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11. 发明申请

US20110200588A1 METHODS FOR GENETIC ANALYSIS 审中-公开
标题翻译：遗传分析方法
公开(公告)号：US20110200588A1
公开(公告)日：2011-08-18
申请号：US13094903
申请日：2011-04-27
申请人： David R. Cox , Mark A. McCamish
发明人： David R. Cox , Mark A. McCamish
IPC分类号： A61K39/395 , A61K31/7088 , C12Q1/68 , A61P43/00
CPC分类号： G16B20/00 , C12Q1/6883 , C12Q2600/106 , C12Q2600/118 , C12Q2600/156 , C12Q2600/16 , G06F19/34 , G16H50/20
摘要： Methods of treating an individual exhibiting a medical condition are disclosed. The methods involve determining a score of an individual based on the individual's genotypic information, comparing the score to at least one threshold value, wherein the result of the comparison is indicative of a beneficial response to a treatment, and providing a suitable treatment to the individual.
摘要翻译：公开了治疗呈现医疗状况的个体的方法。所述方法包括基于个人的基因型信息来确定个体的得分，将得分与至少一个阈值进行比较，其中比较结果指示对治疗的有益应答，并为个体提供适当的治疗。

12. 发明申请

US20090087854A1 METHODS FOR GENETIC ANALYSIS 审中-公开
标题翻译：遗传分析方法
公开(公告)号：US20090087854A1
公开(公告)日：2009-04-02
申请号：US12236036
申请日：2008-09-23
申请人： David R. Cox , Mark A. McCamish
发明人： David R. Cox , Mark A. McCamish
IPC分类号： C12Q1/68 , G06F19/00
CPC分类号： G16B20/00 , C12Q1/6883 , C12Q2600/106 , C12Q2600/118 , C12Q2600/156 , C12Q2600/16 , G06F19/34 , G16H50/20
摘要： Methods of treating an individual exhibiting a medical condition are disclosed. The methods involve determining a score of an individual based on the individual's genotypic information, comparing the score to at least one threshold value, wherein the result of the comparison is indicative of a beneficial response to a treatment, and providing a suitable treatment to the individual.
摘要翻译：公开了治疗呈现医疗状况的个体的方法。所述方法包括基于个人的基因型信息来确定个体的得分，将得分与至少一个阈值进行比较，其中比较结果指示对治疗的有益反应，并且向个体提供适当的治疗。

13. 发明申请

US20080280955A1 Methods and compositions for screening and treatment of disorders of blood glucose regulation 审中-公开
标题翻译：用于筛选和治疗血糖调节障碍的方法和组合物
公开(公告)号：US20080280955A1
公开(公告)日：2008-11-13
申请号：US11541495
申请日：2006-09-29
申请人： Mark A. McCamish
发明人： Mark A. McCamish
IPC分类号： A61K31/4436 , C12Q1/68 , C07H21/04 , C07K2/00
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172
摘要： In one aspect, the invention provides a method of screening and, optionally, treatment of an individual suffering from an insulin resistance disorder by screening an individual in need of treatment for an insulin resistance disorder for one or more genetic variations indicating a predisposition to a response to an insulin sensitizer; and, optionally, administering or not administering an insulin sensitizer to the individual based on the results of the screening. The insulin sensitizer for which the individual is screened and the insulin sensitizer that is administered or not administered may be the same or different. In another aspect, the invention provides methods comprising identifying one or more genetic variations, e.g., one or more single nucleotide polymorphisms, that at least partly differentiate between a subset of a plurality of individuals who experience a response when administered an insulin sensitizer, and a subset of said plurality of individuals who do not experience a response when administered the insulin sensitizer. The invention also provides nucleic acids, polypeptides, antibodies, kits, and business methods associated with these screening and association methods.
摘要翻译：在一个方面，本发明提供了筛选和任选地治疗患有胰岛素抵抗障碍的个体的方法，其通过筛选需要治疗胰岛素抵抗障碍的个体对一种或多种指示反应倾向的遗传变异胰岛素敏化剂; 以及任选地，基于筛选结果向个体施用或不施用胰岛素敏化剂。筛选个体的胰岛素敏化剂和施用或未施用的胰岛素敏化剂可以相同或不同。在另一方面，本发明提供了包括鉴定一种或多种遗传变异（例如，一种或多种单核苷酸多态性）的方法，其在施用胰岛素敏化剂时经历响应的多个个体的亚组中的至少一部分区别，以及在施用胰岛素敏化剂时不经历反应的所述多个个体的子集。本发明还提供与这些筛选和结合方法相关联的核酸，多肽，抗体，试剂盒和商业方法。

