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11. 发明申请

US20080152668A1 Thymosin Alpha 1 Peptide/Polymer Conjugates 审中-公开
标题翻译：胸腺素α1肽/聚合物缀合物
公开(公告)号：US20080152668A1
公开(公告)日：2008-06-26
申请号：US11865816
申请日：2007-10-02
申请人： Alfred R. RUDOLPH , Cynthia W. TUTHILL
发明人： Alfred R. RUDOLPH , Cynthia W. TUTHILL
IPC分类号： A61K39/00 , A61K38/02
CPC分类号： A61K47/64 , A61K47/60
摘要： A pharmaceutical composition includes a physiologically active conjugate including a Thymosin alpha 1 (TA1) peptide conjugated to a material which increases half-life of the TA1 peptide in serum of a patient when the conjugate is administered to a patient. The material may be a substantially non-antigenic polymer. In a method of the invention, the substantially non-antigenic polymer is conjugated to a TA1 peptide. Compositions according to the invention are administered to patients in need of immune stimulation.
摘要翻译：一种药物组合物包括生物活性缀合物，其包括当将缀合物施用于患者时与患者血清中TA1肽的半衰期相结合的材料缀合的胸腺素α1（TA1）肽。该材料可以是基本上非抗原性的聚合物。在本发明的方法中，将基本上非抗原性的聚合物与TA1肽缀合。根据本发明的组合物施用于需要免疫刺激的患者。

12. 发明申请

US20140213506A1 THYMOSIN ALPHA PEPTIDE FOR PREVENTING, REDUCING THE SEVERITY OF, AND TREATING INFECTION 审中-公开
标题翻译：用于预防，减少感染和治疗感染的THYMOSIN ALPHA肽
公开(公告)号：US20140213506A1
公开(公告)日：2014-07-31
申请号：US13984681
申请日：2012-02-03
申请人： Cynthia W. Tuthill
发明人： Cynthia W. Tuthill
IPC分类号： A61K38/22 , A61K45/06
CPC分类号： A61K38/2292 , A61K45/06 , Y02A50/473
摘要： The present invention provides methods for preventing, treating, or reducing the severity of infection, including bacterial, viral, and fungal infections, and including infections of more complex etiology. The invention involves the administration of an alpha thymosin peptide regimen, so as to prime or enhance a patient's immune response for pathogen exposure. In certain embodiments, the alpha thymosin regimen is scheduled or timed with respect to potential or expected pathogen exposures. The regimen of alpha thymosin peptide as described herein provides the patient with a more robust immune response to pathogen exposure, including higher antibody titers and/or a more rapid antibody response. In certain embodiments, the patient is immunodeficient or immunecompromised, and/or the patient is hospitalized or scheduled for hospitalization, such that the regimen of alpha thymosin peptide helps to protect the patient from, or reduce the severity of nosocomial infection or illness.
摘要翻译：本发明提供了预防，治疗或降低感染严重性的方法，包括细菌，病毒和真菌感染，并且包括更复杂的病因的感染。本发明涉及α胸腺素肽方案的施用，以便引发或增强患者对病原体暴露的免疫应答。在某些实施方案中，相对于潜在或预期的病原体暴露而言，α胸腺素方案被安排或定时。如本文所述的α胸腺肽的方案为患者提供对病原体暴露的更强烈的免疫应答，包括较高的抗体滴度和/或更快的抗体应答。在某些实施方案中，患者是免疫缺陷或免疫受损的，和/或患者住院或安排进行住院治疗，使得α胸腺素肽的方案有助于保护患者免受或降低院内感染或疾病的严重性。

13. 发明申请

US20100330093A1 TREATMENT OF MELANOMA WITH ALPHA THYMOSIN PEPTIDES IN COMBINATION WITH ANTIBODIES AGAINST CYTOTOXIC T LYMPHOCYTE-ASSOCIATED ANTIGEN 4 (CTLA4) 审中-公开
标题翻译：用与抗肿瘤T淋巴细胞相关抗原4（CTLA4）的抗体联合治疗阿尔茨海默霉素的MELANOMA
公开(公告)号：US20100330093A1
公开(公告)日：2010-12-30
申请号：US12747817
申请日：2008-12-08
申请人： Israel Rios , Cynthia W. Tuthill
发明人： Israel Rios , Cynthia W. Tuthill
IPC分类号： A61K39/395 , A61P35/00 , A61P35/04
CPC分类号： A61K45/06 , A61K31/4164 , A61K38/2292 , A61K39/39541 , C07K16/2818 , C07K2317/21 , A61K2300/00
摘要： Melanoma or a metastasis thereof is treated in a human patient in a combination therapy which includes administering a melanoma-treating combination to a human melanoma patient during a treatment regimen, the combination including an alpha thymosin peptide and antibodies against cytotoxic T lymphocyte-associated antigen 4 (CTLA4).
摘要翻译：黑素瘤或其转移在人类患者中以组合疗法治疗，其包括在治疗方案期间向人黑素瘤患者施用黑素瘤治疗组合，所述组合包括α胸腺素肽和针对细胞毒性T淋巴细胞相关抗原4的抗体（CTLA4）。

