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11. 发明申请

US20110068882A1 FILTER AND AMPLIFYING CIRCUIT 审中-公开
标题翻译：滤波和放大电路
公开(公告)号：US20110068882A1
公开(公告)日：2011-03-24
申请号：US12881367
申请日：2010-09-14
申请人： Hirotake Honda , Hiroaki Maeda , Yousuke Okazaki , Yoshinobu Shizawa
发明人： Hirotake Honda , Hiroaki Maeda , Yousuke Okazaki , Yoshinobu Shizawa
IPC分类号： H01P1/20
CPC分类号： H01P1/2039 , H01P1/212 , H03F1/56 , H03F3/601 , H03F2200/387 , H03F2200/423
摘要： There is provided a filter which includes a transmission line, a stub branched from the transmission line, the stub electrically coupled with the transmission line, and a resonator configured to electromagnetically couple with the stub and to resonate at an odd harmonic frequency of a fundamental wave, the fundamental wave propagating through the transmission line.
摘要翻译：提供一种滤波器，其包括传输线，从传输线分支的短截线，与传输线电耦合的短截线，以及谐振器，被配置为与短截线电磁耦合并以基波的奇次谐波频率谐振，基波通过传输线传播。

12. 发明申请

US20110064475A1 RECYCLING IMAGE FORMING APPARATUS 失效
标题翻译：回收图像形成装置
公开(公告)号：US20110064475A1
公开(公告)日：2011-03-17
申请号：US12881822
申请日：2010-09-14
申请人： Ryuji YOSHIDA , Mikio Ishibashi , Nobuyuki Koinuma , Hideki Zenba , Naoyuki Ozaki , Hiroaki Maeda , Mugijirou Uno , Shunichi Hashimoto , Yoshinori Nakagawa , Tomoko Takahashi
发明人： Ryuji YOSHIDA , Mikio Ishibashi , Nobuyuki Koinuma , Hideki Zenba , Naoyuki Ozaki , Hiroaki Maeda , Mugijirou Uno , Shunichi Hashimoto , Yoshinori Nakagawa , Tomoko Takahashi
IPC分类号： G03G15/08
CPC分类号： G03G15/0126 , G03G15/0868 , G03G15/0872 , G03G15/0879 , G03G15/0886 , G03G2215/0604 , G03G2221/163 , G03G2221/1815
摘要： An image forming apparatus includes a first image formation unit that forms a black toner image, and a detachable second image formation unit that forms a color toner image. A first toner supply unit is provided to supply the black toner to the first image formation unit. A second toner supply unit is provided to supply one of a black and component color toner to the first and second image formation units in accordance with a color mode. A first conveyance path is provided to convey the black toner to the first image formation unit. A second conveyance path is also provided to convey the component color toner stored in the second toner container section to the second image formation unit. The second toner supply unit is selectively connected to one of the first and second conveyance paths in accordance with the color mode.
摘要翻译：图像形成装置包括形成黑色调色剂图像的第一图像形成单元和形成彩色调色剂图像的可拆卸第二图像形成单元。提供第一调色剂供应单元以将黑色调色剂供应到第一图像形成单元。提供第二调色剂供应单元，以根据颜色模式向黑色和彩色调色剂中的一种提供第一和第二图像形成单元。提供第一输送路径以将黑色调色剂输送到第一图像形成单元。还提供第二传送路径以将存储在第二调色剂容器部分中的部件颜色调色剂传送到第二图像形成单元。第二调色剂供应单元根据颜色模式选择性地连接到第一和第二输送路径中的一个。

