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11. 发明申请

US20020164330A1 Novel molecules of the tango-77 related protein family and uses thereof 审中-公开
标题翻译：探戈-77相关蛋白家族的新分子及其用途
公开(公告)号：US20020164330A1
公开(公告)日：2002-11-07
申请号：US10095407
申请日：2002-03-11
申请人： Millennium BioTherapeutics, Inc.
发明人： Yang Pan
IPC分类号： A61K039/395 , C07H021/04 , C07K014/705 , C12P021/02 , C12N005/06
CPC分类号： C12N15/1136 , A61K38/00 , C07K14/52 , C07K2319/00 , G01N2333/54
摘要： Novel Tango-77 polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length Tango-77 proteins, the invention further provides isolated Tango-77 fusion proteins, antigenic peptides and anti-Tango-77 antibodies. The invention also provides Tango-77 nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which a Tango-77 gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译：公开了新型Tango-77多肽，蛋白质和核酸分子。除了分离的全长探戈-77蛋白之外，本发明还提供了分离的Tango-77融合蛋白，抗原肽和抗Tango-77抗体。本发明还提供了Tango-77核酸分子，含有本发明的核酸分子的重组表达载体，已经引入了表达载体的宿主细胞和其中引入了Tango-77基因的非人转基因动物，或中断了还提供利用本发明组合物的诊断，筛选和治疗方法。

12. 发明授权

US6074841A Don-1 gene and polypeptides and uses therefor 失效
公开(公告)号：US6074841A
公开(公告)日：2000-06-13
申请号：US753007
申请日：1996-11-19
申请人： David P. Gearing , Samantha J. Busfield
发明人： David P. Gearing , Samantha J. Busfield
IPC分类号： G01N33/53 , A61K31/7088 , A61K38/00 , A61K39/395 , A61K48/00 , A61P35/00 , A61P43/00 , C07K14/475 , C07K14/485 , C07K16/22 , C12N5/10 , C12N15/09 , C12N15/12 , C12Q1/68 , G01N33/68
CPC分类号： C07K14/485 , G01N33/6872 , A61K38/00 , C07K2319/00
摘要： The present invention relates to the identification and characterization of a novel gene called don-1 related to epidermal growth factors (EGF) such as the neuregulins, and methods of preparing and using alternate splice forms of this gene to express new Don-1 polypeptides.

13. 发明授权

US5952171A Method for identifying genes encoding secreted or membrane-associated proteins 失效
标题翻译：用于鉴定编码分泌或膜相关蛋白的基因的方法
公开(公告)号：US5952171A
公开(公告)日：1999-09-14
申请号：US752307
申请日：1996-11-19
申请人： Sean Anthony McCarthy , David Paul Gearing , Douglas Adam Levinson
发明人： Sean Anthony McCarthy , David Paul Gearing , Douglas Adam Levinson
IPC分类号： C12N15/10 , C12N15/85 , C12Q1/68
CPC分类号： C12Q1/6811 , C12N15/1034 , C12N15/1051 , C12N15/85 , C12N2800/60 , C12N2830/38
摘要： The invention features a method for identifying a cDNA nucleic acid encoding a mammalian protein having a signal sequence, which method includes the following steps: (a) providing library of mammalian cDNA; (b) ligating the library of mammalian cDNA to DNA encoding alkaline phosphatase lacking both a signal sequence and a membrane anchor sequence to form ligated DNA; (c) transforming bacterial cells with the ligated DNA to create a bacterial cell clone library; (d) isolating DNA comprising the mammalian cDNA from at least one clone in the bacterial cell clone library; (e) separately transfecting DNA isolated from clones in step (d) into mammalian cells which do not express alkaline phosphatase to create a mammalian cell clone library wherein each clone in the mammalian cell clone library corresponds to a clone in the bacterial cell clone library; (f) identifying a clone in the mammalian cell clone library which express alkaline phosphatase; (g) identifying the clone in the bacterial cell clone library corresponding to the clone in the mammalian cell clone library identified in step (f); and (h) isolating and sequencing a portion of the mammalian cDNA present in the bacterial cell library clone identified in step (g) to identify a mammalian cDNA encoding a mammalian protein having a signal sequence.
摘要翻译：本发明的特征在于鉴定编码具有信号序列的哺乳动物蛋白质的cDNA核酸的方法，该方法包括以下步骤：（a）提供哺乳动物cDNA文库; （b）将哺乳动物cDNA文库与编码缺乏信号序列和膜锚定序列的碱性磷酸酶的DNA连接以形成连接的DNA; （c）用连接的DNA转化细菌细胞以产生细菌细胞克隆文库; （d）从细菌细胞克隆文库中的至少一个克隆分离包含哺乳动物cDNA的DNA; （e）将步骤（d）中从克隆分离的DNA分别转染到不表达碱性磷酸酶的哺乳动物细胞中以产生哺乳动物细胞克隆文库，其中哺乳动物细胞克隆文库中的每个克隆对应于细菌细胞克隆文库中的克隆; （f）鉴定表达碱性磷酸酶的哺乳动物细胞克隆文库中的克隆; （g）鉴定对应于步骤（f）中鉴定的哺乳动物细胞克隆文库中克隆的细菌细胞克隆文库中的克隆; 和（h）分离和测序存在于步骤（g）中鉴定的细菌细胞库克隆中的哺乳动物cDNA的一部分，以鉴定编码具有信号序列的哺乳动物蛋白质的哺乳动物cDNA。

14. 发明授权

US5942420A Molecules of the follistatin-related protein family and uses therefor 失效
标题翻译：卵泡抑素相关蛋白家族的分子及其用途
公开(公告)号：US5942420A
公开(公告)日：1999-08-24
申请号：US972008
申请日：1997-11-17
申请人： Douglas A. Holtzman
发明人： Douglas A. Holtzman
IPC分类号： A61K38/00 , C07K14/47 , C07K16/18 , C12P21/06 , C07H21/02 , C07H21/04 , C12N15/00
CPC分类号： C07K16/18 , C07K14/4703 , A01K2217/05 , A61K38/00 , C07K2319/00 , C07K2319/30
摘要： Novel FMCP polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length FMCP proteins, the invention further provides isolated FMCP fusion proteins, antigenic peptides and anti-FMCP antibodies. The invention also provides FMCP nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which a FMCP gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译：公开了新的FMCP多肽，蛋白质和核酸分子。除了分离的全长FMCP蛋白之外，本发明还提供了分离的FMCP融合蛋白，抗原肽和抗FMCP抗体。本发明还提供了FMCP核酸分子，含有本发明的核酸分子的重组表达载体，已经引入了表达载体的宿主细胞和其中FMCP基因被引入或破坏的非人转基因动物。还提供利用本发明组合物的诊断，筛选和治疗方法。

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