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11. 发明申请

US20080220409A1 Antigen of Dengue Virus Type 1 审中-公开
标题翻译：登革热病毒1型抗原
公开(公告)号：US20080220409A1
公开(公告)日：2008-09-11
申请号：US11683817
申请日：2007-03-08
申请人： Han-Chung Wu , Chin-Tarng Lin , Yun-Ching Chen
发明人： Han-Chung Wu , Chin-Tarng Lin , Yun-Ching Chen
IPC分类号： C12Q1/70 , C07K7/08 , C12N7/00
CPC分类号： C07K14/005 , C07K7/08 , C12N2770/24122 , G01N33/56983 , G01N2333/18 , Y02A50/53
摘要： Antigens and B-cell epitopes derived from dengue virus type 1 are provided. The antigens are specifically immunoreactive with sera from individuals infected with dengue virus type 1 but not reactive with sera from healthy individuals and individuals infected with dengue virus type 2. The antigens and epitopes are useful for development of diagnostic kits and reagents, and are useful tools as well in determining whether an individual is infected with dengue virus type 1, and for distinguishing infection from dengue virus type 2.
摘要翻译：提供了源自1型登革病毒的抗原和B细胞表位。抗原与来自感染1型登革热病毒的个体的血清特异性免疫反应，但与来自健康个体和感染了2型登革热病毒的个体的血清无反应。抗原和表位可用于开发诊断试剂盒和试剂，并且是有用的工具以及确定个体是否感染1型登革热病毒，以及区分2型登革热病毒的感染。

12. 发明申请

US20080193510A1 Peptides that target to tumor blood vessels of lung cancer and applications thereof 有权
标题翻译：靶向肺癌肿瘤血管的肽及其应用
公开(公告)号：US20080193510A1
公开(公告)日：2008-08-14
申请号：US11783926
申请日：2007-04-13
申请人： Han-Chung Wu , Chin-Tarng Lin , Tong-Young Lee , Szu-Yao Kuo
发明人： Han-Chung Wu , Chin-Tarng Lin , Tong-Young Lee , Szu-Yao Kuo
IPC分类号： G01N33/53 , A61K31/704 , A61K31/7088 , A61K38/10 , A61K9/127 , A61P35/00 , C07H21/00 , C07K14/00 , C07K16/00 , C07K7/08 , C12N1/00 , C12N15/63 , C12Q1/68
CPC分类号： A61K9/1271 , A61K47/62 , A61K47/6911 , G01N33/5082 , G01N33/57423
摘要： The invention provides nucleic acids, peptides, and antibodies for use in applications including diagnosis and therapy. The peptides target neovasculature and were identified by in vivo phage display. One such peptide, SP5-52, recognized the neovasculature of multiple tumors in SCID mice, but did not target normal blood vessels. This peptide also binds to blood vessels of human lung cancer biopsy specimens. Liposomes comprising SP5-52 and doxorubicin enhanced the efficacy of the drug against multiple human cancer xenografts in SCID mice.
摘要翻译：本发明提供用于包括诊断和治疗在内的应用的核酸，肽和抗体。该肽靶向新血管生成，并通过体内噬菌体展示鉴定。一种这样的肽SP5-52在SCID小鼠中识别出多个肿瘤的新血管，但不能靶向正常的血管。该肽还结合人肺癌活检标本的血管。包含SP5-52和多柔比星的脂质体增强了药物对SCID小鼠中多种人类癌症异种移植物的功效。