13. 发明授权

US07704951B2 Method for ameliorating dyskinesia 失效
标题翻译：改善运动障碍的方法
公开(公告)号：US07704951B2
公开(公告)日：2010-04-27
申请号：US12081991
申请日：2008-04-24
申请人： Masaki Hirashima , Takumi Sasaki , Takeshi Naruse , Hiroaki Maeda , Chikateru Nozaki
发明人： Masaki Hirashima , Takumi Sasaki , Takeshi Naruse , Hiroaki Maeda , Chikateru Nozaki
IPC分类号： A61K38/02 , A61K38/18 , A61K31/095
CPC分类号： A61K38/1709
摘要： A novel medicament for treating neurodegenerative diseases, especially for ameliorating dyskinesia, comprising as an active ingredient selenoprotein P and/or a peptide fragment or a series of peptide fragments derived from said protein is provided. The novel medicament for treating neurodegenerative diseases, especially for ameliorating dyskinesia, according to the present invention is suitably applicable to diseases with decrease in motor function.
摘要翻译：提供了用于治疗神经变性疾病，特别是用于改善运动障碍的新型药物，其包含作为活性成分的硒蛋白P和/或肽片段或一系列源自所述蛋白质的肽片段。根据本发明的用于治疗神经变性疾病，特别是用于改善运动障碍的新型药物适用于运动功能降低的疾病。

14. 发明申请

US20090243626A1 AMPLIFICATION APPARATUS AND AMPLIFIER FAILURE DETECTING METHOD 审中-公开
标题翻译：放大器和放大器故障检测方法
公开(公告)号：US20090243626A1
公开(公告)日：2009-10-01
申请号：US12401734
申请日：2009-03-11
申请人： Hiroaki Maeda , Hirotake Honda , Yousuke Okazaki , Yoshinobu Shizawa
发明人： Hiroaki Maeda , Hirotake Honda , Yousuke Okazaki , Yoshinobu Shizawa
IPC分类号： G01R31/02
CPC分类号： H03F1/523 , H03F1/0288
摘要： An amplification apparatus including a plurality of amplifiers includes a carrier amplifier, a peak amplifier including a gate bias circuit including a resistor for supplying a gate bias voltage, a comparator for outputting a resultant signal determined by comparison of a predetermined threshold voltage with a voltage across the resistor included within the gate bias circuit, and a failure detecting circuit for detecting whether a failure in the plurality of amplifiers is caused or not based on the resultant signal.
摘要翻译：包括多个放大器的放大装置包括载波放大器，包括栅极偏置电路的峰值放大器，该栅极偏置电路包括用于提供栅极偏置电压的电阻器，比较器，用于输出通过比较预定阈值电压确定的合成信号包括在栅极偏置电路内的电阻器，以及用于根据所得到的信号检测是否引起多个放大器的故障的故障检测电路。

15. 发明申请

US20090202982A1 BLOOD-VISCOSITY REDUCING AGENT 有权
公开(公告)号：US20090202982A1
公开(公告)日：2009-08-13
申请号：US12369329
申请日：2009-02-11
申请人： Masahito Hitosugi , Hiroaki Maeda , Kazunobu Omura
发明人： Masahito Hitosugi , Hiroaki Maeda , Kazunobu Omura
IPC分类号： A01N1/02
CPC分类号： C12N9/54
摘要： A blood-viscosity reducing agent contains a protein derived from Bacillus subtilis natto and including, sequentially from an amino group terminal, a first structural amino acid sequence having alanine, threonine, aspartic acid, glycine, valine, glutamic acid, tryptophan, asparagine, valine, aspartic acid, glutamine, isoleucine, aspartic acid, alanine, proline, lysine, alanine, tryptophan, alanine, leucine, glycine, tyrosine aspartic, acid, glycine, threonine, glycine, threonine, valine, valine, alanine, serine, isoleucine, aspartic acid, threonine, glycine, valine, glutamic acid, tryptophan, asparagine, histidine, proline, alanine, leucine, lysine, glutamic acid, lysine, tyrosine, arginine, glycine, tyrosine, asparagine, proline, glutamic acid, asparagine, proline, asparagine, glutamic acid, proline, glutamic acid, asparagine, glutamic acid, methionine, asparagine, tryptophan, tyrosine, aspartic acid, alanine, valine, alanine, glycine, glutamic acid, alanine, serine, proline, tyrosine, aspartic acid, aspartic acid, leucine, alanine, histidine, glycine, threonine, histidine, valine, and threonine, a second structural amino acid sequence having alanine, phenylalanine, serine, glutamic acid, aspartic acid, glycine, glycine, threonine, aspartic acid, alanine, aspartic acid, isoleucine, leucine, glutamic acid, alanine, glycine, glutamic acid, tryptophan, valine, and leucine, a third structural amino acid sequence having aspartic acid, alanine, glutamic acid, glycine, asparagine, proline, histidine, proline, glutamic acid, methionine, alanine, proline, aspartic acid, and valine, and a fourth structural amino acid sequence having valine, proline, glycine, glutamine, alanine, tyrosine, glutamic acid, aspartic acid, glycine, tryptophan, and aspartic acid, thereby reducing the viscosity of whole blood.

