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    • 12. 发明申请
    • Hair Relaxer
    • 头发放松
    • US20080131389A1
    • 2008-06-05
    • US11793798
    • 2006-02-03
    • Akira ShibuyaMakoto Saito
    • Akira ShibuyaMakoto Saito
    • A61K8/46A61Q5/04
    • A61K8/46A61Q5/04
    • A hair relaxer includes at least one specific mercapto compound such as 2-methoxyethyl 3-mercaptopropionate, 2-mercapto-4-butanolide and 2-mercapto-4-butyrolactam. The hair relaxer can achieve an excellent effect of shaping and relaxing hair over a wide range of pH values from weak acidity to weak alkalinity. In particular, the hair relaxer displays a more superior hair shaping and relaxing performance in a weakly acidic to neutral pH range. Consequently, the hair relaxer can drastically reduce the damage to the hair and skin and can reliably perform straightening, uncurling, curling and other hair processing.
    • 头发松弛剂包括至少一种特定的巯基化合物,例如3-巯基丙酸2-甲氧基乙酯,2-巯基-4-丁醇酯和2-巯基-4-丁内酰胺。 头发松弛剂可以在从弱酸性到弱碱性的广泛pH值范围内实现成型和松弛头发的优异效果。 特别地,头发松弛剂在弱酸性至中性pH范围内显示出更优异的头发成型和松弛性能。 因此,头发松弛剂可以大大降低对头发和皮肤的损伤,并可以可靠地进行矫直,卷曲,卷曲和其它头发处理。
    • 16. 发明授权
    • Electric dust collecting apparatus
    • 电动除尘装置
    • US3994704A
    • 1976-11-30
    • US565821
    • 1975-04-07
    • Akira ShibuyaYoshifumi Nitta
    • Akira ShibuyaYoshifumi Nitta
    • B03C3/00B03C3/04B03C3/51B03C3/45
    • B03C3/51B03C3/04
    • An improved dust collecting apparatus is described, in a first section of which are disposed a plurality of linear discharge electrodes and a plurality of planar dust collecting electrodes in an opposed relationship to each other within a casing that has an inlet port for introducing a dust-containing gas formed at one end and that has an outlet port for discharging a dust-free gas formed at the other end, so that the dust in the dust-containing gas may be charged and also collected in said first section. Downstream of said first section of the apparatus are aligned a plurality of rod-shaped driver electrodes spaced apart from each other along a plane transverse of a gas flow, and on the side surfaces of said driver electrodes are provided lengthwise channels having their openings directed to the outlet port side. Downstream of the gas spaces formed between adjacent ones of said driver electrodes are disposed a plurality of rod-shaped collector electrodes, and on the side surfaces of said collector electrodes are provided lengthwise channels having their openings directed to the inlet port side. A negative terminal of a D.C. power source is connected to said driver electrodes, while a positive terminal of a D.C. power source is connected to said collector electrodes, whereby the dust that has been charged in the space between said discharge electrodes and said dust collecting electrodes but has not adhered to the dust collecting electrodes and that has been respattered can be collected within the lengthwise channels of said collector electrodes.
    • 在第一部分中描述了一种改进的集尘装置,其中第一部分在壳体内彼此相对关系地设置有多个线性放电电极和多个平面集尘电极,该壳体具有用于引入除尘装置的入口, 形成在一端的容纳气体,具有用于排出在另一端形成的无尘气体的出口,使得含尘气体中的灰尘可能被填充并收集在所述第一部分中。 所述设备的所述第一部分的下游沿着沿着气流横向的平面彼此间隔开的多个杆状驱动器电极对准,并且在所述驱动电极的侧表面上设置有纵向通道,其开口指向 出口侧。 在相邻的所述驱动电极之间形成的气体空间的下游设置有多个棒状收集电极,并且在所述集电极的侧表面上设有纵向通道,其开口指向入口侧。 直流电源的负端子连接到所述驱动电极,而直流电源的正极端子连接到所述集电极,由此已经充电在所述放电电极和所述集尘电极之间的空间的灰尘 但是没有附着在集尘电极上,并且已经被重新分配的电极可以被收集在所述集电极的纵向通道内。
    • 17. 发明申请
    • METHOD FOR PRODUCING BETA-MERCAPTO CARBOXYLIC ACIDS
    • 生产羧甲基羧酸的方法
    • US20110015436A1
    • 2011-01-20
    • US12921495
    • 2009-03-11
    • Hidemasa AokiAkio KuroiwaAkira Shibuya
    • Hidemasa AokiAkio KuroiwaAkira Shibuya
    • C07C51/347
    • C07C319/04C07C323/56C07C323/52
    • An object of the present invention is to provide a method for industrially producing β-mercapto carboxylic acids that are useful as synthetic raw materials for medicines and agrochemicals or as additives for polymer compounds from easily available α,β-unsaturated carboxylic acids in high yields and productivity.The present invention is characterized in that a solvent having an amide group and represented by the formula (1) is used when the α,β-unsaturated carboxylic acids are reacted with hydrogen sulfides to produce the β-mercapto carboxylic acids. Particularly, it is more preferable to carry out the reaction at a pH range of 6.0 to 8.5: (In the formula (1), R1 represents any one of a hydrogen atom, an alkoxy group having 1 to 5 carbon atoms, an alkyl group having 1 to 5 carbon atoms, an amino group, and an alkylamino group having 1 to 5 carbon atoms; R2 and R3 each represents independently any one of a hydrogen atom and an alkyl group having 1 to 5 carbon atoms; when both R2 and R3 are not a hydrogen atom, R2 and R3 may together form a ring structure through an alkylene group; and when both R1 and R2 are not a hydrogen atom, R1 and R2 may form a ring structure through an alkylene group).
