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11. 发明授权

US09090877B2 Method for obtaining algae extracts and use of these extracts 有权
标题翻译：获取藻类提取物和使用这些提取物的方法
公开(公告)号：US09090877B2
公开(公告)日：2015-07-28
申请号：US13003977
申请日：2009-07-17
申请人： Antoine Piccirilli
发明人： Antoine Piccirilli
IPC分类号： A01N65/00 , C12N1/06 , A61K36/00 , A23K1/14 , A23K1/18 , A23L1/337 , A61K8/37 , A61K8/97 , A61K36/02 , A61Q19/00 , C05F11/10 , C05G3/00 , C10L1/02 , C12N1/12
CPC分类号： C12N1/066 , A23K10/30 , A23K50/80 , A23L17/60 , A61K8/37 , A61K8/9706 , A61K36/00 , A61K36/02 , A61Q19/00 , C05F11/10 , C05G3/0064 , C10L1/023 , C10L1/026 , C12N1/12 , Y02E50/13
摘要： A process for obtaining algae extracts, includes at least the following stages: a) pretreatment of an algal sample, b) rapid heating, c) application of pressure that is greater than or equal to 1 bar, d) instantaneous expansion to a pressure that is less than or equal to 1 bar, and e) recovery of the products that are obtained in d) in liquid, solid and/or gaseous form. The use of algae extract products obtained by the implementation of this process is also described.
摘要翻译：获得藻类提取物的方法至少包括以下阶段：a）预处理藻类样品，b）快速加热，c）施加大于或等于1巴的压力，d）瞬时膨胀至小于或等于1巴，e）回收在d）中以液体，固体和/或气体形式获得的产品。还描述了通过实施该方法获得的藻类提取物产品的使用。

12. 发明授权

US08735615B2 Method for extracting unsaponifiables from renewable raw materials 有权
标题翻译：从可再生原料中提取不皂化物的方法
公开(公告)号：US08735615B2
公开(公告)日：2014-05-27
申请号：US13503509
申请日：2010-10-21
申请人： Antoine Piccirilli
发明人： Antoine Piccirilli
IPC分类号： C11B1/10 , C11B3/06
CPC分类号： C11B3/006 , C11B3/04 , C11B3/06
摘要： A method for extracting an unsaponifiable fraction from a renewable raw material selected among oilfruits, oleaginous seeds, oleoproteaginous seeds, seed husks, oil-yielding almonds, sprouts, stones and cuticles of fruits, high-fat raw materials from animals, algae, fungus or yeast, includes the following steps: a) dehydrating and packaging the renewable raw material, not resulting in any extraction of the fat; b) reactive crushing of the fatty packaged raw material in the presence of a light alcohol and a catalyst; c) evaporating the light alcohol; d) concentrating the liquid phase such as to obtain a concentrate including the unsaponifiable fraction diluted in fatty acid alkyl esters; e) saponifying the unsaponifiable concentrate; f) extracting the unsaponifiable fraction from the saponified mixture. The use of an unsaponifiable fraction or co-products obtained by implementing the method for preparing a composition such as a cosmetic, drug, food, or food additive or supplement is also described.
摘要翻译：从可可原料中提取不可皂化部分的方法，该可再生原料选自油果，油质种子，油蛋白质种子，种子壳，产油杏仁，芽果，果实的石头和角质层，动物，藻类，真菌等的高脂肪原料酵母，包括以下步骤：a）脱水和包装可再生原料，不会导致任何脂肪的提取; b）在轻质醇和催化剂存在下对脂肪包装原料的反应性破碎; c）蒸发轻酒精; d）浓缩液相，以获得包含稀释在脂肪酸烷基酯中的不皂化的级分的浓缩物; e）皂化不皂化的浓缩液; f）从皂化混合物中提取不皂化的部分。还描述了通过实施用于制备组合物如化妆品，药物，食品或食品添加剂或补充剂的方法获得的不皂化部分或共同产品的用途。

