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11. 发明申请

US20060155235A1 Hemostatic compression bandage 审中-公开
标题翻译：止血压缩绷带
公开(公告)号：US20060155235A1
公开(公告)日：2006-07-13
申请号：US11305894
申请日：2005-12-16
申请人： Evelyn S. Sawyer
发明人： Evelyn S. Sawyer
IPC分类号： A61F13/00
CPC分类号： A61F13/0203
摘要： A hemostatic compression bandage includes a flexible backing element, a powdered hemostatic substance, and a flexible film element. The backing element includes a first containment region. The film element includes a second containment region corresponding to the first containment region. The film element is removably attached to the backing element so as to contain the hemostatic substance between the backing element and the film element within a volume defined by the first containment region and the second containment region. The backing element includes a pressure region located outside of the first containment region. The film element includes a pull-tab region located outside of the second containment region and at a first side of the bandage. The pull-tab region has sufficient length to be folded back across the second containment region and extending beyond a second side of the bandage that is opposite the first side of the bandage.
摘要翻译：止血压缩绷带包括柔性背衬元件，粉末状止血物质和柔性膜元件。背衬元件包括第一容纳区域。薄膜元件包括对应于第一容纳区域的第二容纳区域。膜元件可移除地附接到背衬元件，以便在由第一容纳区域和第二容纳区域限定的体积内将止血物质包含在背衬元件和膜元件之间。背衬元件包括位于第一容纳区域外部的压力区域。膜元件包括位于第二容纳区域外侧和绷带第一侧的拉片区域。拉片区域具有足够的长度以折叠穿过第二容纳区域并且延伸超过绷带的与绷带的第一侧相对的第二侧。

12. 发明授权

US08771684B2 Method of using salmon thrombin to alleviate pain 有权
标题翻译：使用鲑鱼凝血酶缓解疼痛的方法
公开(公告)号：US08771684B2
公开(公告)日：2014-07-08
申请号：US13208479
申请日：2011-08-12
申请人： Evelyn S. Sawyer , Paul A. Janmey , Beth A. Winkelstein
发明人： Evelyn S. Sawyer , Paul A. Janmey , Beth A. Winkelstein
IPC分类号： A61K38/48 , C12N9/74 , C12N5/00 , C12N5/02 , A61F13/00 , A61F15/00
CPC分类号： A61K38/4833
摘要： A method of alleviating pain associated with tissue damage includes applying salmon thrombin at a tissue damage site, as a single substance in liquid form, or as a powder, a foam, and/or a gel that includes salmon thrombin. A pain relief substance includes a salmon thrombin preparation.
摘要翻译：减轻与组织损伤相关的疼痛的方法包括在组织损伤部位应用鲑鱼凝血酶，作为液体形式的单一物质，或作为包括鲑鱼凝血酶的粉末，泡沫和/或凝胶。止痛物质包括鲑鱼凝血酶制剂。

13. 发明申请

US20100111926A1 Method of Using Salmon Thrombin to Alleviate Central Nervous System-Mediated Pain 有权
标题翻译：使用鲑鱼凝血酶缓解中枢神经系统介导的疼痛的方法
公开(公告)号：US20100111926A1
公开(公告)日：2010-05-06
申请号：US12582040
申请日：2009-10-20
申请人： Beth A. Winkelstein , Paul A. Janmey , Evelyn S. Sawyer
发明人： Beth A. Winkelstein , Paul A. Janmey , Evelyn S. Sawyer
IPC分类号： A61K38/48 , A61P25/00
CPC分类号： A61K38/4833
摘要： A method of alleviating central nervous system-mediated pain includes applying salmon thrombin at a neural injury site. Applying salmon thrombin can include applying a gel that includes salmon thrombin. The gel can also include fibrinogen, for example, salmon fibrinogen, human fibrinogen, or bovine fibrinogen. The salmon thrombin can be obtained from salmon plasma, or using recombinant technology, or by fractionation. A pain relief substance includes a gel that includes salmon thrombin.
摘要翻译：缓解中枢神经系统介导的疼痛的方法包括在神经损伤部位应用鲑鱼凝血酶。应用三文鱼凝血酶可包括应用包括鲑鱼凝血酶的凝胶。凝胶还可以包括纤维蛋白原，例如鲑鱼纤维蛋白原，人纤维蛋白原或牛纤维蛋白原。鲑鱼凝血酶可以从鲑鱼血浆，或使用重组技术，或通过分级获得。止痛物质包括含有鲑鱼凝血酶的凝胶。

