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11. 发明申请

US20120262703A1 Measuring Volume and Constituents of Cells 有权
标题翻译：测量体积和细胞成分
公开(公告)号：US20120262703A1
公开(公告)日：2012-10-18
申请号：US13446996
申请日：2012-04-13
申请人： Michael Zahniser , Russell Zahniser
发明人： Michael Zahniser , Russell Zahniser
IPC分类号： G01N33/49
CPC分类号： G01N15/0227 , G01N15/1475 , G01N33/49 , G01N2015/0073 , G01N2015/1472 , G06K9/00127 , G06K9/0014 , G06T7/62 , G06T2207/10056 , G06T2207/30024
摘要： A method of determining a volume of a platelet includes: (a) illuminating the platelet with incident light at a plurality of illumination wavelengths; (b) obtaining at least one two-dimensional image of the platelet corresponding to each illumination wavelength; (c) for each illumination wavelength, determining a mean optical density and a maximum optical density for the platelet; (d) determining an area of the platelet; (e) for each illumination wavelength, determining a volume of the platelet; (f) for each illumination wavelength, determining an integrated optical density for the platelet; and (g) determining the volume of the platelet based on a weighted combination of the area of the platelet, the volumes of the platelet corresponding to each of the illumination wavelengths, and the integrated optical densities for the platelet corresponding to each of the illumination wavelengths.
摘要翻译：确定血小板体积的方法包括：（a）用多个照明波长的入射光照射血小板; （b）获得对应于每个照明波长的血小板的至少一个二维图像; （c）对于每个照明波长，确定血小板的平均光密度和最大光密度; （d）确定血小板的面积; （e）对于每个照明波长，确定血小板的体积; （f）对于每个照明波长，确定血小板的综合光密度; 和（g）基于血小板面积，对应于每个照明波长的血小板的体积和对应于每个照明波长的血小板的积分光密度的加权组合来确定血小板的体积。

12. 发明申请

US20130252279A1 FIXATIVE AND STAINING SOLUTIONS 审中-公开
标题翻译：固定和污染解决方案
公开(公告)号：US20130252279A1
公开(公告)日：2013-09-26
申请号：US13795444
申请日：2013-03-12
申请人： CONSTITUTION MEDICAL, INC.
发明人： Daniel Lapen , Kerri Licari
IPC分类号： G01N1/30
CPC分类号： G01N1/30 , Y10T436/10 , Y10T436/101666 , Y10T436/108331 , Y10T436/25
摘要： The formulations, systems, and methods disclosed herein permit automated preparation of specimens (e.g., biological specimens) for examination. The disclosed formulations, systems, and methods provide fast, efficient, and highly uniform specimen processing using minimal quantities of fluids. The methods include at least a fixing phase for fixing a specimen to a substrate such as a microscope slide, a staining phase for staining the specimen, and a rinsing phase for rinsing the specimen. One or more of the fixing, staining, and rinsing phases include one or more agitation phases for distributing reagents evenly and uniformly across the specimen. The systems can be implemented as a standalone device or as a component in a larger system for preparing and examining specimens.
摘要翻译：本文公开的制剂，系统和方法允许自动制备样品（例如，生物样品）用于检查。所公开的配方，系统和方法使用最少量的流体提供快速，有效和高度均匀的样品处理。该方法至少包括用于将样品固定到诸如显微镜载片的基底的固定阶段，用于染色样品的染色阶段和用于漂洗样品的漂洗阶段。固定，染色和漂洗阶段中的一个或多个包括一个或多个用于均匀均匀地分布试剂的搅拌相。这些系统可以作为独立设备或作为更大系统中用于准备和检查样品的组件来实现。

