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11. 发明申请

US20070087995A1 beta-L-2'-Deoxy-Nucleosides for the Treatment of Hepatitis B 审中-公开
标题翻译： β-L-2'-Deoxy-Nucleosides用于治疗乙型肝炎
公开(公告)号：US20070087995A1
公开(公告)日：2007-04-19
申请号：US11558288
申请日：2006-11-09
申请人： Gilles Gosselin , Jean-Louis Imbach , Martin Bryant
发明人： Gilles Gosselin , Jean-Louis Imbach , Martin Bryant
IPC分类号： A61K31/7076 , A61K31/7072
CPC分类号： C07H19/16 , A61K31/70 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K31/708 , C07H19/06 , A61K2300/00
摘要： This invention is directed to a method for treating a host infected with hepatitis B comprising administering an effective amount of an anti-HBV biologically active 2′-deoxy-β-L-erythro-pentofuranonucleoside or a pharmaceutically acceptable salt or prodrug thereof, wherein the 2′-deoxy-β-L-erythro-pentofuranonucleoside has the formula: wherein R is selected from the group consisting of H, straight chained, branched or cyclic alkyl, CO-alkyl, CO-aryl, CO-alkoxyalkyl, CO-aryloxyalkyl, CO-substituted aryl, alkylsulfonyl, arylsulfonyl, aralkylsulfonyl, amino acid residue, mono, di, or triphosphate, or a phosphate derivative; and BASE is a purine or pyrimidine base which may be optionally substituted. The 2′-deoxy-β-L-erythro-pentofuranonucleoside or a pharmaceutically acceptable salt or prodrug thereof may be administered either alone or in combination with another 2′-deoxy-β-L-erythro-pentofuranonucleoside or in combination with another anti-hepatitis B agent.
摘要翻译：本发明涉及一种用于治疗感染乙型肝炎的宿主的方法，其包括施用有效量的抗HBV生物活性2'-脱氧-β-L-赤 - 戊呋喃核苷或其药学上可接受的盐或前药，其中 2'-脱氧-β-L-赤 - 戊呋喃核苷具有下式：其中R选自H，直链，支链或环状烷基，CO-烷基，CO-芳基，CO-烷氧基烷基，CO-芳氧基烷基烷基磺酰基，芳基磺酰基，芳烷基磺酰基，氨基酸残基，单，二或三磷酸酯，或磷酸酯衍生物; 并且BASE是嘌呤或嘧啶碱基，其可任选被取代。 2'-脱氧-β-L-赤 - 戊呋喃核苷或其药学上可接受的盐或前药可以单独或与其它2'-脱氧-β-L-赤 - 戊呋喃核苷组合或与另一种抗 - 乙型肝炎药。

12. 发明授权

US07192936B2 Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections 有权
标题翻译：用于治疗黄病毒科感染的改良的2'和3'-核苷前体药物
公开(公告)号：US07192936B2
公开(公告)日：2007-03-20
申请号：US11005473
申请日：2004-12-06
申请人： Paola LaColla , Richard Storer , Gilles Gosselin , Jean-Pierre Sommadossi
发明人： Paola LaColla , Richard Storer , Gilles Gosselin , Jean-Pierre Sommadossi
IPC分类号： A01N43/04 , A61K31/70 , C07H19/00 , C07H19/048
CPC分类号： C07H19/16 , A61K9/20 , A61K9/48 , A61K31/675 , A61K31/7056 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K31/708 , A61K38/21 , A61K38/212 , A61K45/06 , A61K47/60 , C07H19/00 , C07H19/04 , C07H19/048 , C07H19/056 , C07H19/06 , C07H19/22 , A61K2300/00
摘要： 2′ and/or 3′ prodrugs of 1′, 2′, 3′ or 4′-branchednucleosides, and their pharmaceutically acceptable salts and derivatives are described. These prodrugs are useful in the prevention and treatment of Flaviviridae infections, including HCV infection, and other related conditions. Compounds and compositions of the prodrugs of the present invention are described. Methods and uses are also provided that include the administration of an effective amount of the prodrugs of the present invention, or their pharmaceutically acceptable salts or derivatives. These drugs may optionally be administered in combination or alteration with further anti-viral agents to prevent or treat Flaviviridae infections and other related conditions.
摘要翻译：描述了1'，2'，3'或4'-支链核苷的2'和/或3'前药及其药学上可接受的盐和衍生物。这些前药可用于预防和治疗黄病毒科感染，包括HCV感染和其他相关病症。描述本发明前药的化合物和组合物。还提供了包括施用有效量的本发明前药或其药学上可接受的盐或衍生物的方法和用途。这些药物可以任选地与另外的抗病毒剂组合或改变来施用，以预防或治疗黄病毒科感染和其他相关病症。