14. 发明申请

US20090124548A1 Method of Using Fish Plasma Components to Inhibit Glial Scarring and Promote Functional Recovery in the Mammalian CNS 审中-公开
标题翻译：使用鱼等离子体成分抑制神经胶质瘢痕并促进哺乳动物CNS功能恢复的方法
公开(公告)号：US20090124548A1
公开(公告)日：2009-05-14
申请号：US12265238
申请日：2008-11-05
申请人： Evelyn S. Sawyer
发明人： Evelyn S. Sawyer
IPC分类号： A61K38/17 , A61P25/00
CPC分类号： C12N5/0601 , A61K38/363 , C12N5/0619 , C12N2500/80
摘要： A method includes applying salmon fibrin at a central nervous system injury site. For example, applying salmon fibrin can include injecting salmon fibrin. The method can also include causing the suppression of astrocyte activation, whereby glial scarring is at least reduced. The functional recovery of a patient who has suffered a central nervous system injury is promoted according to this method.
摘要翻译：一种方法包括在中枢神经系统损伤部位应用鲑鱼纤维蛋白。例如，应用鲑鱼纤维蛋白可以包括注射鲑鱼纤维蛋白。该方法还可以包括引起抑制星形胶质细胞活化，由此至少减少胶质瘢痕形成。根据该方法促进患有中枢神经系统损伤的患者的功能恢复。

15. 发明授权

US06986318B2 Sail assembly 失效
标题翻译：帆组件
公开(公告)号：US06986318B2
公开(公告)日：2006-01-17
申请号：US10922612
申请日：2004-08-19
申请人： Evelyn S. Sawyer
发明人： Evelyn S. Sawyer
IPC分类号： B63H9/04
CPC分类号： B63H9/08 , B63B2035/715 , B63H9/06 , B63H16/04
摘要： A sail assembly includes a sail, a mast, a coupler, and a fastener. The mast is attached to a first side of the sail. The coupler is attached to the mast and is used to couple the mast to a handle portion of a paddle. The fastener is attached to the sail at a location opposite the first side of the sail and is used to fasten the sail to the blade portion of the paddle. The sail is held in an open position when the mast is coupled to the handle portion of the paddle at a right angle to the paddle and the sail is fastened to the blade portion of the paddle. Thus, when the mast is supported upright and the end of the sail is connected to the paddle, the sail is open and usable to propel the boat under power of the wind.
摘要翻译：帆组件包括帆，桅杆，联接器和紧固件。桅杆连接在帆的第一侧。联接器连接到桅杆，并用于将桅杆连接到桨叶的手柄部分。紧固件在与帆的第一侧相对的位置处附接到帆，并且用于将帆紧固到桨的叶片部分。当桅杆以与桨形成直角的方式联接到桨叶的手柄部分时，帆被保持在打开位置，并且帆被紧固到桨叶的叶片部分。因此，当桅杆被直立地支撑并且帆的端部连接到桨时，帆是敞开的并且可用于在风的力量下推动船。