13. 发明申请

US20080193375A1 Lung cancer-targeted peptides and applications thereof 有权
标题翻译：肺癌靶向肽及其应用
公开(公告)号：US20080193375A1
公开(公告)日：2008-08-14
申请号：US11783927
申请日：2007-04-13
申请人： Han-Chung Wu , Chin-Tarng Lin , De-Kuan Chang
发明人： Han-Chung Wu , Chin-Tarng Lin , De-Kuan Chang
IPC分类号： A61K9/00 , A61K38/10 , A61P35/00 , C07K16/00 , C07K7/08 , C12N15/63 , G01N33/574 , C12N1/00 , C07K2/00 , C07H21/00 , A61K51/12
CPC分类号： G01N33/57423 , A61K9/1271 , A61K47/62 , A61K47/6911 , A61K51/1234 , C07K7/08
摘要： The invention provides nucleic acids, peptides, and antibodies for use in applications including diagnosis and therapy. The peptides target lung cancer and were identified by phage display. Targeting phage PC5-2 and synthetic peptide SP5-2 were both able to recognize human pulmonary tumor specimens from lung cancer patients. In SCID mice bearing NSCLC xenografts, the targeting phage was able to target tumor masses specifically. When the peptide was coupled to liposomes containing the anti-cancer drugs vinorelbine or doxorubicin, the efficacy of these drugs against human lung cancer xenografts was improved, the survival rate increased, and the drug toxicity was reduced.
摘要翻译：本发明提供用于包括诊断和治疗在内的应用的核酸，肽和抗体。这些肽靶向肺癌，并通过噬菌体展示鉴定。靶向噬菌体PC5-2和合成肽SP5-2均能够识别来自肺癌患者的人肺肿瘤标本。在携带NSCLC异种移植物的SCID小鼠中，靶向噬菌体能够特异性靶向肿瘤块。当肽与含有抗癌药物长春瑞滨或多柔比星的脂质体偶联时，这些药物对人肺癌异种移植物的疗效提高，存活率提高，药物毒性降低。

14. 发明申请

US20050010036A1 Peptide marker targeting to nasopharyngeal carcinoma cell and application thereof 有权
标题翻译：靶向鼻咽癌细胞的肽标记及其应用
公开(公告)号：US20050010036A1
公开(公告)日：2005-01-13
申请号：US10796892
申请日：2004-03-09
申请人： Han-Chung Wu , Chin-Tarng Lin , Tong-Young Lee
发明人： Han-Chung Wu , Chin-Tarng Lin , Tong-Young Lee
IPC分类号： A61K9/127 , A61K39/395 , C07K16/46
CPC分类号： A61K9/1271 , A61K38/00 , A61K47/64 , C07K5/0808 , C07K7/08
摘要： The present invention provides a peptide marker targeting to nasopharyngeal carcinoma (NPC) cells and application thereof. The peptide binds specifically to the cell surface of NPC cells. After conjugated with liposome containing chemotherapeutic drugs, such peptides deliver chemotherapeutic drugs to the tumor cells specifically and destruct tumor cells without damaging normal tissues and organs. Furthermore, such peptide is applied as a detector in the development of NPC diagnosis kit.
摘要翻译：本发明提供靶向鼻咽癌（NPC）细胞的肽标记及其应用。肽特异性结合NPC细胞的细胞表面。在与含有脂质体的化学治疗药物缀合之后，这些肽特异性地向肿瘤细胞递送化学治疗药物并破坏肿瘤细胞而不损害正常的组织和器官。此外，这种肽作为NPC诊断试剂盒开发中的检测器使用。

15. 发明授权

US09541480B2 Capture, purification, and release of biological substances using a surface coating 有权
标题翻译：使用表面涂层捕获，纯化和释放生物物质
公开(公告)号：US09541480B2
公开(公告)日：2017-01-10
申请号：US14128354
申请日：2012-06-28
申请人： Ying-Chih Chang , Han-Chung Wu , Po-Yuan Tseng , Jen-Chia Wu
发明人： Ying-Chih Chang , Han-Chung Wu , Po-Yuan Tseng , Jen-Chia Wu
IPC分类号： G01N1/40 , G01N33/543 , G01N33/574 , C07K16/30 , C07K17/14
CPC分类号： G01N33/54386 , C07K16/30 , C07K17/14 , G01N1/405 , G01N33/54393 , G01N33/57492
摘要： This invention relates to a surface coating for capture circulating rare cells, comprising a nonfouling composition to prevent the binding of non-specific cells and adsorption of serum components; a bioactive composition for binding the biological substance, such as circulating tumor cells; with or without a linker composition that binds the nonfouling and bioactive compositions. The invention also provide a surface coating for capture and purification of a biological substance, comprising a releasable composition to release the non-specific cells and other serum components; a bioactive composition for binding the biological substance, such as circulating tumor cells; with or without a linker composition that binds the releasable and bioactive compositions. The present invention also discloses a novel microfluidic chip, with specific patterned microstructures to create a flow disturbance and increase the capture rate of the biological substance.
摘要翻译：本发明涉及用于捕获循环稀有细胞的表面涂层，其包含防止非特异性细胞结合的非结垢组合物和血清成分的吸附; 用于结合生物物质的生物活性组合物，例如循环肿瘤细胞; 具有或不具有结合非结垢和生物活性组合物的接头组合物。本发明还提供用于捕获和纯化生物物质的表面包衣，其包含可释放组合物以释放非特异性细胞和其它血清成分; 用于结合生物物质的生物活性组合物，例如循环肿瘤细胞; 具有或不具有结合可释放和生物活性组合物的接头组合物。本发明还公开了一种具有特定图案化微结构的新型微流体芯片，以产生流动扰动并增加生物物质的捕获率。