13. 发明授权

US08236836B2 Composition comprising at least one oxazoline for inhibiting langerhans cell migration, and uses thereof 有权
标题翻译：包含至少一种用于抑制朗格汉斯细胞迁移的恶唑啉的组合物及其用途
公开(公告)号：US08236836B2
公开(公告)日：2012-08-07
申请号：US10499976
申请日：2002-12-27
申请人： Philippe Msika , Nathalie Piccardi , Antoine Piccirilli
发明人： Philippe Msika , Nathalie Piccardi , Antoine Piccirilli
IPC分类号： A61K31/42
CPC分类号： A61K31/42 , A61K8/49 , A61K2800/51 , A61K2800/70 , A61K2800/75 , A61K2800/782 , A61Q19/00 , A61Q19/005 , A61Q19/08 , Y10S514/861
摘要： The invention concerns a composition containing at least an oxazolin, optionally combined with at least a compound such as a metalloprotease inhibitor, a PKC inhibitor, an anti-inflammatory agent, a soothing agent, an immunosuppressor, an ion chelating agent, an alkanolamide, an oxazolidinone and a carbamic acid derivative. The invention also concerns the use of such a composition as medicine, in particular for preventing or treating skin pathologies of allergic and/or inflammatory and/or irritative origin or resulting from a danger signal. The invention further concerns a method for cosmetic treatment of sensitive, irritated, intolerant, allergy-prone, ageing skin and/or mucosa exhibiting skin barrier disorder, or exhibiting non-pathological immunologic imbalance, which consists in applying such composition on the skin and/or mucosa.
摘要翻译：本发明涉及至少含有恶唑啉的组合物，任选地与至少一种化合物如金属蛋白酶抑制剂，PKC抑制剂，抗炎剂，舒缓剂，免疫抑制剂，离子螯合剂，链烷醇酰胺，恶唑烷酮和氨基甲酸衍生物。本发明还涉及使用这种组合物作为药物，特别是用于预防或治疗过敏和/或炎性和/或刺激性起源或由危险信号引起的皮肤病理学。本发明还涉及一种用于美容治疗敏感的，刺激的，不耐受的，过敏倾向的，老化的皮肤和/或表现皮肤屏障障碍的皮肤或/或表现出非病理性免疫不平衡的皮肤和/或粘膜的方法，其包括在皮肤和/ 或粘膜。

14. 发明授权

US07883729B2 Natural vegetable oil concentrated in unsaponifiable matters as food ingredient 有权
标题翻译：天然植物油集中在不皂化物质中作为食物成分
公开(公告)号：US07883729B2
公开(公告)日：2011-02-08
申请号：US10239298
申请日：2001-03-19
申请人： Carole Kohler , Philippe Msika , Antoine Piccirilli
发明人： Carole Kohler , Philippe Msika , Antoine Piccirilli
IPC分类号： A61K36/28 , A61K36/00
CPC分类号： C11B3/12 , A21D2/16 , A23D9/00 , A23L27/60 , A23L33/11 , A23L33/115 , A23L33/15 , A23V2002/00 , A61K8/922 , A61K31/01 , A61K31/015 , A61K31/355 , A61K31/56 , A61K45/06 , A61Q19/00 , A61Q19/08 , A61K2300/00 , A23V2250/188 , A23V2250/712 , A23V2250/21368 , A23V2250/211 , A23V2250/1874
摘要： The invention concerns a natural vegetable oil selected among palm oil, corn germ oil, sunflower oil and canola oil, concentrated in unsaponifiable matters, such that said oil unsaponifiable matter content is 3 to 15% m/m. Said concentrated natural vegetable oil constitutes a novel food ingredient enriched in particular in vitamin E and phytosterol, useful as favored food source in vitamin E and phytosterol, meeting recommended daily intake.
摘要翻译：本发明涉及一种选自棕榈油，玉米胚芽油，向日葵油和卡诺拉油中的天然植物油，其浓缩在不皂化物质中，使得所述油不皂化物质含量为3至15％m / m。所述浓缩天然植物油构成特别富含维生素E和植物甾醇的新型食品成分，可用作维生素E和植物甾醇中有利的食物来源，满足推荐的每日摄入量。

15. 发明申请

US20100035816A1 MEDICAMENT COMPRISING A PEPTIDE EXTRACT OF AVOCADO, WHICH IS INTENDED FOR THE TREATMENT AND PREVENTION OF ILLNESSES THAT ARE LINKED TO AN IMMUNE SYSTEM DEFICIENCY OR OXIDATIVE STRESS OR SKIN AGEING OR DRY SKIN 有权
标题翻译：含有AVOCADO的肽提取物的药物，其意在用于治疗和预防与免疫系统缺陷或氧化应激或皮肤老化或干性皮肤相关的不良事件
公开(公告)号：US20100035816A1
公开(公告)日：2010-02-11
申请号：US12539970
申请日：2009-08-12
申请人： Antoine Piccirilli , Nathalie Piccardi , Philippe Msika , François Paul , Stéphanie Bredif
发明人： Antoine Piccirilli , Nathalie Piccardi , Philippe Msika , François Paul , Stéphanie Bredif
IPC分类号： A61K38/00 , A61K38/02 , A61P31/04 , A61P31/10 , A61P31/12 , A61P29/00 , A61P17/00 , A61P17/06 , A61P17/10 , A61P17/02
CPC分类号： A61K36/54 , A61K31/198 , A61K2300/00
摘要： The invention relates to a medicament which comprises a peptide extract of avocado and which can also comprise a composition containing D-mannoheptulose an/or perseitol, such as a water-soluble extract of avocado sugars, and/or a peptide extract of lupine. The inventive medicament is intended for the treatment and/or prevention of illnesses that are linked to an alteration in innate and/or acquired immunity, through an increase in the production of anti-microbial peptides, preferably hBD-2, without inducing inflammatory reactions, irritations or intolerances.
摘要翻译：本发明涉及一种药物，其包含鳄梨的肽提取物，并且还可以包含含有D-甘露庚酮糖和/或去糖醇的组合物，例如鳄梨糖的水溶性提取物和/或羽扇豆肽提取物。本发明的药物旨在通过增加抗微生物肽（优选hBD-2）的产生而不诱导炎症反应来治疗和/或预防与先天和/或获得性免疫的变化有关的疾病，激怒或不宽容

