线传输。

15. 发明申请

US20130315298A1 ADAPTIVE DATA TRANSMISSION RATE CONTROL FOR A WIRELESS DISPLAY DEVICE 有权
标题翻译：一种无线显示设备的自适应数据传输速率控制
公开(公告)号：US20130315298A1
公开(公告)日：2013-11-28
申请号：US13952133
申请日：2013-07-26
申请人： Jie Gao , Xintian E. Lin , Inching Chen
发明人： Jie Gao , Xintian E. Lin , Inching Chen
IPC分类号： H04N7/26
CPC分类号： H04N19/146 , H04L65/4084 , H04L65/80 , H04N21/4122 , H04N21/4143 , H04N21/43637 , H04N21/4402 , H04N21/44227
摘要： A method, a computer readable medium and an apparatus to adaptively control a data transmission rate of a wireless display device. The method includes determining a current data transmission rate capacity of a wireless channel; and controlling a data transmission rate of a wireless transmission device based on the current data transmission rate capacity.
摘要翻译：一种方法，计算机可读介质和用于自适应地控制无线显示设备的数据传输速率的装置。该方法包括确定无线信道的当前数据传输速率容量; 以及基于当前数据传输速率容量来控制无线传输设备的数据传输速率。

16. 发明申请

US20130190297A1 Antiviral Activity of Novel Bicyclic Heterocycles 有权
标题翻译：新型双环杂环的抗病毒活性
公开(公告)号：US20130190297A1
公开(公告)日：2013-07-25
申请号：US13699258
申请日：2011-05-20
申请人： Steven De Jonghe , Ling-Jie Gao , Piet Herdewijn , Jean Herman , Miyeon Jang , Pieter Leyssen , Thierry Louat , Johan Neyts , Christophe Pannecouque , Bart Vanderhoydonck
发明人： Steven De Jonghe , Ling-Jie Gao , Piet Herdewijn , Jean Herman , Miyeon Jang , Pieter Leyssen , Thierry Louat , Johan Neyts , Christophe Pannecouque , Bart Vanderhoydonck
IPC分类号： C07D513/04
CPC分类号： A61K31/551 , A61K31/519 , A61K31/52 , A61K31/5377 , C07D473/00 , C07D513/04 , Y02A50/385 , Y02A50/465
摘要： The present invention relates to compound of Formula I, II, III, or IV, and/or a pharmaceutical acceptable addition salt thereof and/or a stereoisomer thereof and/or a solvate thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R11, and R12 are as defined in the claim 1 or as described in detail in the description of the invention, and to the use of said compounds to treat or prevent viral infections and their use to manufacture a medicine to treat or prevent viral infections, particularly infections with RNA-viruses belonging to the family of the Retroviridae, the family of the Flaviviridae and the family of the Picornaviridae and more preferably infections with Human Immunodeficiency Virus 1 (HIV1), Human Immunodeficiency Virus 2 (HIV2), Hepatitis C virus (HCV), Dengue virus, and enteroviruses like Coxsackievirus, Rhinovirus and Poliovirus. The present invention also relates to pharmaceutical compositions of said compounds and the use of said pharmaceutical compositions to treat or prevent viral infections. The present invention further relates to the use of said compounds as biologically active ingredients, more specifically as medicaments for the treatment of viral disorders and pathologic conditions such as, but not limited to, viral infections with Human Immunodeficiency Virus 1 (HIV1), Human Immunodeficiency Virus 2 (HIV2), Hepatitis C virus (HCV), Dengue virus, and enteroviruses like Coxsackievirus, Rhinovirus and Poliovirus.
摘要翻译：本发明涉及式I，II，III或IV化合物和/或其药学上可接受的加成盐和/或其立体异构体和/或其溶剂合物，其中R1，R2，R3，R4，R5， R6，R7，R8，R9，R11和R12如权利要求1中所定义或如在本发明的描述中详细描述的，以及所述化合物用于治疗或预防病毒感染及其用于制造治疗或预防病毒感染的药物，特别是属于逆转录病毒科的家族，微病毒科的家族和小核糖核酸病毒科家族的RNA病毒的感染，更优选人免疫缺陷病毒1（HIV1），人类免疫缺陷病毒2 （HIV2），丙型肝炎病毒（HCV），登革热病毒和诸如柯萨奇病毒，鼻病毒和脊髓灰质炎病毒的肠道病毒。本发明还涉及所述化合物的药物组合物和所述药物组合物用于治疗或预防病毒感染的用途。本发明还涉及所述化合物作为生物活性成分的用途，更具体地说，作为治疗病毒性病症和病理状况的药物，例如但不限于人免疫缺陷病毒1（HIV1），人类免疫缺陷病毒病毒2（HIV2），丙型肝炎病毒（HCV），登革热病毒和诸如柯萨奇病毒，鼻病毒和脊髓灰质炎病毒的肠道病毒。