16. 发明授权

US09150655B2 Anti-C-met antibody and methods of use thereof 有权
标题翻译：抗C-met抗体及其使用方法
公开(公告)号：US09150655B2
公开(公告)日：2015-10-06
申请号：US13818283
申请日：2011-08-30
申请人： Han-Chung Wu , Ruei-Min Lu
发明人： Han-Chung Wu , Ruei-Min Lu
IPC分类号： C07K16/28 , A61K9/127 , A61K47/48 , A61K49/00 , A61K9/00 , A61K47/24 , A61K39/00
CPC分类号： C07K16/2869 , A61K9/0019 , A61K9/1271 , A61K47/24 , A61K47/6913 , A61K49/0058 , A61K49/0067 , A61K2039/505 , C07K16/2863 , C07K2317/622 , C07K2317/77 , C07K2317/92 , C07K2319/30
摘要： Antibodies that bind to c-Met are provided herein, as well as related compositions and methods of use. Methods of use encompass cancer therapies and diagnostics. In certain embodiments, antibodies bind mammalian cell surface antigen (e.g., cancer cell surface antigen). The antibodies can also be endocytosed upon binding to cells. Cells that can be targeted by the antibodies include carcinomas, such as those in lung, kidney, liver, stomach, breast, and brain, etc.
摘要翻译：本文提供了与c-Met结合的抗体，以及相关组合物和使用方法。使用方法包括癌症治疗和诊断。在某些实施方案中，抗体结合哺乳动物细胞表面抗原（例如癌细胞表面抗原）。抗体还可以在与细胞结合时被内吞。可以由抗体靶向的细胞包括癌，如肺，肾，肝，胃，乳腺和脑等。

17. 发明授权

US08541543B2 Peptides specific for hepatocellular carcinoma cells and applications thereof 有权
公开(公告)号：US08541543B2
公开(公告)日：2013-09-24
申请号：US12292401
申请日：2008-11-18
申请人： Han-Chung Wu , Chin-Tarng Lin , Albert Lo
发明人： Han-Chung Wu , Chin-Tarng Lin , Albert Lo
IPC分类号： C07K5/00
CPC分类号： G01N33/57438 , A61K38/00 , C07K7/08
摘要： Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer death worldwide. Novel treatment strategies derived from increased knowledge of molecular oncology are constantly being developed to cure this disease. Here, we used phage display to identify novel peptides, including (SP94), which binds specifically to HCC cells. In vitro, the phage clone PC94 binds to HCC cell lines. In vivo, PC94 homed specifically to tumor tissues but not to normal visceral organs in SCID mice bearing human HCC xenografts. The homing ability could be competitively inhibited by synthetic peptide, SP94. PC94 localized to tumor tissues but could not be detected in SP94-competed tumor tissues or in normal organs. In addition, PC94 recognized the tumor tissue but not non-tumor tissue in surgical specimens from HCC patients, with a positive rate of 61.3% (19/31). With the conjugation of SP94 and liposomal doxorubicin, a targeted drug delivery system enhanced the therapeutic efficacy against HCC xenografts through enhanced tumor apoptosis and decreased tumor angiogenesis. Our results indicate that SP94 can improve the systemic treatment of patients with advanced HCC.