13. 发明授权

US07163929B2 Methods and compositions for treating flaviviruses and pestiviruses 有权
标题翻译：用于治疗黄病毒和瘟病毒的方法和组合物
公开(公告)号：US07163929B2
公开(公告)日：2007-01-16
申请号：US10602135
申请日：2003-06-20
申请人： Jean-Pierre Sommadossi , Paulo LaColla
发明人： Jean-Pierre Sommadossi , Paulo LaColla
IPC分类号： A61K31/70 , C07H19/00
CPC分类号： A61K31/7072 , A61K31/7052 , A61K31/7056 , A61K31/7064 , A61K31/7076 , A61K38/21 , C07H19/06 , C07H19/073 , C07H19/10 , C07H19/16 , C07H19/20 , C07H19/23 , Y02A50/385 , Y02A50/387 , Y02A50/389
摘要： A method and composition for treating a host infected with flavivirus or pestivirus comprising administering an effective flavivirus or pestivirus treatment amount of a described 1′, 2′ or 3′-modified nucleoside or a pharmaceutically acceptable salt or prodrug thereof, is provided.
摘要翻译：提供用于治疗感染黄病毒或瘟病毒的宿主的方法和组合物，其包括施用有效的黄病毒或瘟病毒处理量的所述1'，2'或3'-修饰的核苷或其药学上可接受的盐或前药。

14. 发明授权

US07157441B2 Methods and compositions for treating hepatitis C virus 有权
公开(公告)号：US07157441B2
公开(公告)日：2007-01-02
申请号：US10602136
申请日：2003-06-20
申请人： Jean-Pierre Sommadossi , Paulo LaColla
发明人： Jean-Pierre Sommadossi , Paulo LaColla
IPC分类号： A01N43/04 , A61K31/70
CPC分类号： A61K31/708 , A61K31/7056 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K38/21 , A61K45/06 , C07H19/04 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , G03C1/0051
摘要： A method and composition for treating a host infected with hepatitis C comprising administering an effective hepatitis C treatment amount of a described 1′, 2′ or 3′-modified nucleoside or a pharmaceutically acceptable salt or prodrug thereof, is provided.

15. 发明申请

US20130315863A1 METHODS AND COMPOSITIONS FOR TREATING FLAVIVIRIDAE INFECTIONS 审中-公开
标题翻译：用于治疗感冒的方法和组合物
公开(公告)号：US20130315863A1
公开(公告)日：2013-11-28
申请号：US13956287
申请日：2013-07-31
申请人： Universita' degli Studi di Cagliari , Idenix Pharmaceuticals, Inc.
发明人： Jean-Pierre SOMMADOSSI , Paolo LaColla
IPC分类号： C07H19/10 , A61K31/7072 , A61K31/7064 , C07H19/06 , A61K31/7056 , A61K38/21
CPC分类号： A61K31/7072 , A61K31/7052 , A61K31/7056 , A61K31/7064 , A61K31/7076 , A61K38/21 , C07H19/06 , C07H19/073 , C07H19/10 , C07H19/16 , C07H19/20 , C07H19/23 , Y02A50/385 , Y02A50/387 , Y02A50/389
摘要： A method and composition for treating a host infected with flavivirus or pestivirus comprising administering an effective flavivirus or pestivirus treatment amount of a described 1′, 2′ or 3′-modified nucleoside or a pharmaceutically acceptable salt or prodrug thereof, is provided.
摘要翻译：提供用于治疗感染黄病毒或瘟病毒的宿主的方法和组合物，其包括施用有效的黄病毒或瘟病毒处理量的所述1'，2'或3'-修饰的核苷或其药学上可接受的盐或前药。

16. 发明申请

US20130217644A1 Pharmaceutical Compositions of 2'-C-Methyl-Guanosine, 5'-[2[(3-Hydroxy-2,2-Dimethyl-1-Oxopropyl)Thio]Ethyl N-(Phenylmethyl)Phosphoramidate] 审中-公开
标题翻译： 2'-C-甲基鸟苷，5' - [2 [（3-羟基-2,2-二甲基-1-氧代丙基）硫代]乙基N-（苯基甲基）氨基磷酸酯的药物组合物]
公开(公告)号：US20130217644A1
公开(公告)日：2013-08-22
申请号：US13763545
申请日：2013-02-08
申请人： IDENIX PHARMACEUTICALS, INC.
发明人： Benjamin Alexander MAYES , Adel M. MOUSSA , Rahela GASPARAC-KNEZIC , Alistair James STEWART , Robert Vincent TUOHY, III , Dana Elaine MOSESON
IPC分类号： A61K31/708
CPC分类号： A61K31/708 , A61K9/2009 , A61K9/2054 , A61K9/4866
摘要： Provided herein are pharmaceutical compositions, and in particular, oral pharmaceutical compositions, and methods of using these pharmaceutical compositions in the treatment of viral infections, including hepatitis C virus infections in hosts in need thereof. In certain embodiments, pharmaceutical compositions of 2′-C-methyl-guanosine, 5′-[2-[(3-hydroxy-2,2-dimethyl-1-oxopropyl)thio]ethyl N-(phenylmethyl)phosphoramidate] are provided which display remarkable efficacy and bioavailability for the treatment of, for example, HCV infection in a human.
摘要翻译：本文提供药物组合物，特别是口服药物组合物，以及使用这些药物组合物治疗病毒感染的方法，包括有需要的宿主中的丙型肝炎病毒感染。在某些实施方案中，提供了2'-C-甲基 - 鸟苷，5' - [2 - [（3-羟基-2,2-二甲基-1-氧代丙基）硫代]乙基N-（苯基甲基）氨基磷酸酯的药物组合物其显示用于治疗例如人的HCV感染的显着的功效和生物利用度。

