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11. 发明申请

US20190144829A1 Uses of Epithelial-to-Mesenchymal Inhibitors in Generating Pacemaker Cells 审中-公开
公开(公告)号：US20190144829A1
公开(公告)日：2019-05-16
申请号：US16098560
申请日：2017-05-02
申请人： Emory University , Children's Healthcare of Atlanta, Inc.
发明人： Hee Cheol Cho
IPC分类号： C12N5/077 , A61K35/34 , A61K31/4709 , A61P9/06
摘要： This disclosure relates to methods of generating pacemaker cells for use in therapeutic strategies that address a heart that beats abnormally. In certain embodiments, one mixes cells with an epithelial-to-mesenchymal transformation inhibitor in combination with a nucleic acid encoding a transcription factor such as a vector that encodes a transcription factor such as Tbx18 in operable combination with a eukaryotic promoter to produce pacemaker cells that are then transplanted into the heart.

12. 发明申请

US20190016772A1 GM-CSF and IL-4 Conjugates, Compositions, and Methods Related Thereto 审中-公开
公开(公告)号：US20190016772A1
公开(公告)日：2019-01-17
申请号：US16149372
申请日：2018-10-02
申请人： Emory University , Children's Healthcare of Atlanta, Inc.
发明人： Jacques Galipeau , Jiusheng Deng
IPC分类号： C07K14/54 , A61K47/42 , A61K38/19 , A61K38/20 , A61K39/00 , A61K39/39 , A61K35/14 , C07K14/535 , A61K38/00
摘要： In certain embodiments, this disclosure relates to conjugates comprising a polypeptide of GM-CSF and a polypeptide IL-4. Typically, the GM-CSF and IL-4 are connected by a linker, e.g., polypeptide. In certain embodiments, the disclosure relates to isolated nucleic acids encoding these polypeptide conjugates, vectors comprising nucleic acid encoding polypeptide conjugates, and protein expression systems comprising these vectors such as infectious viral particles and host cells comprising such nucleic acids.

13. 发明申请

US20180289799A1 Conjugates of GM-CSF and IL-7, and Compositions Thereof 审中-公开
公开(公告)号：US20180289799A1
公开(公告)日：2018-10-11
申请号：US16007392
申请日：2018-06-13
申请人： Emory University , Children's Healthcare of Atlanta, Inc.
发明人： Jacques Galipeau , Hsiang-Chuan Hsieh
IPC分类号： A61K39/39 , C07K14/535 , A61K38/19 , A61K38/20 , A61K39/00 , C07K14/54 , A61K35/14 , A61K39/245 , A61K38/00
摘要： In certain embodiments, this disclosure relates to conjugates comprising GM-CSF and IL-7 and uses related thereto, e.g., enhancing the adaptive immune system. Typically the GM-CSF and IL-7 are connected by a polymer linker, e.g., polypeptide. In certain embodiments, the disclosure relates to nucleic acids encoding these polypeptide conjugates, vectors comprising nucleic acid encoding polypeptide conjugates, and protein expression systems comprising these vectors such as infectious viral particles and host cells comprising such a nucleic acids.

14. 发明授权

US10093709B2 GM-CSF and IL-4 conjugates, compositions, and methods related thereto 有权
公开(公告)号：US10093709B2
公开(公告)日：2018-10-09
申请号：US15491777
申请日：2017-04-19
申请人： Emory University , Children's Healthcare of Atlanta, Inc.
发明人： Jacques Galipeau , Jiusheng Deng
IPC分类号： C07K14/54 , C07K14/535 , A61K38/19 , A61K35/14 , A61K38/20 , A61K38/00
摘要： In certain embodiments, this disclosure relates to conjugates comprising a polypeptide of GM-CSF and a polypeptide IL-4. Typically, the GM-CSF and IL-4 are connected by a linker, e.g., polypeptide. In certain embodiments, the disclosure relates to isolated nucleic acids encoding these polypeptide conjugates, vectors comprising nucleic acid encoding polypeptide conjugates, and protein expression systems comprising these vectors such as infectious viral particles and host cells comprising such nucleic acids.