16. 发明授权

US07456687B2 Amplifier unit and method of detecting failure in the same 有权
标题翻译：放大器单元及其检测方法相同
公开(公告)号：US07456687B2
公开(公告)日：2008-11-25
申请号：US11790982
申请日：2007-04-30
申请人： Akira Seino , Hiroaki Maeda , Takashi Ono , Yousuke Okazaki
发明人： Akira Seino , Hiroaki Maeda , Takashi Ono , Yousuke Okazaki
IPC分类号： H03F3/68
CPC分类号： H03F1/0288 , H03F1/52 , H03F2200/207 , H03F2200/465 , H03F2200/471
摘要： The present invention provides an amplifier unit including a carrier amplifier biased for Class A or Class AB operation; a peak amplifier biased for Class B or Class C operation, wherein an input signal is input to the carrier amplifier and the peak amplifier, and wherein output signals from the carrier amplifier and the peak amplifier are synthesized to output therefrom; a comparator configured to compare a gate bias voltage of a transistor device in the peak amplifier with a predetermined threshold voltage and output a first output signal; and a failure detection circuit configured to output a second output signal indicating presence or absence of failure, based on the first output signal received from the comparator.
摘要翻译：本发明提供一种放大器单元，其包括偏置用于A类或AB类操作的载波放大器; 偏置用于B类或C类工作的峰值放大器，其中输入信号被输入到载波放大器和峰值放大器，并且其中来自载波放大器和峰值放大器的输出信号被合成以从其输出; 比较器，用于将所述峰值放大器中的晶体管器件的栅极偏置电压与预定阈值电压进行比较，并输出第一输出信号; 以及故障检测电路，被配置为基于从所述比较器接收到的所述第一输出信号，输出指示故障有无的第二输出信号。

17. 发明申请

US20070117180A1 Enzyme producing plasma protein fragment having inhibitory activity to metastasis and growth of cancer and plasma protein fragment produced by fragmentation by said enzyme 审中-公开
标题翻译：产生产生血浆蛋白质的蛋白质片段，其具有通过所述酶片段产生的癌转移和生长抑制活性和血浆蛋白质片段
公开(公告)号：US20070117180A1
公开(公告)日：2007-05-24
申请号：US11542180
申请日：2006-10-04
申请人： Wataru Morikawa , Kazuyoshi Kaminaka , Sumiyo Takemoto , Hiroaki Maeda , Chikateru Nozaki , Seiji Miyamoto
发明人： Wataru Morikawa , Kazuyoshi Kaminaka , Sumiyo Takemoto , Hiroaki Maeda , Chikateru Nozaki , Seiji Miyamoto
IPC分类号： C12P21/06
CPC分类号： C12N9/6454 , A61K35/00 , C12N9/6435 , C12N9/6478 , C12Y304/21007
摘要： An aspartic enzyme having a high homology with a cathepsin D precursor, which is a protein having the N-terminal amino acid sequence LVRIPLHKFT (SEQ ID NO: 1) and showing a molecular weight of about 45 kDa in non-reductive SDS electrophoresis and can degrade plasma proteins, typically plasminogen, to produce plasma protein fragments having an inhibitory activity to metastasis and growth of cancer; the plasma protein fragments having an inhibitory activity to metastasis and growth of cancer which is prepared via the degradation with the above enzyme; a process for preparing the protein fragments which comprises degrading plasma proteins with the above enzyme; and a medicament for treating and preventing metastasis and growth of cancer which comprises as a major ingredient the above enzyme or the plasma protein fragments.
摘要翻译：与组织蛋白酶D前体具有高同源性的天冬氨酸酶，其是具有N-末端氨基酸序列LVRIPLHKFT（SEQ ID NO：1）并且在非还原性SDS电泳中显示约45kDa的分子量的蛋白质，并且可以降解血浆蛋白质，通常是纤溶酶原，产生具有对癌症转移和生长具有抑制活性的血浆蛋白片段; 血浆蛋白片段通过用上述酶的降解制备具有对癌症转移和生长的抑制活性; 一种制备蛋白片段的方法，包括用上述酶降解血浆蛋白; 以及用于治疗和预防癌症转移和生长的药物，其包含作为上述酶或血浆蛋白片段的主要成分。