13. 发明申请

US20130196370A1 FIXATIVE AND STAINING SOLUTIONS 有权
公开(公告)号：US20130196370A1
公开(公告)日：2013-08-01
申请号：US13795536
申请日：2013-03-12
申请人： Constitution Medical, Inc.
发明人： Daniel Lapen , Kerri Licari
IPC分类号： G01N1/30
CPC分类号： G01N1/30 , Y10T436/10 , Y10T436/101666 , Y10T436/108331 , Y10T436/25
摘要： The formulations, systems, and methods disclosed herein permit automated preparation of specimens (e.g., biological specimens) for examination. The disclosed formulations, systems, and methods provide fast, efficient, and highly uniform specimen processing using minimal quantities of fluids. The methods include at least a fixing phase for fixing a specimen to a substrate such as a microscope slide, a staining phase for staining the specimen, and a rinsing phase for rinsing the specimen. One or more of the fixing, staining, and rinsing phases include one or more agitation phases for distributing reagents evenly and uniformly across the specimen. The systems can be implemented as a standalone device or as a component in a larger system for preparing and examining specimens.

14. 发明授权

US08477294B2 Measuring volume and constituents of cells 有权
标题翻译：测量细胞体积和成分
公开(公告)号：US08477294B2
公开(公告)日：2013-07-02
申请号：US13679664
申请日：2012-11-16
申请人： Constitution Medical, Inc.
发明人： Michael Zahniser , Russell Zahniser
IPC分类号： G01N33/48 , G06K9/00 , A61B5/00
CPC分类号： G01N15/0227 , G01N15/1475 , G01N33/49 , G01N2015/0073 , G01N2015/1472 , G06K9/00127 , G06K9/0014 , G06T7/62 , G06T2207/10056 , G06T2207/30024
摘要： A method of determining a volume of a platelet includes: (a) illuminating the platelet with incident light at a plurality of illumination wavelengths; (b) obtaining at least one two-dimensional image of the platelet corresponding to each illumination wavelength; (c) for each illumination wavelength, determining a mean optical density and a maximum optical density for the platelet; (d) determining an area of the platelet; (e) for each illumination wavelength, determining a volume of the platelet; (f) for each illumination wavelength, determining an integrated optical density for the platelet; and (g) determining the volume of the platelet based on a weighted combination of the area of the platelet, the volumes of the platelet corresponding to each of the illumination wavelengths, and the integrated optical densities for the platelet corresponding to each of the illumination wavelengths.
摘要翻译：确定血小板体积的方法包括：（a）用多个照明波长的入射光照射血小板; （b）获得对应于每个照明波长的血小板的至少一个二维图像; （c）对于每个照明波长，确定血小板的平均光密度和最大光密度; （d）确定血小板的面积; （e）对于每个照明波长，确定血小板的体积; （f）对于每个照明波长，确定血小板的综合光密度; 和（g）基于血小板面积，对应于每个照明波长的血小板的体积和对应于每个照明波长的血小板的积分光密度的加权组合来确定血小板的体积。

15. 发明授权

US08454908B2 Automated systems and methods for preparing biological specimens for examination 有权
公开(公告)号：US08454908B2
公开(公告)日：2013-06-04
申请号：US13293050
申请日：2011-11-09
申请人： Daniel Lapen , David Zahniser , Mark Licari , Brian J. McKeen , Eric D. Yeaton , Dennis Poole
发明人： Daniel Lapen , David Zahniser , Mark Licari , Brian J. McKeen , Eric D. Yeaton , Dennis Poole
IPC分类号： A61B10/00
CPC分类号： G01N1/312 , G01N1/30 , G01N35/00029 , G01N35/0099 , G01N2035/00079 , G01N2035/00138 , G01N2035/00524 , G01N2035/1037
摘要： The systems and methods disclosed herein permit automated preparation of biological specimens for examination. The disclosed systems and methods provide fast, efficient, and highly uniform specimen processing using minimal quantities of fluids. The methods include at least a fixing phase for fixing a biological specimen to a substrate such as a microscope slide, a staining phase for staining the specimen, and a rinsing phase for rinsing the specimen. One or more of the fixing, staining, and rinsing phases include one or more agitation cycles for distributing reagents evenly and uniformly across the specimen. The systems can be implemented as a standalone device or as a component in a larger system for preparing and examining biological specimens.