16. 发明授权

US5443984A Method for culturing mammalian cells in a medium containing fish serum 失效
标题翻译：在含有鱼血清的培养基中培养哺乳动物细胞的方法
公开(公告)号：US5443984A
公开(公告)日：1995-08-22
申请号：US361763
申请日：1994-12-22
申请人： Evelyn S. Sawyer , Philip J. Sawyer
发明人： Evelyn S. Sawyer , Philip J. Sawyer
IPC分类号： C12N5/00 , A61K35/56 , A61K35/60
CPC分类号： C12N5/0018 , C12N2500/80
摘要： A method for culturing mammalian cells using fish serum. The method uses serum extracted from the blood of fishes to culture mammalian cells for various purposes. The technique has the key advantages of 1) freedom from mammalian infectious agents that could contaminate cell lines or endanger researchers or recipients of therapeutants derived from mammalian cell culture; 2) consistent and reproducible serum content and quality; 3) low cross-reactivity; and 4) provision of the appropriate serum nutrients to maintain the growth of mammalian cells. Fish serum is used together with designated defined media to allow mammalian cells to grow and populations of these cells to be maintained. Blood serum is derived from captive stocks of fish raised under controlled conditions such that the diet, habitat, genetics, life history, and reproductive status of the fish remains substantially consistent and reproducible.
摘要翻译：使用鱼血清培养哺乳动物细胞的方法。该方法使用从鱼血液提取的血清培养哺乳动物细胞用于各种目的。该技术具有以下主要优点：1）免受可能污染细胞系或危及来自哺乳动物细胞培养物的治疗剂的研究人员或受体的哺乳动物感染因子的免疫; 2）血清含量和质量一致可重复; 3）低交叉反应性; 和4）提供适当的血清营养物质以维持哺乳动物细胞的生长。鱼血清与指定的定义培养基一起使用，以允许哺乳动物细胞生长，并维持这些细胞群体。血清来源于受控条件下饲养的鱼类养殖，使得鱼类的饮食，栖息地，遗传学，生命史和生殖状况保持基本一致和可重复性。

17. 发明授权

US5426045A Method for culturing mammalian cells in a medium containing fish serum 失效
标题翻译：在含有鱼血清的培养基中培养哺乳动物细胞的方法
公开(公告)号：US5426045A
公开(公告)日：1995-06-20
申请号：US263250
申请日：1994-06-21
申请人： Evelyn S. Sawyer , Philip J. Sawyer
发明人： Evelyn S. Sawyer , Philip J. Sawyer
IPC分类号： C12N5/00 , A61K35/56 , A61K35/60
CPC分类号： C12N5/0018 , C12N2500/80
摘要： A method for culturing mammalian cells using fish serum. The method uses serum extracted from the blood of fishes to culture mammalian cells for various purposes. The technique has the key advantages of 1) freedom from mammalian infectious agents that could contaminate cell lines or endanger researchers or recipients of therapeutants derived from mammalian cell culture; 2) consistent and reproducible serum content and quality; 3) low cross-reactivity; and 4) the appropriate serum nutrients to maintain the growth of mammalian cells. Fish serum is used together with designated defined media to allow mammalian cells to grow and populations of these cells to be maintained. Blood serum is derived from captive stocks of fish raised under controlled conditions such that the diet, habitat, genetics, life history, and reproductive status of the fish remains substantially consistent and reproducible.
摘要翻译：使用鱼血清培养哺乳动物细胞的方法。该方法使用从鱼血液提取的血清培养哺乳动物细胞用于各种目的。该技术具有以下主要优点：1）免受可能污染细胞系或危及来自哺乳动物细胞培养物的治疗剂的研究人员或受体的哺乳动物感染因子的免疫; 2）血清含量和质量一致可重复; 3）低交叉反应性; 和4）适当的血清营养保持哺乳动物细胞的生长。鱼血清与指定的定义培养基一起使用，以允许哺乳动物细胞生长，并维持这些细胞群体。血清来源于受控条件下饲养的鱼类养殖，使得鱼类的饮食，栖息地，遗传学，生命史和生殖状况保持基本一致和可重复性。

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