18. 发明授权

US07112666B2 Von Willebrand Factor (Vwf)-cleaving protease 有权
标题翻译： Von Willebrand因子（Vwf） - 切蛋白酶
公开(公告)号：US07112666B2
公开(公告)日：2006-09-26
申请号：US10475538
申请日：2002-04-25
申请人： Kenji Soejima , Noriko Mimura , Hiroaki Maeda , Chikateru Nozaki , Takayoshi Hamamoto , Tomohiro Nakagaki
发明人： Kenji Soejima , Noriko Mimura , Hiroaki Maeda , Chikateru Nozaki , Takayoshi Hamamoto , Tomohiro Nakagaki
IPC分类号： C07H21/04
CPC分类号： C12N9/6489 , A61K31/711 , A61K38/00 , C12N9/50 , C12N9/6421
摘要： This invention is intended to isolate and identify a vWF-specific cleaving protease.The vWF-specific cleaving protease cleaves a bond between residues Tyr 842 and Met 843 of vWF and comprises a polypeptide chain having Leu-Leu-Val-Ala-Val as a partial sequence, and more preferably comprises a polypeptide chain having the partial N-terminal amino acid sequence of a mature protein, Ala-Ala-Gly-Gly-Ile-Leu-His-Leu-Glu-Leu-Leu-Val-Ala-Val, and having a molecular weight of 105 to 160 kDa in SDS-PAGE under reducing or non-reducing conditions. Isolation and identification of this vWF-specific cleaving protease have led to the possibility of replacement therapy for patients having diseases resulting from a deficiency of the protease, such as thrombotic thrombocytopenic purpura.
摘要翻译：本发明旨在分离和鉴定vWF特异性切割蛋白酶。 vWF特异性切割蛋白酶切割vWF的残基Tyr 842和Met 843之间的键，并且包含具有Leu-Leu-Val-Ala-Val作为部分序列的多肽链，更优选包含具有部分N- Ala-Ala-Gly-Gly-Ile-Leu-His-Leu-Glu-Leu-Leu-Val-Ala-Val的成熟蛋白的末端氨基酸序列，SDS- PAGE在还原或非还原条件下。这种vWF特异性切割蛋白酶的分离和鉴定已经导致了患有由蛋白酶缺乏引起的疾病的患者（例如血栓性血小板减少性紫癜）的替代疗法的可能性。