16. 发明申请

US20090137453A1 COMPOSITION COMPRISING AT LEAST ONE OXAZOLINE TO INHIBIT MIGRATION OF LANGERHANS CELLS, AND USES THEREOF 有权
标题翻译：包含至少一种氧化氮以抑制兰格细胞迁移的组合物及其用途
公开(公告)号：US20090137453A1
公开(公告)日：2009-05-28
申请号：US12352973
申请日：2009-01-13
申请人： Philippe MSIKA , Nathalie PICCARDI , Antoine PICCIRILLI
发明人： Philippe MSIKA , Nathalie PICCARDI , Antoine PICCIRILLI
IPC分类号： A61K38/02 , A61K31/421 , A61P35/00
CPC分类号： A61K31/42 , A61K8/49 , A61K2800/51 , A61K2800/70 , A61K2800/75 , A61K2800/782 , A61Q19/00 , A61Q19/005 , A61Q19/08 , Y10S514/861
摘要： The invention concerns a composition containing at least an oxazolin, optionally combined with at least a compound such as a metalloprotease inhibitor, a PKC inhibitor, an anti-inflammatory agent, a soothing agent, an immunosuppressor, an ion chelating agent, an alkanolamide, an oxazolidinone and a carbamic acid derivative. The invention also concerns the use of such a composition as medicine, in particular for preventing or treating skin pathologies of allergic and/or inflammatory and/or irritative origin or resulting from a danger signal. The invention further concerns a method for cosmetic treatment of sensitive, irritated, intolerant, allergy-prone, ageing skin and/or mucosa exhibiting skin barrier disorder, or exhibiting non-pathological immunologic imbalance, which consists in applying such composition on the skin and/or mucosa.
摘要翻译：本发明涉及至少含有恶唑啉的组合物，任选地与至少一种化合物如金属蛋白酶抑制剂，PKC抑制剂，抗炎剂，舒缓剂，免疫抑制剂，离子螯合剂，链烷醇酰胺，恶唑烷酮和氨基甲酸衍生物。本发明还涉及使用这种组合物作为药物，特别是用于预防或治疗过敏和/或炎性和/或刺激性起源或由危险信号引起的皮肤病理学。本发明还涉及一种用于美容治疗敏感的，刺激的，不耐受的，过敏倾向的，老化的皮肤和/或表现皮肤屏障障碍的皮肤或/或表现出非病理性免疫不平衡的皮肤和/或粘膜的方法，其包括在皮肤和/ 或粘膜。

17. 发明申请

US20080311100A1 Treatment of Keratinous Dryness With Glycerides 审中-公开
标题翻译：用甘油酯处理角质干燥
公开(公告)号：US20080311100A1
公开(公告)日：2008-12-18
申请号：US11920259
申请日：2006-05-15
申请人： Patricia Manissier , Christiane Montastier , Antoine Piccirilli
发明人： Patricia Manissier , Christiane Montastier , Antoine Piccirilli
IPC分类号： A61K31/122 , A61K31/202 , A61K31/385 , A61P17/08 , A61K31/715 , A61K38/02
CPC分类号： A61K8/02 , A23L33/12 , A23V2002/00 , A61K8/375 , A61K8/922 , A61K8/925 , A61K2800/92 , A61Q19/00 , A61Q19/007 , A61Q19/08 , A23V2250/1878 , A23V2200/318
摘要： The present invention provides the use of medium chain glyceride(s) as an active ingredient for the preparation of a composition for oral and/or parenteral absorption and intended to prevent and/or treat dry and/or delicate keratinous substances.
摘要翻译：本发明提供了中链甘油酯作为活性成分用于制备用于口服和/或肠胃外吸收的组合物并用于预防和/或治疗干性和/或微妙角化物质的用途。

