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11. 发明授权

US5946550A Self-assembled semiconductor and method of making same 失效
标题翻译：自组装半导体及其制作方法
公开(公告)号：US5946550A
公开(公告)日：1999-08-31
申请号：US818382
申请日：1997-03-14
申请人： Fotios Papadimitrakopoulos
发明人： Fotios Papadimitrakopoulos
IPC分类号： H01L51/00 , H01L51/30 , H01L51/50 , H01L35/24 , B23B27/00 , H01L33/00
CPC分类号： H01L51/5012 , B82Y10/00 , B82Y30/00 , H01L51/0077 , H01L51/0079 , H01L51/0034 , H01L51/0595 , Y10S257/918 , Y10T428/31551 , Y10T428/31573
摘要： A method for producing a ultrathin semiconducting film, utilizes a substrate with a reactive functionalized surface which is contacted with a reactant compound of a divalent and trivalent chelating metal to produce a metallo-functionalized surface. The metallo-functionalized surface is contacted with bisquinoline or a bisquinoline to produce a deposit of an oligomeric metallo-bisquinoline chelate, which is then contacted with the reactant metal compound to produce a fresh metallo-functionalized surface on the deposit. The fresh metallo-functionalized surface is contacted with the bisquinoline reactant to produce a further deposit of the oligomeric metallo-bisquinoline chelate, and these steps are repeated until a desired thickness of the deposit has been attained.
摘要翻译：一种制造超薄半导体膜的方法，利用具有与二价和三价螯合金属的反应物化合物接触的反应性官能化表面的基底以产生金属官能化表面。金属官能化的表面与双喹啉或双喹啉接触以产生低聚金属 - 双喹啉螯合物的沉积物，然后与反应物金属化合物接触以在沉积物上产生新的金属官能化表面。新鲜的金属官能化表面与双喹啉反应物接触以产生低聚金属 - 双喹啉螯合物的进一步沉积，并重复这些步骤，直至达到所需的沉积厚度。

12. 发明授权

US09509400B2 Circuit architecture and system for implantable multi-function and multi-analyte biosensing device 有权
公开(公告)号：US09509400B2
公开(公告)日：2016-11-29
申请号：US15149908
申请日：2016-05-09
申请人： Faquir C Jain , Fotios Papadimitrakopoulos , Robert A Croce, Jr. , Pawan Gogna , Syed Kamrul Islam , Liang Zuo , Kai Zhu
发明人： Faquir C Jain , Fotios Papadimitrakopoulos , Robert A Croce, Jr. , Pawan Gogna , Syed Kamrul Islam , Liang Zuo , Kai Zhu
IPC分类号： H04J14/02 , H04B10/11 , G01N27/414 , A61B5/00 , A61B5/145
CPC分类号： H04B10/11 , A61B5/0031 , A61B5/14503 , G01N27/4145 , H04B10/1149 , H04J14/02
摘要： An implantable bio-sensing platform architecture that enables the wireless selection, calibration and reading of multiple sensors, as well as checking the power levels of the solar powering source energizing various electronic and optoelectronic devices and circuits embedded in the platform. It also permits checking the operation of the potentiostats interfacing with each amperometric analyte sensor. The platform is flexible to include FET based sensors for protein sensing as well as other applications including pH sensing. In addition, other physiological sensors can be integrated in the platform.

13. 发明授权

US09101301B2 Control of biofouling in implantable biosensors 有权
标题翻译：可植入生物传感器中生物污损的控制
公开(公告)号：US09101301B2
公开(公告)日：2015-08-11
申请号：US13586436
申请日：2012-08-15
申请人： Fotios Papadimitrakopoulos , Santhisagar Vaddiraju
发明人： Fotios Papadimitrakopoulos , Santhisagar Vaddiraju
IPC分类号： A61B5/145 , A61B5/1459 , A61B5/1486 , A61B5/1495 , C12Q1/00 , G01N33/52
CPC分类号： A61B5/145 , A61B5/14503 , A61B5/1459 , A61B5/14865 , A61B5/1495 , A61B2562/18 , A61B2562/247 , C12Q1/001 , G01N33/52
摘要： Disclosed herein is a device comprising a biosensor having disposed upon it a coating; the coating comprising a polymer matrix; where the polymer matrix is operative to facilitate the inwards and outwards diffusion of analytes and byproducts to and from the sensing element of the biosensor; and a sacrificial moiety; the sacrificial moiety being dispersed in the polymer matrix, where the sacrificial moiety erodes with time and increases the porosity of the polymer matrix thus offsetting decreases in analyte permeability as a result of biofouling.
摘要翻译：本文公开了一种包括生物传感器的装置，其上设置有涂层; 所述涂层包含聚合物基质; 其中聚合物基质可操作以促进分析物和副产物向和从生物传感器的感测元件向外和向外扩散; 和牺牲部分; 牺牲部分分散在聚合物基体中，其中牺牲部分随时间而侵蚀，并增加聚合物基体的孔隙率，从而抵消作为生物污损的结果的分析物渗透性的降低。