16. 发明申请

US20130024130A1 BLOOD ANALYZER CALIBRATION AND ASSESSMENT 有权
标题翻译：血液分析仪校准和评估
公开(公告)号：US20130024130A1
公开(公告)日：2013-01-24
申请号：US13549148
申请日：2012-07-13
申请人： Russell Zahniser
发明人： Russell Zahniser
IPC分类号： G01N33/49 , G06F19/00
CPC分类号： G01N15/14 , G06F19/00 , G16H40/63
摘要： Systems and methods for displaying measured values of a complete blood count (“CBC”) parameter include displaying the measured values of the CBC parameter obtained from a plurality of samples from a first lot of a quality control composition, where the displaying includes displaying a marker corresponding to each measured value from the first lot on a plot that includes a two dimensional coordinate system, and where the two dimensional coordinate system includes a first dimension corresponding to a time at which measured values of the CBC parameter were obtained, and a second dimension corresponding to a numerical value of the CBC parameter.
摘要翻译：用于显示完整血液计数（CBC）参数的测量值的系统和方法包括显示从质量控制组合物的第一批中获得的多个样本获得的CBC参数的测量值，其中显示包括显示对应于来自包括二维坐标系的绘图中的第一批次的每个测量值，并且其中二维坐标系包括对应于获得CBC参数的测量值的时间的第一尺寸，以及对应于 CBC参数的数值。

17. 发明申请

US20130019697A1 FLUID SAMPLE PREPARATION SYSTEMS AND METHODS 有权
公开(公告)号：US20130019697A1
公开(公告)日：2013-01-24
申请号：US13548773
申请日：2012-07-13
申请人： Brian J. McKeen , Eric D. Yeaton , James L. Dowling
发明人： Brian J. McKeen , Eric D. Yeaton , James L. Dowling
IPC分类号： G01N1/10
CPC分类号： G01N1/312 , G01N1/30 , G01N35/00029 , G01N35/0099 , G01N35/10 , G01N35/1004
摘要： Sample application systems can include an extraction mechanism to remove a sample from sample containers, a sample vessel disposed on a deployment mechanism, where the deployment mechanism is arranged to move the sample vessel to receive a sample, an extraction mechanism washing station to wash the extraction mechanism, a sample applicator to remove a portion of the sample in the sample vessel and apply it onto a sample carrier, where the deployment mechanism can move the sample vessel to a sample application position, a sample vessel washing station to wash the sample vessel, where the deployment mechanism can move the sample vessel to the sample vessel washing station, a sample applicator washing station to wash the sample applicator after the sample has been dispensed onto the sample carrier, and a fluid control system to control flow of a fluid provided to the extraction mechanism and the sample applicator.

18. 发明授权

US08345227B2 Measuring volume and constituents of cells 有权
标题翻译：测量细胞体积和成分
公开(公告)号：US08345227B2
公开(公告)日：2013-01-01
申请号：US13446967
申请日：2012-04-13
申请人： Michael Zahniser , Russell Zahniser
发明人： Michael Zahniser , Russell Zahniser
IPC分类号： G01N33/48 , G06K9/00 , A61B5/00
CPC分类号： G01N15/0227 , G01N15/1475 , G01N33/49 , G01N2015/0073 , G01N2015/1472 , G06K9/00127 , G06K9/0014 , G06T7/62 , G06T2207/10056 , G06T2207/30024
摘要： A method of determining a hemoglobin content value of a red blood cell includes: (a) illuminating the cell with incident light at a plurality of illumination wavelengths; (b) obtaining at least one two-dimensional image of the cell corresponding to each illumination wavelength; (c) for each illumination wavelength, determining a mean optical density and a maximum optical density for the cell; (d) determining an area of the cell; (e) for each illumination wavelength, determining a volume of the cell; (f) for each illumination wavelength, determining an integrated optical density for the cell; and (g) determining the hemoglobin content value of the cell based on the area of the cell, the volumes of the cell corresponding to each of the illumination wavelengths, and the integrated optical densities for the cell corresponding to each of the illumination wavelengths.
摘要翻译：确定红细胞血红蛋白含量值的方法包括：（a）以多个照明波长的入射光照射细胞; （b）获得与每个照明波长对应的所述单元的至少一个二维图像; （c）对于每个照明波长，确定细胞的平均光密度和最大光密度; （d）确定细胞的面积; （e）对于每个照明波长，确定所述单元的体积; （f）对于每个照明波长，确定单元的集成光密度; 和（g）基于单元的面积，对应于每个照明波长的单元的体积以及与每个照明波长对应的单元的积分光密度来确定单元的血红蛋白含量值。