19. 发明申请

US20060105071A1 Blood-viscosity reducing agent 审中-公开
公开(公告)号：US20060105071A1
公开(公告)日：2006-05-18
申请号：US11093373
申请日：2005-03-29
申请人： Masahito Hitosugi , Hiroaki Maeda , Kazunobu Omura
发明人： Masahito Hitosugi , Hiroaki Maeda , Kazunobu Omura
IPC分类号： A61K35/74 , A61K38/16
CPC分类号： C12N9/54
摘要： A blood-viscosity reducing agent contains a protein derived from Bacillus subtilis natto and including, sequentially from an amino group terminal, a first structural amino acid sequence having alanine, threonine, aspartic acid, glycine, valine, glutamic acid, tryptophan, asparagine, valine, aspartic acid, glutamine, isoleucine, aspartic acid, alanine, proline, lysine, alanine, tryptophan, alanine, leucine, glycine, tyrosine aspartic, acid, glycine, threonine, glycine, threonine, valine, valine, alanine, serine, isoleucine, aspartic acid, threonine, glycine, valine, glutamic acid, tryptophan, asparagine, histidine, proline, alanine, leucine, lysine, glutamic acid, lysine, tyrosine, arginine, glycine, tyrosine, asparagine, proline, glutamic acid, asparagine, proline, asparagine, glutamic acid, proline, glutamic acid, asparagine, glutamic acid, methionine, asparagine, tryptophan, tyrosine, aspartic acid, alanine, valine, alanine, glycine, glutamic acid, alanine, serine, proline, tyrosine, aspartic acid, aspartic acid, leucine, alanine, histidine, glycine, threonine, histidine, valine, and threonine, a second structural amino acid sequence having alanine, phenylalanine, serine, glutamic acid, aspartic acid, glycine, glycine, threonine, aspartic acid, alanine, aspartic acid, isoleucine, leucine, glutamic acid, alanine, glycine, glutamic acid, tryptophan, valine, and leucine, a third structural amino acid sequence having aspartic acid, alanine, glutamic acid, glycine, asparagine, proline, histidine, proline, glutamic acid, methionine, alanine, proline, aspartic acid, and valine, and a fourth structural amino acid sequence having valine, proline, glycine, glutamine, alanine, tyrosine, glutamic acid, aspartic acid, glycine, tryptophan, and aspartic acid, thereby reducing the viscosity of whole blood.

20. 发明授权

US5773247A Recombinant anti-HIV antibody and process for preparing the same 失效
标题翻译：重组抗HIV抗体及其制备方法
公开(公告)号：US5773247A
公开(公告)日：1998-06-30
申请号：US491845
申请日：1995-07-14
申请人： Hiroaki Maeda , Kazuhiko Kimachi , Yasuyuki Eda , Kouichi Shiosaki , Kiyoshi Osatomi , Sachio Tokiyoshi
发明人： Hiroaki Maeda , Kazuhiko Kimachi , Yasuyuki Eda , Kouichi Shiosaki , Kiyoshi Osatomi , Sachio Tokiyoshi
IPC分类号： A61K38/00 , A61K39/395 , C07K16/10 , C12N15/13 , C12P21/08 , C12P21/06 , C07H21/04 , C12N5/00
CPC分类号： C07K16/1063 , A61K38/00 , C07K2319/00
摘要： The present invention relates to a gene fragment coding for a variable region of an antibody having a neutralizing activity against human immunodeficiency virus (HIV) and a process for preparing the same. A mouse-human chimeric antibody and a mouse-human reshaped antibody having a neutralizing activity against HIV can be prepared by obtaining a specific nucleotide sequence of a gene fragment coding for a variable region of H chain and L chain of an antibody having a neutralizing activity against HIV, and then artificially fusing DNAs synthesized based on these nucleotide sequences with a gene coding for a human immunoglobulin. The novel recombinant anti-HIV antibody of the present invention is useful for treatment and prevention of AIDS.
摘要翻译： PCT No.PCT / JP93 / 00039 Sec。 371 1995年7月14日第 102（e）日期1995年7月14日PCT提交1993年1月14日PCT公布。第WO94 / 15969号公报日期：1994年7月12日本发明涉及编码对人免疫缺陷病毒（HIV）具有中和活性的抗体的可变区的基因片段及其制备方法。可以通过获得编码具有中和活性的抗体的H链和L链的可变区的基因片段的特异性碱基序列来制备具有针对HIV的中和活性的小鼠 - 人嵌合抗体和小鼠 - 人重整抗体然后人造地将基于这些核苷酸序列合成的DNA与编码人免疫球蛋白的基因融合。本发明的新型重组抗HIV抗体可用于治疗和预防艾滋病。

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