14. 发明授权

US08608922B2 Biosensor for continuous monitoring of metabolites and proteins and methods of manufacture thereof 有权
标题翻译：用于连续监测代谢物和蛋白质的生物传感器及其制备方法
公开(公告)号：US08608922B2
公开(公告)日：2013-12-17
申请号：US12614893
申请日：2009-11-09
申请人： Fotios Papadimitrakopoulos , Santhisagar Vaddiraju , Faquir Chand Jain , Ioannis C. Tomazos
发明人： Fotios Papadimitrakopoulos , Santhisagar Vaddiraju , Faquir Chand Jain , Ioannis C. Tomazos
IPC分类号： G01N27/327
CPC分类号： C12Q1/002 , G01N33/6803
摘要： A biosensor comprises a substrate; a reference electrode; a working electrode; a counter electrode; and a plurality of permeability adjusting spacers. The reference electrode, the working electrode and the plurality of permeability adjusting spacers are all being disposed to be substantially parallel to each other to create a plurality of enzyme containing porous sections. The enzyme containing porous sections contain an enzyme; where the enzyme is operative to react with a metabolite to determine the concentration of the metabolite. By combining a number of the aforementioned biosensors, the differential concentration of a target enzyme or protein is determined by monitoring the changes on its metabolite substrates.
摘要翻译：生物传感器包括基底; 参考电极; 工作电极对电极和多个导磁率调节间隔件。参考电极，工作电极和多个磁导率调节间隔物都被设置成基本上彼此平行，以产生多个含酶多孔部分。含有多孔切片的酶含有酶; 其中酶可用于与代谢物反应以确定代谢物的浓度。通过组合上述生物传感器，通过监测其代谢物底物的变化来确定靶酶或蛋白质的不同浓度。

15. 发明申请

US20110315563A1 SENSORS FOR ANALYTE DETECTION AND METHODS OF MANUFACTURE THEREOF 有权
标题翻译：用于分析物检测的传感器及其制造方法
公开(公告)号：US20110315563A1
公开(公告)日：2011-12-29
申请号：US13164656
申请日：2011-06-20
申请人： Liangliang Qiang , Santhisagar Vaddiraju , Fotios Papadimitrakopoulos
发明人： Liangliang Qiang , Santhisagar Vaddiraju , Fotios Papadimitrakopoulos
IPC分类号： G01N27/30 , G01N27/327
CPC分类号： A61B5/14865 , A61B5/14532 , A61B5/1473 , A61B5/1495 , A61B2560/0223 , A61B2562/028 , A61B2562/0285 , A61B2562/04 , A61B2562/125
摘要： Disclosed herein is a sensor comprising a conduit; the conduit comprising an organic polymer; a working electrode; the working electrode being etched and decorated with a nanostructured material; a reference electrode; and a counter electrode; the working electrode, the reference electrode and the counter electrode being disposed in the conduit; the working electrode, the reference electrode and the counter electrode being separated from each other by an electrically insulating material; and wherein a cross-sectional area of the conduit that comprises a section of the working electrode, a section of the reference electrode and a section of the counter electrode is exposed to detect analytes.
摘要翻译：本文公开了一种传感器，其包括导管; 导管包含有机聚合物; 工作电极工作电极用纳米结构材料进行蚀刻和装饰; 参考电极; 和对电极; 工作电极，参比电极和对电极设置在导管中; 工作电极，参考电极和对电极通过电绝缘材料彼此分离; 并且其中包括所述工作电极的一部分，参考电极的一部分和所述对电极的一部分的所述导管的横截面面积被暴露以检测分析物。

16. 发明申请

US20100025660A1 SEMICONDUCTOR DEVICES, METHODS OF MANUFACTURE THEREOF AND ARTICLES COMPRISING THE SAME 有权
标题翻译：半导体器件及其制造方法和包含其的文章
公开(公告)号：US20100025660A1
公开(公告)日：2010-02-04
申请号：US12533770
申请日：2009-07-31
申请人： Faquir C. Jain , Fotios Papadimitrakopoulos
发明人： Faquir C. Jain , Fotios Papadimitrakopoulos
IPC分类号： H01L29/66 , H01L29/78 , H01L29/788
CPC分类号： H01L29/66977 , B82Y10/00 , G01N27/4146 , H01L29/0665 , H01L29/0673 , H01L29/1606 , H01L29/42356 , H01L29/7781 , H01L29/7836
摘要： Disclosed herein is a device comprising a source region, a drain region and a gate layer; the source region, the drain region and the gate layer being disposed on a semiconductor host; the gate layer being disposed between source and drain regions; the gate layer comprising a first gate-insulator layer; a gate layer comprising carbon nanotubes and/or graphene. Disclosed herein too is a method comprising disposing a source region, a drain region and a gate layer on a semiconductor host; the gate layer being disposed between the source region and the drain region; the gate layer comprising carbon nanotubes and/or graphene.
摘要翻译：本文公开了一种包括源极区，漏极区和栅极层的器件; 源极区，漏极区和栅极层设置在半导体主体上; 所述栅极层设置在源极和漏极区之间; 所述栅极层包括第一栅绝缘体层; 包含碳纳米管和/或石墨烯的栅极层。本文还公开了一种方法，其包括在半导体主机上设置源极区域，漏极区域和栅极层; 所述栅极层设置在所述源极区域和所述漏极区域之间; 所述栅极层包括碳纳米管和/或石墨烯。