    • 本发明的一个目的是提供一种工业上生产和/或巯基羧酸的方法,其可用作药物和农用化学品的合成原料或作为高分子化合物的添加剂,其易于获得的α,β-不饱和羧酸在高 产量和生产力。 本发明的特征在于,当α,bgr-不饱和羧酸与硫化氢反应以制备β-巯基羧酸时,使用具有酰胺基并由式(1)表示的溶剂。 特别优选在6.0〜8.5的pH范围进行反应(式(1)中,R 1表示氢原子,碳原子数1〜5的烷氧基,烷基 具有1至5个碳原子,氨基和具有1至5个碳原子的烷基氨基; R 2和R 3各自独立地表示氢原子和具有1至5个碳原子的烷基中的任一个;当R 2和R 3均为 不是氢原子,R2和R3可以一起通过亚烷基形成环结构;当R1和R2都不是氢原子时,R1和R2可以通过亚烷基形成环结构)。
    • 18. 发明申请
    • Graft-Versus-Host Disease Predicting Marker and Use Thereof
    • 移植物抗宿主病预测标记及其用途
    • US20090186017A1
    • 2009-07-23
    • US12296345
    • 2007-04-05
    • Akira ShibuyaHiroshi Kojima
    • Akira ShibuyaHiroshi Kojima
    • A61K39/395C12Q1/02G01N33/53
    • G01N33/573A61K39/3955A61K2039/505C07K16/2803G01N2333/91245G01N2800/245
    • A test method that provides data useful in predicting the probability of onset of acute graft-versus-host disease (GVHD) is described along with a kit for performing the method, and a pharmaceutical preparation and a molecular targeted therapy for treating or preventing GVHD. The test method includes measuring the blood DNAM-1 concentration of a patient of hematopoietic stem cell transplantation from bone marrow or the like over a period after the transplantation to provide data concerning the transition of the concentration to an abnormally high level deviating from the normal range, whereby the probability of the development of acute graft-versus-host disease is predicted, the risk of the development is estimated, or therapeutic effects after the development are evaluated. Concerning the molecular targeted therapy and pharmaceutical preparation used therefor wherein blood DNAM-1 of a GVHD patient or a graft recipient that is a possible patient is used as a target molecule, GVHD is treated or prevented by administering an anti-DNAM-1 antibody that is a neutralizing antibody.
    • 描述了提供用于预测急性移植物抗宿主病(GVHD)发病概率的数据的测试方法以及用于进行该方法的试剂盒以及用于治疗或预防GVHD的药物制剂和分子靶向治疗。 测试方法包括在移植后的一段时间内测量来自骨髓等的造血干细胞移植患者的血液DNAM-1浓度,以提供关于浓度向偏离正常范围的异常高水平转变的数据 预测急性移植物抗宿主病发展的可能性,估计发展的风险,或发展后的治疗效果。 关于其中使用的分子靶向治疗和药物制剂,其中GVHD患者的血液DNAM-1或作为可能患者的移植物接受体用作靶分子,通过施用抗-DNAM-1抗体来治疗或预防GVHD, 是中和抗体。
    • 20. 发明授权
    • Halftone image device and its driving circuit
    • 半色调图像设备及其驱动电路
    • US5541542A
    • 1996-07-30
    • US420308
    • 1995-04-11
    • Akira ShibuyaHiroyuki KadowakiTomohiro ShinboMasayuki Iijima
    • Akira ShibuyaHiroyuki KadowakiTomohiro ShinboMasayuki Iijima
    • H04N1/40H03K3/017
    • H04N1/40043H04N1/40056H04N1/40081
    • The invention makes it possible to drive a halftone image device and achieve high halftone reproduction by allowing at least one of the leading and trailing edges of a pulse width-modulated signal applied to a recording head, or forming amplitude- and width-modulated pulses, respectively, as driving pulses for placing one dot under halftone control, and changing a pulse width change of pulse width modulation in a stepwise manner, using the pulse width of the amplitude-modulated pulse as a unit pulse width. The invention intends to achieve high-voltage and high-speed pulse output and low power consumption by converting input data such as halftone image data to a voltage signal, superposing pulse voltages of opposite polarities and applying the resulting signal to a switching circuit constituting an output state in the form of a switching signal, and also makes it possible to achieve high speed and high-voltage driving by connecting at least one of equivalent two-terminal elements in series to at least one of the respective driving elements of a complementary FET driving circuit, said equivalent two-terminal elements are each put on with a current of a certain or higher value passing therethrough to show constant-voltage characteristics and put off with a current of a certain or lower value passing therethrough to become a constant resistance.
    • 本发明通过允许施加到记录头的脉冲宽度调制信号的前沿和后沿中的至少一个或形成幅度和宽度调制脉冲,驱动半色调图像装置并实现高半色调再现, 分别作为用于在半色调控制下放置一个点的驱动脉冲,并且使用幅度调制脉冲的脉冲宽度来逐步改变脉宽调制的脉冲宽度变化。 本发明旨在通过将诸如半色调图像数据的输入数据转换为电压信号来实现高电压和高速脉冲输出以及低功耗,从而叠加具有相反极性的脉冲电压,并将所得到的信号施加到构成输出的开关电路 状态,并且还可以通过将等效的两端元件中的至少一个串联连接到互补FET驱动的各个驱动元件中的至少一个而实现高速和高电压驱动 电路中,所述等效的两端子元件各自具有通过其中的一定或更高值的电流以显示恒定电压特性,并且通过其中通过的一定或更低值的电流变为恒定电阻。