15. 发明授权

US10081678B2 Specific binding antibodies of glycoprotein IB alpha as selective ectodomain shedding inhibitors 有权
公开(公告)号：US10081678B2
公开(公告)日：2018-09-25
申请号：US14764541
申请日：2014-02-03
申请人： EMORY UNIVERSITY , CHILDREN'S HEALTHCARE OF ATLANTA, INC.
发明人： Renhao Li
IPC分类号： C07K16/28 , A61K39/395 , C07K16/40
CPC分类号： C07K16/28 , C07K16/2896 , C07K16/40 , C07K2317/24 , C07K2317/33 , C07K2317/35 , C07K2317/55 , C07K2317/565 , C07K2317/70 , C07K2317/92
摘要： This disclosure relates to specific binding agents, such as isolated recombinant monoclonal antibodies, that bind Glycoprotein Ib alpha (GPIba). More specifically, the disclosure relates to methods of preventing platelet ectodomain shedding, preventing platelet clearance and degradation, maintaining and increasing platelet blood serum levels for in vitro or in vivo applications. In some embodiments, the disclosure relates to the production, diagnostic use, and therapeutic use of monoclonal and polyclonal antibodies, and the antigen-binding fragments thereof, which specifically bind GPIba. Aspects of the disclosure also relate to hybridomas or other cell lines expressing such antibodies for specific binding agent. Compositions and methods for inhibiting shedding, clearance, or degradation, or treating diseases associated with GPIba ectodomain shedding are also described.

16. 发明申请

US20180116958A1 NANOCARRIER THERAPY FOR TREATING INVASIVE TUMORS 审中-公开
公开(公告)号：US20180116958A1
公开(公告)日：2018-05-03
申请号：US15858367
申请日：2017-12-29
申请人： Emory University , Georgia Tech Research Corporation , Children's Healthcare of Atlanta, Inc.
发明人： Jennifer M. Munson , Ravi V. Bellamkonda , Jack L. Arbiser
IPC分类号： A61K9/127 , A61K45/06 , A61K9/00 , A61K31/55
CPC分类号： A61K9/1271 , A61K9/0019 , A61K31/55 , A61K45/06
摘要： Liposomes of a size of less than 200 nanometers target tumors and preferentially deliver imipramine blue to tumors, including brain tumors such as gliomas. The imipramine blue decreases the invasiveness of the tumors, and inhibits tumor metastasis. The liposomes include cholesterol and chemically pure phospholipids that are essentially neutral and contain saturated fatty acids of between 16 and 18 carbon atoms, such as distearoylphosphatidyl choline, and can also include one or more pegylated phospholipids, such as DSPE-PEG.

17. 发明申请

US20170226173A1 GM-CSF and IL-4 Conjugates, Compositions, and Methods Related Thereto 审中-公开
公开(公告)号：US20170226173A1
公开(公告)日：2017-08-10
申请号：US15491777
申请日：2017-04-19
申请人： Emory University , Children's Healthcare of Atlanta, Inc.
发明人： Jacques Galipeau , Jiusheng Deng
IPC分类号： C07K14/54 , A61K35/14 , C07K14/535
CPC分类号： C07K14/5406 , A61K35/14 , A61K38/00 , A61K38/193 , A61K38/2026 , A61K39/0011 , A61K39/39 , A61K47/42 , A61K2039/5152 , A61K2039/5156 , A61K2039/55522 , A61K2039/55527 , C07K14/535 , C07K2319/00
摘要： In certain embodiments, this disclosure relates to conjugates comprising a polypeptide of GM-CSF and a polypeptide IL-4. Typically, the GM-CSF and IL-4 are connected by a linker, e.g., polypeptide. In certain embodiments, the disclosure relates to isolated nucleic acids encoding these polypeptide conjugates, vectors comprising nucleic acid encoding polypeptide conjugates, and protein expression systems comprising these vectors such as infectious viral particles and host cells comprising such nucleic acids.