19. 发明申请

US20130077085A1 Measuring Volume and Constituents of Cells 有权
标题翻译：测量体积和细胞成分
公开(公告)号：US20130077085A1
公开(公告)日：2013-03-28
申请号：US13679664
申请日：2012-11-16
申请人： Constitution Medical, Inc.
发明人： Michael Zahniser , Russell Zahniser
IPC分类号： G01N33/49
CPC分类号： G01N15/0227 , G01N15/1475 , G01N33/49 , G01N2015/0073 , G01N2015/1472 , G06K9/00127 , G06K9/0014 , G06T7/62 , G06T2207/10056 , G06T2207/30024
摘要： A method of determining a volume of a platelet includes: (a) illuminating the platelet with incident light at a plurality of illumination wavelengths; (b) obtaining at least one two-dimensional image of the platelet corresponding to each illumination wavelength; (c) for each illumination wavelength, determining a mean optical density and a maximum optical density for the platelet; (d) determining an area of the platelet; (e) for each illumination wavelength, determining a volume of the platelet; (f) for each illumination wavelength, determining an integrated optical density for the platelet; and (g) determining the volume of the platelet based on a weighted combination of the area of the platelet, the volumes of the platelet corresponding to each of the illumination wavelengths, and the integrated optical densities for the platelet corresponding to each of the illumination wavelengths.
摘要翻译：确定血小板体积的方法包括：（a）用多个照明波长的入射光照射血小板; （b）获得对应于每个照明波长的血小板的至少一个二维图像; （c）对于每个照明波长，确定血小板的平均光密度和最大光密度; （d）确定血小板的面积; （e）对于每个照明波长，确定血小板的体积; （f）对于每个照明波长，确定血小板的综合光密度; 和（g）基于血小板面积，对应于每个照明波长的血小板的体积和对应于每个照明波长的血小板的积分光密度的加权组合来确定血小板的体积。

20. 发明申请

US20130070077A1 Systems and Methods for Analyzing Body Fluids 有权
标题翻译：体液分析系统和方法
公开(公告)号：US20130070077A1
公开(公告)日：2013-03-21
申请号：US13619381
申请日：2012-09-14
申请人： James Winkelman , Milenko Tanasijevic , David Zahniser , James Linder
发明人： James Winkelman , Milenko Tanasijevic , David Zahniser , James Linder
IPC分类号： H04N7/18 , G06K9/00
CPC分类号： H04N7/18 , G01N1/2813 , G01N1/312 , G01N15/1475 , G01N35/00029 , G01N2015/0073 , G01N2015/008 , G01N2015/0084 , G01N2015/1006 , G06K9/00
摘要： Systems and methods analyzing body fluids contain cells including blood, bone marrow, urine, vaginal tissue, epithelial tissue, tumors, semen, and spittle are disclosed. The systems and methods utilize an improved technique for applying a monolayer of cells to a slide and generating a substantially uniform distribution of cells on the slide. Additionally aspects of the invention also relate to systems and method for utilizing multi-color microscopy for improving the quality of images captured by a light receiving device.
摘要翻译：公开了分析体液的系统和方法，其中包含血液，骨髓，尿液，阴道组织，上皮组织，肿瘤，精液和唾液等细胞。该系统和方法利用改进的技术将单层细胞施加到载玻片上并在载玻片上产生基本均匀的细胞分布。本发明的另外方面还涉及用于利用多色显微术来提高由光接收装置捕获的图像的质量的系统和方法。

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