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11. 发明授权

US09180282B2 Implantable drug delivery system having periodic drug delivery regimen to avoid granulomas 有权
标题翻译：具有定期药物递送方案的植入药物递送系统以避免肉芽肿
公开(公告)号：US09180282B2
公开(公告)日：2015-11-10
申请号：US12555257
申请日：2009-09-08
申请人： Steven C. Adler , Paul Burke
发明人： Steven C. Adler , Paul Burke
IPC分类号： A61K9/22 , A61M31/00 , A61M5/142
CPC分类号： A61M31/002 , A61M5/14276 , A61M2205/50
摘要： An implantable drug delivery system including: a biocompatible or bio-inert housing containing a drug infusion pump, a drug chamber from which a liquid drug is dispensed when the pump applies a force to the drug chamber, and an internal controller actuating the pump; a delivery catheter extending from the housing to one or more drug delivery treatment sites in a target tissue, wherein the catheter includes a lumen having an inlet to receive a drug pumped from the drug chamber and an outlet are positioned at the target tissue, wherein the drug flows through the outlet to the target tissue, and wherein the internal controller stores and executes an automatic periodic flow regimen which commands the pump and drug chamber to periodically dispense an intermittent bolus or pulse of the liquid drug, wherein the periodic flow regimen provides a prophylactic treatment for granuloma.
摘要翻译：一种可植入药物递送系统，包括：生物相容性或生物惰性的壳体，其包含药物输注泵，药物腔室，当泵向药物腔施加力时，液体药物被分配;以及驱动泵的内部控制器; 输送导管，其从所述壳体延伸到目标组织中的一个或多个药物递送处理部位，其中所述导管包括具有入口以接收从所述药物室泵出的药物的入口并且出口位于所述靶组织处，药物流过出口到目标组织，并且其中内部控制器存储并执行自动周期性流动方案，其命令泵和药物腔室周期性地分配液体药物的间歇推注或脉冲，其中周期性流动方案提供肉芽肿的预防性治疗

12. 发明申请

US20130023857A1 TWO WAY ACCUMULATOR PROGRAMMABLE VALVE PUMP 有权
标题翻译：两路蓄能器可编程阀门泵
公开(公告)号：US20130023857A1
公开(公告)日：2013-01-24
申请号：US13608583
申请日：2012-09-10
申请人： Paul F. Burke , Patrick O'Connor
发明人： Paul F. Burke , Patrick O'Connor
IPC分类号： A61M5/142
CPC分类号： G01F11/086 , A61M5/14276 , A61M5/14586 , A61M5/14593 , A61M5/16809 , A61M2005/14513
摘要： An improved implantable valve accumulator pump for the delivery of medication is disclosed. The implantable pump comprises a pressurized drug reservoir. The medication metering assembly comprises a fixed volume accumulator positioned between a pair of valves. The valves alternately open and close to admit medication from the reservoir into the accumulator and to dispense a precise volume pulse to an outlet catheter. In order to improve the pump's accuracy and to increase pumping volume while optimizing the pump's overall size and energy usage a two way diaphragm accumulator is used. The unit can be externally programmed or can be used in a fixed rate configuration that is never programmed but set at the factory or in the current programmable configuration.
摘要翻译：公开了一种用于输送药物的改进的可植入阀蓄能器泵。可植入泵包括加压药物储存器。药物计量组件包括位于一对阀之间的固定容积蓄积器。阀交替地打开和关闭，以将药物从储存器进入蓄能器并且将精确的体积脉冲分配给出口导管。为了提高泵的精度和增加泵送量，同时优化泵的总体尺寸和能量使用，使用双向隔膜蓄能器。该单元可以进行外部编程，也可以以固定速率配置使用，从未编程，但在出厂时或当前的可编程配置中设置。

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