17. 发明申请

US20130009907A1 Magnetic Stylus 审中-公开
标题翻译：磁笔
公开(公告)号：US20130009907A1
公开(公告)日：2013-01-10
申请号：US13247412
申请日：2011-09-28
申请人： Ilya D. Rosenberg , Bradley J. Bozarth , Julien G. Beguin , Tomer Moscovich , Susan Jie Gao , Tiffany Yun
发明人： Ilya D. Rosenberg , Bradley J. Bozarth , Julien G. Beguin , Tomer Moscovich , Susan Jie Gao , Tiffany Yun
IPC分类号： G06F3/046 , G06F3/033
CPC分类号： G06F3/0418 , G06F3/046 , G06F2203/04101 , G06F2203/04106
摘要： A stylus comprising a magnetic field source when combined with a touch sensor provides for several input modes for an electronic device. Magnetometers in the electronic device may detect the presence, location, orientation, and angle of the magnet and thus the stylus. Presence of the magnetic field in conjunction with touches on the force sensitive touch sensor provides additional comparisons to distinguish whether a touch is from a human hand, a particular portion of a stylus, or other object.
摘要翻译：当与触摸传感器组合时，包括磁场源的触笔提供用于电子设备的几种输入模式。电子设备中的磁力计可以检测磁体的存在，位置，取向和角度，并因此检测触针。存在与力敏感触摸传感器上的触摸相关联的磁场提供额外的比较，以区分触摸是来自人的手，触针的特定部分还是其他对象。

18. 发明申请

US20120147946A1 Wireless channel aware adaptive video bit rate encoding 有权
标题翻译：无线信道感知自适应视频比特率编码
公开(公告)号：US20120147946A1
公开(公告)日：2012-06-14
申请号：US12928333
申请日：2010-12-09
申请人： Jie Gao , Xintian E. Lin , Babu P. Lukose
发明人： Jie Gao , Xintian E. Lin , Babu P. Lukose
IPC分类号： H04N7/26
CPC分类号： H04N19/146 , H04N19/10 , H04N19/115 , H04N19/164 , H04N19/184
摘要： A determination and query is performed on wireless channel on which video data is transmitted from a transmitting wireless display or WiDi device. Based on a channel capacity and implementing an algorithm, the encoding bit rate at the transmitting WiDi device is adaptively adjusted based on the determined channel capacity.
摘要翻译：在从发送无线显示器或WiDi设备发送视频数据的无线信道上执行确定和查询。基于信道容量和实现算法，基于确定的信道容量自适应地调整发射WiDi设备处的编码比特率。