14. 发明申请

US20100311656A1 TREATMENT OR PREVENTION OF RESPIRATORY VIRAL INFECTIONS WITH ALPHA THYMOSIN PEPTIDES 审中-公开
标题翻译：治疗或预防ALPHA THYMOSIN PEPTIDES的呼吸道病毒感染
公开(公告)号：US20100311656A1
公开(公告)日：2010-12-09
申请号：US12816959
申请日：2010-06-16
申请人： Alfred R. RUDOLPH , Cynthia W. TUTHILL
发明人： Alfred R. RUDOLPH , Cynthia W. TUTHILL
IPC分类号： A61K38/22 , A61P31/14 , A61P37/04 , A61P31/12
CPC分类号： A61K9/0043 , A61K9/0019 , A61K38/2292 , A61K47/60
摘要： An alpha thymosin peptide is administered to a patient having, or at risk of a respiratory viral infection, coronavirus infection and/or SARS.
摘要翻译：向具有或具有呼吸道病毒感染风险的冠状病毒感染和/或SARS的患者施用α胸腺肽。

15. 发明申请

US20100016211A1 Treatment of Melanoma With Alpha Thymosin Peptides 审中-公开
标题翻译：用α-胸腺素肽治疗黑色素瘤
公开(公告)号：US20100016211A1
公开(公告)日：2010-01-21
申请号：US12501829
申请日：2009-07-13
申请人： Cynthia W. Tuthill , Israel Rios
发明人： Cynthia W. Tuthill , Israel Rios
IPC分类号： A61K38/00 , A61P35/00
CPC分类号： A61K31/64 , A61K38/2292 , A61K2300/00
摘要： A method of treating melanoma or a metastasis thereof in a human patient by administering a melanoma-treating effective amount of an alpha thymosin peptide to a human melanoma patient, wherein the human melanoma patient does not have a substantially elevated LDH blood level.
摘要翻译：一种通过对人黑素瘤患者施用黑素瘤治疗有效量的α胸腺素肽来治疗人类患者的黑素瘤或其转移的方法，其中所述人黑素瘤患者不具有显着升高的LDH血液水平。

16. 发明授权

US08163702B2 Treatment of melanoma 有权
标题翻译：治疗黑色素瘤
公开(公告)号：US08163702B2
公开(公告)日：2012-04-24
申请号：US12297699
申请日：2007-04-13
申请人： Cynthia W. Tuthill , Alfred R. Rudolph
发明人： Cynthia W. Tuthill , Alfred R. Rudolph
IPC分类号： A61K38/05 , A61K38/00
CPC分类号： A61K38/05
摘要： An immunomodulatory compound is administered to treat, prevent, inhibit, or reduce melanoma in a subject.
摘要翻译：施用免疫调节化合物以治疗，预防，抑制或减少受试者中的黑素瘤。

17. 发明申请

US20110200558A1 Treatment or Prevention of Hepatitis C with Immunomodulator Compounds 审中-公开
标题翻译：用免疫调节剂化合物治疗或预防丙型肝炎
公开(公告)号：US20110200558A1
公开(公告)日：2011-08-18
申请号：US13057745
申请日：2009-08-04
申请人： Israel Rios , Cynthia W. Tuthill
发明人： Israel Rios , Cynthia W. Tuthill
IPC分类号： A61K38/21 , A61K38/05 , A61P31/14
CPC分类号： C07K14/56 , A61K38/05 , A61K38/212 , A61K45/06 , C07D209/20 , A61K2300/00
摘要： A method of treatment for treating or preventing hepatitis C (HepC) in a target subject, including administering to the target subject an effective amount of an immunomodulator compound of Formula A wherein, n is 1 or 2, R is hydrogen, acyl, alkyl or a peptide fragment, and X is an aromatic or heterocyclic amino acid or a derivative thereof, wherein; (i) the immunomodulator compound is administered to the subject at a dosage of greater than 0.001 mg/kg; (ii) the immunomodulator compound is administered in a combination treatment regimen further including administration to the subject of ribavirin, wherein the immunomodulator compound and the ribavirin are administered to the subject separately or together in the treatment regimen; (iii) the immunomodulator compound is administered in a combination treatment regimen with a specifically targeted antiviral therapy for hepatitis C (STAT-C) agent, wherein the immunomodulator compound and the STAT-C agent are administered to the subject separately or together in the treatment regimen; or (iv) a combination of at least two of (i), (ii), and (iii).
摘要翻译：一种用于治疗或预防目标受试者中丙型肝炎（HepC）的治疗方法，包括向目标受试者施用有效量的式A的免疫调节剂化合物，其中n为1或2，R为氢，酰基，烷基或肽片段，X是芳族或杂环氨基酸或其衍生物，其中：（i）免疫调节剂化合物以大于0.001mg / kg的剂量施用于受试者; （ii）免疫调节剂化合物以联合治疗方案给药，其进一步包括向受试者施用利巴韦林，其中免疫调节剂化合物和利巴韦林在治疗方案中单独或一起施用于受试者; （iii）免疫调节剂化合物以联合治疗方案与丙型肝炎（STAT-C）试剂的特异性靶向抗病毒治疗剂一起施用，其中将免疫调节剂化合物和STAT-C试剂分别或一起施用于受试者方案或（iv）（i），（ii）和（iii）中的至少两个的组合。