17. 发明授权

US08507460B2 Substituted 3′,5′-cyclic phosphates of purine nucleotide compounds and pharmaceutical compositions for the treatment of viral infections 有权
标题翻译：嘌呤核苷酸化合物的3'，5'-环磷酸酯和用于治疗病毒感染的药物组合物
公开(公告)号：US08507460B2
公开(公告)日：2013-08-13
申请号：US13650739
申请日：2012-10-12
申请人： Idenix Pharmaceuticals, Inc.
发明人： Dominique Surleraux , Cyril B. Dousson , Christophe Claude Parsy
IPC分类号： A01N43/04 , A61K31/70 , C07H19/00
CPC分类号： A61K31/7076 , A61K31/7088 , A61K38/20 , A61K38/21 , A61K38/212 , A61K38/215 , A61K38/217 , A61K38/38 , C07H19/20 , C07H19/213
摘要： Provided herein are compounds, compositions and methods for the treatment of Flaviviridae infections, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents.
摘要翻译：本文提供了用于治疗黄病毒科感染（包括HCV感染）的化合物，组合物和方法。在某些实施方案中，公开了核苷衍生物的化合物和组合物，其可以单独施用或与其它抗病毒剂组合施用。

18. 发明授权

US08481748B2 Phosphinate ruthenium complexes 有权
公开(公告)号：US08481748B2
公开(公告)日：2013-07-09
申请号：US13765578
申请日：2013-02-12
申请人： Idenix Pharmaceuticals, Inc.
发明人： Christophe Claude Parsy , Francois-Rene Alexandre , Florence Marie-Emilie Bonnaterre , Dominique Surleraux
IPC分类号： C07F15/00
CPC分类号： C07D255/04 , B01J31/2278 , C07C67/30 , C07C67/333 , C07D207/22 , C07D207/46 , C07D487/04 , C07F9/3229 , C07F9/4419 , C07F9/4476 , C07F15/0046
摘要： Provided herein are ruthenium complexes of Formula I, and processes of preparation thereof. Also provided are methods of their use as a metathesis catalyst.

19. 发明申请

US20130149283A1 METHODS AND COMPOSITIONS FOR TREATING HEPATITIS C VIRUS 审中-公开
公开(公告)号：US20130149283A1
公开(公告)日：2013-06-13
申请号：US13730669
申请日：2012-12-28
申请人： IDENIX PHARMACEUTICALS, INC. , UNIVERSITA DEGLI STUDI DI CAGLIARI
发明人： Jean-Pierre Sommadossi , Paolo LaColla
IPC分类号： A61K31/708 , A61K31/7076 , A61K45/06 , A61K31/7072 , A61K31/7068 , C07H19/16 , C07H19/06
CPC分类号： A61K31/708 , A61K31/7056 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K38/21 , A61K45/06 , C07H19/04 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , G03C1/0051
摘要： A method and composition for treating a host infected with hepatitis C comprising administering an effective hepatitis C treatment amount of a described 1′, 2′ or 3′-modified nucleoside or a pharmaceutically acceptable salt or prodrug thereof, is provided.

20. 发明授权

US08410313B2 Phosphinate ruthenium complexes 有权
公开(公告)号：US08410313B2
公开(公告)日：2013-04-02
申请号：US13627828
申请日：2012-09-26
申请人： Idenix Pharmaceuticals, Inc.
发明人： Christophe Claude Parsy , Francois-Rene Alexandre , Florence Marie-Emilie Bonnaterre , Dominique Surleraux
IPC分类号： C07F9/32
CPC分类号： C07D255/04 , B01J31/2278 , C07C67/30 , C07C67/333 , C07D207/22 , C07D207/46 , C07D487/04 , C07F9/3229 , C07F9/4419 , C07F9/4476 , C07F15/0046
摘要： Provided herein are ruthenium complexes of Formula I, and processes of preparation thereof. Also provided are methods of their use as a metathesis catalyst.

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