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11. 发明申请

US20220339250A1 HLA-B57 OPEN CONFORMERS 有权
公开(公告)号：US20220339250A1
公开(公告)日：2022-10-27
申请号：US17849643
申请日：2022-06-26
申请人： UNIVERSITAT ZURICH , UNIVERSITAT BASEL
发明人： Osiris MARROQUIN BELAUNZARAN , Ulf PETRAUSCH , Christoph RENNER
IPC分类号： A61K38/17 , C07K14/74 , A61P37/02 , A61P35/00
摘要： The invention relates to a HLA-B57 open conformer or a HLA-B57 Fc fusion protein for use in the treatment or prevention of cancer. The Fc open conformer comprises or consists of a first and a second monomer, and each monomer comprises a HLA-B57 chain. The Fc fusion protein further comprises a protein stabilizing polypeptide sequence and optionally an amino acid linker. Further aspects of the invention provide combination medicaments comprising the HLA-B57 Fc open conformer and immune checkpoint inhibitors and/or checkpoint agonist agents. Furthermore, the invention relates to the use of HLA-B57 open conformer as an immunomodulator, particularly in diseases where modulation of diverse immune cell components (e.g. cytotoxic CD8+T cells, Tregs) is a therapeutic strategy, e.g. infectious diseases.

12. 发明授权

US11279747B2 MHC class Ia fusion dimers for treatment of cancer 有权
公开(公告)号：US11279747B2
公开(公告)日：2022-03-22
申请号：US16323902
申请日：2017-08-09
申请人： UNIVERSITAT ZURICH , UNIVERSITAT BASEL
发明人： Osiris Marroquin Belaunzaran , Christoph Renner
IPC分类号： C07K14/74 , A61K39/395 , A61K48/00 , A61P31/22 , A61P31/18 , A61P31/16 , A61P35/00
摘要： The invention relates to MHC-Ia open conformers as immunomodulatory agents, particularly in the treatment or prevention of cancer. The open conformer comprises or consists of a first and a second monomer, and each monomer comprises a HLA-heavy chain from the MHC-Ia molecules. The open conformer further comprises a protein stabilizing polypeptide sequence and optionally an amino acid linker. Further aspects of the invention provide combination medicaments comprising the MHC-Ia open conformers and immune checkpoint inhibitors.
Furthermore, the invention relates to the use of MHC-Ia open conformers as immunomodulators, particularly in diseases where the interaction to diverse immunoregulatory receptors such as KIR3DL1, KIR3DL2, KIR3DL3, LILRB1, LILRB2, and PTPRJ modulates an immune response, and in diseases were the negative modulation of Tregs is a therapeutic strategy, e.g. infectious diseases.

13. 发明申请

US20190247466A1 HLA-B57 OPEN CONFORMERS 审中-公开
公开(公告)号：US20190247466A1
公开(公告)日：2019-08-15
申请号：US16083508
申请日：2017-03-07
申请人： UNIVERSITAT ZURICH , UNIVERSITAT BASEL
发明人： Osiris MARROQUIN BELAUNZARAN , Ulf PETRAUSCH , Christoph RENNER
IPC分类号： A61K38/17 , A61P37/02 , A61P35/00
CPC分类号： A61K38/1774 , A61P35/00 , A61P37/02 , C07K14/70539 , C07K2319/30
摘要： The invention relates to a HLA-B57 open conformer or a HLA-B57 Fc fusion protein for use in the treatment or prevention of cancer. The Fc open conformer comprises or consists of a first and a second monomer, and each monomer comprises a HLA-B57 chain. The Fc fusion protein further comprises a protein stabilizing polypeptide sequence and optionally an amino acid linker. Further aspects of the invention provide combination medicaments comprising the HLA-B57 Fc open conformer and immune checkpoint inhibitors and/or checkpoint agonist agents.Furthermore, the invention relates to the use of HLA-B57 open conformer as an immunomodulator, particularly in diseases where modulation of diverse immune cell components (e.g. cytotoxic CD8+ T cells, Tregs) is a therapeutic strategy, e.g. infectious diseases.

14. 发明申请

US20180369148A1 ABUSE DETERRENT PHARMACEUTICAL DOSAGE FORMS 审中-公开
公开(公告)号：US20180369148A1
公开(公告)日：2018-12-27
申请号：US16062122
申请日：2016-12-16
申请人： UNIVERSITAT BASEL
发明人： Jorg HUWYLER , Maxim PUCHKOV
IPC分类号： A61K9/20 , A61K31/485 , A61P25/22 , A61P25/18 , A61P25/04 , A61P25/20 , A61P3/04
摘要： The present invention relates to solid oral pharmaceutical dosage forms that provide extended release of active ingredients and have abuse deterrent properties and the methods of making the same. More particularly, the present invention relates to solid oral extended release abuse deterrent dosage forms comprising at least one polycaprolactone (PCL) and at least one gelling agent.