18. 发明授权

US07371420B2 Method for producing an avocado unsaponifiable rich in furan lipids 有权
标题翻译：用于生产不可皂化的鳄梨富含呋喃油脂的方法
公开(公告)号：US07371420B2
公开(公告)日：2008-05-13
申请号：US10522907
申请日：2003-07-28
申请人： Antoine Piccirilli , Jacques Legrand
发明人： Antoine Piccirilli , Jacques Legrand
IPC分类号： A61K35/78
CPC分类号： C11B1/06 , A23L33/105 , A61K36/54 , C11B1/04 , C11B1/10 , C11B3/12
摘要： The present invention relates to a process for obtaining a furan lipid-rich unsaponifiable material from avocado, which comprises the successive steps (1) of controlled dehydration of fresh avocados or of avocados that have undergone preliminary transformations, (2) of extraction of the oil from dehydrated fruit, (3) of a heat treatment of the extracted oil and of a step of concentration of the unsaponifiable fraction of the oil or alternately, these two operations possibly being carried out successively in this order or in the reverse order, and finally (4) a step of saponification and of extraction of the unsaponifiable material.
摘要翻译：本发明涉及一种从鳄梨中获得富含呋喃富含脂肪的不可皂化物质的方法，该方法包括以下步骤（1）：经过初步转化的新鲜鳄梨或鳄梨的受控脱水步骤（1），（2）提取油脱水果，（3）提取油的热处理和不皂化部分浓缩的步骤，或者这两个操作可能依次顺序或以相反的顺序进行，最后（4）皂化和提取不皂化物质的步骤。

19. 发明申请

US20080045594A1 Use of at Least One Conjugated Triene-Containing Fatty Acid for Preparing a Medicine for Treating Inflammation 审中-公开
标题翻译：使用至少一种含共轭三烯的脂肪酸来制备治疗炎症的药物
公开(公告)号：US20080045594A1
公开(公告)日：2008-02-21
申请号：US11572769
申请日：2005-07-20
申请人： Antoine Piccirilli , Nathalie Piccardi , Philippe Miska
发明人： Antoine Piccirilli , Nathalie Piccardi , Philippe Miska
IPC分类号： A61K31/20 , A61P29/00 , C07C51/41
CPC分类号： A61K31/202 , A61K36/185 , A61K36/28 , A61K36/42 , A61K36/428 , A61K36/73 , A61K36/84
摘要： The invention concerns the use of at least one conjugated triene-containing fatty acid for preparing a medicine for treating inflammation selected among the group consisting of alpha-eleostearic acid, catalpic acid, calendic acid, jacaric acid, licanic acid and beta-eleostearic acid for making a medicine for treating inflamatory diseases and/or metabolic disorders following an inflammation. The inflammatory diseases and/or metabolic disorders following an inflammation may be skin cancers, sun burn, benign summer light eruption, allergic and/or irritative reactions, gingivitis and periodontitis, vulvitis and vaginitis or arthritis and arthrosis. The medicine also enables healing to be promoted. Said fatty acid conjugates can also be used in the cosmetic treatment of cellulitis.
摘要翻译：本发明涉及使用至少一种含共轭三烯的脂肪酸来制备用于治疗炎症的药物，所述药物选自由α-蓖麻酸，catal酸，胼ic酸，茉莉酸，ican酸和β-蒿酸组成的组，其用于制造治疗炎性疾病和/或炎症后的代谢紊乱的药物。炎性疾病和/或炎症后的代谢紊乱可能是皮肤癌，太阳烧伤，良性夏季光线爆发，过敏性和/或刺激性反应，牙龈炎和牙周炎，外阴炎和阴道炎或关节炎和关节炎。该药也能使愈合得到提升。所述脂肪酸缀合物也可用于蜂窝织炎的美容治疗。

20. 发明申请

US20070098823A1 Maca extract and cosmetic composition containing such an extract 有权
标题翻译：含有这种提取物的麦汁提取物和化妆品组合物
公开(公告)号：US20070098823A1
公开(公告)日：2007-05-03
申请号：US10561271
申请日：2004-06-17
申请人： Nathalie Piccardi , Antoine Piccirilli , Philippe Msika , Francois Paul
发明人： Nathalie Piccardi , Antoine Piccirilli , Philippe Msika , Francois Paul
IPC分类号： A61K36/31
CPC分类号： A61K8/645 , A61K8/97 , A61Q19/08
摘要： The invention relates to a method for extracting substances from maca, to the obtained extract, to a cosmetic and pharmaceutical composition containing said extract, and to the use thereof as an anti-aging cosmetic agent. The method is characterized by a step involving the use of an enzymatic hydrolysis of proteins.
摘要翻译：本发明涉及从马卡提取物质，所得提取物，含有所述提取物的化妆品和药物组合物的方法及其作为抗衰老化妆剂的用途。该方法的特征在于涉及使用蛋白质的酶水解的步骤。

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