17. 发明授权

US07326303B2 Single-pass growth of multilayer patterned electronic and photonic devices using a scanning localized evaporation methodology (SLEM) 失效
标题翻译：使用扫描局部蒸发方法（SLEM）的多层图案化电子和光子器件的单通道生长
公开(公告)号：US07326303B2
公开(公告)日：2008-02-05
申请号：US11327756
申请日：2006-01-09
申请人： Fotios Papadimitrakopoulos , Thomas Samuel Phely-Bobin , Daniel Harrison Grantham, deceased , Faquir C Jain
发明人： Fotios Papadimitrakopoulos , Thomas Samuel Phely-Bobin , Daniel Harrison Grantham, deceased , Faquir C Jain
IPC分类号： C23C14/26 , C23C14/12
CPC分类号： C23C14/042 , C23C14/246 , C23C14/26 , C23C14/568 , H01L51/56
摘要： This invention describes an apparatus, Scanning Localized Evaporation Methodology (SLEM) for the close proximity deposition of thin films with high feature definition, high deposition rates, and significantly improved material economy. An array of fixed thin film heating elements, each capable of being individually energized, is mounted on a transport mechanism inside a vacuum chamber. The evaporable material is deposited on a heating element. The SLEM system loads the surface of heating elements, made of foils, with evaporable material. The loaded thin film heating element is transported to the substrate site for re-evaporation. The re-evaporation onto a substrate, which is maintained at the desired temperature, takes place through a mask. The mask, having patterned openings dictated by the structural requirements of the fabrication, may be heated to prevent clogging of the openings. The translation of the substrate past the evaporation site permits replication of the pattern over its entire surface. A multiplicity of fixed thin film heating element arrays is provided that can operate simultaneously or in sequence. Multi-layered structures of evaporable materials with high in-plane spatial pattern resolution can be deposited using this apparatus. In one version of the invention, the transport of the evaporant-loaded thin film heating elements is accomplished by the use of cylindrical rotors on whose circumference the heating elements are mounted.
摘要翻译：本发明描述了一种用于紧密沉积具有高特征定义，高沉积速率和显着提高的材料经济性的薄膜的扫描定位蒸发方法（SLEM）的装置。一组固定的薄膜加热元件，每个固定的薄膜加热元件均能分别通电，安装在真空室内的输送机构上。蒸发材料沉积在加热元件上。 SLEM系统用可蒸发材料加载由箔制成的加热元件的表面。负载的薄膜加热元件被输送到基底部位以进行再蒸发。通过掩模将保持在所需温度下的基底上的再蒸发发生。可以加热具有由制造的结构要求所规定的图案化开口的掩模，以防止开口堵塞。衬底经过蒸发位置的平移允许在其整个表面上复制图案。提供了可以同时或依次操作的多个固定薄膜加热元件阵列。可以使用该装置沉积具有高面内空间图案分辨率的蒸发材料的多层结构。在本发明的一个实施例中，通过使用圆周转子来实现蒸发负载的薄膜加热元件的输送，圆柱形转子的圆周上装有加热元件。

18. 发明申请

US20050183670A1 Patterned thin-film deposition using collimating heated masked assembly 失效
标题翻译：使用准直加热屏蔽组件的图案化薄膜沉积
公开(公告)号：US20050183670A1
公开(公告)日：2005-08-25
申请号：US11045034
申请日：2005-05-03
申请人： Daniel Grantham , Thomas Phely-Bobin , Fotios Papadimitrakopoulos , Faquir Jain
发明人： Daniel Grantham , Thomas Phely-Bobin , Fotios Papadimitrakopoulos , Faquir Jain
IPC分类号： C23C14/04 , C23C14/22 , H01L51/00 , H01L51/40 , C23C16/00
CPC分类号： C23C14/044 , C23C14/22 , H01L51/001
摘要： Scanning localized evaporation and deposition of an evaporant on a substrate utilizes a mask assembly comprised of a series of mask elements with openings thereon and spaced apart in a stack. The openings are aligned so as to direct the evaporant therethrough onto the substrate. The mask elements are heated and the stack may include a movable shutter element to block openings in adjacent mask elements. The evaporant streams are usually vertical but some may be oblique to the substrate, and they may be of different materials.
摘要翻译：将蒸发器的局部蒸发和沉积扫描在基底上使用掩模组件，该掩模组件由其上具有开口的一系列掩模元件组成并且在堆叠中间隔开。开口对准，以将蒸发器引导到基板上。掩模元件被加热并且堆叠可以包括可移动的快门元件以阻挡相邻的掩模元件中的开口。蒸发剂流通常是垂直的，但是一些可以与衬底倾斜，并且它们可以是不同的材料。