14. 发明申请

US20070258898A1 MARKERS FOR ADDICTION 有权
标题翻译：添加标记
公开(公告)号：US20070258898A1
公开(公告)日：2007-11-08
申请号：US11681177
申请日：2007-03-01
申请人： Dennis Ballinger , Karel Konvicka , Laura Bierut , John Rice , Frank Saccone , Anthony Hinrichs , Alison Goate , Jen Wang
发明人： Dennis Ballinger , Karel Konvicka , Laura Bierut , John Rice , Frank Saccone , Anthony Hinrichs , Alison Goate , Jen Wang
IPC分类号： C12Q1/68 , A61K49/00 , G01N33/48
CPC分类号： C12Q1/6883 , A61K49/0004 , C12Q2600/112 , C12Q2600/136 , C12Q2600/156 , C12Q2600/172 , G01N33/5088 , G01N33/6893 , G01N2500/00
摘要： Correlations between polymorphisms and addiction are provided. Methods of diagnosing, prognosing, and treating addiction are provided. Systems and kits for diagnosis, prognosis and treatment of addiction are provided. Methods of identifying addiction modulators are also described.
摘要翻译：提供多态性与成瘾之间的相关性。提供诊断，预后和治疗成瘾的方法。提供了用于诊断，预后和治疗成瘾的系统和试剂盒。还描述了识别成瘾调节剂的方法。

15. 发明授权

US07135286B2 Pharmaceutical and diagnostic business systems and methods 有权
公开(公告)号：US07135286B2
公开(公告)日：2006-11-14
申请号：US10107508
申请日：2002-03-26
申请人： Bradley A. Margus , David R. Cox , Stephen P. A. Fodor
发明人： Bradley A. Margus , David R. Cox , Stephen P. A. Fodor
IPC分类号： C12Q1/68
CPC分类号： G06F19/18 , G06Q50/22 , G06Q50/24 , G06Q99/00 , Y02A90/22
摘要： Improved pharmaceutical and diagnostic business systems and methods are disclosed. One or more genomes are scanned for single nucleotide polymorphisms. The polymorphisms are assigned to haplotype blocks, and representative SNPs from the haplotype blocks are used in association studies for pharmaceutical and diagnostic development.

16. 发明授权

US07124033B2 Method for identifying matched groups 有权
标题翻译：识别匹配组的方法
公开(公告)号：US07124033B2
公开(公告)日：2006-10-17
申请号：US10427696
申请日：2003-04-30
申请人： David Hinds , Renee Stokowski
发明人： David Hinds , Renee Stokowski
IPC分类号： G01N33/48 , G06G7/48 , C12Q1/00
CPC分类号： G06F19/18 , C12Q1/6827 , G06F19/24 , C12Q2565/501
摘要： Methods, code, and apparatus are used to ensure that groups of experimental subjects selected for inclusion in a study are matched. Individuals are genotyped and the genotype data is used to determine the extent of mismatch between study groups. If groups show evidence of poor matching, then the genotype data is used to better match the study groups.
摘要翻译：方法，代码和设备用于确保选择纳入研究的实验对象组相匹配。将个体进行基因分型，并使用基因型数据来确定研究组之间的错配程度。如果组显示不良匹配的证据，则使用基因型数据来更好地匹配研究组。

17. 发明授权

US06898531B2 Algorithms for selection of primer pairs 失效
标题翻译：用于选择引物对的算法
公开(公告)号：US06898531B2
公开(公告)日：2005-05-24
申请号：US10042406
申请日：2002-01-09
申请人： John B. Sheehan , Daryl J. Thomas , Wade A. Barrett
发明人： John B. Sheehan , Daryl J. Thomas , Wade A. Barrett
IPC分类号： C12Q1/68 , G01N33/48 , G06F19/00
CPC分类号： C12Q1/6806 , C12Q1/686
摘要： The presently claimed invention provides methods for amplifying a DNA target sequence. One embodiment of the present invention provides robust methods for amplification of target sequences. In a first aspect of the invention, a method for designing primer pairs for the amplification reaction is provided. In a further aspect of the invention, reagents and cycling parameters for the amplification reaction are provided.
摘要翻译：本发明提供的扩增DNA靶序列的方法。本发明的一个实施方案提供用于扩增靶序列的鲁棒方法。在本发明的第一方面，提供了一种设计用于扩增反应的引物对的方法。在本发明的另一方面，提供了用于扩增反应的试剂和循环参数。