15. 发明授权

US09500670B2 Method and device for controlling a scanning probe microscope 有权
标题翻译：用于控制扫描探针显微镜的方法和装置
公开(公告)号：US09500670B2
公开(公告)日：2016-11-22
申请号：US14651233
申请日：2013-12-12
申请人： UNIVERSITAT BASEL
发明人： Roderick Lim , Marija Plodinec , Marko Loparic , Pascal Oehler , Leon Camenzind
IPC分类号： B82Y35/00 , G01Q40/00 , G01Q30/06 , G01Q20/00 , G01Q10/06 , G01Q10/00
CPC分类号： G01Q20/00 , G01Q10/00 , G01Q10/065 , G01Q30/06
摘要： The present invention relates to a method for controlling a scanning probe microscope having a probe (2) with a tip (21) for interacting with a sample (4), and a nanoscanner (1) for retaining the sample (4) or the probe (2), comprising the steps of monitoring the extension of the piezo element (1) along a first direction (R) along which the tip (21) is moved towards the sample (4), and adjusting the level of the probe (2) along the first direction (R) by means of an additional actuator (3), when the nanoscanner (1) exhibits an extension below or above a threshold value. The invention further relates to a device (100) for controlling a scanning probe microscope.
摘要翻译：本发明涉及一种用于控制扫描探针显微镜的方法，所述扫描探针显微镜具有带有用于与样品（4）相互作用的尖端（21）的探针（2）和用于保持样品（4）或探针（2），包括以下步骤：沿尖端（21）朝向样品（4）移动的第一方向（R）监测压电元件（1）的延伸，并且调节探针（2）的水平）当所述纳米扫描仪（1）展现出低于或高于阈值的延伸时，通过附加致动器（3）沿所述第一方向（R）。本发明还涉及一种用于控制扫描探针显微镜的装置（100）。

16. 发明授权

US07560070B1 Cantilever sensors and transducers 有权
标题翻译：悬臂传感器和传感器
公开(公告)号：US07560070B1
公开(公告)日：2009-07-14
申请号：US10129254
申请日：2000-10-16
申请人： Marko K. Baller , Juergen Fritz , Christoph Gerber , James Gimzewski , Hans Peter Lang
发明人： Marko K. Baller , Juergen Fritz , Christoph Gerber , James Gimzewski , Hans Peter Lang
IPC分类号： G01N33/00
CPC分类号： G01N33/54373 , Y10T436/11
摘要： Sensor system (70) for detecting a target substance in a reference liquid, comprising a measurement cantilever (71) being functionalized by application of a first coating to one of the measurement cantilever's surfaces, whereby this first coating is sensitive to the target substance. In addition, the system (70) comprises a reference cantilever (72) with a reference coating on one of the reference cantilever's surfaces, whereby this reference coating is less sensitive to the target substance than the first coating. Both cantilevers are arranged such that they can be exposed in a reference step to the reference liquid and in a detection step to the reference liquid with the target substance. A detector unit (73, 74, 83) is employed for determining the difference in the deflection of the measurement cantilever (71) and the reference cantilever (72) during the reference step and the detection step.
摘要翻译：用于检测参考液体中的目标物质的传感器系统（70），包括通过向测量悬臂表面之一施加第一涂层而被功能化的测量悬臂（71），由此该第一涂层对目标物质敏感。此外，系统（70）包括在参考悬臂表面之一上具有参考涂层的参考悬臂（72），由此该参考涂层比第一涂层对目标物质的敏感性较低。两个悬臂布置成使得它们可以在参考步骤中暴露于参考液体，并且在用目标物质进行参考液体的检测步骤中。采用检测器单元（73,74,83）来确定参考步骤和检测步骤期间测量悬臂（71）和参考悬臂（72）的偏转差。