19. 发明申请

US20130213110A1 CONTROL OF BIOFOULING IN IMPLANTABLE BIOSENSORS 有权
标题翻译：可植入生物传感器中的生物控制控制
公开(公告)号：US20130213110A1
公开(公告)日：2013-08-22
申请号：US13586436
申请日：2012-08-15
申请人： Fotios Papadimitrakopoulos , Santhisagar Vaddiraju
发明人： Fotios Papadimitrakopoulos , Santhisagar Vaddiraju
IPC分类号： A61B5/145 , A61B5/1459 , A61B5/1495 , A61B5/1486
CPC分类号： A61B5/145 , A61B5/14503 , A61B5/1459 , A61B5/14865 , A61B5/1495 , A61B2562/18 , A61B2562/247 , C12Q1/001 , G01N33/52
摘要： Disclosed herein is a device comprising a biosensor having disposed upon it a coating; the coating comprising a polymer matrix; where the polymer matrix is operative to facilitate the inwards and outwards diffusion of analytes and byproducts to and from the sensing element of the biosensor; and a sacrificial moiety; the sacrificial moiety being dispersed in the polymer matrix, where the sacrificial moiety erodes with time and increases the porosity of the polymer matrix thus offsetting decreases in analyte permeability as a result of biofouling.
摘要翻译：本文公开了一种包括生物传感器的装置，其上设置有涂层; 所述涂层包含聚合物基质; 其中聚合物基质可操作以促进分析物和副产物向和从生物传感器的感测元件向外和向外扩散; 和牺牲部分; 牺牲部分分散在聚合物基体中，其中牺牲部分随时间而侵蚀，并增加聚合物基体的孔隙率，从而抵消作为生物污损的结果的分析物渗透性的降低。

20. 发明授权

US08390047B2 Miniaturized implantable sensor platform having multiple devices and sub-chips 有权
标题翻译：具有多个器件和子芯片的小型植入式传感器平台
公开(公告)号：US08390047B2
公开(公告)日：2013-03-05
申请号：US12590883
申请日：2009-11-16
申请人： Faquir Chand Jain , Fotios Papadimitrakopoulos
发明人： Faquir Chand Jain , Fotios Papadimitrakopoulos
IPC分类号： A61B5/00
CPC分类号： A61B5/6846 , A61B5/0017 , A61B5/0031 , A61B5/14532 , A61B5/1473 , A61B2560/0214 , A61B2562/12 , G06F19/00 , H01L21/02532 , H01L23/481 , H01L23/58 , H01L31/02 , H01L31/02005 , H01L31/0203 , H01L31/048 , H01L31/18 , H01L2224/32225 , Y02E10/50
摘要： An implantable, miniaturized platform and a method for fabricating the platform is provided, where the e platform includes a top cover plate and a bottom substrate, top cover plate including an epitaxial, Si-encased substrate and is configured to include monolithically grown devices and device contact pads, the Si-encased substrate cover plate including a gold perimeter fence deposited on its Si covered outer rim and wherein the bottom substrate is constructed of Si and includes a plurality of partial-Si-vias (PSVs), electronic integrated circuits, device pads, pad interconnects and a gold perimeter fence, wherein the device pads are aligned with a respective device contact pad on the top cover plate and includes gold bumps having a predetermined height, the top cover plate and the bottom substrate being flip-chip bonded to provide a perimeter seal and to ensure electrical connectivity between the plurality of internal devices and at least one external component.
摘要翻译：提供了一种可植入的小型化平台和用于制造平台的方法，其中e平台包括顶盖板和底部基板，顶盖板包括外延Si包覆的基板，并且被配置成包括单片生长的装置和装置接触垫，Si封装的基板盖板包括沉积在其Si覆盖的外边缘上的金周边栅栏，并且其中底部基板由Si构成，并且包括多个部分Si通孔（PSV），电子集成电路，器件垫，衬垫互连件和金周边围栏，其中装置垫与顶盖板上的相应装置接触垫对准，并且包括具有预定高度的金凸块，顶盖板和底底板被倒装芯片结合到提供周边密封并确保多个内部装置与至少一个外部部件之间的电连接。

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