18. 发明申请

US20100197595A1 TREATMENT OF MELANOMA WITH ALPHA THYMOSIN PEPTIDES 审中-公开
标题翻译：用ALPHA THYMOSIN PEPTIDES治疗MELANOMA
公开(公告)号：US20100197595A1
公开(公告)日：2010-08-05
申请号：US12758714
申请日：2010-04-12
申请人： Cynthia W. Tuthill , Israel Rios
发明人： Cynthia W. Tuthill , Israel Rios
IPC分类号： A61K38/22 , A61P35/00
CPC分类号： A61K31/64 , A61K38/2292 , A61K2300/00
摘要： A method of treating melanoma or a metastasis thereof in a human patient by administering a melanoma-treating effective amount of an alpha thymosin peptide to a human melanoma patient, wherein the human melanoma patient does not have a substantially elevated LDH blood level.
摘要翻译：一种通过对人黑素瘤患者施用黑素瘤治疗有效量的α胸腺素肽来治疗人类患者的黑素瘤或其转移的方法，其中所述人黑素瘤患者不具有显着升高的LDH血液水平。

19. 发明申请

US20090088392A1 TREATMENT OF MELANOMA 有权
标题翻译：治疗梅毒
公开(公告)号：US20090088392A1
公开(公告)日：2009-04-02
申请号：US12297699
申请日：2007-04-13
申请人： Cynthia W. Tuthill , Alfred R. Rudolph
发明人： Cynthia W. Tuthill , Alfred R. Rudolph
IPC分类号： A61K38/05 , A61P35/00 , A61K31/197
CPC分类号： A61K38/05
摘要： An immunomodulatory compound is administered to treat, prevent, inhibit, or reduce melanoma in a subject.
摘要翻译：施用免疫调节化合物以治疗，预防，抑制或减少受试者中的黑素瘤。

20. 发明申请

US20090074815A1 Immunomodulator Compounds as Vaccine Enhancers 审中-公开
标题翻译：免疫调节剂化合物作为疫苗增强剂
公开(公告)号：US20090074815A1
公开(公告)日：2009-03-19
申请号：US11912266
申请日：2006-04-21
申请人： Cynthia W. Tuthill , Alfred R. Rudolph
发明人： Cynthia W. Tuthill , Alfred R. Rudolph
IPC分类号： A61K39/145 , A61K39/00 , A61K39/29 , A61K39/12 , A61K39/275
CPC分类号： A61K39/39 , A61K39/04 , A61K39/12 , A61K39/292 , A61K2039/542 , A61K2039/55516 , A61K2039/57 , C12N2730/10134 , Y02A50/464 , Y02A50/466
摘要： A vaccination method utilizes a pharmaceutical combination for enhancing vaccine effectiveness. The method utilizes an immune response-triggering vaccine capable of stimulating production in an immunodefficicent animal of antibodies to a disease-causing agent foreign to the animal. As an adjuvant, a vaccine effectiveness-enhancing amount of an immunomodulator compound is administered, which enhances production and affinity of the antibodies in the animal, in response to the vaccine.
摘要翻译：疫苗接种方法利用药物组合来增强疫苗的有效性。该方法利用能够在免疫功能动物中刺激对动物异源的致病因子的抗体的免疫应答触发疫苗。作为辅助剂，施用疫苗有效性增强量的免疫调节剂化合物，其响应于疫苗增强抗体在动物中的产生和亲和力。

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