18. 发明授权

US08394758B2 Tumor-targeting peptides and uses thereof 有权
标题翻译：肿瘤靶向肽及其用途
公开(公告)号：US08394758B2
公开(公告)日：2013-03-12
申请号：US12607334
申请日：2009-10-28
申请人： Han-Chung Wu , De-Kuan Chang , Chien-Yu Chiu
发明人： Han-Chung Wu , De-Kuan Chang , Chien-Yu Chiu
IPC分类号： A61K38/00 , A61K38/04 , A61K51/00 , C07K2/00 , C07K4/00 , C07K5/00 , C07K7/00 , C07K14/00 , C07K16/00 , C07K17/00
CPC分类号： G01N33/586 , A61K47/6911 , C07K7/08 , G01N33/57484
摘要： Tumor targeting peptides and uses thereof in tumor diagnosis and treatment.
摘要翻译：肿瘤靶向肽及其在肿瘤诊断和治疗中的应用。

19. 发明申请

US20120014945A1 Anti-Dengue Virus Antibodies 有权
标题翻译：抗登革热病毒抗体
公开(公告)号：US20120014945A1
公开(公告)日：2012-01-19
申请号：US13182771
申请日：2011-07-14
申请人： Han-Chung Wu , Pi-Chun Li , Mei-Ying Liao , Chien-Yu Chiu
发明人： Han-Chung Wu , Pi-Chun Li , Mei-Ying Liao , Chien-Yu Chiu
IPC分类号： A61K39/42 , C12Q1/70 , G01N33/53 , C07K16/08 , A61P31/12
CPC分类号： G01N33/56983 , A61K2039/505 , C07K16/1081 , C07K2317/24 , C07K2317/34 , C07K2317/76 , C07K2317/92 , G01N2333/185 , Y02A50/386 , Y02A50/53
摘要： Provided herein are monoclonal antibodies specific to dengue virus as well as their antigen-binding fragments, and functional variants. Also disclosed are uses thereof for treating or diagnosing dengue virus infection.
摘要翻译：本文提供了对登革热病毒及其抗原结合片段和功能变体特异性的单克隆抗体。还公开了其用于治疗或诊断登革热病毒感染的用途。

20. 发明授权

US07612957B1 Voice coil driving auto-focus lens module 失效
标题翻译：音圈驱动自动对焦镜头模组
公开(公告)号：US07612957B1
公开(公告)日：2009-11-03
申请号：US12422718
申请日：2009-04-13
申请人： Han-Chung Wu , Chin-Yi Chou , San-Woei Shyu
发明人： Han-Chung Wu , Chin-Yi Chou , San-Woei Shyu
IPC分类号： G02B7/02
CPC分类号： G02B7/08
摘要： A voice coil driving auto-focus lens module is disclosed. The voice coil driving auto-focus lens module includes a base, two conductive plates, an insulation spacer, four permanent magnets, a lens holder, an optical lens, a spring set, a coil, and a top cover. The lens holder, the optical lens and the coil form a lens set that moves synchronously while the permanent magnets are fixed on an outer circle of a leaf spring. The spring set includes a coil spring and a leaf spring. By resultant spring force due to extension or compression of the coil spring as well as the leaf spring, together with the electromagnetic force, the lens module moves fast, focuses stably and the tilt of the lens module is reduced.
摘要翻译：公开了一种音圈驱动自动对焦透镜模块。音圈驱动自动对焦透镜模块包括基座，两个导电板，绝缘垫片，四个永磁体，透镜架，光学透镜，弹簧组件，线圈和顶盖。透镜架，光学透镜和线圈形成同时移动的透镜组，同时将永磁体固定在板簧的外圆上。弹簧组包括螺旋弹簧和板簧。由于由于螺旋弹簧以及板簧的延伸或压缩而产生的弹簧力，与电磁力一起，透镜模块快速移动，稳定地聚焦，并且减少了透镜模块的倾斜。

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