18. 发明申请

US20140253876A1 SYSTEMS AND METHODS FOR DETECTION OF COGNITIVE AND DEVELOPMENTAL CONDITIONS 有权
标题翻译：用于检测认知和发展条件的系统和方法
公开(公告)号：US20140253876A1
公开(公告)日：2014-09-11
申请号：US14205012
申请日：2014-03-11
申请人： Children's Healthcare of Atlanta, Inc.
发明人： Ami Klin , Warren Jones , Peter Lewis
IPC分类号： A61B3/113
CPC分类号： A61B3/113 , A61B3/0025 , A61B3/005 , A61B3/0083 , A61B3/0091 , A61B3/032 , A61B5/168
摘要： Systems, devices, and methods are described for the assessment, screening, monitoring, or diagnosis of developmental or cognitive conditions, including autism spectrum disorders (ASD) by analysis of eye tracking data generated from feedback received as a result of display of specific predetermined visual stimuli to a subject or patient. Subsequent to a calibration phase, a testing procedure is performed by presenting predetermined stimuli (e.g., videos) to a subject via a display device. Eye tracking data (from the subject moving his or her eyes in response to predetermined movies or other visual stimuli) are collected. During the data collection period, the system periodically presents targets to reflexively elicit the subject's gaze. These data are used to later verify accuracy. Analysis of the subject's viewing patterns during these stimuli is used for the assessment, screening, monitoring, or diagnosis of developmental or cognitive conditions such as ASD.
摘要翻译：描述了系统，设备和方法，用于通过分析由于通过显示特定预定视觉而收到的反馈产生的眼睛跟踪数据来评估，筛选，监测或诊断发育或认知状况，包括自闭症谱系障碍（ASD）对受试者或患者的刺激。在校准阶段之后，通过经由显示装置向对象呈现预定的刺激（例如，视频）来执行测试程序。收集眼睛跟踪数据（来自受试者移动他或她的眼睛以响应预定的电影或其他视觉刺激）。在数据收集期间，系统定期提出目标，以反思地引出受试者的注视。这些数据用于稍后验证准确性。在这些刺激下对主体观察模式的分析用于评估，筛选，监测或诊断发育或认知状况，如ASD。

19. 发明公开

US20230203447A1 Methods of Producing Specialized Cardio-Like Cells from Stem Cells 审中-公开
公开(公告)号：US20230203447A1
公开(公告)日：2023-06-29
申请号：US18115283
申请日：2023-02-28
申请人： Emory University , Children's Healthcare of Atlanta, Inc.
发明人： Hee Cheol Cho
IPC分类号： C12N5/077 , C12N5/0735
CPC分类号： C12N5/0657 , C12N5/0606 , C12N2501/385 , C12N2501/155 , C12N2501/16 , C12N2501/115 , C12N2501/415 , C12N2506/02
摘要： This disclosure relates to method of differentiating stem cells to specific cardiac-like cells. In certain embodiments, the disclosure contemplates methods of generating left ventricular-like cells and the atrial-like cells by timing the exposure of dividing stem cells to retinoic acid (RA) or retinoic acid receptor inhibitors.

20. 发明授权

US11471524B2 Recombinant RSV with silent mutations, vaccines, and methods related thereto 有权
公开(公告)号：US11471524B2
公开(公告)日：2022-10-18
申请号：US17025568
申请日：2020-09-18
申请人： Emory University , Children's Healthcare of Atlanta, Inc.
发明人： Martin L. Moore , Jia Meng , Anne Hotard , Elizabeth Littauer , Christopher Stobart
IPC分类号： A61K39/155 , C12N7/00 , C07K14/005 , A61K39/12 , A61K45/06 , A61K39/00
摘要： In certain embodiments, the disclosure relates to the polynucleotide sequences of respiratory syncytial virus (RSV). In certain embodiments, the disclosure relates to isolated or recombinant nucleic acids and polypeptides comprising desirable nucleic acid sequences and mutations disclosed herein. In certain embodiments, isolated or recombinant RSV comprising the nucleic acids and polypeptides disclosed herein (e.g., attenuated recombinant RSV) are also provided, as are immunogenic compositions including such nucleic acids, polypeptides, and RSV genomes that are suitable for use as vaccines. Attenuated or killed RSV containing these nucleic acids and mutation in the form of copied nucleic acids (e.g., cDNAs) are also contemplated.

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