19. 发明申请

US20120140647A1 Communications Techniques For Bursty Noise Environments 有权
标题翻译：突发噪声环境的通信技术
公开(公告)号：US20120140647A1
公开(公告)日：2012-06-07
申请号：US12960614
申请日：2010-12-06
申请人： Jie Gao , Xintian Lin , Qinghua Li , Hsin-Yuo Liu
发明人： Jie Gao , Xintian Lin , Qinghua Li , Hsin-Yuo Liu
IPC分类号： H04L12/26
CPC分类号： H04L43/0811 , H04L43/10 , H04L47/14 , H04L47/22 , H04L47/263
摘要： Techniques are disclosed that involve communicating in bursty noise environments. For instance, a source device may send a probing packet to a destination device. This probing packet is for determining whether the communications medium (e.g., one or more frequency channels) is currently exhibiting a busy or jammed (e.g., due to bursty noise) condition. More particularly, based on whether an acknowledgment of the probing packet is received, the source device determines whether the channel is jammed (or busy) or clear. For example, an unacknowledged probing packet indicates that the channel is jammed or busy, while an acknowledged probing packet indicates that the channel is clear. If the channel is determined to be clear, then the source device may transmit one or more data packets to the destination device. Such data packet transmissions may be in accordance with a non rate-adaptive technique.
摘要翻译：公开了涉及在突发噪声环境中进行通信的技术。例如，源设备可以向目的地设备发送探测分组。该探测分组用于确定通信介质（例如，一个或多个频率信道）当前是否正在呈现忙或卡住（例如，由于突发噪声）条件。更具体地，基于是否接收到探测分组的确认，源设备确定信道是否被卡住（或忙）或清除。例如，未确认的探测分组指示信道被卡住或占线，而确认的探测分组指示信道是清除的。如果信道被确定为清除，则源设备可以向目的设备发送一个或多个数据分组。这样的数据分组传输可以是根据非速率自适应技术。

20. 发明申请

US20120046278A1 THIAZOLOPYRIMIDINE MODULATORS AS IMMUNOSUPPRESSIVE AGENTS 有权
标题翻译：作为免疫抑制剂的三氮丙啶调节剂
公开(公告)号：US20120046278A1
公开(公告)日：2012-02-23
申请号：US13255429
申请日：2010-03-15
申请人： Piet Herdewijn , Steven De Jonghe , Ling-Jie Gao , Mi-Yeon Jang , Bart Vanderhoydonck , Mark Jozef Albert Waer , Yuan Lin , Jean Ferdinand Herman , Thierry Andre Michel Louat
发明人： Piet Herdewijn , Steven De Jonghe , Ling-Jie Gao , Mi-Yeon Jang , Bart Vanderhoydonck , Mark Jozef Albert Waer , Yuan Lin , Jean Ferdinand Herman , Thierry Andre Michel Louat
IPC分类号： A61K31/519 , A61K31/496 , A61K31/5377 , A61P35/00 , A61K31/551 , A61P37/02 , A61P37/06 , C07D495/04 , C07D487/04
CPC分类号： C07D473/32 , A61K31/517 , A61K31/519 , A61K31/5377 , A61K31/5513 , A61K45/06 , C07D473/18 , C07D513/04
摘要： The present invention relates to compound of formula I, II, III, or IV, and/or a pharmaceutical acceptable addition salt thereof and/or a stereoisomer thereof and/or a solvate thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R11, and R12 are as defined in the claim 1. The present invention also relates to a method for their preparation, as well as to pharmaceutical compositions thereof. The present invention further relates to the use of said compounds as biologically active ingredients, more specifically as medicaments for the treatment of disorders and pathologic conditions such as, but not limited to, immune and auto-immune disorders, organ and cells transplant rejections.
摘要翻译：本发明涉及式I，II，III或IV化合物和/或其药学上可接受的加成盐和/或其立体异构体和/或其溶剂合物，其中R1，R2，R3，R4，R5， R6，R7，R8，R9，R11和R12如权利要求1中所定义。本发明还涉及其制备方法及其药物组合物。本发明还涉及所述化合物作为生物活性成分的用途，更具体地说，作为用于治疗疾病和病理状况的药物，例如但不限于免疫和自身免疫病症，器官和细胞移植排斥。

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