18. 发明申请

US20050100911A1 Methods for enriching populations of nucleic acid samples 审中-公开
标题翻译：富集核酸样品群体的方法
公开(公告)号：US20050100911A1
公开(公告)日：2005-05-12
申请号：US10635175
申请日：2003-08-06
申请人： Nila Patil , David Cox , Charit Pethiyagoda , Andrew Sparks , Huang-Tsu Chen
发明人： Nila Patil , David Cox , Charit Pethiyagoda , Andrew Sparks , Huang-Tsu Chen
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6806 , C12Q1/6855 , C12Q2531/113 , C12Q2565/501 , C12Q2521/313 , C12Q2525/191 , C12Q2525/313 , C12Q2533/101
摘要： The invention provides several methods for reducing the complexity of a population of nucleic acids prior to performing an analysis of the nucleic acids on a nucleic acid probe array. The methods result in a subset of the initial population enriched for a desired property, or lacking nucleic acids having an undesired properly. The resulting nucleic acids in the subset are then applied to the array for various types of analysis. The methods are particularly useful for analyzing populations having a high decree of complexity, for example, chromosomal-derived DNA, or whole genomic DNA, or mRNA population. In addition, such methods allow for analysis of pooled samples.
摘要翻译：本发明提供了在对核酸探针阵列上的核酸进行分析之前降低核酸群体的复杂性的几种方法。该方法导致富集所需性质的初始群体的子集，或缺少具有不理想的核酸。然后将该子集中得到的核酸应用于阵列进行各种类型的分析。该方法对于分析具有高复杂度的群体特别有用，例如染色体衍生的DNA或全基因组DNA或mRNA群体。此外，这种方法允许对合并的样品进行分析。

19. 发明申请

US20050019787A1 Apparatus and methods for analyzing and characterizing nucleic acid sequences 审中-公开
标题翻译：用于分析和表征核酸序列的装置和方法
公开(公告)号：US20050019787A1
公开(公告)日：2005-01-27
申请号：US10768788
申请日：2004-01-30
申请人： Anthony Berno , Karel Konvicka , David Hinds , Nila Patil , Naiping Shen , David Stern , John Sheehan
发明人： Anthony Berno , Karel Konvicka , David Hinds , Nila Patil , Naiping Shen , David Stern , John Sheehan
IPC分类号： C12Q1/68 , G01N33/48 , G01N33/50 , G06F20060101 , G06F19/00
CPC分类号： G16B20/00 , G16B25/00 , G16B40/00
摘要： Computer-implemented methods, data processing apparatus and computer program codes for characterizing an interrogation position, such as a SNP position, in a nucleic acid sequence are provided herein. Computer-implemented methods involving various statistical analyses are provided for characterizing an interrogation position as being associated with a phenotypic trait of interest.
摘要翻译：本文提供了用于表征核酸序列中的询问位置（例如SNP位置）的计算机实现的方法，数据处理设备和计算机程序代码。提供涉及各种统计分析的计算机实现的方法，用于将询问位置表征为与感兴趣的表型性状相关联。

20. 发明申请

US20040229224A1 Allele-specific expression patterns 审中-公开
标题翻译：等位基因特异性表达模式
公开(公告)号：US20040229224A1
公开(公告)日：2004-11-18
申请号：US10438184
申请日：2003-05-13
申请人： Perlegen Sciences, Inc.
发明人： Kelly A. Frazer , David R. Cox , Heng Tao , Krishna Pant , Geoffrey Nilsen
IPC分类号： C12Q001/68
CPC分类号： C12Q1/6809 , C12Q1/6827 , C12Q2531/113 , C12Q2565/501
摘要： The invention provides methods of analyzing genes for differential relative allelic expression patterns. Haplotype blocks throughout the genomes of individuals are analyzed to identify haplotype patterns that are associated with specific differential relative allelic expression patterns. Haplotype blocks that contain associated haplotype patterns may be further investigated to identify genes or variants of genes involved in differential relative allelic expression patterns.
摘要翻译：本发明提供了分析差异相对等位基因表达模式的基因的方法。分析个体基因组中的单倍型区域，以鉴定与特异性差异相对等位基因表达模式相关联的单倍型模式。可以进一步研究包含相关单体型模式的单倍型区域，以鉴定参与差异相对等位基因表达模式的基因的基因或变体。

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