17. 发明申请

US20190250078A1 LOSSLESS CRYO-GRID PREPARATION BY CONTROLLED SAMPLE EVAPORATION 审中-公开
公开(公告)号：US20190250078A1
公开(公告)日：2019-08-15
申请号：US16342529
申请日：2017-10-17
申请人： UNIVERSITAT BASEL
发明人： Thomas BRAUN , Stefan ARNOLD , Henning STAHLBERG
IPC分类号： G01N1/28 , G01N1/42 , G01N1/44
CPC分类号： G01N1/2813 , G01N1/42 , G01N1/44
摘要： Method for preparing a sample, wherein the sample is provided as a thin film on a support structure; the temperature of the support structure is adjusted to a value above the dew point temperature of the environment to decrease the film thickness, light is directed at the support structure, an intensity value of the transmitted light is measured, and the support structure is automatically inserted into a liquid cryogen dependent on the measured intensity value. The application further relates to a system comprising a support structure, a temperature-controlled stage for keeping the support structure at a pre-defined temperature, a transfer mechanism for moving the support structure into a container containing a liquid cryogen, a light source, a photodetector for measuring an intensity value of the transmitted light, and a control device for triggering the transfer mechanism dependent on the measured intensity value.

18. 发明申请

US20190169263A1 MHC CLASS IA OPEN CONFORMERS 审中-公开
公开(公告)号：US20190169263A1
公开(公告)日：2019-06-06
申请号：US16323902
申请日：2017-08-09
申请人： UNIVERSITAT ZURICH , UNIVERSITAT BASEL
发明人： Osiris MARROQUIN BELAUNZARAN , Christoph RENNER
IPC分类号： C07K14/74 , A61P35/00 , A61P31/18 , A61P31/22 , A61P31/16
摘要： The invention relates to MHC-Ia open conformers as immunomodulatory agents, particularly in the treatment or prevention of cancer. The open conformer comprises or consists of a first and a second monomer, and each monomer comprises a HLA-heavy chain from the MHC-Ia molecules. The open conformer further comprises a protein stabilizing polypeptide sequence and optionally an amino acid linker. Further aspects of the invention provide combination medicaments comprising the MHC-Ia open conformers and immune checkpoint inhibitors.Furthermore, the invention relates to the use of MHC-Ia open conformers as immunomodulators, particularly in diseases where the interaction to diverse immunoregulatory receptors such as KIR3DL1, KIR3DL2, KIR3DL3, LILRB1, LILRB2, and PTPRJ modulates an immune response, and in diseases were the negative modulation of Tregs is a therapeutic strategy, e.g. infectious diseases.

19. 发明授权

US07129081B2 Apparatus and method for detecting microorganisms 失效
公开(公告)号：US07129081B2
公开(公告)日：2006-10-31
申请号：US10375712
申请日：2003-02-26
申请人： Urs Christian Hubler , Felice Mauro Battiston , Bianca Antje Hermann
发明人： Urs Christian Hubler , Felice Mauro Battiston , Bianca Antje Hermann
IPC分类号： C12M1/34
CPC分类号： G01N29/036 , C12Q1/02 , C12Q1/04 , G01N2291/0257
摘要： The present invention relates to the fast detection of microorganisms, i.e. of bacteria, fungi, cells and other organisms, making use of methods and apparatuses coming from nanotechnology. According to the present invention, such organisms are detected using micromechanical sensor means known from many physical and chemical applications. One or more micromechanical cantilever sensors are either coated with a nutritive medium or at least partially built from a nutritive medium. By depositing a microorganism on the cantilever surface, preferably in a targeted way and in a controlled dosage, a “biological reaction” is started. This reaction results in a change of the mechanical and/or electrical properties of the sensor, i.e. the cantilever. These changes are determined, preferably at certain points in time, and thus allow the detection and detailed observation of the applied microorganism.

20. 发明授权

US11484572B2 Use of HLA-B27 homodimers for cancer treatment 有权
公开(公告)号：US11484572B2
公开(公告)日：2022-11-01
申请号：US15668705
申请日：2017-08-04
申请人： UNIVERSITAT ZURICH , UNIVERSITAT BASEL
发明人： Osiris Marroquin Belaunzaran , Christoph Renner , Ulf Petrausch
IPC分类号： A61K38/17 , A61K48/00 , A61K39/00 , A61K39/395 , C07K16/28 , A61K45/06 , C07K14/74 , C07K16/00
摘要： The invention relates to a HLA-B27 Fc open conformer or a HLA-B27 Fc fusion protein for use in the treatment or prevention of cancer. The Fc open conformer comprises or consists of a first and a second monomer, and each monomer comprises a HLA-B27 chain. The Fc fusion protein further comprises a protein stabilizing polypeptide sequence and optionally an amino acid linker. Further aspects of the invention provide combination medicaments comprising the HLA-B27 Fc open conformer and immune checkpoint inhibitors.

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